lysyl oxidase-like 1 - PMC

Takeshi Chida, Kazuyoshi Ohta, Hidenao Noritake, Masahiro Matsushita, Gou Murohisa, Fujito Kageyama, Yuzo Sasada, Tatsuki Oyaizu, Minoru Tsugiki, Katsutoshi Tamakoshi, Takeyuki Nakajima, Takafumi Suda, Kazuhito Kawata

Sci Rep. 2024; 14: 10864. Published online 2024 May 13. doi: 10.1038/s41598-024-61366-y

PMCID:: PMC11091085

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Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation

Weiping Lin, Liangliang Xu, Gang Li

Front Bioeng Biotechnol. 2020; 8: 359. Published online 2020 Apr 30. doi: 10.3389/fbioe.2020.00359

Correction in:: Front Bioeng Biotechnol. 2020; 8: 598323.

PMCID:: PMC7204390

Abstract Article PDF–3.5M

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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Jessica L. Chitty, Michelle Yam, Lara Perryman, Amelia L. Parker, Joanna N. Skhinas, Yordanos F. I. Setargew, Ellie T. Y. Mok, Emmi Tran, Rhiannon D. Grant, Sharissa L. Latham, Brooke A. Pereira, Shona C. Ritchie, Kendelle J. Murphy, Michael Trpceski, Alison D. Findlay, Pauline Melenec, Elysse C. Filipe, Audrey Nadalini, Sipiththa Velayuthar, Gretel Major, Kaitlin Wyllie, Michael Papanicolaou, Shivanjali Ratnaseelan, Phoebe A. Phillips, George Sharbeen, Janet Youkhana, Alice Russo, Antonia Blackwell, Jordan F. Hastings, Morghan C. Lucas, Cecilia R. Chambers, Daniel A. Reed, Janett Stoehr, Claire Vennin, Ruth Pidsley, Anaiis Zaratzian, Andrew M. Da Silva, Michael Tayao, Brett Charlton, David Herrmann, Max Nobis, Susan J. Clark, Andrew V. Biankin, Amber L. Johns, David R. Croucher, Adnan Nagrial, Anthony J. Gill, Sean M. Grimmond, Australian Pancreatic Cancer Genome Initiative (APGI), Australian Pancreatic Cancer Matrix Atlas (APMA), Marina Pajic, Paul Timpson, Wolfgang Jarolimek, Thomas R. Cox

Nat Cancer. 2023; 4(9): 1326–1344. Published online 2023 Aug 28. doi: 10.1038/s43018-023-00614-y

PMCID:: PMC10518255

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Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening

Jochen Steppan, Huilei Wang, Yehudit Bergman, Marcel J. Rauer, Siqi Tan, Sandeep Jandu, Kavitha Nandakumar, Sebastian Barreto-Ortiz, Robert N. Cole, Tatiana N. Boronina, Wanqu Zhu, Marc K. Halushka, Steven S. An, Dan E. Berkowitz, Lakshmi Santhanam

Am J Physiol Heart Circ Physiol. 2019 Jul 1; 317(1): H49–H59. Published online 2019 Apr 19. doi: 10.1152/ajpheart.00670.2018

PMCID:: PMC6692735

Abstract Article

Select item 1108266511.

The dual role of LOXL4 in the pathogenesis and development of human malignant tumors: a narrative review

Ruai Liu, Bin Li, Jiaji Zi, Ruopeng Zhang, Min Yu, Jinghua Zhou, Yuanqian Pu, Wei Xiong

Transl Cancer Res. 2024 Apr 30; 13(4): 2026–2042. Published online 2024 Apr 17. doi: 10.21037/tcr-23-2003

PMCID:: PMC11082665

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Silencing of lysyl oxidase-like 2 inhibits the migration, invasion and epithelial-to-mesenchymal transition of renal cell carcinoma cells through the Src/FAK signaling pathway

Xi Hong, Jian-Jun Yu

Int J Oncol. 2019 May; 54(5): 1676–1690. Published online 2019 Feb 27. doi: 10.3892/ijo.2019.4726

PMCID:: PMC6438419

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The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction

Dalia Guadarrama-Vallejo, Antonio Miranda-Duarte, Juan Carlos Zenteno

Mol Vis. 2013; 19: 1937–1944. Published online 2013 Sep 16.

PMCID:: PMC3782368

Abstract Article PDF–535K

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Inhibition of lysyl oxidase‐like 2 overcomes adhesion‐dependent drug resistance in the collagen‐enriched liver cancer microenvironment

Lanqi Gong, Yu Zhang, Yuma Yang, Qian Yan, Jifeng Ren, Jie Luo, Yuen Chak Tiu, Xiaona Fang, Beilei Liu, Raymond Hiu Wai Lam, Ka‐On Lam, Anne Wing‐Mui Lee, Xin‐Yuan Guan

Hepatol Commun. 2022 Nov; 6(11): 3194–3211. Published online 2022 Jul 27. doi: 10.1002/hep4.1966

PMCID:: PMC9592791

Abstract Article PDF–6.8M

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Lysyl oxidase‐like protein secreted from an acidophilic red alga, Cyanidium caldarium

