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Select item 110730671.

Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation

Parash Prasad, Sampurna Ghosh, Sib Sankar Roy

Cell Mol Life Sci. 2021 May; 78(10): 4821–4845. Published online 2021 Apr 24. doi: 10.1007/s00018-021-03818-6

PMCID:: PMC11073067

Abstract Article PDF–9.0M

Select item 108811512.

Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin

Ao Liu, Anna L. Hatch, Henry N. Higgs

Mol Biol Cell. 2024 Feb 1; 35(2): ar16. Published online 2024 Jan 12. doi: 10.1091/mbc.E23-11-0427

PMCID:: PMC10881151

Abstract Article PDF–5.4M

Select item 108588213.

Enhanced T cell immune activity mediated by Drp1 promotes the efficacy of PD-1 inhibitors in treating lung cancer

Jietao Ma, Jun Song, Xiaofang Yi, Shuling Zhang, Li Sun, Letian Huang, Chengbo Han

Cancer Immunol Immunother. 2024 Feb; 73(2): 40. Published online 2024 Feb 10. doi: 10.1007/s00262-023-03582-5

PMCID:: PMC10858821

Abstract Article PDF–3.6M

Select item 106572124.

DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs

Gabriella L. Robertson, Stellan Riffle, Mira Patel, Caroline Bodnya, Andrea Marshall, Heather K. Beasley, Edgar Garza-Lopez, Jianqiang Shao, Zer Vue, Antentor Hinton, Jr, Maria S. Stoll, Sholto de Wet, Rensu P. Theart, Ram Prosad Chakrabarty, Ben Loos, Navdeep S. Chandel, Jason A. Mears, Vivian Gama

J Cell Sci. 2023 Feb 1; 136(3): jcs260370. Published online 2023 Feb 10. doi: 10.1242/jcs.260370

PMCID:: PMC10657212

Abstract Article

Select item 102442235.

Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery

Brianna L Bauer, Kristy Rochon, Jasmine C Liu, Rajesh Ramachandran, Jason A Mears

Hum Mol Genet. 2023 Jun 15; 32(12): 1975–1987. Published online 2023 Feb 16. doi: 10.1093/hmg/ddad029

PMCID:: PMC10244223

Abstract Article PDF–2.7M

Select item 101937266.

Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells

Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng, Xiaoyu Sun

J Transl Med. 2023; 21: 328. Published online 2023 May 18. doi: 10.1186/s12967-023-04188-2

PMCID:: PMC10193726

Abstract Article PDF–3.5M

Select item 93540387.

Novel DNM1L variants impair mitochondrial dynamics through divergent mechanisms

Kelsey A Nolden, John M Egner, Jack J Collier, Oliver M Russell, Charlotte L Alston, Megan C Harwig, Michael E Widlansky, Souphatta Sasorith, Inês A Barbosa, Andrew GL Douglas, Julia Baptista, Mark Walker, Deirdre E Donnelly, Andrew A Morris, Hui Jeen Tan, Manju A Kurian, Kathleen Gorman, Santosh Mordekar, Charu Deshpande, Rajib Samanta, Robert McFarland, R Blake Hill, Robert W Taylor, Monika Oláhová

Life Sci Alliance. 2022 Dec; 5(12): e202101284. Published online 2022 Aug 1. doi: 10.26508/lsa.202101284

PMCID:: PMC9354038

Abstract Article PDF–3.1M

Select item 89675748.

Drp1-Mediated Mitochondrial Metabolic Dysfunction Inhibits the Tumor Growth of Pituitary Adenomas

Kexia Fan, Xiao Ding, Zhenle Zang, Yin Zhang, Xiaoshuang Tang, Xiangdong Pei, Qingbo Chen, Huachun Yin, Xin Zheng, Yong Chen, Song Li, Hui Yang

Oxid Med Cell Longev. 2022; 2022: 5652586. Published online 2022 Mar 23. doi: 10.1155/2022/5652586

PMCID:: PMC8967574

Abstract Article PDF–4.8M

Select item 88209229.

Bojjibabu Chidipi, Mariana Burgos Angulo, Syed Islamuddin Shah, Michelle Rieser, Ganim Ullah, Thomas V McDonald, Sami F. Noujaim

Int J Biochem Cell Biol. Author manuscript; available in PMC 2022 Feb 7.

Published in final edited form as: Int J Biochem Cell Biol. 2022 Feb; 143: 106137. Published online 2021 Dec 16. doi: 10.1016/j.biocel.2021.106137

PMCID:: PMC8820922

Abstract Article PDF–2.1M

Select item 849846510.

