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Select item 97922141.

Upregulated UBE4B expression correlates with poor prognosis and tumor immune infiltration in hepatocellular carcinoma

Xuyang Shao, Jun Zhu, Yanlong Shi, Hanlu Fang, Jingsi Chen, Yixiao Zhang, Jingyan Wang, Haokun Jian, Sheng Lan, Fei Jiang, Fei Zhong, Yewei Zhang, Chenxi Cao

Aging (Albany NY) 2022 Dec 15; 14(23): 9632–9646. Published online 2022 Dec 5. doi: 10.18632/aging.204414

PMCID:: PMC9792214

Abstract Article PDF–2.1M

Select item 68048092.

Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition

Kimiya Memarzadeh, David J. Savage, Andrew J. Bean

Cancer Biol Ther. 2019; 20(12): 1416–1429. Published online 2019 Sep 1. doi: 10.1080/15384047.2019.1647049

PMCID:: PMC6804809

Abstract Article PDF–6.4M

Select item 35276373.

UBE4B Levels Are Correlated with Clinical Outcomes in Neuroblastoma Patients and with Altered Neuroblastoma Cell Proliferation and Sensitivity to EGFR Inhibitors

Peter E. Zage, Natalie Sirisaengtaksin, Yin Liu, Monica Gireud, Brandon S. Brown, Shana Palla, Kristen N. Richards, Dennis P.M. Hughes, Andrew J. Bean

Cancer. Author manuscript; available in PMC 2014 Feb 15.

Published in final edited form as: Cancer. 2013 Feb 15; 119(4): 915–923. Published online 2012 Sep 18. doi: 10.1002/cncr.27785

PMCID:: PMC3527637

Abstract Article PDF–794K

Select item 106436744.

UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis

Christophe Le Clorennec, Divya Subramonian, Yuchen Huo, Peter E. Zage

Cell Death Dis. 2023 Nov; 14(11): 739. Published online 2023 Nov 13. doi: 10.1038/s41419-023-06252-7

PMCID:: PMC10643674

Abstract Article PDF–10M

Select item 102350805.

A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling

Yingcheng Lyu, Binghua Tan, Lin Li, Ruihao Liang, Kai Lei, Kefeng Wang, Duoguang Wu, Huayue Lin, Minghui Wang

Cell Death Dis. 2023 Jun; 14(6): 346. Published online 2023 Jun 1. doi: 10.1038/s41419-023-05865-2

PMCID:: PMC10235080

Abstract Article PDF–12M

Select item 36661766.

Activation of UbcH5c~Ub is the result of a shift in inter-domain motions of the conjugate when bound to the U-box E3 ligase E4B

Sarah E. Soss, Rachel E. Klevit, Walter J Chazin

Biochemistry. Author manuscript; available in PMC 2014 Apr 30.

Published in final edited form as: Biochemistry. 2013 Apr 30; 52(17): 2991–2999. Published online 2013 Apr 15. doi: 10.1021/bi3015949

PMCID:: PMC3666176

Abstract Article PDF–1.8M

Select item 30733537.

U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of ΔNp63α

Aditi Chatterjee, Sunil Upadhyay, Xiaofei Chang, Jatin K. Nagpal, Barry Trink, David Sidransky

Cell Cycle. Author manuscript; available in PMC 2011 Apr 11.

Published in final edited form as: Cell Cycle. 2008 May 1; 7(9): 1231–1237. Published online 2008 Feb 19. doi: 10.4161/cc.7.9.5795

PMCID:: PMC3073353

Abstract Article PDF–775K

Select item 75301338.

The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion

Monica Gireud-Goss, Sahily Reyes, Ritika Tewari, Anthony Patrizz, Matthew D. Howe, Julia Kofler, M. Neal Waxham, Louise D. McCullough, Andrew J. Bean

Mol Cell Neurosci. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Mol Cell Neurosci. 2020 Oct; 108: 103542. Published online 2020 Aug 22. doi: 10.1016/j.mcn.2020.103542

PMCID:: PMC7530133

Abstract Article PDF–798K

Select item 48230749.

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation

Cheng Du, Hong Wu, Roger P. Leng

Oncotarget. 2016 Jan 19; 7(3): 2823–2836. Published online 2015 Dec 10. doi: 10.18632/oncotarget.6555

PMCID:: PMC4823074

Abstract Article PDF–7.8M

Select item 393600210.

Regulation of p53 Level by UBE4B in Breast Cancer

Ying Zhang, Yanrong Lv, Yongyang Zhang, Haidong Gao

PLoS One. 2014; 9(2): e90154. Published online 2014 Feb 26. doi: 10.1371/journal.pone.0090154

Correction in:: PLoS One. 2014; 9(6): e99968.

Correction in:: PLoS One. 2015; 10(4): e0125136.

PMCID:: PMC3936002

Abstract Article PDF–1.9M

Select item 226779211.

Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins

Amanda M Goh, Kylie J Walters, Suzanne Elsasser, Rati Verma, Raymond J Deshaies, Daniel Finley, Peter M Howley

BMC Biochem. 2008; 9: 4. Published online 2008 Jan 30. doi: 10.1186/1471-2091-9-4

PMCID:: PMC2267792

Abstract Article PDF–1.1M

Select item 958937112.

SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression

Hyungmin Kim, Jeehan Lee, Soon-Young Jung, Hye Hyeon Yun, Jeong-Heon Ko, Jeong-Hwa Lee

Mol Cells. 2022 Oct 31; 45(10): 718–728. Published online 2022 Aug 23. doi: 10.14348/molcells.2022.0037

PMCID:: PMC9589371

Abstract Article PDF–2.3M

Select item 916356013.

Differential Degradation of TRA2A and PYCR2 Mediated by Ubiquitin E3 Ligase E4B

Yao Lu, Bo Jiang, Kangli Peng, Shasha Li, Xiangnan Liu, Bufan Wang, Yuntian Chen, Tiepeng Wang, Bo Zhao

Front Cell Dev Biol. 2022; 10: 833396. Published online 2022 May 20. doi: 10.3389/fcell.2022.833396

PMCID:: PMC9163560

Abstract Article PDF–2.1M

Select item 779042314.

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation

Suchitra Mohanty, Teng Han, Young Bong Choi, Alfonso Lavorgna, Jiawen Zhang, Edward William Harhaj

PLoS Pathog. 2020 Dec; 16(12): e1008504. Published online 2020 Dec 23. doi: 10.1371/journal.ppat.1008504

PMCID:: PMC7790423

Abstract Article PDF–2.8M

Select item 565554715.

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

Mads Gabrielsen, Lori Buetow, Mark A. Nakasone, Syed Feroj Ahmed, Gary J. Sibbet, Brian O. Smith, Wei Zhang, Sachdev S. Sidhu, Danny T. Huang

Mol Cell. 2017 Oct 19; 68(2): 456–470.e10. doi: 10.1016/j.molcel.2017.09.027

PMCID:: PMC5655547

Abstract Article PDF–5.4M

Select item 390843316.

UBE4B Protein Couples Ubiquitination and Sorting Machineries to Enable Epidermal Growth Factor Receptor (EGFR) Degradation

Natalie Sirisaengtaksin, Monica Gireud, Qing Yan, Yoshihisa Kubota, Denisse Meza, Jack C. Waymire, Peter E. Zage, Andrew J. Bean

J Biol Chem. 2014 Jan 31; 289(5): 3026–3039. Published online 2013 Dec 16. doi: 10.1074/jbc.M113.495671

PMCID:: PMC3908433

Abstract Article PDF–2.4M

Select item 300514717.

Molecular Basis for the Association of Human E4B U box Ubiquitin Ligase with E2 Conjugating Enzymes UbcH5c and Ubc4

Robert C. Benirschke, James R. Thompson, Yves Nominé, Emeric Wasielewski, Nenad Juranić, Slobodan Macura, Shigetsugu Hatakeyama, Keiichi I. Nakayama, Maria Victoria Botuyan, Georges Mer

Structure. Author manuscript; available in PMC 2011 Aug 11.

Published in final edited form as: Structure. 2010 Aug 11; 18(8): 955–965. doi: 10.1016/j.str.2010.04.017

PMCID:: PMC3005147

Abstract Article PDF–2.5M

Select item 997118118.

The SWIB/MDM2 motif of UBE4B activates the p53 pathway

H. Helena Wu, Sarah Leng, Yasser Abuetabh, Consolato Sergi, David D. Eisenstat, Roger Leng

Mol Ther Nucleic Acids. 2023 Mar 14; 31: 466–481. Published online 2023 Feb 4. doi: 10.1016/j.omtn.2023.02.002

PMCID:: PMC9971181

Abstract Article PDF–4.7M

Select item 313529519.

Cellular Functions of Ufd2 and Ufd3 in Proteasomal Protein Degradation Depend on Cdc48 Binding

Stefanie Böhm, Giorgia Lamberti, Vanesa Fernández-Sáiz, Christopher Stapf, Alexander Buchberger

Mol Cell Biol. 2011 Apr; 31(7): 1528–1539. doi: 10.1128/MCB.00962-10

PMCID:: PMC3135295

Abstract Article PDF–1.9M

Select item 127181120.

Molecular clearance of ataxin-3 is regulated by a mammalian E4

Masaki Matsumoto, Masayoshi Yada, Shigetsugu Hatakeyama, Hiroshi Ishimoto, Teiichi Tanimura, Shoji Tsuji, Akira Kakizuka, Masatoshi Kitagawa, Keiichi I Nakayama

EMBO J. 2004 Feb 11; 23(3): 659–669. Published online 2004 Jan 29. doi: 10.1038/sj.emboj.7600081