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Select item 78988871.

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

Eva Moreno, Mathilda J.M. Toussaint, Saskia C. van Essen, Laura Bongiovanni, Elsbeth A. van Liere, Mirjam H. Koster, Ruixue Yuan, Jan M. van Deursen, Bart Westendorp, Alain de Bruin

Hepatology. 2021 Jan; 73(1): 303–317. Published online 2021 Feb 6. doi: 10.1002/hep.31259

PMCID:: PMC7898887

Abstract Article PDF–1.6M

Select item 58289932.

The polyploid state plays a tumor suppressive role in the liver

Shuyuan Zhang, Kejin Zhou, Xin Luo, Lin Li, Ho-Chou Tu, Alfica Sehgal, Liem Nguyen, Yu Zhang, Purva Gopal, Branden Tarlow, Daniel Siegwart, Hao Zhu

Dev Cell. Author manuscript; available in PMC 2019 Feb 26.

Published in final edited form as: Dev Cell. 2018 Feb 26; 44(4): 447–459.e5. Published online 2018 Feb 8. doi: 10.1016/j.devcel.2018.01.010

Correction in:: Dev Cell. 2018 Nov 5; 47(3): 390.

PMCID:: PMC5828993

Abstract Article PDF–3.2M

Select item 57706003.

Atypical E2Fs inhibit tumor angiogenesis

B G M W Weijts, B Westendorp, B T Hien, L M Martínez-López, M Zijp, I Thurlings, R E Thomas, S Schulte-Merker, W J Bakker, A de Bruin

Oncogene. 2018 Jan 11; 37(2): 271–276. Published online 2017 Sep 18. doi: 10.1038/onc.2017.336

PMCID:: PMC5770600

Abstract Article PDF–1.4M

Select item 53112514.

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer

I Thurlings, L M Martínez-López, B Westendorp, M Zijp, R Kuiper, P Tooten, L N Kent, G Leone, H J Vos, B Burgering, A de Bruin

Oncogene. 2017 Feb 9; 36(6): 829–839. Published online 2016 Jul 25. doi: 10.1038/onc.2016.251

PMCID:: PMC5311251

Abstract Article PDF–1.5M

Select item 49663215.

E2f8 mediates tumor suppression in postnatal liver development

Lindsey N. Kent, Jessica B. Rakijas, Shusil K. Pandit, Bart Westendorp, Hui-Zi Chen, Justin T. Huntington, Xing Tang, Sooin Bae, Arunima Srivastava, Shantibhusan Senapati, Christopher Koivisto, Chelsea K. Martin, Maria C. Cuitino, Miguel Perez, Julian M. Clouse, Veda Chokshi, Neelam Shinde, Raleigh Kladney, Daokun Sun, Antonio Perez-Castro, Ramadhan B. Matondo, Sathidpak Nantasanti, Michal Mokry, Kun Huang, Raghu Machiraju, Soledad Fernandez, Thomas J. Rosol, Vincenzo Coppola, Kamal S. Pohar, James M. Pipas, Carl R. Schmidt, Alain de Bruin, Gustavo Leone

J Clin Invest. 2016 Aug 1; 126(8): 2955–2969. Published online 2016 Jul 25. doi: 10.1172/JCI85506

PMCID:: PMC4966321

Abstract Article PDF–6.8M

Select item 46141106.

Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization

Qian-Rong Qi, Xu-Yu Zhao, Ru-Juan Zuo, Tong-Song Wang, Xiao-Wei Gu, Ji-Long Liu, Zeng-Ming Yang

Cell Cycle. 2015 Jun 15; 14(12): 1842–1858. Published online 2015 Apr 18. doi: 10.1080/15384101.2015.1033593

PMCID:: PMC4614110

Abstract Article PDF–2.4M

Select item 57661447.

