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Items: 1 to 20 of 46

1.
A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family
Anabel Cámara-Checa, Francesca Perin, Marcos Rubio-Alarcón, María Dago, Teresa Crespo-García, Josu Rapún, María Marín, Jorge Cebrián, Ricardo Gómez, Francisco Bermúdez-Jiménez, Lorenzo Monserrat, Juan Tamargo, Ricardo Caballero, Juan Jiménez-Jáimez, Eva Delpón
Proc Natl Acad Sci U S A. 2023 Dec 5; 120(49): e2305135120. Published online 2023 Nov 30. doi: 10.1073/pnas.2305135120
PMCID:
PMC10710060
AbstractArticlePDF–2.4M
2.
Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation
Hongrui Wang, Tong Wu, Zhuo Huang, Jinghan Huang, Ze Geng, Bing Cui, Yupeng Yan, Yu Zhang, Yibo Wang
J Biol Chem. 2022 Nov; 298(11): 102599. Published online 2022 Oct 14. doi: 10.1016/j.jbc.2022.102599
PMCID:
PMC9663530
AbstractArticlePDF–4.4M
3.
Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system
Stefan Peischard, Melina Möller, Paul Disse, Huyen Tran Ho, Arie O. Verkerk, Nathalie Strutz-Seebohm, Thomas Budde, Sven G. Meuth, Patrick A. Schweizer, Silke Morris, Lena Mücher, Verónica Eisner, Dierk Thomas, Karin Klingel, Karin Busch, Guiscard Seebohm
Cell Mol Life Sci. 2022 Aug; 79(8): 440. Published online 2022 Jul 21. doi: 10.1007/s00018-022-04435-7
PMCID:
PMC9304080
AbstractArticlePDF–2.6M
4.
Altered cyclic nucleotide binding and pore opening in a diseased human HCN4 channel
Leo C.T. Ng, Yue Xian Li, Filip Van Petegem, Eric A. Accili
Biophys J. 2022 Apr 5; 121(7): 1166–1183. Published online 2022 Feb 24. doi: 10.1016/j.bpj.2022.02.035
PMCID:
PMC9034293
AbstractArticlePDF–1.4M
5.
Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes
Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Satoshi Akagi, Toru Miyoshi, Hiroshi Morita, Hiroshi Ito
Stem Cell Res Ther. 2022; 13: 141. Published online 2022 Apr 1. doi: 10.1186/s13287-022-02818-y
PMCID:
PMC8973792
AbstractArticlePDF–3.9M
6.
Clinical Presentation of Left Ventricular Noncompaction Cardiomyopathy and Bradycardia in Three Families Carrying HCN4 Pathogenic Variants
Agata Paszkowska, Dorota Piekutowska-Abramczuk, Elżbieta Ciara, Alicja Mirecka-Rola, Monika Brzezinska, Dorota Wicher, Grażyna Kostrzewa, Jędrzej Sarnecki, Lidia Ziółkowska
Genes (Basel) 2022 Mar; 13(3): 477. Published online 2022 Mar 8. doi: 10.3390/genes13030477
PMCID:
PMC8949387
AbstractArticlePDF–2.2M
7.
Gating movements and ion permeation in HCN4 pacemaker channels
Andrea Saponaro, Daniel Bauer, M. Hunter Giese, Paolo Swuec, Alessandro Porro, Federica Gasparri, Atiyeh Sadat Sharifzadeh, Antonio Chaves-Sanjuan, Laura Alberio, Giacomo Parisi, Gabriele Cerutti, Oliver B. Clarke, Kay Hamacher, Henry M. Colecraft, Filippo Mancia, Wayne A. Hendrickson, Steven A. Siegelbaum, Dario DiFrancesco, Martino Bolognesi, Gerhard Thiel, Bina Santoro, Anna Moroni
Mol Cell. 2021 Jul 15; 81(14): 2929–2943.e6. doi: 10.1016/j.molcel.2021.05.033
PMCID:
PMC8294335
AbstractArticle
8.
Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking
Nadine Erlenhardt, Olaf Kletke, Franziska Wohlfarth, Marlene A. Komadowski, Lukas Clasen, Hisaki Makimoto, Susanne Rinné, Malte Kelm, Christiane Jungen, Niels Decher, Christian Meyer, Nikolaj Klöcker
Pflugers Arch. 2020; 472(12): 1733–1742. Published online 2020 Oct 23. doi: 10.1007/s00424-020-02481-3
PMCID:
PMC7691308
AbstractArticlePDF–1.3M
9.
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing
Anna M. D. Végh, A. Dénise den Haan, Lucía Cócera Ortega, Arie O. Verkerk, Joost P. G. Sluijter, Diane Bakker, Shirley van Amersfoorth, Toon A. B. van Veen, Mischa Klerk, Jurgen Seppen, Jacques M. T. de Bakker, Vincent M. Christoffels, Dirk Geerts, Marie José T. H. Goumans, Hanno L. Tan, Gerard J. J. Boink
Molecules. 2019 Jan; 24(1): 181. Published online 2019 Jan 5. doi: 10.3390/molecules24010181
PMCID:
PMC6337610
AbstractArticlePDF–3.1M
10.
Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia
Stephen Boulton, Madoka Akimoto, Sam Akbarizadeh, Giuseppe Melacini
J Biol Chem. 2017 Apr 14; 292(15): 6414–6428. Published online 2017 Feb 7. doi: 10.1074/jbc.M116.773697
PMCID:
PMC5391768
AbstractArticlePDF–4.4M
11.
Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels
Bryan VanSchouwen, Madoka Akimoto, Maryam Sayadi, Federico Fogolari, Giuseppe Melacini
J Biol Chem. 2015 Jul 17; 290(29): 17642–17654. Published online 2015 May 4. doi: 10.1074/jbc.M115.651877
PMCID:
PMC4505013
AbstractArticlePDF–2.9M
12.
A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP
Madoka Akimoto, Zaiyong Zhang, Stephen Boulton, Rajeevan Selvaratnam, Bryan VanSchouwen, Melanie Gloyd, Eric A. Accili, Oliver F. Lange, Giuseppe Melacini
J Biol Chem. 2014 Aug 8; 289(32): 22205–22220. Published online 2014 May 30. doi: 10.1074/jbc.M114.572164
PMCID:
PMC4139233
AbstractArticlePDF–4.4M
13.
A Novel Trafficking-defective HCN4 Mutation is Associated with Early-Onset Atrial Fibrillation
Vincenzo Macri, Saagar N. Mahida, Michael L. Zhang, Moritz F. Sinner, Elena V. Dolmatova, Nathan R. Tucker, Micheal McLellan, Marisa A. Shea, David J. Milan, Kathryn L. Lunetta, Emelia J. Benjamin, Patrick T. Ellinor
Heart Rhythm. Author manuscript; available in PMC 2015 Jun 1.
Published in final edited form as: Heart Rhythm. 2014 Jun; 11(6): 1055–1062. Published online 2014 Mar 4. doi: 10.1016/j.hrthm.2014.03.002
PMCID:
PMC4130372
AbstractArticlePDF–741K
14.
Association of polymorphisms in HCN4 with a broad mood-anxiety disorder phenotype
Benjamin Kelmendi, Márcia Holsbach-Beltrame, Andrew M. McIntosh, Lori Hilt, Elizabeth D. George, Robert R. Kitchen, Becky C. Carlyle, Christopher Pittenger, Vladimir Coric, Susan Nolen-Hoeksema, Gerard Sanacora, Arthur A. Simen
Neurosci Lett. Author manuscript; available in PMC 2013 Jun 4.
Published in final edited form as: Neurosci Lett. 2011 Jun 8; 496(3): 195–199. Published online 2011 Apr 20. doi: 10.1016/j.neulet.2011.04.026
PMCID:
PMC3672234
AbstractArticlePDF–50K
15.
A NOVEL MUTATION IN THE HCN4 GENE CAUSES SYMPTOMATIC SINUS BRADYCARDIA IN MOROCCAN JEWS
Avishag Laish-Farkash, Dovrat Brass, Dina Marek-Yagel, Elon Pras, Nathan Dascal, Charles Antzelevitch, Eyal Nof, Haya Reznik, Michael Eldar, Michael Glikson, David Luria
J Cardiovasc Electrophysiol. Author manuscript; available in PMC 2011 Dec 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2010 Dec; 21(12): 1365–1372. doi: 10.1111/j.1540-8167.2010.01844.x
PMCID:
PMC3005590
AbstractArticlePDF–832K
16.
Rescue of a Trafficking Defective Human Pacemaker Channel via a Novel Mechanism: ROLES OF Src, Fyn, AND Yes TYROSINE KINASES
Yen-Chang Lin, Jianying Huang, Hong Kan, Jefferson C. Frisbee, Han-Gang Yu
J Biol Chem. 2009 Oct 30; 284(44): 30433–30440. Published online 2009 Sep 11. doi: 10.1074/jbc.M109.039180
PMCID:
PMC2781598
AbstractArticlePDF–2.6M
17.
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels
A Bucchi, A Tognati, R Milanesi, M Baruscotti, D DiFrancesco
J Physiol. 2006 Apr 15; 572(Pt 2): 335–346. Published online 2006 Feb 16. doi: 10.1113/jphysiol.2005.100776
PMCID:
PMC1779671
AbstractArticlePDF–244K
18.
Calcium influx through hyperpolarization-activated cation channels (Ih channels) contributes to activity-evoked neuronal secretion
Xiao Yu, Kai-Lai Duan, Chun-Feng Shang, Han-Gang Yu, Zhuan Zhou
Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4): 1051–1056. Published online 2004 Jan 14. doi: 10.1073/pnas.0305167101
PMCID:
PMC327149
AbstractArticlePDF–432K
19.
Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis
Reinhard Seifert, Alexander Scholten, Renate Gauss, Antoaneta Mincheva, Peter Lichter, U. Benjamin Kaupp
Proc Natl Acad Sci U S A. 1999 Aug 3; 96(16): 9391–9396. doi: 10.1073/pnas.96.16.9391
PMCID:
PMC17793
AbstractArticlePDF–554K
20.
Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia
Alicia D’Souza, Charles M. Pearman, Yanwen Wang, Shu Nakao, Sunil Jit R.J. Logantha, Charlotte Cox, Hayley Bennett, Yu Zhang, Anne Berit Johnsen, Nora Linscheid, Pi Camilla Poulsen, Jonathan Elliott, Jessica Coulson, Jamie McPhee, Abigail Robertson, Paula A. da Costa Martins, Ashraf Kitmitto, Ulrik Wisløff, Elizabeth J. Cartwright, Oliver Monfredi, Alicia Lundby, Halina Dobrzynski, Delvac Oceandy, Gwilym M. Morris, Mark R. Boyett
Circ Res. 2017 Oct 13; 121(9): 1058–1068. Published online 2017 Oct 12. doi: 10.1161/CIRCRESAHA.117.311607
PMCID:
PMC5636198
AbstractArticlePDF–2.6M

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