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Select item 109256481.

Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant

Yan Wang, Chao Yang, Jun Wen, Lingling Ju, Zhengyun Ren, Tongtong Zhang, Yanjun Liu

Front Endocrinol (Lausanne) 2024; 15: 1334342. Published online 2024 Feb 26. doi: 10.3389/fendo.2024.1334342

PMCID:: PMC10925648

Abstract Article PDF–781K

Select item 109146262.

CaMKK2 as an emerging treatment target for bipolar disorder

Jacqueline Kaiser, Kevin Nay, Christopher R. Horne, Luke M. McAloon, Oliver K. Fuller, Abbey G. Muller, Douglas G. Whyte, Anthony R. Means, Ken Walder, Michael Berk, Anthony J. Hannan, James M. Murphy, Mark A. Febbraio, Andrew L. Gundlach, John W. Scott

Mol Psychiatry. 2023; 28(11): 4500–4511. Published online 2023 Sep 20. doi: 10.1038/s41380-023-02260-3

PMCID:: PMC10914626

Abstract Article PDF–1.2M

Select item 104721103.

Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis

Debarati Mukherjee, Rebecca A. Previs, Corinne Haines, Muthana Al Abo, Patrick K. Juras, Kyle C. Strickland, Binita Chakraborty, Sandeep Artham, Regina S. Whitaker, Katherine Hebert, Jake Fontenot, Steven R. Patierno, Jennifer A. Freedman, Frank H. Lau, Matthew E. Burow, Ching-Yi Chang, Donald P. McDonnell

Cancer Res. 2023 Sep 1; 83(17): 2889–2907. Published online 2023 Jun 19. doi: 10.1158/0008-5472.CAN-22-1622

PMCID:: PMC10472110

Abstract Article PDF–19M

Select item 99879984.

The role of CaMKK2 in Golgi-associated vesicle trafficking

Grace Kennedy, Olivia Gibson, Dáire T. O'Hare, Ian G. Mills, Emma Evergren

Biochem Soc Trans. 2023 Feb 27; 51(1): 331–342. Published online 2023 Feb 23. doi: 10.1042/BST20220833

PMCID:: PMC9987998

Abstract Article PDF–2.3M

Select item 98442535.

Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ

Fan Wu, Kayla Hill, Qiaojun Fang, Zuhong He, Hongwei Zheng, Xianren Wang, Hao Xiong, Su-Hua Sha

Cell Mol Life Sci. 2022 May; 79(5): 249. Published online 2022 Apr 19. doi: 10.1007/s00018-022-04268-4

PMCID:: PMC9844253

Abstract Article PDF–5.4M

Select item 96179496.

Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma

William H. Tomaszewski, Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, Mustafa Khasraw, David M. Ashley, Peter E. Fecci, Luigi Racioppi, Luis Sanchez-Perez, Michael D. Gunn, John H. Sampson

Nat Commun. 2022; 13: 6483. Published online 2022 Oct 29. doi: 10.1038/s41467-022-34175-y

PMCID:: PMC9617949

Abstract Article PDF–8.1M

Select item 86993607.

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid

Faten Merhi, Karla Alvarez-Valadez, Jenifer Trepiana, Claire Lescoat, Alexis Groppi, Jean-William Dupuy, Pierre Soubeyran, Guido Kroemer, Pierre Vacher, Mojgan Djavaheri-Mergny

Cells. 2021 Dec; 10(12): 3364. Published online 2021 Nov 30. doi: 10.3390/cells10123364

PMCID:: PMC8699360

Abstract Article PDF–3.2M

Select item 85607708.

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation

Lorna M. Stewart, Lisa Gerner, Mandy Rettel, Frank Stein, James F. Burrows, Ian G. Mills, Emma Evergren

Cell Death Dis. 2021 Nov; 12(11): 1040. Published online 2021 Nov 1. doi: 10.1038/s41419-021-04335-x

PMCID:: PMC8560770

Abstract Article PDF–4.7M

Select item 75592249.

Effects of Single-Nucleotide Polymorphisms in Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2): A Comprehensive Study

Zoya Khalid, Omar Almaghrabi

Comput Math Methods Med. 2020; 2020: 7419512. Published online 2020 Oct 6. doi: 10.1155/2020/7419512

PMCID:: PMC7559224

Abstract Article PDF–2.2M

Select item 686731810.

Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex

Ping Yu, Xiongying Chen, Wan Zhao, Zhifang Zhang, Qiumei Zhang, Bingqian Han, Jinguo Zhai, Min Chen, Boqi Du, Xiaoxiang Deng, Feng Ji, Chuanyue Wang, Yu‐Tao Xiang, Dawei Li, Hongjie Wu, Jun Li, Qi Dong, Chuansheng Chen

Hum Brain Mapp. 2016 Jul; 37(7): 2398–2406. Published online 2016 Mar 23. doi: 10.1002/hbm.23181

PMCID:: PMC6867318

Abstract Article PDF–242K

Select item 662591111.