Atypical E2f functions are critical for pancreas polyploidization

Ramadhan B. Matondo, Eva Moreno, Mathilda J. M. Toussaint, Peter C. J. Tooten, Saskia C. van Essen, Elsbeth A. van Liere, Sameh A. Youssef, Laura Bongiovanni, Alain de Bruin

PLoS One. 2018; 13(1): e0190899. Published online 2018 Jan 12. doi: 10.1371/journal.pone.0190899

PMCID:: PMC5766144

Abstract Article PDF–3.5M

Select item 33338928.

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

Bart Westendorp, Michal Mokry, Marian J.A. Groot Koerkamp, Frank C.P. Holstege, Edwin Cuppen, Alain de Bruin

Nucleic Acids Res. 2012 Apr; 40(8): 3511–3523. Published online 2011 Dec 16. doi: 10.1093/nar/gkr1203

PMCID:: PMC3333892

Abstract Article PDF–890K

Select item 12367229.

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription

Jesper Christensen, Paul Cloos, Ulla Toftegaard, David Klinkenberg, Adrian P. Bracken, Emmanuelle Trinh, Mel Heeran, Luisa Di Stefano, Kristian Helin

Nucleic Acids Res. 2005; 33(17): 5458–5470. Published online 2005 Sep 22. doi: 10.1093/nar/gki855

PMCID:: PMC1236722

Abstract Article PDF–806K

Select item 982615210.

Inhibition of polyploidization in Pten‐deficient livers reduces steatosis

Eva Moreno, Augustine B. Matondo, Laura Bongiovanni, Chris H. A. van de Lest, Martijn R. Molenaar, Mathilda J. M. Toussaint, Saskia C. van Essen, Martin Houweling, J. Bernd Helms, Bart Westendorp, Alain de Bruin

Liver Int. 2022 Nov; 42(11): 2442–2452. Published online 2022 Sep 2. doi: 10.1111/liv.15384

PMCID:: PMC9826152

Abstract Article PDF–3.8M

Select item 336236611.

Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia

Tinghui Hu, Seda Ghazaryan, Chandler Sy, Charles Wiedmeyer, Victor Chang, Lizhao Wu

Blood. 2012 May 10; 119(19): 4532–4542. Prepublished online 2012 Mar 14. doi: 10.1182/blood-2011-10-388231

PMCID:: PMC3362366

Abstract Article

Select item 654705912.

Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury

Patrick D. Wilkinson, Frances Alencastro, Evan R. Delgado, Madeleine P. Leek, Matthew P. Weirich, P. Anthony Otero, Nairita Roy, Whitney K. Brown, Michael Oertel, Andrew W. Duncan

Am J Pathol. 2019 Jun; 189(6): 1241–1255. doi: 10.1016/j.ajpath.2019.02.008

PMCID:: PMC6547059

Abstract Article PDF–2.7M

Select item 413556513.

Inactivation of Rb and E2f8 Synergizes To Trigger Stressed DNA Replication during Erythroid Terminal Differentiation

Seda Ghazaryan, Chandler Sy, Tinghui Hu, Xiuli An, Narla Mohandas, Haiqing Fu, Mirit I. Aladjem, Victor T. Chang, Rene Opavsky, Lizhao Wu

Mol Cell Biol. 2014 Aug; 34(15): 2833–2847. doi: 10.1128/MCB.01651-13

PMCID:: PMC4135565

Abstract Article PDF–5.6M

Select item 667364914.

Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation

Maria C. Cuitiño, Thierry Pécot, Daokun Sun, Raleigh Kladney, Takayuki Okano-Uchida, Neelam Shinde, Resham Saeed, Antonio J. Perez-Castro, Amy Webb, Tom Liu, Soo In Bae, Linda Clijsters, Nicholas Selner, Vincenzo Coppola, Cynthia Timmers, Michael C. Ostrowski, Michele Pagano, Gustavo Leone

Cell Rep. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Cell Rep. 2019 Jun 18; 27(12): 3547–3560.e5. Published online 2019 May 23. doi: 10.1016/j.celrep.2019.05.004

PMCID:: PMC6673649

Abstract Article PDF–3.3M

Select item 956856315.

Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation

Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui, Liu-Ya Tang, Cheryl Chia, Peter Zanvit, Zuojia Chen, Wenwen Jin, Dandan Wang, Junji Xu, Ousheng Liu, Fu Wang, Alexander Cain, Nancy Guo, Hiroko Nakatsukasa, Chuan Wu, Ying E. Zhang, Keji Zhao, WanJun Chen

Nat Commun. 2022; 13: 6069. Published online 2022 Oct 14. doi: 10.1038/s41467-022-33733-8

PMCID:: PMC9568563

Abstract Article PDF–1.8M

Select item 225367716.

Synergistic Function of E2F7 and E2F8 is Essential for Cell Survival and Embryonic Development

Jing Li, Cong Ran, Edward Li, Faye Gordon, Grant Comstock, Hasan Siddiqui, Whitney Cleghorn, Hui-zi Chen, Karl Kornacker, Shusil K. Pandit, Mehrbod Khanizadeh, Michael Weinstein, Gustavo Leone, Alain de Bruin

Dev Cell. Author manuscript; available in PMC 2009 Jan 15.

Published in final edited form as: Dev Cell. 2008 Jan; 14(1): 62–75. doi: 10.1016/j.devcel.2007.10.017

PMCID:: PMC2253677

Abstract Article PDF–2.8M

Select item 175990317.

Rb is critical in a mammalian tissue stem cell population

Pamela L. Wenzel, Lizhao Wu, Alain de Bruin, Jean-Leon Chong, Wen-Yi Chen, Geoffrey Dureska, Emily Sites, Tony Pan, Ashish Sharma, Kun Huang, Randall Ridgway, Kishore Mosaliganti, Richard Sharp, Raghu Machiraju, Joel Saltz, Hideyuki Yamamoto, James C. Cross, Michael L. Robinson, Gustavo Leone

Genes Dev. 2007 Jan 1; 21(1): 85–97. doi: 10.1101/gad.1485307

PMCID:: PMC1759903

Abstract Article PDF–1.7M

Select item 361648718.

Canonical and Atypical E2Fs Regulate the Mammalian Endocycle

Hui-Zi Chen, Madhu M. Ouseph, Jing Li, Thierry Pécot, Veda Chokshi, Lindsey Kent, Sooin Bae, Morgan Byrne, Camille Duran, Grant Comstock, Prashant Trikha, Markus Mair, Shantibhusan Senapati, Chelsea K. Martin, Sagar Gandhi, Nicholas Wilson, Bin Liu, Yi-Wen Huang, John C. Thompson, Sundaresan Raman, Shantanu Singh, Marcelo Leone, Raghu Machiraju, Kun Huang, Xiaokui Mo, Soledad Fernandez, Ilona Kalaszczynska, Debra J. Wolgemuth, Piotr Sicinski, Tim Huang, Victor Jin, Gustavo Leone

Nat Cell Biol. Author manuscript; available in PMC 2013 May 1.

Published in final edited form as: Nat Cell Biol. 2012 Nov; 14(11): 1192–1202. Published online 2012 Oct 14. doi: 10.1038/ncb2595

PMCID:: PMC3616487

Abstract Article PDF–3.6M

Select item 346384319.

E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1

Bart G M W Weijts, Walbert J Bakker, Peter W A Cornelissen, Kuo-Hsuan Liang, Frank H Schaftenaar, Bart Westendorp, Charlotte A C M T de Wolf, Maya Paciejewska, Colinda L G J Scheele, Lindsey Kent, Gustavo Leone, Stefan Schulte-Merker, Alain de Bruin

EMBO J. 2012 Oct 3; 31(19): 3871–3884. Published online 2012 Aug 17. doi: 10.1038/emboj.2012.231