PMC

A) Overall impact of ONC on contrast sensitivity for both cohorts (n=12 animals) between ONC eyes and contralateral eyes (CTRL). ONC caused a significant decrease in contrast sensitivity at 4, 8 and 12 weeks. B) Contrast sensitivity following Sham (n=6) and OVX (n=6) after inducing ONC vs. the contralateral eyes (CTRL). Menopausal status did not have a significant impact on contrast sensitivity after ONC. However, ONC caused a significant decrease in contrast sensitivity in OVX (n=6, purple asterisks) and Sham (n=6, orange asterisks) animals. C) Contrast sensitivity did not vary over time in CTRL eyes, but contrast sensitivity in the Sham ONC (orange asterisks) and OVX ONC (purple asterisks) eyes decreased over 12 weeks. However, OVX animals did not have a different rate of loss in contrast sensitivity after ONC compared to Sham animals (p=0.07059). Results in (A) and (B) are displayed as boxplots with error bars representing the 10^th and 90^th percentile. Results in (C) represent the mean slope and the 95% confidence interval. Statistical significance: ***p < 0.001.

a) Contrast sensitivity for stationary gratings (0Hz) for test subjects with glaucoma and early cataract compared with controls (cataract only); b) Contrast sensitivity for flickering gratings (20Hz) for controls with cataract only. Error bars represent 95% confidence intervals.

Column A: contrast sensitivity functions at zero (circle) and the highest external noise (triangle) levels are plotted as functions of spatial frequency; at zero external noise, the contrast sensitivity functions show a typical band-pass or low-pass profile. At high external noise, the contrast sensitivity functions have much lower amplitudes and don’t vary much with spatial frequency. Column B, C, D and E: N_add, β, N_mul, and γ as functions of spatial frequency, respectively.

Equipercentile equating of LEA and Pelli-Robson contrast sensitivity scores. Red line: Pelli-Robson contrast sensitivity scores. Blue line: LEA contrast sensitivity scores