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Select item 108476871.

Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model

Yufei Wang, Jae-Won Cho, Gabriella Kastrunes, Alicia Buck, Cecile Razimbaud, Aedin C. Culhane, Jiusong Sun, David A. Braun, Toni K. Choueiri, Catherine J. Wu, Kristen Jones, Quang-De Nguyen, Zhu Zhu, Kevin Wei, Quan Zhu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco

iScience. 2024 Feb 16; 27(2): 108879. Published online 2024 Jan 15. doi: 10.1016/j.isci.2024.108879

PMCID:: PMC10847687

Abstract Article PDF–3.3M

Select item 106059702.

Regulation of HHLA2 expression in kidney cancer and myeloid cells

Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Kathleen M. Mahoney

BMC Cancer. 2023; 23: 1039. Published online 2023 Oct 27. doi: 10.1186/s12885-023-11496-9

PMCID:: PMC10605970

Abstract Article PDF–2.6M

Select item 105242673.

The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

Apoorvi Chaudhri, Xia Bu, Yunfei Wang, Michael Gomez, James A. Torchia, Ping Hua, Shao-Hsi Hung, Michael A. Davies, Gregory A. Lizee, Ulrich von Andrian, Patrick Hwu, Gordon J. Freeman

Front Immunol. 2023; 14: 1237715. Published online 2023 Sep 13. doi: 10.3389/fimmu.2023.1237715

PMCID:: PMC10524267

Abstract Article PDF–4.5M

Select item 103946764.

Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD‐L1) expression in colorectal carcinoma

Tomotaka Ugai, Takashi Shimizu, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Genki Usui, Juha P Väyrynen, Kazuo Okadome, Koichiro Haruki, Naohiko Akimoto, Yohei Masugi, Annacarolina da Silva, Kosuke Mima, Xuehong Zhang, Andrew T Chan, Molin Wang, Wendy S Garrett, Gordon J Freeman, Jeffrey A Meyerhardt, Jonathan A Nowak, Mingyang Song, Marios Giannakis, Shuji Ogino

Clin Transl Immunology. 2023; 12(8): e1453. Published online 2023 Aug 2. doi: 10.1002/cti2.1453

PMCID:: PMC10394676

Abstract Article PDF–5.1M

Select item 101990795.

ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi Li, Yan Ren, Baoxiang Chen, Congqing Jiang, Geng Meng, Yu-Ru Lee, Wenyi Wei, Gordon J. Freeman, Conghua Xie, Jinfang Zhang

Nat Commun. 2023; 14: 2859. Published online 2023 May 19. doi: 10.1038/s41467-023-38605-3

PMCID:: PMC10199079

Abstract Article PDF–3.3M

Select item 101885896.

PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity

Jing Liu, Xia Bu, Chen Chu, Xiaoming Dai, John M. Asara, Piotr Sicinski, Gordon J. Freeman, Wenyi Wei

Nat Commun. 2023; 14: 2806. Published online 2023 May 17. doi: 10.1038/s41467-023-38443-3

PMCID:: PMC10188589

Abstract Article PDF–3.6M

Select item 102195777.

Targeting PD-L2/RGMb overcomes microbiome-related immunotherapy resistance

Joon Seok Park, Francesca S. Gazzaniga, Meng Wu, Amalia K. Luthens, Jacob Gillis, Wen Zheng, Martin W. LaFleur, Sarah B. Johnson, Golnaz Morad, Elizabeth M. Park, Yifan Zhou, Stephanie S. Watowich, Jennifer A. Wargo, Gordon J. Freeman, Dennis L. Kasper, Arlene H. Sharpe

Nature. Author manuscript; available in PMC 2023 Nov 3.

Published in final edited form as: Nature. 2023 May; 617(7960): 377–385. Published online 2023 May 3. doi: 10.1038/s41586-023-06026-3

Correction in:: Nature. 2023 Jun 1

PMCID:: PMC10219577

Abstract Article PDF–4.7M

Select item 104945208.

