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Items: 1 to 20 of 40

1.
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
Kentaro Hosokawa, Ben D. MacArthur, Yoshiko Matsumoto Ikushima, Hirofumi Toyama, Yoshikazu Masuhiro, Shigemasa Hanazawa, Toshio Suda, Fumio Arai
Nat Commun. 2017; 8: 804. Published online 2017 Oct 6. doi: 10.1038/s41467-017-00935-4
PMCID:
PMC5630588
AbstractArticlePDF–3.1M
2.
POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis
Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S. Stumpf, Ben D. MacArthur, Dongchon Kang, Koichi Akashi, Shouichi Ohga, Fumio Arai
Commun Biol. 2023; 6: 996. Published online 2023 Sep 29. doi: 10.1038/s42003-023-05374-0
PMCID:
PMC10541440
AbstractArticlePDF–5.5M
3.
The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
Rekha Rai, Peili Gu, Cayla Broton, Chandan Kumar-Sinha, Yong Chen, Sandy Chang
Cell Rep. Author manuscript; available in PMC 2020 Feb 5.
Published in final edited form as: Cell Rep. 2019 Dec 10; 29(11): 3708–3725.e5. Published online 2019 Dec 10. doi: 10.1016/j.celrep.2019.11.012
PMCID:
PMC7001145
AbstractArticlePDF–3.0M
4.
Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Alexandra M. Pinzaru, Robert A. Hom, Angela Beal, Aaron F. Phillips, Eric Ni, Timothy Cardozo, Nidhi Nair, Jaehyuk Choi, Deborah S. Wuttke, Agnel Sfeir, Eros Lazzerini Denchi
Cell Rep. Author manuscript; available in PMC 2018 Sep 19.
Published in final edited form as: Cell Rep. 2016 Jun 7; 15(10): 2170–2184. Published online 2016 May 26. doi: 10.1016/j.celrep.2016.05.008
PMCID:
PMC6145145
AbstractArticlePDF–3.8M
5.
Human Pot1 OB-fold mutations unleash rampant telomere instability to initiate tumorigenesis
Peili Gu, Yang Wang, Kamlesh K. Bisht, Ling Wu, Lidiya Kukova, Eric M. Smith, Yang Xiao, Susan Bailey, Ming Lei, Jayakrishnan Nandakumar, Sandy Chang
Oncogene. Author manuscript; available in PMC 2017 May 21.
Published in final edited form as: Oncogene. 2017 Apr 6; 36(14): 1939–1951. Published online 2016 Nov 21. doi: 10.1038/onc.2016.405
PMCID:
PMC5383532
AbstractArticlePDF–1.2M
6.
Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis
E A Akbay, C G Peña, D Ruder, J A Michel, Y Nakada, S Pathak, A S Multani, S Chang, D H Castrillon
Oncogene. 2013 Apr 25; 32(17): 2211–2219. Published online 2012 Jun 11. doi: 10.1038/onc.2012.232
PMCID:
PMC3636499
AbstractArticlePDF–2.9M
7.
Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative Splicing
Peter Baumann, Elaine Podell, Thomas R. Cech
Mol Cell Biol. 2002 Nov; 22(22): 8079–8087. doi: 10.1128/MCB.22.22.8079-8087.2002
PMCID:
PMC134737
AbstractArticlePDF–724K
8.
A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations
Paula Martínez, Raúl Sánchez-Vázquez, Iole Ferrara-Romeo, Rosa Serrano, Juana M. Flores, Maria A. Blasco
PLoS Genet. 2022 Jun; 18(6): e1010260. Published online 2022 Jun 21. doi: 10.1371/journal.pgen.1010260
PMCID:
PMC9212151
AbstractArticlePDF–3.4M
9.
Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b
Katja Kratz, Titia de Lange
J Biol Chem. 2018 Sep 14; 293(37): 14384–14392. Published online 2018 Aug 6. doi: 10.1074/jbc.RA118.004598
PMCID:
PMC6139565
AbstractArticlePDF–2.5M
10.
A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion
Yi Gong, Titia de Lange
Mol Cell. Author manuscript; available in PMC 2011 Nov 12.
