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Select item 101072651.

New perspectives on the molecular mechanisms of stress signalling by the nucleotide guanosine tetraphosphate (ppGpp), an emerging regulator of photosynthesis in plants and algae

Marwa Mehrez, Shanna Romand, Ben Field

New Phytol. 2023 Feb; 237(4): 1086–1099. Published online 2022 Dec 2. doi: 10.1111/nph.18604

PMCID:: PMC10107265

Abstract Article PDF–1.8M

Select item 76661502.

ppGpp functions as an alarmone in metazoa

Doshun Ito, Hinata Kawamura, Akira Oikawa, Yuta Ihara, Toshio Shibata, Nobuhiro Nakamura, Tsunaki Asano, Shun-Ichiro Kawabata, Takashi Suzuki, Shinji Masuda

Commun Biol. 2020; 3: 671. Published online 2020 Nov 13. doi: 10.1038/s42003-020-01368-4

PMCID:: PMC7666150

Abstract Article PDF–1.5M

Select item 65118613.

Growth suppression by altered (p)ppGpp levels results from non-optimal resource allocation in Escherichia coli

Manlu Zhu, Xiongfeng Dai

Nucleic Acids Res. 2019 May 21; 47(9): 4684–4693. Published online 2019 Mar 27. doi: 10.1093/nar/gkz211

PMCID:: PMC6511861

Abstract Article PDF–1.2M

Select item 73549384.

The alarmones (p)ppGpp directly regulate translation initiation during entry into quiescence

Simon Diez, Jaewook Ryu, Kelvin Caban, Ruben L. Gonzalez, Jr, Jonathan Dworkin

Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 15565–15572. Published online 2020 Jun 23. doi: 10.1073/pnas.1920013117

PMCID:: PMC7354938

Abstract Article PDF–1.1M

Select item 56973485.

Monitoring of nutrient limitation in growing E. coli: a mathematical model of a ppGpp-based biosensor

Alexandra Pokhilko

BMC Syst Biol. 2017; 11: 106. Published online 2017 Nov 21. doi: 10.1186/s12918-017-0490-5

PMCID:: PMC5697348

Abstract Article PDF–661K

Select item 104340556.

Functional Characterization of Small Alarmone Synthetase and Small Alarmone Hydrolase Proteins from Treponema denticola

Miao Wang, Nga-Yeung Tang, Shujie Xie, Rory M. Watt

Microbiol Spectr. 2023 Jul-Aug; 11(4): e05100-22. Published online 2023 Jun 8. doi: 10.1128/spectrum.05100-22

PMCID:: PMC10434055

Abstract Article PDF–5.7M

Select item 82527177.

ppGpp influences protein protection, growth and photosynthesis in Phaeodactylum tricornutum

Luisana Avilan, Regine Lebrun, Carine Puppo, Sylvie Citerne, Stephane Cuiné, Yonghua Li‐Beisson, Benoît Menand, Ben Field, Brigitte Gontero

New Phytol. 2021 May; 230(4): 1517–1532. Published online 2021 Mar 19. doi: 10.1111/nph.17286

PMCID:: PMC8252717

Abstract Article PDF–2.1M

Select item 60134438.

Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region

Timothy Tapscott, Ju-Sim Kim, Matthew A. Crawford, Liam Fitzsimmons, Lin Liu, Jessica Jones-Carson, Andrés Vázquez-Torres

Sci Rep. 2018; 8: 9465. Published online 2018 Jun 21. doi: 10.1038/s41598-018-27780-9

PMCID:: PMC6013443

Abstract Article PDF–2.0M

Select item 76769129.

Guanosine Tetraphosphate Has a Similar Affinity for Each of Its Two Binding Sites on Escherichia coli RNA Polymerase

Angela R. Myers, Danielle P. Thistle, Wilma Ross, Richard L. Gourse

Front Microbiol. 2020; 11: 587098. Published online 2020 Nov 5. doi: 10.3389/fmicb.2020.587098

PMCID:: PMC7676912

Abstract Article PDF–7.3M

Select item 836227310.

ppGpp coordinates nucleotide and amino-acid synthesis in E. coli during starvation

Boyuan Wang, Robert A. Grant, Michael T. Laub

Mol Cell. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Mol Cell. 2020 Oct 1; 80(1): 29–42.e10. Published online 2020 Aug 27. doi: 10.1016/j.molcel.2020.08.005

PMCID:: PMC8362273

Abstract Article PDF–2.9M

Select item 758465211.

