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Items: 1 to 20 of 117

1.
Identification of PAK4 as a putative target gene for amplification within 19q13.12‐q13.2 in oral squamous‐cell carcinoma
Asma Begum, Issei Imoto, Ken‐ichi Kozaki, Hitoshi Tsuda, Emina Suzuki, Teruo Amagasa, Johji Inazawa
Cancer Sci. 2009 Oct; 100(10): 1908–1916. Published online 2009 Jun 23. doi: 10.1111/j.1349-7006.2009.01252.x
PMCID:
PMC11158222
AbstractArticlePDF–6.0M
2.
PAK4 expression is associated with the prognosis in non-small cell lung cancer
Chenghui Li, Dongdong Ji, Aixiong Duan, Qian Jiang
Medicine (Baltimore) 2022 Aug 19; 101(33): e30050. Published online 2022 Aug 19. doi: 10.1097/MD.0000000000030050
PMCID:
PMC9388013
AbstractArticlePDF–561K
3.
Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair
Leon J. Blankenstein, Nils Cordes, Leoni A. Kunz-Schughart, Anne Vehlow
Cells. 2022 Jul; 11(14): 2133. Published online 2022 Jul 6. doi: 10.3390/cells11142133
PMCID:
PMC9316146
AbstractArticlePDF–3.1M
4.
cAMP Response Element-Binding Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy
So-Yoon Won, Soon-Tae You, Seung-Won Choi, Catriona McLean, Eun-Young Shin, Eung-Gook Kim
Mol Cells. 2021 Jul 31; 44(7): 493–499. Published online 2021 Jul 7. doi: 10.14348/molcells.2021.2250
PMCID:
PMC8334344
AbstractArticlePDF–2.8M
5.
Targeting PAK4 inhibits Ras-mediated signaling and multiple oncogenic pathways in high-risk Rhabdomyosarcoma
Atreyi Dasgupta, Laura Sierra, Susan V. Tsang, Lyazat Kurenbekova, Tajhal Patel, Kimal Rajapakse, Ryan L. Shuck, Nino Rainusso, Yosef Landesman, Thaddeus Unger, Cristian Coarfa, Jason T. Yustein
Cancer Res. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Cancer Res. 2021 Jan 1; 81(1): 199–212. Published online 2020 Nov 9. doi: 10.1158/0008-5472.CAN-20-0854
PMCID:
PMC7878415
AbstractArticlePDF–1.9M
6.
Recognition of physiological phosphorylation sites by p21-activated kinase 4
Ashwin K. Chetty, Joel A. Sexton, Byung Hak Ha, Benjamin E. Turk, Titus J. Boggon
J Struct Biol. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: J Struct Biol. 2020 Sep 1; 211(3): 107553. Published online 2020 Jun 23. doi: 10.1016/j.jsb.2020.107553
PMCID:
PMC7395882
AbstractArticlePDF–914K
7.
PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
Elizabeth Foxall, Adela Staszowska, Liisa M. Hirvonen, Mirella Georgouli, Mariacristina Ciccioli, Alexander Rimmer, Lynn Williams, Yolanda Calle, Victoria Sanz Moreno, Susan Cox, Gareth E. Jones, Claire M. Wells
Cell Rep. 2019 Dec 10; 29(11): 3385–3393.e6. Published online 2019 Dec 10. doi: 10.1016/j.celrep.2019.11.016
Correction in:
Cell Rep. 2020 Apr 21; 31(3): 107593.
PMCID:
PMC6915307
AbstractArticle
8.
PAK4, a target of miR-9-5p, promotes cell proliferation and inhibits apoptosis in colorectal cancer
Meihua Wang, Qianqian Gao, Yufang Chen, Ziyan Li, Lingping Yue, Yun Cao
Cell Mol Biol Lett. 2019; 24: 58. Published online 2019 Nov 8. doi: 10.1186/s11658-019-0182-9
PMCID:
PMC6842216
AbstractArticlePDF–2.3M
9.
Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity
Tianxiao Wu, Yu Pang, Jing Guo, Wenbo Yin, Mingyue Zhu, Chenzhou Hao, Kai Wang, Jian Wang, Dongmei Zhao, Maosheng Cheng
Molecules. 2018 Feb; 23(2): 417. Published online 2018 Feb 14. doi: 10.3390/molecules23020417
PMCID:
PMC6100240
AbstractArticlePDF–4.0M
10.
Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4
Zhiheng Li, Xiaolu Li, Lixiao Xu, Yanfang Tao, Chun Yang, Xiaolan Chen, Fang Fang, Yi Wu, Xin Ding, He Zhao, Mei Li, Guanghui Qian, Yunyun Xu, Junli Ren, Weiwei Du, Jian Wang, Jun Lu, Shaoyan Hu, Jian Pan
Oncol Rep. 2017 Nov; 38(5): 2705–2716. Published online 2017 Sep 22. doi: 10.3892/or.2017.5989
PMCID:
PMC5780023
AbstractArticlePDF–1.7M
11.
DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors
Austin L Brown, Kayla L Foster, Philip J Lupo, Erin C Peckham-Gregory, Jeffrey C Murray, M Fatih Okcu, Ching C Lau, Surya P Rednam, Murali Chintagumpala, Michael E Scheurer
Neuro Oncol. 2017 Oct; 19(10): 1372–1379. Published online 2017 Apr 24. doi: 10.1093/neuonc/nox076
PMCID:
PMC5596178
AbstractArticlePDF–1.2M
12.
P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation
Xiaochen Xie, Xiaoguang Shi, Haixia Guan, Qiqiang Guo, Chenling Fan, Wenwu Dong, Guiling Wang, Feng Li, Zhongyan Shan, Liu Cao, Weiping Teng
Oncotarget. 2017 Apr 11; 8(15): 24882–24891. Published online 2017 Feb 4. doi: 10.18632/oncotarget.15079
PMCID:
PMC5421896
AbstractArticlePDF–5.5M
13.
Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma
Mariateresa Fulciniti, Joaquin Martinez-Lopez, William Senapedis, Stefania Oliva, Rajya Lakshmi Bandi, Nicola Amodio, Yan Xu, Raphael Szalat, Annamaria Gulla, Mehmet K. Samur, Aldo Roccaro, Maria Linares, Michele Cea, Erkan Baloglu, Christian Argueta, Yosef Landesman, Sharon Shacham, Siyuan Liu, Monica Schenone, Shiaw-Lin Wu, Barry Karger, Rao Prabhala, Kenneth C. Anderson, Nikhil C. Munshi
Blood. 2017 Apr 20; 129(16): 2233–2245. Prepublished online 2017 Jan 17. doi: 10.1182/blood-2016-06-724831
PMCID:
PMC5399480
AbstractArticle
14.
Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling
Li-Fang He, Hong-Wu Xu, Min Chen, Zhi-Rong Xian, Xiao-Fen Wen, Min-Na Chen, Cai-Wen Du, Wen-He Huang, Jun-Dong Wu, Guo-Jun Zhang
Oncotarget. 2017 Mar 14; 8(11): 17573–17585. Published online 2016 Feb 17. doi: 10.18632/oncotarget.7466
PMCID:
PMC5392270
AbstractArticlePDF–10M
15.
The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1
Valérie Bergeron, Julien Ghislain, Vincent Poitout
Islets. 2016; 8(6): 157–164. Published online 2016 Oct 4. doi: 10.1080/19382014.2016.1243191
PMCID:
PMC5161145
AbstractArticlePDF–735K
16.
PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway
Xiang-Rong Shu, Jing Wu, He Sun, Li-Qun Chi, Jin-Huan Wang
Diagn Pathol. 2015; 10: 177. Published online 2015 Sep 28. doi: 10.1186/s13000-015-0404-z
PMCID:
PMC4584462
AbstractArticlePDF–1.3M
17.
Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion
Songwang Cai, Zhiqiang Ye, Xiaohong Wang, Yuhang Pan, Yimin Weng, Sen Lao, Hongbo Wei, Lian Li
J Exp Clin Cancer Res. 2015; 34(1): 48. Published online 2015 May 15. doi: 10.1186/s13046-015-0165-2
PMCID:
PMC4443662
AbstractArticlePDF–3.3M
18.
p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway
Nikhil Tyagi, Arun Bhardwaj, Ajay P. Singh, Steven McClellan, James E. Carter, Seema Singh
Oncotarget. 2014 Sep; 5(18): 8778–8789. Published online 2014 Aug 27. doi: 10.18632/oncotarget.2398
PMCID:
PMC4226721
AbstractArticlePDF–1.8M
19.
Protein Kinase D-mediated phosphorylation at serine 99 regulates localization of p21-activated kinase 4
Ligia I. Bastea, Heike Döppler, Sarah E. Pearce, Nisha Durand, Samantha J. Spratley, Peter Storz
Biochem J. Author manuscript; available in PMC 2014 Jan 4.
Published in final edited form as: Biochem J. 2013 Oct 15; 455(2): 10.1042/BJ20130281. doi: 10.1042/BJ20130281
PMCID:
PMC3880571
AbstractArticlePDF–3.9M
20.
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate
Byung Hak Ha, Matthew J. Davis, Catherine Chen, Hua Jane Lou, Jia Gao, Rong Zhang, Michael Krauthammer, Ruth Halaban, Joseph Schlessinger, Benjamin E. Turk, Titus J. Boggon
Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40): 16107–16112. Published online 2012 Sep 17. doi: 10.1073/pnas.1214447109
PMCID:
PMC3479536
AbstractArticlePDF–787K

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