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Select item 76135091.

Sickle Cell Anemia and Its Phenotypes

Thomas N. Williams, Swee Lay Thein

Annu Rev Genomics Hum Genet. Author manuscript; available in PMC 2022 Sep 3.

Published in final edited form as: Annu Rev Genomics Hum Genet. 2018 Aug 31; 19: 113–147. Published online 2018 Apr 11. doi: 10.1146/annurev-genom-083117-021320

PMCID:: PMC7613509

Abstract Article PDF–1.9M

Select item 70200642.

World Health Organization’s Growth Reference Overestimates the Prevalence of Severe Malnutrition in Children with Sickle Cell Anemia in Africa

Djamila L. Ghafuri, Shehu U. Abdullahi, Binta W. Jibir, Safiya Gambo, Halima Bello-Manga, Lawal Haliru, Khadija Bulama, Fahd M. Usman, Awwal Gambo, Muktar H. Aliyu, Brittany C. Greene, Adetola A. Kassim, Chris Slaughter, Mark Rodeghier, Michael R. DeBaun

J Clin Med. 2020 Jan; 9(1): 119. Published online 2020 Jan 2. doi: 10.3390/jcm9010119

PMCID:: PMC7020064

Abstract Article PDF–1.6M

Select item 114596963.

Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission

Frédéric B Piel, David C Rees, Michael R DeBaun, Obiageli Nnodu, Brigitte Ranque, Alexis A Thompson, Russell E Ware, Miguel R Abboud, Allistair Abraham, Emmanuela E Ambrose, Biree Andemariam, Roshan Colah, Raffaella Colombatti, Nicola Conran, Fernando F Costa, Robert M Cronin, Mariane de Montalembert, Jacques Elion, Erica Esrick, Anthea L Greenway, Ibrahim M Idris, David-Zacharie Issom, Dipty Jain, Lori C Jordan, Zane S Kaplan, Allison A King, Michele Lloyd-Puryear, Samuel A Oppong, Akshay Sharma, Lillian Sung, Leon Tshilolo, Diana J Wilkie, Kwaku Ohene-Frempong

Lancet Haematol. Author manuscript; available in PMC 2024 Oct 8.

Published in final edited form as: Lancet Haematol. 2023 Aug; 10(8): e633–e686. Published online 2023 Jul 11. doi: 10.1016/S2352-3026(23)00096-0

PMCID:: PMC11459696

Abstract Article PDF–1.2M

Select item 98323864.

The nephropathy of sickle cell trait and sickle cell disease

Kenneth I. Ataga, Santosh L. Saraf, Vimal K. Derebail

Nat Rev Nephrol. Author manuscript; available in PMC 2023 Jan 11.

Published in final edited form as: Nat Rev Nephrol. 2022 Jun; 18(6): 361–377. Published online 2022 Feb 21. doi: 10.1038/s41581-022-00540-9

PMCID:: PMC9832386

Abstract Article PDF–985K

Select item 101427005.

Bacterial Infection in the Sickle Cell Population: Development and Enabling Factors

Lucrèce M. Délicat-Loembet, Mohamed Ag Baraïka, Flabou Bougoudogo, Dapa A. Diallo

Microorganisms. 2023 Apr; 11(4): 859. Published online 2023 Mar 28. doi: 10.3390/microorganisms11040859

PMCID:: PMC10142700

Abstract Article PDF–319K

Select item 91218446.

Revisiting anemia in sickle cell disease and finding the balance with therapeutic approaches

Julia Zhe Xu, Swee Lay Thein

Blood. 2022 May 19; 139(20): 3030–3039. doi: 10.1182/blood.2021013873

PMCID:: PMC9121844

Abstract Article

Select item 105854227.

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis

Justin K. Kirkham, Jeremie H. Estepp, Mitch J. Weiss, Sara R. Rashkin

JAMA Netw Open. 2023 Oct; 6(10): e2337484. Published online 2023 Oct 18. doi: 10.1001/jamanetworkopen.2023.37484

PMCID:: PMC10585422

Abstract Article

Select item 70535588.