The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p)ppGpp

Jin Yang, Brent W. Anderson, Asan Turdiev, Husan Turdiev, David M. Stevenson, Daniel Amador-Noguez, Vincent T. Lee, Jue D. Wang

Nat Commun. 2020; 11: 5388. Published online 2020 Oct 23. doi: 10.1038/s41467-020-19166-1

Correction in:: Nat Commun. 2021; 12: 3857.

PMCID:: PMC7584652

Abstract Article PDF–942K

Select item 939149112.

An expanded whole-cell model of E. coli links cellular physiology with mechanisms of growth rate control

Travis A. Ahn-Horst, Luis Santiago Mille, Gwanggyu Sun, Jerry H. Morrison, Markus W. Covert

NPJ Syst Biol Appl. 2022; 8: 30. Published online 2022 Aug 19. doi: 10.1038/s41540-022-00242-9

PMCID:: PMC9391491

Abstract Article PDF–5.7M

Select item 473831013.

Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth

Nityananda Chowdhury, Brian W. Kwan, Thomas K. Wood

Sci Rep. 2016; 6: 20519. Published online 2016 Feb 3. doi: 10.1038/srep20519

PMCID:: PMC4738310

Abstract Article PDF–909K

Select item 377437214.

A Proximal Promoter Element Required for Positive Transcriptional Control by Guanosine Tetraphosphate and DksA Protein during the Stringent Response

Bertil Gummesson, Martin Lovmar, Thomas Nyström

J Biol Chem. 2013 Jul 19; 288(29): 21055–21064. Published online 2013 Jun 7. doi: 10.1074/jbc.M113.479998

PMCID:: PMC3774372

Abstract Article PDF–928K

Select item 996561115.

Protein–Ligand Interactions in Scarcity: The Stringent Response from Bacteria to Metazoa, and the Unanswered Questions

Sailen Barik

Int J Mol Sci. 2023 Feb; 24(4): 3999. Published online 2023 Feb 16. doi: 10.3390/ijms24043999

PMCID:: PMC9965611

Abstract Article PDF–3.0M

Select item 888789216.

A guanosine tetraphosphate (ppGpp) mediated brake on photosynthesis is required for acclimation to nitrogen limitation in Arabidopsis

Shanna Romand, Hela Abdelkefi, Cécile Lecampion, Mohamed Belaroussi, Melanie Dussenne, Brigitte Ksas, Sylvie Citerne, Jose Caius, Stefano D'Alessandro, Hatem Fakhfakh, Stefano Caffarri, Michel Havaux, Ben Field

eLife. 2022; 11: e75041. Published online 2022 Feb 14. doi: 10.7554/eLife.75041

PMCID:: PMC8887892

Abstract Article PDF–2.0M

Select item 600335517.

Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems

Madeline E. Sherlock, Narasimhan Sudarsan, Ronald R. Breaker

Proc Natl Acad Sci U S A. 2018 Jun 5; 115(23): 6052–6057. Published online 2018 May 21. doi: 10.1073/pnas.1720406115

PMCID:: PMC6003355

Abstract Article PDF–900K

Select item 663806218.

Guanosine tetraphosphate modulates salicylic acid signalling and the resistance of Arabidopsis thaliana to Turnip mosaic virus

Hela Abdelkefi, Matteo Sugliani, Hang Ke, Seddik Harchouni, Ludivine Soubigou‐Taconnat, Sylvie Citerne, Gregory Mouille, Hatem Fakhfakh, Christophe Robaglia, Ben Field

Mol Plant Pathol. 2018 Mar; 19(3): 634–646. Published online 2017 Mar 27. doi: 10.1111/mpp.12548