alcoholism - PMC

William R. Lovallo, Mary-Anne Enoch, Eldad Yechiam, David C. Glahn, Ashley Acheson, Kristen H. Sorocco, Colin A. Hodgkinson, Bojeong Kim, Andrew J. Cohoon, Andrea S. Vincent, David Goldman

Alcohol Clin Exp Res. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Alcohol Clin Exp Res. 2014 Jun; 38(6): 1575–1581. Published online 2014 May 5. doi: 10.1111/acer.12412

PMCID:: PMC4047646

Abstract Article PDF–1.0M

Select item 38604145.

Epigenetics—Beyond the Genome in Alcoholism

Bela G. Starkman, Amul J. Sakharkar, Subhash C. Pandey

Alcohol Res. 2012; 34(3): 293–305.

PMCID:: PMC3860414

Abstract Article PDF–801K

Select item 38603916.

Stress, Epigenetics, and Alcoholism

Sachin Moonat, Subhash C. Pandey

Alcohol Res. 2012; 34(4): 495–505.

PMCID:: PMC3860391

Abstract Article PDF–487K

Select item 37467017.

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

Elise E DeVito, Shashwath A Meda, Rachel Jiantonio, Marc N Potenza, John H Krystal, Godfrey D Pearlson

Neuropsychopharmacology. 2013 Sep; 38(10): 1854–1863. Prepublished online 2013 Apr 12. Published online 2013 May 1. doi: 10.1038/npp.2013.92

PMCID:: PMC3746701

Abstract Article PDF–451K

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Alcoholism and Timing of Separation in Parents: Findings in a Midwestern Birth Cohort

Mary Waldron, Kathleen K. Bucholz, Michael T. Lynskey, Pamela A. F. Madden, Andrew C. Heath

J Stud Alcohol Drugs. 2013 Mar; 74(2): 337–348. doi: 10.15288/jsad.2013.74.337

PMCID:: PMC3568171

Abstract Article PDF–1.7M

Select item 36486229.

Familial influence and childhood trauma in female alcoholism

Å. Magnusson, C. Lundholm, M. Göransson, W. Copeland, M. Heilig, N. L. Pedersen

Psychol Med. Author manuscript; available in PMC 2013 May 8.

Published in final edited form as: Psychol Med. 2012 Feb; 42(2): 381–389. Published online 2011 Jul 29. doi: 10.1017/S0033291711001310

PMCID:: PMC3648622

Abstract Article PDF–99K

Select item 415913210.

Genetic Influences on the Development of Alcoholism

Mary-Anne Enoch

Curr Psychiatry Rep. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Curr Psychiatry Rep. 2013 Nov; 15(11): 412. doi: 10.1007/s11920-013-0412-1

PMCID:: PMC4159132

Abstract Article PDF–282K

Select item 401291911.

Risks for Early Substance Involvement Associated with Parental Alcoholism and Parental Separation in an Adolescent Female Cohort

Mary Waldron, Ellen L. Vaughan, Kathleen K. Bucholz, Michael T. Lynskey, Carolyn E. Sartor, Alexis E. Duncan, Pamela A.F. Madden, Andrew C. Heath

Drug Alcohol Depend. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Drug Alcohol Depend. 2014 May 1; 138: 130–136. Published online 2014 Feb 26. doi: 10.1016/j.drugalcdep.2014.02.020

PMCID:: PMC4012919

Abstract Article PDF–319K

Select item 257785312.

The Role of GABA_A Receptors in the Development of Alcoholism

Mary-Anne Enoch

Pharmacol Biochem Behav. Author manuscript; available in PMC 2009 Jul 1.

Published in final edited form as: Pharmacol Biochem Behav. 2008 Jul; 90(1): 95–104. Published online 2008 Mar 15. doi: 10.1016/j.pbb.2008.03.007

PMCID:: PMC2577853

Abstract Article PDF–920K

Select item 543401213.

Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism

Hsin-Chou Yang, I-Chen Chen, Yuh-Chyuan Tsay, Zheng-Rong Li, Chun-houh Chen, Hai-Gwo Hwu, Chen-Hsin Chen

Sci Rep. 2017; 7: 1975. Published online 2017 May 16. doi: 10.1038/s41598-017-01791-4

PMCID:: PMC5434012

Abstract Article PDF–2.9M

Select item 274840914.

Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations

I Belfer, H Hipp, C McKnight, C Evans, B Buzas, A Bollettino, B Albaugh, M Virkkunen, Q Yuan, MB Max, D Goldman, MA Enoch

Mol Psychiatry. Author manuscript; available in PMC 2009 Sep 22.