Pathophysiology of Sickle Cell Disease

Prithu Sundd, Mark T. Gladwin, Enrico M. Novelli

Annu Rev Pathol. Author manuscript; available in PMC 2020 Mar 3.

Published in final edited form as: Annu Rev Pathol. 2019 Jan 24; 14: 263–292. Published online 2018 Oct 17. doi: 10.1146/annurev-pathmechdis-012418-012838

PMCID:: PMC7053558

Abstract Article PDF–1.7M

Select item 33316909.

Hematopoietic Stem Cell Transplantation in Thalassemia and Sickle Cell Anemia

Guido Lucarelli, Antonella Isgrò, Pietro Sodani, Javid Gaziev

Cold Spring Harb Perspect Med. 2012 May; 2(5): a011825. doi: 10.1101/cshperspect.a011825

PMCID:: PMC3331690

Abstract Article PDF–428K

Select item 683306210.

Why, Who, When, and How? Rationale for Considering Allogeneic Stem Cell Transplantation in Children with Sickle Cell Disease

Françoise Bernaudin

J Clin Med. 2019 Oct; 8(10): 1523. Published online 2019 Sep 22. doi: 10.3390/jcm8101523

PMCID:: PMC6833062

Abstract Article PDF–953K

Select item 1104976611.

Management of diabetes mellitus patients with sickle cell anemia: Challenges and therapeutic approaches

Emmanuel Ifeanyi Obeagu, Getrude Uzoma Obeagu

Medicine (Baltimore) 2024 Apr 26; 103(17): e37941. Published online 2024 Apr 26. doi: 10.1097/MD.0000000000037941

PMCID:: PMC11049766

Abstract Article PDF–468K

Select item 1125279912.

Ferroptosis as an emerging target in sickle cell disease

Vitor Fortuna, Jaqueline Lima, Gabriel F. Oliveira, Yasmin S. Oliveira, Bruk Getachew, Sergei Nekhai, Michael Aschner, Yousef Tizabi

Curr Res Toxicol. 2024; 7: 100181. Published online 2024 Jun 18. doi: 10.1016/j.crtox.2024.100181

PMCID:: PMC11252799

Abstract Article PDF–4.7M

Select item 992665613.

Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes

Kun Wang, Zhiqiang Li, Ogechukwu Egini, Raj Wadgaonkar, Xian-Cheng Jiang, Yong Chen

BMC Biol. 2023; 21: 31. Published online 2023 Feb 13. doi: 10.1186/s12915-023-01523-3

PMCID:: PMC9926656

Abstract Article PDF–3.2M

Select item 664540014.

Therapeutic strategies for sickle cell disease: towards a multi-agent approach

Marilyn J. Telen, Punam Malik, Gregory M. Vercellotti

Nat Rev Drug Discov. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Nat Rev Drug Discov. 2019 Feb; 18(2): 139–158. doi: 10.1038/s41573-018-0003-2

PMCID:: PMC6645400

Abstract Article PDF–877K

Select item 768521015.

Fetal hemoglobin in sickle cell anemia

Martin H. Steinberg

Blood. 2020 Nov 19; 136(21): 2392–2400. Prepublished online 2020 Aug 17. doi: 10.1182/blood.2020007645

PMCID:: PMC7685210

Abstract Article

Select item 1066040916.

Sickle cell anemia and pregnancy: Profile of hemodynamic changes in sickle cell pregnant women in Kinshasa

Tite Minga Mikobi, Nelly Ciombo Kamuanya, Emmanuelle Ketsia Bokashanga Mikobi, Thérèse Ilunga Kalela, Pierre Zalagile Akilimali, Prosper Tshilobo Lukusa

EJHaem. 2023 Nov; 4(4): 977–983. Published online 2023 Sep 11. doi: 10.1002/jha2.789

PMCID:: PMC10660409

Abstract Article PDF–701K

Select item 726957917.

The multifaceted role of ischemia/reperfusion in sickle cell anemia

Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti

J Clin Invest. 2020 Mar 2; 130(3): 1062–1072. Published online 2020 Mar 2. doi: 10.1172/JCI133639

PMCID:: PMC7269579

Abstract Article PDF–2.3M

Select item 943559318.