PI3Kβ controls immune evasion in PTEN-deficient breast tumors

Johann S. Bergholz, Qiwei Wang, Qi Wang, Michelle Ramseier, Sanjay Prakadan, Weihua Wang, Rong Fang, Sheheryar Kabraji, Qian Zhou, G. Kenneth Gray, Kayley Abell-Hart, Shaozhen Xie, Xiaocan Guo, Hao Gu, Thanh Von, Tao Jiang, Shuang Tang, Gordon J. Freeman, Hye-Jung Kim, Alex K. Shalek, Thomas M. Roberts, Jean J. Zhao

Nature. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Nature. 2023 May; 617(7959): 139–146. Published online 2023 Apr 19. doi: 10.1038/s41586-023-05940-w

PMCID:: PMC10494520

Abstract Article PDF–7.0M

Select item 99636919.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

Meenal Datta, Sampurna Chatterjee, Elizabeth M. Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X. Chen, Kamila Naxerova, Ashwin S. Kumar, Mitrajit Ghosh, Kyrre E. Emblem, Mei R. Ng, William W. Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C. Speranza, Martha R. Neagu, J. Bryan Iorgulescu, Raymond Y. Huang, Gilbert Youssef, David A. Reardon, Arlene H. Sharpe, Gordon J. Freeman, Mario L. Suvà, Lei Xu, Rakesh K. Jain

Proc Natl Acad Sci U S A. 2023 Feb 7; 120(6): e2219199120. Published online 2023 Feb 1. doi: 10.1073/pnas.2219199120

PMCID:: PMC9963691

Abstract Article PDF–2.1M

Select item 984306110.

mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki

J Clin Invest. 2023 Jan 17; 133(2): e160025. Published online 2023 Jan 17. doi: 10.1172/JCI160025

PMCID:: PMC9843061

Abstract Article PDF–1.5M

Select item 982725511.

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

Liya Ding, Qiwei Wang, Antons Martincuks, Michael J Kearns, Tao Jiang, Ziying Lin, Xin Cheng, Changli Qian, Shaozhen Xie, Hye-Jung Kim, Inga-Maria Launonen, Anniina Färkkilä, Thomas M Roberts, Gordon J Freeman, Joyce F Liu, Panagiotis A Konstantinopoulos, Ursula Matulonis, Hua Yu, Jean J Zhao

J Immunother Cancer. 2023; 11(1): e005627. Published online 2023 Jan 6. doi: 10.1136/jitc-2022-005627

PMCID:: PMC9827255

Abstract Article PDF–6.4M

Select item 972897312.

Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo

James A. Torchia, Alexander H. Tavares, Laura S. Carstensen, Da-Yuan Chen, Jessie Huang, Tianshu Xiao, Sonia Mukherjee, Patrick M. Reeves, Hua Tu, Ann E. Sluder, Bing Chen, Darrell N. Kotton, Richard A. Bowen, Mohsan Saeed, Mark C. Poznansky, Gordon J. Freeman

Sci Adv. 2022 Dec; 8(49): eabq6527. Published online 2022 Dec 7. doi: 10.1126/sciadv.abq6527

PMCID:: PMC9728973

Abstract Article PDF–1.9M

Select item 967648113.

Immunoregulatory effects of RGMb in gut inflammation

Magdiel Pérez-Cruz, Bettina P. Iliopoulou, Katie Hsu, Hsin-Hsu Wu, Tom Erkers, Kavya Swaminathan, Sai-Wen Tang, Cameron S. Bader, Neeraja Kambham, Bryan Xie, Rosemarie H. Dekruyff, Gordon J. Freeman, Everett Meyer

Front Immunol. 2022; 13: 960329. Published online 2022 Nov 7. doi: 10.3389/fimmu.2022.960329

PMCID:: PMC9676481

Abstract Article PDF–7.3M

Select item 945114014.

