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Items: 20

1.
Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma
Mingzhi Han, Shuai Wang, Ning Yang, Xu Wang, Wenbo Zhao, Halala Sdik Saed, Thomas Daubon, Bin Huang, Anjing Chen, Gang Li, Hrvoje Miletic, Frits Thorsen, Rolf Bjerkvig, Xingang Li, Jian Wang
EMBO Mol Med. 2020 Jan 9; 12(1): e10924. Published online 2019 Nov 28. doi: 10.15252/emmm.201910924
PMCID:
PMC6949512
AbstractArticlePDF–4.1M
2.
In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds
Natalia Mast, Kyle W. Anderson, Kevin M. Johnson, Thanh T. N. Phan, F. Peter Guengerich, Irina A. Pikuleva
J Biol Chem. 2017 Aug 4; 292(31): 12934–12946. Published online 2017 Jun 22. doi: 10.1074/jbc.M117.794909
PMCID:
PMC5546033
AbstractArticlePDF–2.9M
3.
Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1
Natalia Mast, Wenchao Zheng, C. David Stout, Irina A. Pikuleva
Mol Pharmacol. 2013 Jul; 84(1): 86–94. Published online 2013 Jul. doi: 10.1124/mol.113.085902
PMCID:
PMC3684827
AbstractArticlePDF–1.1M
4.
Role of cholesterol 24S-hydroxylase gene polymorphism (rs754203) in primary open angle glaucoma
Georg Mossböck, Martin Weger, Christoph Faschinger, Otto Schmut, Wilfried Renner, Andreas Wedrich, Christina Zimmermann, Yosuf El-Shabrawi
Mol Vis. 2011; 17: 616–620. Published online 2011 Feb 26.
PMCID:
PMC3049739
AbstractArticlePDF–693K
5.
Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis
Afroditi Tsitsou-Kampeli, Stefano Suzzi, Mor Kenigsbuch, Akisawa Satomi, Romano Strobelt, Oded Singer, Ester Feldmesser, Maitreyee Purnapatre, Sarah Phoebeluc Colaiuta, Eyal David, Liora Cahalon, Oliver Hahn, Tony Wyss-Coray, Yosef Shaul, Ido Amit, Michal Schwartz
Cell Rep Med. 2023 Nov 21; 4(11): 101278. Published online 2023 Nov 8. doi: 10.1016/j.xcrm.2023.101278
PMCID:
PMC10694665
AbstractArticlePDF–6.4M
6.
Polymorphism of CYP46A1 and PPARγ2 Genes in Risk Prediction of Primary Open Angle Glaucoma Among North Indian Population
Anu Chandra, Shania Abbas, Syed Tasleem Raza, Luxmi Singh, Saliha Rizvi, Farzana Mahdi
Middle East Afr J Ophthalmol. 2016 Apr-Jun; 23(2): 172–176. doi: 10.4103/0974-9233.171772
PMCID:
PMC4845614
AbstractArticle
7.
Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1
Sandeep Goyal, Yi Xiao, Ned A. Porter, Libin Xu, F. Peter Guengerich
J Lipid Res. 2014 Sep; 55(9): 1933–1943. doi: 10.1194/jlr.M051508
Correction in:
J Lipid Res. 2015 Nov; 56(11): 2226.
PMCID:
PMC4617353
AbstractArticlePDF–663K
8.
Quantification of Cholesterol-Metabolizing P450s CYP27A1 and CYP46A1 in Neural Tissues Reveals a Lack of Enzyme-Product Correlations in Human Retina but not Human Brain
Wei-Li Liao, Gun-Young Heo, Nathan G. Dodder, Rachel E. Reem, Natalia Mast, Suber Huang, Pier Luigi DiPatre, Illarion V. Turko, Irina A. Pikuleva
J Proteome Res. Author manuscript; available in PMC 2012 Jan 7.
