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Items: 1 to 20 of 34

1.
IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models
Francesca Ferraro, Anja Steinle, Harini Narasimhan, Andreas Bleilevens, Paula-Marie Stolzenberg, Till Braunschweig, Elmar Stickeler, Jochen Maurer
Int J Mol Sci. 2023 Feb; 24(3): 2520. Published online 2023 Jan 28. doi: 10.3390/ijms24032520
PMCID:
PMC9917074
AbstractArticlePDF–2.8M
2.
IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes
Hao Zhou, Han Wang, Minjia Yu, Rebecca C. Schugar, Wen Qian, Fangqiang Tang, Weiwei Liu, Hui Yang, Ruth E. McDowell, Junjie Zhao, Ji Gao, Ashok Dongre, Julie A. Carman, Mei Yin, Judith A. Drazba, Robert Dent, Christopher Hine, Yeong-Renn Chen, Jonathan D. Smith, Paul L. Fox, J. Mark Brown, Xiaoxia Li
Nat Immunol. Author manuscript; available in PMC 2021 Feb 10.
Published in final edited form as: Nat Immunol. 2020 Oct; 21(10): 1219–1231. Published online 2020 Aug 10. doi: 10.1038/s41590-020-0750-1
PMCID:
PMC7566776
AbstractArticlePDF–6.5M
3.
IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs
Hao Zhou, Katarzyna Bulek, Xiao Li, Tomasz Herjan, Minjia Yu, Wen Qian, Han Wang, Gao Zhou, Xing Chen, Hui Yang, Lingzi Hong, Junjie Zhao, Luke Qin, Koichi Fukuda, Annette Flotho, Ji Gao, Ashok Dongre, Julie A Carman, Zizhen Kang, Bing Su, Timothy S Kern, Jonathan D Smith, Thomas A Hamilton, Frauke Melchior, Paul L Fox, Xiaoxia Li
eLife. 2017; 6: e29630. Published online 2017 Oct 9. doi: 10.7554/eLife.29630
PMCID:
PMC5675595
AbstractArticlePDF–5.9M
4.
The Kinase Activity of Interleukin-1 Receptor–Associated Kinase 2 Is Essential for Lipopolysaccharide-Mediated Cytokine and Chemokine mRNA Stability and Translation
Weiguo Yin, Youzhong Wan, Tae Whan Kim, Peng Yao, Hui Xiao, Hao Zhou, Jianhua Xiao, Paul Fox, Xiaoxia Li
J Interferon Cytokine Res. 2011 May; 31(5): 415–422. doi: 10.1089/jir.2010.0094
PMCID:
PMC3083721
AbstractArticlePDF–433K
5.
A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice
James R. Conner, Irina I. Smirnova, Alexander Poltorak
J Exp Med. 2009 Jul 6; 206(7): 1615–1631. doi: 10.1084/jem.20090490
PMCID:
PMC2715079
AbstractArticlePDF–7.4M
6.
Interleukin-1 Receptor-associated Kinase 2 Is Critical for Lipopolysaccharide-mediated Post-transcriptional Control
Youzhong Wan, Hui Xiao, Jeremy Affolter, Tae Whan Kim, Katarzyna Bulek, Sujan Chaudhuri, Deborah Carlson, Thomas Hamilton, Barsanjit Mazumder, George R. Stark, James Thomas, Xiaoxia Li
J Biol Chem. 2009 Apr 17; 284(16): 10367–10375. doi: 10.1074/jbc.M807822200
PMCID:
PMC2667724
AbstractArticlePDF–703K
7.
Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
Meng-Yuan Jiang, Wan-Rong Man, Xue-Bin Zhang, Xiao-Hua Zhang, Yu Duan, Jie Lin, Yan Zhang, Yang Cao, De-Xi Wu, Xiao-Fei Shu, Lei Xin, Hao Wang, Xiao Zhang, Cong-Ye Li, Xiao-Ming Gu, Xuan Zhang, Dong-Dong Sun
Mil Med Res. 2023; 10: 63. Published online 2023 Dec 11. doi: 10.1186/s40779-023-00493-5
PMCID:
PMC10712050
AbstractArticlePDF–13M
8.
Interleukin-1 Receptor-Associated Kinase 2- and Protein Kinase D1-Dependent Regulation of IRAK-Monocyte Expression by CpG DNA
Young-In Kim, Jeoung-Eun Park, Ki Han Kwon, Cheol Yi Hong, Ae-Kyung Yi
PLoS One. 2012; 7(8): e43970. Published online 2012 Aug 23. doi: 10.1371/journal.pone.0043970
PMCID:
PMC3426515
AbstractArticlePDF–727K
9.
IRAK-2 Regulates IL-1-Mediated Pathogenic Th17 Cell Development in Helminthic Infection
Patrick M. Smith, Berri Jacque, James R. Conner, Alexander Poltorak, Miguel J. Stadecker
PLoS Pathog. 2011 Oct; 7(10): e1002272. Published online 2011 Oct 6. doi: 10.1371/journal.ppat.1002272
PMCID:
PMC3188523
AbstractArticlePDF–1.2M
10.
lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p
Ting Xiao, Chuihua Sun, Ying Xiao, Yunbao Li
Biol Open. 2020 Jun 15; 9(6): bio049353. Published online 2020 Jun 24. doi: 10.1242/bio.049353
PMCID:
PMC7327994
AbstractArticlePDF–2.0M
11.