Tatsuya Tomo, Akinori Okumura, Takehiro Suzuki, Mirai Okuhara, Ruriko Katayama, Noboru Isayama, Ryo Nagao, Masako Iwai, Naoshi Dohmae, Isao Enami

Plant Direct. 2018 Oct; 2(10): e00084. Published online 2018 Oct 8. doi: 10.1002/pld3.84

PMCID:: PMC6508830

Abstract Article PDF–2.1M

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Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

Naoki Ikenaga, Zhen-Wei Peng, Kahini A Vaid, Susan B Liu, Shuhei Yoshida, Deanna Y Sverdlov, Amanda Mikels-Vigdal, Victoria Smith, Detlef Schuppan, Yury V Popov

Gut. 2017 Sep; 66(9): 1697–1708. Published online 2017 Jan 10. doi: 10.1136/gutjnl-2016-312473

PMCID:: PMC5561383

Abstract Article PDF–12M

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Multiple Functions of Lysyl Oxidase Like-2 in Oral Fibroproliferative Processes

D. Saxena, F. Mahjour, A.D. Findlay, E.A. Mously, A. Kantarci, P.C. Trackman

J Dent Res. 2018 Oct; 97(11): 1277–1284. Published online 2018 May 22. doi: 10.1177/0022034518775971

PMCID:: PMC6151912

Abstract Article PDF–640K

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Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface

Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, I Made Winarsa Ruma, I Wayan Sumardika, Jin Zhou, Tomoko Honjo, Yoshihiko Sakaguchi, Akira Yamauchi, Futoshi Kuribayashi, Eisaku Kondo, Yusuke Inoue, Junichiro Futami, Shinichi Toyooka, Yoshito Zamami, Masakiyo Sakaguchi

Front Oncol. 2024; 14: 1371342. Published online 2024 Mar 26. doi: 10.3389/fonc.2024.1371342

PMCID:: PMC11002074

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Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling

Jopeth Ramis, Robert Middlewick, Francesco Pappalardo, Jennifer T. Cairns, Iain D. Stewart, Alison E. John, Shams-Un-Nisa Naveed, Ramaswamy Krishnan, Suzanne Miller, Dominick E. Shaw, Christopher E. Brightling, Lee Buttery, Felicity Rose, Gisli Jenkins, Simon R. Johnson, Amanda L. Tatler

Eur Respir J. 2022 Jul; 60(1): 2004361. Published online 2022 Jul 7. doi: 10.1183/13993003.04361-2020

PMCID:: PMC9260127

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Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy

Philip C. Trackman, Yaser Peymanfar, Sayon Roy

Int J Mol Sci. 2022 May; 23(9): 5088. Published online 2022 May 3. doi: 10.3390/ijms23095088

PMCID:: PMC9105217

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PMC Images search for lysyl oxidase-like 1

Figure 1

Partial alignment of lysyl oxidase-like 1, lysyl oxidase-like 2, lysyl oxidase-like 3, and lysyl oxidase-like 4 genes by CLC Sequence Workbench. Sequences of lysyl oxidase-like 1 (LOXL1) primers are boxed in a red frame, probes for the R141L single nucleotide polymorphism (SNP) in blue, and probes for the G153D SNP in green (only these areas are shown).

Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population

Mol Vis. 2013;19:1006-1016.
Fig. 1Expressions of lysyl oxidase-like 1 (A) and fibulin-5 (B) by immunohistochemistry (magnification: ×400; scale bar: 50 µm).

Positive expression was indicated by brown-yellow granules in the cardinal ligament tissues of patients with pelvic organ prolapse.

Expression and significance of lysyl oxidase-like 1 and fibulin-5 in the cardinal ligament tissue of patients with pelvic floor dysfunction

J Biomed Res. 2013 Jan;27(1):23-28.
FIGURE 1

Haplotype frequency of LOXL1 exon 1 variants. Graph depicts the percentage of individuals in each cohort (control, PXF and PXFG) with the G-G-G, T-G-G, and G-A-C haplotypes comprising the 2 coding SNPs rs1048661 and rs3825942 within exon 1 of LOXL1 and the intronic SNP rs6495085. LOXL1 indicates lysyl oxidase-like 1; PXFG, pseudoexfoliation glaucoma; PXF, pseudoexfoliation syndrome; SNP, single nucleotide polymorphism.

Prevalence of Pseudoexfoliation Glaucoma Risk–associated Variants Within Lysyl Oxidase–like 1 in an Irish Population

J Glaucoma. 2020 Jun;29(6):417-422.
Figure 1

Partial nucleotide sequence of lysyl oxidase-like 1 gene exon 1 showing single nucleotide polymorphism rs41435250 in deoxyribonucleic acid from individuals with pseudoexfoliation syndrome or pseudoexfoliation glaucoma. The arrow indicates the polymorphic nucleotide and sequence traces for homozygous G, heterozygous G/T , and homozygous T samples are shown in A, B, and C, respectively.

The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction

Mol Vis. 2013;19:1937-1944.