Published in final edited form as: J Proteome Res. 2011 Jan 7; 10(1): 241–248. Published online 2010 Nov 16. doi: 10.1021/pr1008898
PMCID:
PMC3064498
AbstractArticlePDF–414K
9.
Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain
Natalia Mast, Casey Charvet, Irina A. Pikuleva, C. David Stout
J Biol Chem. 2010 Oct 8; 285(41): 31783–31795. Published online 2010 Jul 28. doi: 10.1074/jbc.M110.143313
PMCID:
PMC2951250
AbstractArticlePDF–2.4M
10.
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase
Natalia Mast, Wei-Li Liao, Irina A. Pikuleva, Illarion V. Turko
Arch Biochem Biophys. Author manuscript; available in PMC 2010 Mar 1.
Published in final edited form as: Arch Biochem Biophys. 2009 Mar 1; 483(1): 81–89. Published online 2009 Jan 10. doi: 10.1016/j.abb.2009.01.002
PMCID:
PMC2644731
AbstractArticlePDF–1003K
11.
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain
Natalia Mast, Mark Andrew White, Ingemar Bjorkhem, Eric F. Johnson, C. David Stout, Irina A. Pikuleva
Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28): 9546–9551. Published online 2008 Jul 9. doi: 10.1073/pnas.0803717105
PMCID:
PMC2474539
AbstractArticlePDF–923K
12.
Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1: UNUSUAL FEATURES AND SPECTRAL RESPONSE
Natalia Mast, Wenchao Zheng, C. David Stout, Irina A. Pikuleva
J Biol Chem. 2013 Feb 15; 288(7): 4613–4624. Published online 2013 Jan 3. doi: 10.1074/jbc.M112.438754
PMCID:
PMC3576067
AbstractArticlePDF–4.5M
13.
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
Erik G. Lund, Joseph M. Guileyardo, David W. Russell
Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13): 7238–7243. doi: 10.1073/pnas.96.13.7238
PMCID:
PMC22064
AbstractArticlePDF–523K
14.
A Pilot Study of Gene/Gene and Gene/Environment Interactions in Alzheimer Disease
Nader Ghebranious, Bickol Mukesh, Philip F. Giampietro, Ingrid Glurich, Susan F. Mickel, Stephen C. Waring, Catherine A. McCarty
Clin Med Res. 2011 Mar; 9(1): 17–25. doi: 10.3121/cmr.2010.894
PMCID:
PMC3064752
AbstractArticlePDF–207K
15.
Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease
Guilian Tian, Qiongman Kong, Liching Lai, Abhik Ray-Chaudhury, Chien-liang Glenn Lin
J Neurochem. Author manuscript; available in PMC 2011 May 1.
Published in final edited form as: J Neurochem. 2010 May; 113(4): 978–989. Published online 2010 Feb 27. doi: 10.1111/j.1471-4159.2010.06661.x
PMCID:
PMC3010752
AbstractArticlePDF–1.2M
16.
Association between the SERPING1 gene and age-related macular degeneration: a two-stage case–control study
Sarah Ennis, Catherine Jomary, Robert Mullins, Angela Cree, Xiaoli Chen, Alex MacLeod, Stephen Jones, Prof Andrew Collins, Prof Edwin Stone, Prof Andrew Lotery
Lancet. Author manuscript; available in PMC 2018 Jun 1.
Published in final edited form as: Lancet. 2008 Nov 22; 372(9652): 1828–1834. Published online 2008 Oct 6. doi: 10.1016/S0140-6736(08)61348-3
PMCID:
PMC5983350
AbstractArticlePDF–675K
17.
Phospho-tyrosine dependent protein–protein interaction network
Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl
Mol Syst Biol. 2015 Mar; 11(3): 0794. Published online 2015 Mar 26. doi: 10.15252/msb.20145968
PMCID:
PMC4380928
AbstractArticlePDF–1.9M
18.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
19.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Mammalian Gene Collection (MGC) Program Team
Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899
PMCID:
PMC139241
AbstractArticlePDF–118K
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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