Published in final edited form as: Mol Psychiatry. 2006 Mar; 11(3): 301–311. doi: 10.1038/sj.mp.4001768

PMCID:: PMC2748409

Abstract Article PDF–712K

Select item 466823915.

Role of the α₁ Blocker Doxazosin in Alcoholism: a Proof-of-Concept Randomized Controlled Trial

George A. Kenna, Carolina L. Haass-Koffler, William H. Zywiak, Steven M. Edwards, Michael B. Brickley, Robert M. Swift, Lorenzo Leggio

Addict Biol. Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: Addict Biol. 2016 Jul; 21(4): 904–914. Published online 2015 Jun 2. doi: 10.1111/adb.12275

PMCID:: PMC4668239

Abstract Article PDF–617K

Select item 646178916.

Altered frontostriatal white matter microstructure is associated with familial alcoholism and future binge drinking in adolescence

Scott A. Jones, Bonnie J. Nagel

Neuropsychopharmacology. 2019 May; 44(6): 1076–1083. Published online 2019 Jan 12. doi: 10.1038/s41386-019-0315-x

PMCID:: PMC6461789

Abstract Article PDF–1.7M

Select item 525334317.

Alcoholism and sexual dimorphism in the Middle Longitudinal Fascicle: A pilot study

Johanna Seitz, Kayle S. Sawyer, George Papadimitriou, Marlene Oscar-Berman, Isaac Ng, Antoni Kubicki, Palig Mouradian, Susan M. Ruiz, Marek Kubicki, Gordon J. Harris, Nikos Makris

Brain Imaging Behav. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Brain Imaging Behav. 2017 Aug; 11(4): 1006–1017. doi: 10.1007/s11682-016-9579-5

PMCID:: PMC5253343

Abstract Article PDF–1.1M

Select item 961962518.

Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers

Khushbu Agarwal, Jeremy W Luk, Peter Manza, Christian McDuffie, Leann To, Rosario B Jaime-Lara, Bethany L Stangl, Melanie L Schwandt, Reza Momenan, David Goldman, Nancy Diazgranados, Vijay A Ramchandani, Paule V Joseph

Alcohol Alcohol. 2023 Jan; 58(1): 84–92. Published online 2022 Oct 7. doi: 10.1093/alcalc/agac047

PMCID:: PMC9619625

Abstract Article PDF–478K

Select item 647629819.

Efficacy of extended-release naltrexone on HIV-related and drinking outcomes among HIV-positive patients: A randomized-controlled trial

E. Jennifer Edelman, Brent A. Moore, Stephen R. Holt, Nathan Hansen, Tassos C. Kyriakides, Michael Virata, Sheldon Brown, Amy C. Justice, Kendall Bryant, David A. Fiellin, Lynn E. Fiellin

AIDS Behav. Author manuscript; available in PMC 2020 Jan 1.

Published in final edited form as: AIDS Behav. 2019 Jan; 23(1): 211–221. doi: 10.1007/s10461-018-2241-z

PMCID:: PMC6476298

Abstract Article PDF–692K

Select item 850545220.

Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study

Joanna M. Biernacka, Brandon J. Coombes, Anthony Batzler, Ada Man-Choi Ho, Jennifer R. Geske, Josef Frank, Colin Hodgkinson, Michelle Skime, Colin Colby, Lea Zillich, Sofia Pozsonyiova, Ming-Fen Ho, Falk Kiefer, Marcella Rietschel, Richard Weinshilboum, Stephanie S. O’Malley, Karl Mann, Ray Anton, David Goldman, Victor M. Karpyak

Neuropsychopharmacology. 2021 Nov; 46(12): 2132–2139. Published online 2021 Jul 23. doi: 10.1038/s41386-021-01097-0

PMCID:: PMC8505452

Abstract Article PDF–1.3M

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Figure 2

Schematic models of mechanisms underlying comorbidity between alcoholism and other psychiatric disorders among relatives. (A) According to the phenotypic association model, alcoholism develops because of a combination of individual and familial risk factors; moreover, alcoholism increases the risk of depression. In this scenario, relatives of an alcoholic (relative #1) are at increased risk for depression only if the relatives also have alcoholism. (B) Under the correlated causes model, individual and familial risk factors contribute to a general risk of developing alcoholism or depression. In this case, relatives of an alcoholic would be at increased risk for either alcoholism or depression.