William T. King, Christopher L. Axelrod, Elizabeth R.M. Zunica, Robert C. Noland, Gangarao Davuluri, Hisashi Fujioka, Bernard Tandler, Kathryn Pergola, Gerlinda E. Hermann, Richard C. Rogers, Sandra López-Domènech, Wagner S. Dantas, Krisztian Stadler, Charles L. Hoppel, John P. Kirwan

J Biol Chem. 2021 Oct; 297(4): 101196. Published online 2021 Sep 13. doi: 10.1016/j.jbc.2021.101196

PMCID:: PMC8498465

Abstract Article PDF–3.2M

Select item 849705811.

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra

eLife. 2021; 10: e68394. Published online 2021 Sep 21. doi: 10.7554/eLife.68394

PMCID:: PMC8497058

Abstract Article PDF–5.0M

Select item 846731112.

Pathogenic DNM1L Variant (1085G>A) Linked to Infantile Progressive Neurological Disorder: Evidence of Maternal Transmission by Germline Mosaicism and Influence of a Contemporary in cis Variant (1535T>C)

Claudia Piccoli, Rosella Scrima, Annamaria D’Aprile, Massimiliano Chetta, Olga Cela, Consiglia Pacelli, Maria Ripoli, Giovanna D’Andrea, Maurizio Margaglione, Nenad Bukvic, Nazzareno Capitanio

Genes (Basel) 2021 Sep; 12(9): 1295. Published online 2021 Aug 24. doi: 10.3390/genes12091295

PMCID:: PMC8467311

Abstract Article PDF–3.5M

Select item 830785413.

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission

Mukesh Mahajan, Nikhil Bharambe, Yutong Shang, Bin Lu, Abhishek Mandal, Pooja Madan Mohan, Rihua Wang, Jennifer C. Boatz, Juan Manuel Martinez Galvez, Anna V. Shnyrova, Xin Qi, Matthias Buck, Patrick C. A. van der Wel, Rajesh Ramachandran

Proc Natl Acad Sci U S A. 2021 Jul 20; 118(29): e2023079118. Published online 2021 Jul 14. doi: 10.1073/pnas.2023079118

PMCID:: PMC8307854

Abstract Article PDF–2.8M

Select item 826869514.

DRP1 Inhibition Rescues Mitochondrial Integrity and Excessive Apoptosis in CS-A Disease Cell Models

Barbara Pascucci, Francesca Spadaro, Donatella Pietraforte, Chiara De Nuccio, Sergio Visentin, Paola Giglio, Eugenia Dogliotti, Mariarosaria D’Errico

Int J Mol Sci. 2021 Jul; 22(13): 7123. Published online 2021 Jul 1. doi: 10.3390/ijms22137123

PMCID:: PMC8268695

Abstract Article PDF–43M

Select item 817663915.

De novo DNM1L variant in a teenager with progressive paroxysmal dystonia and lethal super-refractory myoclonic status epilepticus

Conor S. Ryan, Anthony L. Fine, Alexander L. Cohen, Brenda M. Schiltz, Deborah L. Renaud, Elaine C. Wirrell, Marc C. Patterson, Nicole J. Boczek, Raymond Liu, Dusica Babovic-Vuksanovic, David C. Chan, Eric T. Payne

J Child Neurol. Author manuscript; available in PMC 2021 Jun 4.

Published in final edited form as: J Child Neurol. 2018 Sep; 33(10): 651–658. Published online 2018 Jun 7. doi: 10.1177/0883073818778203

PMCID:: PMC8176639

Abstract Article PDF–746K

Select item 812884316.

Latent HIV-Exosomes Induce Mitochondrial Hyperfusion Due to Loss of Phosphorylated Dynamin-Related Protein 1 in Brain Endothelium

Partha K. Chandra, Ibolya Rutkai, Hogyoung Kim, Stephen E. Braun, Asim B. Abdel-Mageed, Debasis Mondal, David W. Busija

Mol Neurobiol. 2021; 58(6): 2974–2989. Published online 2021 Feb 14. doi: 10.1007/s12035-021-02319-8

PMCID:: PMC8128843

Abstract Article PDF–6.3M

Select item 785828017.

Multi‐kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin‐related protein 1

Kuei‐Pin Chung, Yen‐Lin Huang, Yi‐Jung Chen, Yi‐Hsiu Juan, Chia‐Lang Hsu, Kiichi Nakahira, Yen‐Tsung Huang, Mong‐Wei Lin, Shang‐Gin Wu, Jin‐Yuan Shih, Yih‐Leong Chang, Chong‐Jen Yu

Mol Oncol. 2021 Feb; 15(2): 560–578. Published online 2020 Dec 11. doi: 10.1002/1878-0261.12843