A Comparison of Murine PD-1 and PD-L1 Monoclonal Antibodies

Melissa T. Bu, Long Yuan, Alyssa N. Klee, Gordon J. Freeman

Monoclon Antib Immunodiagn Immunother. August 2022; 41(4): 202–209. Published online 2022 Aug 25. doi: 10.1089/mab.2021.0068

PMCID:: PMC9451140

Abstract Article PDF–550K

Select item 938815615.

PD-1 blockade following ART interruption enhances control of pathogenic SIV in rhesus macaques

Vijayakumar Velu, Kehmia Titanji, Hasan Ahmed, Ravi Dyavar Shetty, Lakshmi S. Chennareddi, Gordon J. Freeman, Rafi Ahmed, Rama Rao Amara

Proc Natl Acad Sci U S A. 2022 Aug 16; 119(33): e2202148119. Published online 2022 Aug 8. doi: 10.1073/pnas.2202148119

PMCID:: PMC9388156

Abstract Article PDF–1.1M

Select item 935476816.

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup

MAbs. 2022; 14(1): 2088454. Published online 2022 Aug 4. doi: 10.1080/19420862.2022.2088454

Correction in:: MAbs. 2024; 16(1): 2364972.

PMCID:: PMC9354768

Abstract Article PDF–4.6M

Select item 935716217.

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8⁺ T cells

Ilaria Elia, Jared Rowe, Sheila Johnson, Shakchhi Joshi, Giulia Notarangelo, Kiran Kurmi, Gordon J. Freeman, Arlene H. Sharpe, Marcia C. Haigis

Cell Metab. Author manuscript; available in PMC 2023 Aug 2.

Published in final edited form as: Cell Metab. 2022 Aug 2; 34(8): 1137–1150.e6. Published online 2022 Jul 11. doi: 10.1016/j.cmet.2022.06.008

PMCID:: PMC9357162

Abstract Article PDF–1.1M

Select item 881632918.

Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non–small cell lung cancer

Qingyuan Huang, Fei Li, Hai Hu, Zhaoyuan Fang, Zhendong Gao, Guozhan Xia, Wai-Lung Ng, Alireza Khodadadi-Jamayran, Ting Chen, Jiehui Deng, Hua Zhang, Christina Almonte, Kristen Labbe, Han Han, Ke Geng, Sittinon Tang, Gordon J. Freeman, Yuan Li, Haiquan Chen, Kwok-Kin Wong

Sci Adv. 2022 Feb; 8(5): eabi9533. Published online 2022 Feb 4. doi: 10.1126/sciadv.abi9533

PMCID:: PMC8816329

Abstract Article PDF–5.4M

Select item 879210319.

Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model

Yufei Wang, Alicia Buck, Marion Grimaud, Aedin C. Culhane, Sreekumar Kodangattil, Cecile Razimbaud, Dennis M. Bonal, Quang-De Nguyen, Zhu Zhu, Kevin Wei, Madison L. O'Donnell, Ying Huang, Sabina Signoretti, Toni K. Choueiri, Gordon J. Freeman, Quan Zhu, Wayne A. Marasco

Mol Ther Oncolytics. 2022 Mar 17; 24: 385–399. Published online 2021 Dec 31. doi: 10.1016/j.omto.2021.12.019

PMCID:: PMC8792103

Abstract Article PDF–6.2M

Select item 872830320.

TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response

Zexian Zeng, Cheryl J Wong, Lin Yang, Nofal Ouardaoui, Dian Li, Wubing Zhang, Shengqing Gu, Yi Zhang, Yang Liu, Xiaoqing Wang, Jingxin Fu, Liye Zhou, Boning Zhang, Sarah Kim, Kathleen B Yates, Myles Brown, Gordon J Freeman, Ravindra Uppaluri, Robert Manguso, X Shirley Liu

Nucleic Acids Res. 2022 Jan 7; 50(D1): D1391–D1397. Published online 2021 Sep 17. doi: 10.1093/nar/gkab804

PMCID:: PMC8728303

Abstract Article PDF–1.0M

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