Sex Differences in the Genetic Risk for Alcoholism

Alcohol Res Health. 2002;26(4):264-273.
Figure 2

Age-varying effects of parental alcoholism on lifetime persistent depressive disorder for respondents aged 18–90 years, National Epidemiologic Survey on Alcohol and Related Conditions, Wave III, 2012–2013. Age-varying effects are presented as odds ratios (ORs) across ages; the solid line represents the OR point estimates, and the surrounding shading represents 95% confidence intervals. The horizontal line represents an OR of 1.00.
AgeParental Alcoholism Lower LimitParental Alcoholism Upper LimitParental Alcoholism Estimate (Odds Ratio)18.02.1213339686.5511768063.72789939418.72727272.0755740175.8607817043.48776235219.45454552.0298487895.2838199563.27495886120.18181821.9840356474.8002385753.08607265720.90909091.9380496964.394007512.9181852121.63636361.8918632294.0522136872.76879650322.36363641.845526543.7643609412.63575947823.09090911.7991860173.5218286122.51722561423.81818181.7530937563.3174559942.41159934224.54545451.7076032713.1452301462.31749979225.27272731.6631493063.0000607432.23372982826.01.6202128542.8776210242.15924953926.72727271.5792786572.7742367032.09315379627.45454551.5407944752.6868043672.03465312128.18181821.5051388752.6127218551.9830555328.90909091.47260452.5498290071.93775376929.63636361.4433951742.4963513131.89821532930.36363641.4176319892.4508428721.8639724431.09090911.3953652592.4121329591.83461345631.81818181.3765887122.3792779581.8097754532.54545451.3612530182.3515189781.78913730833.27272731.3492751072.3282415841.7724103434.01.340549292.3089506151.75933570134.72727271.3349561192.2932500661.74968231635.45454551.3323675352.2808243881.7432430636.18181821.3326501572.2714236761.73983134836.90909091.3356671152.2648520121.73927811237.63636361.3412778362.2609569841.74142800338.36363641.3493333362.2596164511.74613166839.09090911.3596782412.2607382681.75324745339.81818181.3721513792.2642582851.7626415240.54545451.3865844432.2701361721.7741858741.27272731.4028007062.2783516481.78775649942.01.4206139862.2889008551.80323170142.72727271.4398259892.3017903211.82048826643.45454551.460219742.31702621.83939321444.18181821.4815658372.3346165711.85980863444.90909091.5036262782.3545678751.88159244645.63636361.526157362.3768782061.90459711446.36363641.5489134882.4015299131.92866847147.09090911.5716516692.4284817941.95364466247.81818181.5941329972.4576581611.97935190748.54545451.6161212572.4889355492.00559757949.27272731.6373943772.5221427522.03217675550.01.6577491642.5570570442.05887327850.72727271.6770029962.5934011092.08545952551.45454551.6949938382.6308424192.11169640152.18181821.7115786212.6689950552.1373335952.90909091.7266278282.7074213642.16210755353.63636361.7400197322.7456346072.18573978254.36363641.7516410312.7831096562.2079422755.09090911.7613831352.8192924242.22841964855.81818181.7691378972.8536101832.24687113956.54545451.7747935882.8854830382.26299288457.27272731.7782312372.9143364552.27648064358.01.7793216662.9396151612.2870332258.72727271.7779232952.9607967342.29435600759.45454551.7738797472.9774051562.29816420360.18181821.7670178482.9890259712.29818672960.90909091.7571461922.9953214972.29417038661.63636361.744054492.9960453922.28588416562.36363641.7275140472.991055842.27312361763.09090911.707279832.9803263672.25571520763.81818181.6830956552.9639547542.23352174164.54545451.654702972.9421682412.20644839665.27272731.6218495462.9153162542.17444345666.01.5843040692.8838592122.1375008566.72727271.5418756792.8483504042.09566271567.45454551.4944375122.8094103652.04902128768.18181821.4419526842.7676950971.99772004468.90909091.3845000162.7238607921.94195399369.63636361.3222958862.6785287461.88196905970.36363641.2557083022.6322546591.81806051371.09090911.185259992.5855059371.75057040571.81818181.1116190452.5386494441.67988424372.54545451.0355774472.4919498541.60642680173.27272730.9580188762.4455763391.53065616574.00.8798807022.3996160681.45305742274.72727270.8021138892.354091051.37413577575.45454550.7256443182.3089755031.29440911376.18181820.6513382992.2642118021.21440020876.90909090.5799740612.2197239381.13462870977.63636360.5122201042.1754280951.05560314878.36363640.4486206732.131240460.97781313779.09090910.3895880732.0870826470.90172196879.81818180.3354012732.0428851830.82775980380.54545450.2862100241.998589540.75631763281.27272730.2420435851.9541490910.68774214182.00.2028230991.9095293380.6223316382.72727270.1683766061.8647076330.56033306383.45454550.1384557141.8196725970.50194030584.18181820.1127529851.7744233470.4472935684.90909090.0909191691.7289686260.39647999985.63636360.072579571.6833258910.34953550486.36363640.0573489221.6375204030.30644743487.09090910.0448443461.5915843320.26715830187.81818180.0346960951.5455558890.23157019288.54545450.0265559751.4994785120.19954977889.27272730.0201034381.4534000770.17093372690.00.0150494991.4073721630.145534345

