PMC Links for Gene (Select 1022) - PMC

Katrina M. Piemonte, Bryan M. Webb, Jessica R. Bobbitt, Parth R. Majmudar, Leslie Cuellar-Vite, Benjamin L. Bryson, Nicholas C. Latina, Darcie D. Seachrist, Ruth A. Keri

J Biol Chem. 2023 Jul; 299(7): 104834. Published online 2023 May 17. doi: 10.1016/j.jbc.2023.104834

PMCID:: PMC10300262

Abstract Article PDF–4.0M

Select item 59937484.

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma

Cun Wang, Haojie Jin, Dongmei Gao, Liqin Wang, Bastiaan Evers, Zheng Xue, Guangzhi Jin, Cor Lieftink, Roderick L. Beijersbergen, Wenxin Qin, René Bernards

Cell Res. 2018 Jun; 28(6): 690–692. Published online 2018 Mar 5. doi: 10.1038/s41422-018-0020-z

PMCID:: PMC5993748

Article PDF–891K

Select item 55642265.

Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications

Christopher C. Ebmeier, Benjamin Erickson, Benjamin L. Allen, Mary A. Allen, Hyunmin Kim, Nova Fong, Jeremy R. Jacobsen, Kaiwei Liang, Ali Shilatifard, Robin D. Dowell, William M. Old, David L. Bentley, Dylan J. Taatjes

Cell Rep. Author manuscript; available in PMC 2017 Aug 21.

Published in final edited form as: Cell Rep. 2017 Aug 1; 20(5): 1173–1186. doi: 10.1016/j.celrep.2017.07.021

PMCID:: PMC5564226

Abstract Article PDF–2.0M

Select item 52902696.

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rosella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti

Nat Commun. 2017; 8: 14290. Published online 2017 Jan 30. doi: 10.1038/ncomms14290

Correction in:: Nat Commun. 2017; 8: 14747.

PMCID:: PMC5290269

Abstract Article PDF–2.3M

Select item 45836597.

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

Yubao Wang, Tinghu Zhang, Nicholas Kwiatkowski, Brian J. Abraham, Tong Ihn Lee, Shaozhen Xie, Haluk Yuzugullu, Thanh Von, Heyuan Li, Ziao Lin, Daniel G. Stover, Elgene Lim, Zhigang C. Wang, J. Dirk Iglehart, Richard A. Young, Nathanael S. Gray, Jean J. Zhao

Cell. Author manuscript; available in PMC 2016 Sep 24.

Published in final edited form as: Cell. 2015 Sep 24; 163(1): 174–186. doi: 10.1016/j.cell.2015.08.063

PMCID:: PMC4583659

Abstract Article PDF–2.5M

Select item 45465728.

THZ1 reveals roles for Cdk7 in co-transcriptional capping and pausing

Kyle A. Nilson, Jiannan Guo, Michael E. Turek, John E. Brogie, Elizabeth Delaney, Donal S. Luse, David H. Price

Mol Cell. Author manuscript; available in PMC 2016 Aug 20.

Published in final edited form as: Mol Cell. 2015 Aug 20; 59(4): 576–587. Published online 2015 Aug 6. doi: 10.1016/j.molcel.2015.06.032

PMCID:: PMC4546572

Abstract Article PDF–1.5M

Select item 41877229.

Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells

Timothy W. R. Kelso, Karen Baumgart, Jan Eickhoff, Thomas Albert, Claudia Antrecht, Sarah Lemcke, Bert Klebl, Michael Meisterernst

Mol Cell Biol. 2014 Oct; 34(19): 3675–3688. doi: 10.1128/MCB.00595-14

PMCID:: PMC4187722

Abstract Article PDF–2.2M

Select item 212021510.

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)

J Cell Biol. 1994 Oct 2; 127(2): 467–478. doi: 10.1083/jcb.127.2.467

PMCID:: PMC2120215

Summary PDF–2.0M

Select item 31723911.

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7

Sasha Akoulitchev, Danny Reinberg

Genes Dev. 1998 Nov 15; 12(22): 3541–3550. doi: 10.1101/gad.12.22.3541

PMCID:: PMC317239

Abstract Article PDF–1.2M

Select item 1076897712.

CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity

Isha Bhutada, Fatema Khambati, Shi-Yuan Cheng, Deanna M Tiek, Derek Duckett, Harshani Lawrence, Michael A Vogelbaum, Qianxing Mo, Srikumar P Chellappan, Jaya Padmanabhan

Neuro Oncol. 2024 Jan; 26(1): 70–84. Published online 2023 Aug 8. doi: 10.1093/neuonc/noad143

PMCID:: PMC10768977

Abstract Article PDF–28M

Select item 1044545613.

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall

Virus Res. 2023 Oct 2; 335: 199200. Published online 2023 Aug 19. doi: 10.1016/j.virusres.2023.199200

PMCID:: PMC10445456

Abstract Article PDF–11M

Select item 1031077514.

Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression

Zhigang Chen, Dasheng Tian, Xueran Chen, Meng Cheng, Han Xie, JiaJia Zhao, Jun Liu, Zhiyou Fang, Bing Zhao, Erbao Bian

Cell Death Dis. 2023 Jun; 14(6): 383. Published online 2023 Jun 29. doi: 10.1038/s41419-023-05892-z

PMCID:: PMC10310775

Abstract Article PDF–11M

Select item 841969915.

CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma

Pietro Berico, Max Cigrang, Guillaume Davidson, Cathy Braun, Jeremy Sandoz, Stephanie Legras, Bujamin Hektor Vokshi, Nevena Slovic, François Peyresaubes, Carlos Mario Gene Robles, Jean‐Marc Egly, Emmanuel Compe, Irwin Davidson, Frederic Coin

EMBO Rep. 2021 Sep 6; 22(9): e51683. Published online 2021 Jul 23. doi: 10.15252/embr.202051683

PMCID:: PMC8419699

Abstract Article PDF–3.3M

Select item 820497016.

An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles

Chen Ruan, Chenwei Wang, Xuanqing Gong, Ying Zhang, Wankun Deng, Jiaqi Zhou, Dengtong Huang, Zining Wang, Qiong Zhang, Anyuan Guo, Jiahong Lu, Jinhao Gao, Di Peng, Yu Xue

Autophagy. 2021; 17(6): 1426–1447. Published online 2020 May 23. doi: 10.1080/15548627.2020.1763019

PMCID:: PMC8204970

Abstract Article PDF–22M

Select item 776180917.

Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines

Wonjun Ji, Yun Jung Choi, Myoung-Hee Kang, Ki Jung Sung, Dong Ha Kim, Sangyong Jung, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho

Cells. 2020 Dec; 9(12): 2596. Published online 2020 Dec 3. doi: 10.3390/cells9122596

PMCID:: PMC7761809

Abstract Article PDF–3.2M

Select item 693721218.

Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers

Bowen Sun, Seth Mason, Robert C. Wilson, Starr E. Hazard, Yubao Wang, Rong Fang, Qiwei Wang, Elizabeth S. Yeh, Meixiang Yang, Thomas M. Roberts, Jean J. Zhao, Qi Wang

Oncogene. 2020; 39(1): 50–63. Published online 2019 Aug 28. doi: 10.1038/s41388-019-0953-9

Correction in:: Oncogene. 2024; 43(25): 1972.

PMCID:: PMC6937212

Abstract Article PDF–5.5M

Select item 693340219.

Inhibition of cyclin‐dependent kinase 7 down‐regulates yes‐associated protein expression in mesothelioma cells

Jinbai Miao, Hiroyuki Kyoyama, Luwei Liu, Geraldine Chan, Yucheng Wang, Anatoly Urisman, Yi‐Lin Yang, Shu Liu, Zhidong Xu, Hu Bin, Hui Li, David M. Jablons, Liang You

J Cell Mol Med. 2020 Jan; 24(1): 1087–1098. Published online 2019 Nov 21. doi: 10.1111/jcmm.14841

PMCID:: PMC6933402

Abstract Article PDF–1.7M

Select item 674807720.

Targeting CDK7 increases the stability of Snail to promote the dissemination of colorectal cancer

Yan Zhou, Linlin Lu, Guanmin Jiang, Zhuojia Chen, Jiexin Li, Panpan An, Likun Chen, Jun Du, Hongsheng Wang

Cell Death Differ. 2019 Aug; 26(8): 1442–1452. Published online 2018 Nov 19. doi: 10.1038/s41418-018-0222-4

PMCID:: PMC6748077

Abstract Article PDF–3.5M

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