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Items: 1 to 20 of 46

1.
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids
María José Pérez, Dina Ivanyuk, Vasiliki Panagiotakopoulou, Gabriele Di Napoli, Stefanie Kalb, Dario Brunetti, Rawaa Al-Shaana, Stephan A. Kaeser, Sabine Anne-Kristin Fraschka, Mathias Jucker, Massimo Zeviani, Carlo Viscomi, Michela Deleidi
Mol Psychiatry. 2021; 26(10): 5733–5750. Published online 2020 Jul 7. doi: 10.1038/s41380-020-0807-4
PMCID:
PMC8758476
AbstractArticlePDF–5.6M
2.
Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy
Jillian E. Smith‐Carpenter, Benjamin J. Alper
Protein Sci. 2018 Apr; 27(4): 861–873. Published online 2018 Feb 23. doi: 10.1002/pro.3380
PMCID:
PMC5866943
AbstractArticlePDF–801K
3.
In vitro oxidative inactivation of human presequence protease (hPreP)
Pedro Filipe Teixeira, Catarina Moreira Pinho, Rui M. Branca, Janne Lehtiö, Rodney L. Levine, Elzbieta Glaser
Free Radic Biol Med. Author manuscript; available in PMC 2013 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2012 Dec 1; 53(11): 2188–2195. Published online 2012 Oct 3. doi: 10.1016/j.freeradbiomed.2012.09.039
PMCID:
PMC3589710
AbstractArticlePDF–2.7M
4.
Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria
Nyosha Alikhani, Lan Guo, Shiqiang Yan, Heng Du, Catarina Moreira Pinho, John Xi Chen, Elzbieta Glaser, Shirley ShiDu Yan
J Alzheimers Dis. Author manuscript; available in PMC 2012 Jun 25.
Published in final edited form as: J Alzheimers Dis. 2011; 27(1): 75–87. doi: 10.3233/JAD-2011-101716
PMCID:
PMC3381900
AbstractArticlePDF–2.2M
5.
Mammalian pitrilysin: substrate specificity and mitochondrial targeting
K. Martin Chow, O. Gakh, I. C. Payne, Maria Aparecida Juliano, Luiz Juliano, G. Isaya, Louis B. Hersh
Biochemistry. Author manuscript; available in PMC 2010 Apr 7.
Published in final edited form as: Biochemistry. 2009 Apr 7; 48(13): 2868–2877. doi: 10.1021/bi8016125
PMCID:
PMC2765508
AbstractArticlePDF–2.3M
6.
Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer’s disease
Fang Du, Qing Yu, Shijun Yan, Zhihua Zhang, Jhansi Rani Vangavaragu, Doris Chen, Shi Fang Yan, Shirley ShiDu Yan
Aging Cell. 2021 May; 20(5): e13368. Published online 2021 May 5. doi: 10.1111/acel.13368
PMCID:
PMC8135081
AbstractArticlePDF–2.9M
7.
An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations
Keran Jiang, Zhongli Yang, Wenyan Cui, Kunkai Su, Jennie Z Ma, Thomas J Payne, Ming D Li
Nicotine Tob Res. 2019 Jun; 21(6): 707–713. Published online 2017 Dec 5. doi: 10.1093/ntr/ntx262
PMCID:
PMC6528158
AbstractArticlePDF–3.6M
8.
Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration
Dario Brunetti, Janniche Torsvik, Cristina Dallabona, Pedro Teixeira, Pawel Sztromwasser, Erika Fernandez‐Vizarra, Raffaele Cerutti, Aurelio Reyes, Carmela Preziuso, Giulia D'Amati, Enrico Baruffini, Paola Goffrini, Carlo Viscomi, Ileana Ferrero, Helge Boman, Wenche Telstad, Stefan Johansson, Elzbieta Glaser, Per M Knappskog, Massimo Zeviani, Laurence A Bindoff
EMBO Mol Med. 2016 Mar; 8(3): 176–190. Published online 2015 Dec 23. doi: 10.15252/emmm.201505894
PMCID:
PMC4772954
AbstractArticlePDF–3.0M
9.
Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease
John V. King, Wenguang G. Liang, Kathryn P. Scherpelz, Alexander B. Schilling, Stephen C. Meredith, Wei-Jen Tang
Structure. Author manuscript; available in PMC 2015 Jul 8.
Published in final edited form as: Structure. 2014 Jul 8; 22(7): 996–1007. Published online 2014 Jun 12. doi: 10.1016/j.str.2014.05.003
PMCID:
PMC4128088
AbstractArticlePDF–1.8M
10.
VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability
Xiao Yu, Shuliang Chen, Panpan Hou, Min Wang, Yu Chen, Deyin Guo
Biochem Biophys Res Commun. 2015 Apr 3; 459(2): 270–276. Published online 2015 Feb 27. doi: 10.1016/j.bbrc.2015.02.097
PMCID:
PMC7092858
AbstractArticlePDF–1.4M
11.
Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption
Marilyn C. Cornelis, Keri L. Monda, Kai Yu, Nina Paynter, Elizabeth M. Azzato, Siiri N. Bennett, Sonja I. Berndt, Eric Boerwinkle, Stephen Chanock, Nilanjan Chatterjee, David Couper, Gary Curhan, Gerardo Heiss, Frank B. Hu, David J. Hunter, Kevin Jacobs, Majken K. Jensen, Peter Kraft, Maria Teresa Landi, Jennifer A. Nettleton, Mark P. Purdue, Preetha Rajaraman, Eric B. Rimm, Lynda M. Rose, Nathaniel Rothman, Debra Silverman, Rachael Stolzenberg-Solomon, Amy Subar, Meredith Yeager, Daniel I. Chasman, Rob M. van Dam, Neil E. Caporaso
PLoS Genet. 2011 Apr; 7(4): e1002033. Published online 2011 Apr 7. doi: 10.1371/journal.pgen.1002033
PMCID:
PMC3071630
AbstractArticlePDF–281K
12.
