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Items: 1 to 20 of 65

1.
POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase
Yanmei Peng, Wenbo Zheng, Yuehong Chen, Xuetao Lei, Zhijing Yang, Yuxuan Yang, Weiqi Liang, Kai Sun, Guoxin Li, Jiang Yu
Cell Death Dis. 2024 Apr; 15(4): 248. Published online 2024 Apr 4. doi: 10.1038/s41419-024-06618-5
PMCID:
PMC10995193
ArticlePDF–15M
2.
DNA polymerase θ promotes CAG•CTG repeat expansions in Huntington’s disease via insertion sequences of its catalytic domain
Kara Y. Chan, Xueying Li, Janice Ortega, Liya Gu, Guo-Min Li
J Biol Chem. 2021 Oct; 297(4): 101144. Published online 2021 Aug 30. doi: 10.1016/j.jbc.2021.101144
PMCID:
PMC8463855
ArticlePDF–1.9M
3.
Human DNA polymerase θ harbors a DNA end-trimming activity critical for DNA repair
Karl E. Zahn, Ryan B. Jensen, Richard D. Wood, Sylvie Doublié
Mol Cell. Author manuscript; available in PMC 2022 Apr 1.
Published in final edited form as: Mol Cell. 2021 Apr 1; 81(7): 1534–1547.e4. Published online 2021 Feb 11. doi: 10.1016/j.molcel.2021.01.021
Retraction in:
Mol Cell. 2024 Apr 18; 84(8): 1626.
PMCID:
PMC8231307
Article
4.
A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors
Jia Zhou, Camille Gelot, Constantia Pantelidou, Adam Li, Hatice Yücel, Rachel E. Davis, Anniina Farkkila, Bose Kochupurakkal, Aleem Syed, Geoffrey I. Shapiro, John A. Tainer, Brian S. J. Blagg, Raphael Ceccaldi, Alan D. D’Andrea
Nat Cancer. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Nat Cancer. 2021 Jun; 2(6): 598–610. Published online 2021 Jun 17. doi: 10.1038/s43018-021-00203-x
PMCID:
PMC8224818
ArticlePDF–5.0M
5.
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
Nat Commun. 2021; 12: 3636. Published online 2021 Jun 17. doi: 10.1038/s41467-021-23463-8
PMCID:
PMC8211653
ArticlePDF–31M
6.
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair
Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba A. Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M. Stark, Xiaojiang S. Chen, Richard T. Pomerantz
Sci Adv. 2021 Jun; 7(24): eabf1771. Published online 2021 Jun 11. doi: 10.1126/sciadv.abf1771
PMCID:
PMC8195485
ArticlePDF–1.7M
7.
POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks
Luther Davis, Kevin J. Khoo, Yinbo Zhang, Nancy Maizels
Proc Natl Acad Sci U S A. 2020 Sep 15; 117(37): 22900–22909. Published online 2020 Sep 1. doi: 10.1073/pnas.2008073117
PMCID:
PMC7502765
ArticlePDF–1.4M
8.
DNA Polymerase theta (Polθ) – an error-prone polymerase necessary for genome stability
Alessandra Brambati, Raymond Barry, Agnel Sfeir
Curr Opin Genet Dev. Author manuscript; available in PMC 2021 Apr 14.
Published in final edited form as: Curr Opin Genet Dev. 2020 Feb; 60: 119–126. Published online 2020 Apr 14. doi: 10.1016/j.gde.2020.02.017
PMCID:
PMC7230004
ArticlePDF–1005K
9.
Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells
Jung-Hoon Yoon, Robert E. Johnson, Louise Prakash, Satya Prakash
J Biol Chem. 2020 May 1; 295(18): 5918–5927. Published online 2020 Mar 13. doi: 10.1074/jbc.RA120.012816
PMCID:
PMC7196657
ArticlePDF–1.5M
10.
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
Samuel J. Black, Ahmet Y. Ozdemir, Ekaterina Kashkina, Tatiana Kent, Timur Rusanov, Dejan Ristic, Yeonoh Shin, Antonio Suma, Trung Hoang, Gurushankar Chandramouly, Labiba A. Siddique, Nikita Borisonnik, Katherine Sullivan-Reed, Joseph S. Mallon, Tomasz Skorski, Vincenzo Carnevale, Katsuhiko S. Murakami, Claire Wyman, Richard T. Pomerantz
Nat Commun. 2019; 10: 4423. Published online 2019 Sep 27. doi: 10.1038/s41467-019-12272-9
Correction in:
Nat Commun. 2020; 11: 1831.