Published in final edited form as: Mol Cell. 2010 Nov 12; 40(3): 377–387. doi: 10.1016/j.molcel.2010.10.016
PMCID:
PMC3111920
AbstractArticlePDF–4.3M
11.
Functional Dissection of Human and Mouse POT1 Proteins
Wilhelm Palm, Dirk Hockemeyer, Tatsuya Kibe, Titia de Lange
Mol Cell Biol. 2009 Jan; 29(2): 471–482. Published online 2008 Oct 27. doi: 10.1128/MCB.01352-08
PMCID:
PMC2612509
AbstractArticlePDF–4.5M
12.
The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection
Rekha Rai, Ju-Mei Li, Hong Zheng, Gabriel Tsz-Mei Lok, Yu Deng, Michael Huen, Junjie Chen, Jianping Jin, Sandy Chang
Nat Struct Mol Biol. Author manuscript; available in PMC 2013 May 20.
Published in final edited form as: Nat Struct Mol Biol. 2011 Nov 20; 18(12): 1400–1407. Published online 2011 Nov 20. doi: 10.1038/nsmb.2172
PMCID:
PMC3657743
AbstractArticlePDF–1.5M
13.
Functional interaction between telomere protein TPP1 and telomerase
Arthur J. Zaug, Elaine R. Podell, Jayakrishnan Nandakumar, Thomas R. Cech
Genes Dev. 2010 Mar 15; 24(6): 613–622. doi: 10.1101/gad.1881810
PMCID:
PMC2841338
AbstractArticlePDF–831K
14.
Telomere Protection by TPP1 Is Mediated by POT1a and POT1b
Tatsuya Kibe, Gail A. Osawa, Catherine E. Keegan, Titia de Lange
Mol Cell Biol. 2010 Feb; 30(4): 1059–1066. Published online 2009 Dec 7. doi: 10.1128/MCB.01498-09
PMCID:
PMC2815557
AbstractArticlePDF–2.2M
15.
No Overt Nucleosome Eviction at Deprotected Telomeres
Peng Wu, Titia de Lange
Mol Cell Biol. 2008 Sep; 28(18): 5724–5735. Published online 2008 Jul 14. doi: 10.1128/MCB.01764-07
PMCID:
PMC2546919
AbstractArticlePDF–1.2M
16.
Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection
David Frescas, Titia de Lange
J Biol Chem. 2014 Aug 29; 289(35): 24180–24187. Published online 2014 Jul 23. doi: 10.1074/jbc.M114.592592
PMCID:
PMC4148849
AbstractArticlePDF–2.5M
17.
Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease
Tanveer Ahmad, Isaac K. Sundar, Ana M. Tormos, Chad A. Lerner, Janice Gerloff, Hongwei Yao, Irfan Rahman
Am J Respir Cell Mol Biol. 2017 Jan; 56(1): 38–49. doi: 10.1165/rcmb.2016-0198OC
PMCID:
PMC5248966
AbstractArticlePDF–3.0M
18.
TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1
David Frescas, Titia de Lange
Mol Cell Biol. 2014 Apr; 34(7): 1349–1362. doi: 10.1128/MCB.01052-13
PMCID:
PMC3993560
AbstractArticlePDF–5.2M
19.
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
Xiaolan Guo, Yibin Deng, Yahong Lin, Wilfredo Cosme-Blanco, Suzanne Chan, Hua He, Guohua Yuan, Eric J Brown, Sandy Chang
EMBO J. 2007 Nov 14; 26(22): 4709–4719. Published online 2007 Oct 18. doi: 10.1038/sj.emboj.7601893
PMCID:
PMC2080807
AbstractArticlePDF–519K
20.
Telomere protection by TPP1/POT1 requires tethering to TIN2
Kaori K. Takai, Tatsuya Kibe, Jill R. Donigian, David Frescas, Titia de Lange
Mol Cell. Author manuscript; available in PMC 2012 Nov 18.
Published in final edited form as: Mol Cell. 2011 Nov 18; 44(4): 647–659. doi: 10.1016/j.molcel.2011.08.043
Correction in:
Mol Cell. 2017 Jul 6; 67(1): 162.
PMCID:
PMC3222871
AbstractArticlePDF–4.7M

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