The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1
Richard J. Giannone, Hayes W. McDonald, Gregory B. Hurst, Rong-Fong Shen, Yisong Wang, Yie Liu
PLoS One. 2010; 5(8): e12407. Published online 2010 Aug 25. doi: 10.1371/journal.pone.0012407
PMCID:
PMC2928292
AbstractArticlePDF–1.3M
13.
Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
Jo Ishizawa, Sarah F. Zarabi, R. Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, John Man Chun Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer, Michael Andreeff
Cancer Cell. Author manuscript; available in PMC 2020 May 13.
Published in final edited form as: Cancer Cell. 2019 May 13; 35(5): 721–737.e9. Published online 2019 May 2. doi: 10.1016/j.ccell.2019.03.014
PMCID:
PMC6620028
AbstractArticlePDF–2.9M
14.
The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins
Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo
BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y
PMCID:
PMC8744257
AbstractArticlePDF–6.0M
15.
Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
Bhaskar Saha, Michelle Salemi, Geneva L. Williams, Seeun Oh, Michael L. Paffett, Brett Phinney, Michael A. Mandell
Cell Rep. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell Rep. 2022 May 10; 39(6): 110797. doi: 10.1016/j.celrep.2022.110797
PMCID:
PMC9136943
AbstractArticlePDF–3.2M
16.
A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Huettenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J.P. Mathy, Tina Perica, Kala B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Ramachandran Rakesh, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A. Wankowicz, Markus Bohn, Maliheh Safari, Fatima S. Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J Fletcher, Michael C. O’Neal, Yiming Cai, Jason C.J.Chang, David J. Broadhurst, Saker Klippsten, Phillip P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu, Hao-Yuan Wang, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M. Stroud, Alan D. Frankel, Oren S. Rosenberg, Kliment A Verba, David A. Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen N. Floor, James S. Fraser, John D. Gross, Andrej Sali, Bryan L. Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M. Shokat, Brian K. Shoichet, Nevan J. Krogan
Nature. Author manuscript; available in PMC 2020 Oct 30.
Published in final edited form as: Nature. 2020 Jul; 583(7816): 459–468. Published online 2020 Apr 30. doi: 10.1038/s41586-020-2286-9
PMCID:
PMC7431030
AbstractArticlePDF–7.7M
17.
Mitochondrial protein interaction mapping identifies new regulators of respiratory chain function
Brendan J. Floyd, Emily M. Wilkerson, Mike T. Veling, Catie E. Minogue, Chuanwu Xia, Emily T. Beebe, Russell L. Wrobel, Holly Cho, Laura S. Kremer, Charlotte L. Alston, Katarzyna A. Gromek, Brendan K. Dolan, Arne Ulbrich, Jonathan A. Stefely, Sarah L. Bohl, Kelly M. Werner, Adam Jochem, Michael S. Westphall, Jarred W. Rensvold, Robert W. Taylor, Holger Prokisch, Jung-Ja P. Kim, Joshua J. Coon, David J. Pagliarini
Mol Cell. Author manuscript; available in PMC 2017 Aug 18.
Published in final edited form as: Mol Cell. 2016 Aug 18; 63(4): 621–632. Published online 2016 Aug 4. doi: 10.1016/j.molcel.2016.06.033
PMCID:
PMC4992456
AbstractArticlePDF–1.7M
18.
A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease
Andrew Grupe, Yonghong Li, Charles Rowland, Petra Nowotny, Anthony L. Hinrichs, Scott Smemo, John S. K. Kauwe, Taylor J. Maxwell, Sara Cherny, Lisa Doil, Kristina Tacey, Ryan van Luchene, Amanda Myers, Fabienne Wavrant-De Vrièze, Mona Kaleem, Paul Hollingworth, Luke Jehu, Catherine Foy, Nicola Archer, Gillian Hamilton, Peter Holmans, Chris M. Morris, Joseph Catanese, John Sninsky, Thomas J. White, John Powell, John Hardy, Michael O’Donovan, Simon Lovestone, Lesley Jones, John C. Morris, Leon Thal, Michael Owen, Julie Williams, Alison Goate
Am J Hum Genet. 2006 Jan; 78(1): 78–88. Published online 2005 Nov 15. doi: 10.1086/498851
PMCID:
PMC1380225
AbstractArticlePDF–329K
19.
ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold
Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo
Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134
PMCID:
PMC9475462
AbstractArticlePDF–4.6M
20.
Mapping the genetic landscape of human cells
Max A. Horlbeck, Albert Xu, Min Wang, Neal K. Bennett, Chong Y. Park, Derek Bogdanoff, Britt Adamson, Eric D. Chow, Martin Kampmann, Tim R. Peterson, Ken Nakamura, Michael A. Fischbach, Jonathan S. Weissman, Luke A. Gilbert
Cell. Author manuscript; available in PMC 2019 Aug 9.
Published in final edited form as: Cell. 2018 Aug 9; 174(4): 953–967.e22. Published online 2018 Jul 19. doi: 10.1016/j.cell.2018.06.010
PMCID:
PMC6426455
AbstractArticlePDF–3.6M

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