Hydroxyurea (hydroxycarbamide) for sickle cell disease

Cochrane Database Syst Rev. 2022; 2022(9): CD002202. Published online 2022 Sep 1. doi: 10.1002/14651858.CD002202.pub3

PMCID:: PMC9435593

Abstract Article PDF–1.2M

Select item 622429819.

Rheological properties of sickle erythrocytes in patients with sickle cell anaemia: the effect of hydroxyurea, fetal hemoglobin and α-thalassaemia

Samir K. Ballas, Philippe Connes, Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia

Eur J Haematol. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Eur J Haematol. 2018 Dec; 101(6): 798–803. Published online 2018 Oct 9. doi: 10.1111/ejh.13173

PMCID:: PMC6224298

Abstract Article PDF–534K

Select item 681682420.

Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α^3.7 triplication in congolese patients than in worldwide series

Tite Minga Mikobi, Prosper Tshilobo Lukusa, Michel Ntetani Aloni, Aimé Lumaka, Pierre Zalagile Akilimali, Koenraad Devriendt, Gert Matthijs, Jean‐Marie Mbuyi Muamba, Valerie Race

J Clin Lab Anal. 2018 Jan; 32(1): e22186. Published online 2017 Mar 9. doi: 10.1002/jcla.22186

PMCID:: PMC6816824

Abstract Article PDF–399K

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Figure 2

(A) Hypertension stage in sickle cell anemia patients <18 years old from the Ibadan and Chicago cohorts. Lower proportions of sickle cell anemia patients from Chicago were normotensive (84.0 vs. 98.0%), and higher proportions were pre hypertensive or hypertensive (16.0 vs. 3.0%) compared to sickle cell anemia patients from Ibadan, respectively. (B) Hypertension stage in sickle cell anemia patients ≥18 years old from the Ibadan and Chicago cohorts. Lower proportions of sickle cell anemia patients from Chicago were normotensive (53.0 vs. 83.0%) and higher proportions were pre hypertensive or hypertensive (47.0 vs. 17.0%) compared to sickle cell anemia patients from Ibadan, respectively.

Comparison of Patients from Nigeria and the USA Highlights Modifiable Risk Factors for Sickle Cell Anemia Complications

Hemoglobin. ;38(4):236-243.
Figure 1

(A) Weight status in sickle cell anemia patients <18 years old from the Ibadan and Chicago cohorts. A higher proportion of sickle cell anemia patients from Ibadan were underweight (42.0 vs. 13.0%), while higher proportions of sickle cell anemia patients from Chicago were overweight or obese (6.0 vs. 3.0%), respectively. (B) Weight status in sickle cell anemia patients ≥18 years old from the Ibadan and Chicago cohorts. A higher proportion of sickle cell anemia patients from Ibadan were underweight (34.0 vs. 9.0%), while higher proportions of sickle cell anemia patients from Chicago were overweight or obese (25.0 vs. 3.0%), respectively.

Comparison of Patients from Nigeria and the USA Highlights Modifiable Risk Factors for Sickle Cell Anemia Complications

Hemoglobin. ;38(4):236-243.
Figure 4Unadjusted changes in VO2peak over time among children with and without sickle cell anemia

Children with sickle cell anemia have significantly lower baseline VO_2peak and significantly reduced change in VO_2peak over time compared to controls.

Longitudinal Differences in Aerobic Capacity between Children with Sickle Cell Anemia and Matched Controls

Pediatr Blood Cancer. ;62(4):648-653.
Figure 5Changes in VO2peak over time among children with and without sickle cell anemia adjusted for age, gender, FFM, Tanner stage, and hemoglobin

Baseline differences in VO_2peak between children with and without sickle cell anemia are no longer evident, but children with SCA continue to have significantly reduced VO_2peak over time.

Longitudinal Differences in Aerobic Capacity between Children with Sickle Cell Anemia and Matched Controls

Pediatr Blood Cancer. ;62(4):648-653.