CaMKK2 Signaling in Metabolism and Skeletal Disease: A New Axis with Therapeutic Potential

Justin N. Williams, Uma Sankar

Curr Osteoporos Rep. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Curr Osteoporos Rep. 2019 Aug; 17(4): 169–177. doi: 10.1007/s11914-019-00518-w

PMCID:: PMC6625911

Abstract Article PDF–788K

Select item 532239712.

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca²⁺-Calmodulin and Multisite Phosphorylation

Matthew T. O’Brien, Jonathan S. Oakhill, Naomi X. Y. Ling, Christopher G. Langendorf, Ashfaqul Hoque, Toby A. Dite, Anthony R. Means, Bruce E. Kemp, John W. Scott

Sci Rep. 2017; 7: 43264. Published online 2017 Feb 23. doi: 10.1038/srep43264

PMCID:: PMC5322397

Abstract Article PDF–1.1M

Select item 462254913.

Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma

Yashwanth Subbannayya, Nazia Syed, Mustafa A Barbhuiya, Remya Raja, Arivusudar Marimuthu, Nandini Sahasrabuddhe, Sneha M Pinto, Srikanth Srinivas Manda, Santosh Renuse, HC Manju, Mohammed Abdul Lateef Zameer, Jyoti Sharma, Mariana Brait, Kotteazeth Srikumar, Juan Carlos Roa, M Vijaya Kumar, KV Veerendra Kumar, TS Keshava Prasad, Girija Ramaswamy, Rekha Vijay Kumar, Akhilesh Pandey, Harsha Gowda, Aditi Chatterjee

Cancer Biol Ther. 2015 Feb; 16(2): 336–345. Published online 2015 Mar 10. doi: 10.4161/15384047.2014.972264

PMCID:: PMC4622549

Abstract Article PDF–879K

Select item 451515114.

The CaMKK2/CaMKIV Relay Is an Essential Regulator of Hepatic Cancer

Fumin Lin, Kathrina L. Marcelo, Kimal Rajapakshe, Cristian Coarfa, Adam Dean, Nathaniel Wilganowski, Holly Robinson, Eva Sevick, Karl-Dimiter Bissig, Lauren C. Goldie, Anthony R. Means, Brian York

Hepatology. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Hepatology. 2015 Aug; 62(2): 505–520. Published online 2015 May 9. doi: 10.1002/hep.27832

PMCID:: PMC4515151

Abstract Article PDF–2.5M

Select item 347826615.

CaMKKβ Is Involved in AMP-Activated Protein Kinase Activation by Baicalin in LKB1 Deficient Cell Lines

Ying Ma, Fuzhen Yang, Ying Wang, Zhiyan Du, Daihua Liu, Hongxia Guo, Jingkang Shen, Hongli Peng

PLoS One. 2012; 7(10): e47900. Published online 2012 Oct 22. doi: 10.1371/journal.pone.0047900

PMCID:: PMC3478266

Abstract Article PDF–1.1M

Select item 344250016.

Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology

Luigi Racioppi, Anthony R. Means

J Biol Chem. 2012 Sep 14; 287(38): 31658–31665. Published online 2012 Jul 9. doi: 10.1074/jbc.R112.356485

PMCID:: PMC3442500

Abstract Article PDF–4.2M

Select item 301999917.

Inhibition of Calmodulin-Dependent Kinase Kinase Blocks Human Cytomegalovirus-Induced Glycolytic Activation and Severely Attenuates Production of Viral Progeny

Jessica McArdle, Xenia L. Schafer, Joshua Munger

J Virol. 2011 Jan; 85(2): 705–714. Published online 2010 Nov 17. doi: 10.1128/JVI.01557-10

Correction in:: J Virol. 2013 Jun; 87(12): 7197.

PMCID:: PMC3019999

Abstract Article PDF–1.6M

Select item 846690818.

CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner

Mohammad Golam Sabbir, Carla G. Taylor, Peter Zahradka

Cell Commun Signal. 2021; 19: 98. Published online 2021 Sep 25. doi: 10.1186/s12964-021-00778-z

PMCID:: PMC8466908

Abstract Article PDF–8.0M

Select item 770530019.

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Christopher G. Langendorf, Matthew T. O'Brien, Kevin R. W. Ngoei, Luke M. McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi X. Y. Ling, Toby A. Dite, Sandra Galic, Kim Loh, Michael W. Parker, Jonathan S. Oakhill, Bruce E. Kemp, John W. Scott

J Biol Chem. 2020 Nov 27; 295(48): 16239–16250. Published online 2020 Sep 9. doi: 10.1074/jbc.RA120.013756

PMCID:: PMC7705300

Abstract Article PDF–15M

Select item 649290420.

CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas

Da‐Ming Liu, Hong‐Jun Wang, Bo Han, Xiang‐Qi Meng, Ming‐Hui Chen, Dong‐Bo Yang, Ying Sun, Yong‐Li Li, Chuan‐Lu Jiang

CNS Neurosci Ther. 2016 Jun; 22(6): 518–524. Published online 2016 Mar 25. doi: 10.1111/cns.12531

PMCID:: PMC6492904

Abstract Article PDF–1.1M

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