Comprehensive siRNA-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use
Jing Sun, Ning Li, Kyu-Seon Oh, Bhaskar Dutta, Sharat J. Vayttaden, Bin Lin, Thomas S. Ebert, Dominic De Nardo, Joie Davis, Rustam Bagirzadeh, Nicolas W. Lounsbury, Chandrashekhar Pasare, Eicke Latz, Veit Hornung, Iain D. C. Fraser
Sci Signal. Author manuscript; available in PMC 2017 Apr 5.
Published in final edited form as: Sci Signal. 2016 Jan 5; 9(409): ra3. Published online 2016 Jan 5. doi: 10.1126/scisignal.aab2191
PMCID:
PMC5381726
AbstractArticlePDF–1.5M
12.
Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice
Eduardo Pauls, Sambit K. Nanda, Hilary Smith, Rachel Toth, J. Simon C. Arthur, Philip Cohen
J Immunol. Author manuscript; available in PMC 2014 Mar 1.
Published in final edited form as: J Immunol. 2013 Sep 1; 191(5): 10.4049/jimmunol.1203268. Published online 2013 Aug 5. doi: 10.4049/jimmunol.1203268
Correction in:
volume 191 on page 5317
PMCID:
PMC3849919
AbstractArticlePDF–9.5M
13.
The dual functions of IRAK2 in TLR9–mediated interferon and proinflammatory cytokine production
Youzhong Wan, Tae Whan Kim, Michifumi Yamashita, Zizhen Kang, Hao Zhou, Weiguo Yin, James Thomas, Ganes C. Sen, George R. Stark, Xiaoxia Li
J Immunol. Author manuscript; available in PMC 2012 Mar 1.
Published in final edited form as: J Immunol. 2011 Mar 1; 186(5): 3006–3014. Published online 2011 Jan 26. doi: 10.4049/jimmunol.1003217
PMCID:
PMC3163905
AbstractArticlePDF–715K
14.
Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1
James R. Conner, Irina I. Smirnova, Alexander Poltorak
J Exp Med. 2008 Feb 18; 205(2): 305–314. doi: 10.1084/jem.20071499
PMCID:
PMC2271017
AbstractArticlePDF–2.6M
15.
An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-Like Receptor Signaling
Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M. Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A. Carr, Aviv Regev, Nir Hacohen, Nicolas Chevrier
Cell Rep. Author manuscript; available in PMC 2017 Aug 10.
Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2853–2866. doi: 10.1016/j.celrep.2017.06.016
PMCID:
PMC5551420
AbstractArticlePDF–4.1M
16.
Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling
Samir Benosman, Palaniyandi Ravanan, Ricardo G. Correa, Ying-Chen Hou, Minjia Yu, Muhammet Fatih Gulen, Xiaoxia Li, James Thomas, Michael Cuddy, Yasuko Matsuzawa, Renata Sano, Paul Diaz, Shu-ichi Matsuzawa, John C. Reed
PLoS One. 2013; 8(5): e64256. Published online 2013 May 28. doi: 10.1371/journal.pone.0064256
PMCID:
PMC3665826
AbstractArticlePDF–1.7M
17.
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins
Sirish K. Ippagunta, Julie A. Pollock, Naina Sharma, Wenwei Lin, Taosheng Chen, Kazuki Tawaratsumida, Anthony A. High, Jaeki Min, Yizhe Chen, R. Kiplin Guy, Vanessa Redecke, John A. Katzenellenbogen, Hans Häcker
Sci Signal. Author manuscript; available in PMC 2020 May 2.
Published in final edited form as: Sci Signal. 2018 Aug 14; 11(543): eaaq1077. Published online 2018 Aug 14. doi: 10.1126/scisignal.aaq1077
PMCID:
PMC7195875
AbstractArticlePDF–1.7M
18.
The Tumor Necrosis Family Member 4-1BBL Sustains Inflammation by Interacting with Mediators of Toll-Like Receptor Signaling
Jianhui Ma, Bo-Ram Bang, Jiawei Lu, So-Young Eun, Motoyuki Otsuka, Michael Croft, Peter Tobias, Jiahuai Han, Osamu Takeuchi, Shizuo Akira, Michael Karin, Hideo Yagita, Young Jun Kang
Sci Signal. Author manuscript; available in PMC 2014 Apr 29.
Published in final edited form as: Sci Signal. 2013 Oct 1; 6(295): ra87. Published online 2013 Oct 1. doi: 10.1126/scisignal.2004431
PMCID:
PMC4004444
AbstractArticlePDF–1.4M
19.
Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans
John C. Reed, Kutbuddin Doctor, Ana Rojas, Juan M. Zapata, Christian Stehlik, Loredana Fiorentino, Jason Damiano, Wilfried Roth, Shu-ichi Matsuzawa, Ruchi Newman, Shinichi Takayama, Hiroyuki Marusawa, Famming Xu, Guy Salvesen, RIKEN GER Group, GSL Members, Adam Godzik
Genome Res. 2003 Jun; 13(6b): 1376–1388. doi: 10.1101/gr.1053803
PMCID:
PMC403667
AbstractArticlePDF–157K
20.
Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks
Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian, Michelle Letarte
Mol Cell Proteomics. 2014 Feb; 13(2): 489–502. Published online 2013 Dec 7. doi: 10.1074/mcp.M113.033464
PMCID:
PMC3916649
AbstractArticlePDF–4.1M

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