PMCID:
PMC6764996
ArticlePDF–4.3M
11.
One-step enzymatic modification of RNA 3′ termini using polymerase θ
Crystal Thomas, Timur Rusanov, Trung Hoang, Taurai Augustin, Tatiana Kent, Imre Gaspar, Richard T Pomerantz
Nucleic Acids Res. 2019 Apr 23; 47(7): 3272–3283. Published online 2019 Mar 1. doi: 10.1093/nar/gkz029
PMCID:
PMC6468238
ArticlePDF–8.0M
12.
DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse
Zi Wang, Yadong Song, Shibo Li, Sunil Kurian, Rong Xiang, Takuya Chiba, Xiaohua Wu
J Biol Chem. 2019 Mar 15; 294(11): 3909–3919. Published online 2019 Jan 17. doi: 10.1074/jbc.RA118.005188
PMCID:
PMC6422074
ArticlePDF–2.1M
13.
DNA polymerase θ accomplishes translesion synthesis opposite 1,N6-ethenodeoxyadenosine with a remarkably high fidelity in human cells
Jung-Hoon Yoon, Robert E. Johnson, Louise Prakash, Satya Prakash
Genes Dev. 2019 Mar 1; 33(5-6): 282–287. doi: 10.1101/gad.320531.118
Correction in:
Genes Dev. 2020 Jan 1; 34(1-2): 146.
PMCID:
PMC6411006
ArticlePDF–265K
14.
DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA
Simon Wisnovsky, Tanja Sack, David J. Pagliarini, Rebecca R. Laposa, Shana O. Kelley
ACS Chem Biol. 2018 Apr 20; 13(4): 900–908. Published online 2018 Mar 6. doi: 10.1021/acschembio.8b00072
PMCID:
PMC5914477
ArticlePDF–2.9M
15.
In Vitro Bypass of Thymidine Glycol by DNA Polymerase Theta Forms Sequence-Dependent Frameshift Mutations
Daniel J. Laverty, Marc M. Greenberg
Biochemistry. Author manuscript; available in PMC 2018 Dec 26.
Published in final edited form as: Biochemistry. 2017 Dec 26; 56(51): 6726–6733. Published online 2017 Dec 15. doi: 10.1021/acs.biochem.7b01093
PMCID:
PMC5743609
ArticlePDF–531K
16.
Expression and Structural Analyses of Human DNA polymerase θ (POLQ)
Andrew W. Malaby, Sara K. Martin, Richard D. Wood, Sylvie Doublié
Methods Enzymol. Author manuscript; available in PMC 2017 Oct 2.
Published in final edited form as: Methods Enzymol. 2017; 592: 103–121. Published online 2017 May 24. doi: 10.1016/bs.mie.2017.03.026
PMCID:
PMC5624038
ArticlePDF–1.5M
17.
Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival
Chun-Hua Dai, Ping Chen, Jian Li, Tin Lan, Yong-Chang Chen, Hai Qian, Kang Chen, Mei-Yu Li
Oncotarget. 2016 Oct 4; 7(40): 65157–65170. Published online 2016 Aug 11. doi: 10.18632/oncotarget.11214
PMCID:
PMC5323145
ArticlePDF–4.0M
18.
DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides
Tatiana Kent, Timur D. Rusanov, Trung M. Hoang, Willem A. Velema, Andrew T. Krueger, William C. Copeland, Eric T. Kool, Richard T. Pomerantz
Nucleic Acids Res. 2016 Nov 2; 44(19): 9381–9392. Published online 2016 Sep 2. doi: 10.1093/nar/gkw721
PMCID:
PMC5100566
ArticlePDF–2.1M
19.
Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites
Leila Family, Jeannette T. Bensen, Melissa A. Troester, Michael C. Wu, Carey K. Anders, Andrew F. Olshan
Breast Cancer Res Treat. Author manuscript; available in PMC 2015 Jul 10.
Published in final edited form as: Breast Cancer Res Treat. 2015 Jan; 149(1): 181–190. Published online 2014 Nov 23. doi: 10.1007/s10549-014-3203-4
PMCID:
PMC4498665
ArticlePDF–404K
20.
Human DNA polymerase ? grasps the primer terminus to mediate DNA repair
Karl E. Zahn, April M. Averill, Pierre Aller, Richard D. Wood, Sylvie Doublié
Nat Struct Mol Biol. Author manuscript; available in PMC 2015 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2015 Apr; 22(4): 304–311. Published online 2015 Mar 16. doi: 10.1038/nsmb.2993
PMCID:
PMC4385486
ArticlePDF–3.0M

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