Time-Varying Effects of Parental Alcoholism on Depression

Prev Chronic Dis. 2017;14:E136.
Figure 1

Age-varying effects of parental alcoholism on lifetime major depressive disorder for respondents aged 18–90 years, National Epidemiologic Survey on Alcohol and Related Conditions, Wave III, 2012–2013. Age-varying effects are presented as odds ratios (ORs) across ages; the solid line represents the OR point estimates, and the surrounding shading represents 95% confidence intervals. The horizontal line represents an OR of 1.00.
Age, yParental Alcoholism Lower LimitParental Alcoholism Upper LimitParental Alcoholism Estimate (Odds Ratio)18.01.1954271792.2722603091.64812673418.72727271.2602841892.2757784161.6935547119.45454551.3237728992.2809275311.73765072820.18181821.3853517092.2878499511.78030245820.90909091.4444773682.2966900581.82140517521.63636361.5006226992.3075809841.86086227522.36363641.5533001662.3206253261.89858571123.09090911.602090562.3358705511.93449635823.81818181.6466737872.3532820511.96852428724.54545451.6868561142.372719412.00060896825.27272731.7225868152.3939229022.03069939326.01.7539583992.4165159952.0587541226.72727271.7811888882.4400253572.08474124427.45454551.8045900732.4639144162.10863830428.18181821.8245294892.4876227152.13043211628.90909091.8413942022.5106029892.15011855229.63636361.855561972.5323503922.16770225930.36363641.8673818682.5524218072.18319632731.09090911.8771637242.5704459282.19662191831.81818181.8851743142.5861261862.20800784932.54545451.8916380122.5992388752.21739014533.27272731.8967399462.6096284462.22481156934.01.9006302852.6172014242.23032111834.72727271.9034287822.6219198412.2339735235.45454551.9052290752.6237947322.23582870836.18181821.9061025462.6228799642.23595129136.90909091.9061016392.6192665152.23441003337.63636361.9052626772.6130772182.23127732438.36363641.9036082232.6044619652.22662866639.09090911.9011490812.5935933122.22054217339.81818181.8978860192.5806624232.21309808440.54545451.8938113062.5658753032.20437829341.27272731.8889101672.5494492432.19446590242.01.8831622242.5316094022.18344479942.72727271.8765430322.5125854642.1713992643.45454551.8690257792.4926082972.15841357544.18181821.86058322.4719065582.14457170944.90909091.8511897752.450703222.12995698145.63636361.8408241712.4292120022.11465178546.36363641.8294719082.407633782.09873732647.09090911.8171281032.3861530722.08229340147.81818181.8038001352.3649347882.06539819248.54545451.7895099652.3441214622.04812810149.27272731.7742958912.3238312232.03055760650.01.7582134662.3041567232.01275914550.72727271.7413354422.2851651781.99480302751.45454551.7237506862.2668995611.97675736352.18181821.7055621282.2493808531.95868802952.90909091.6868839712.2326111541.94065864353.63636361.6678384062.2165773551.92273056954.36363641.6485521562.2012550721.90496293855.09090911.6291531152.1866125531.88741268755.81818181.6097672972.172614331.8701346256.54545451.5905162282.1592244891.85318147857.27272731.5715148482.1464094841.83660403358.01.5528698932.1341404991.82045118958.72727271.5346787242.1223954281.80477009859.45454551.5170285092.1111605161.78960629560.18181821.4999956692.1004317981.77500383160.90909091.48364552.0902163841.76100543261.63636361.4680318822.080533711.7476526662.36363641.4531970032.071416811.73498608163.09090911.4391710432.0629136851.72304545563.81818181.425971772.0550888131.71186992364.54545451.4136040262.0480248411.70149821165.27272731.4020590912.0418244671.6919688466.01.3913139472.036612521.68332035166.72727271.3813304942.0325381931.67559153367.45454551.3720547962.0297773691.66882167268.18181821.3634164882.0285349331.66305080368.90909091.3553285122.0290469311.65831998169.63636361.3476874022.0315823821.65467156370.36363641.3403743162.0364445771.65214951171.09090911.3332570582.0439716811.65079970671.81818181.3261931892.0545365651.65067028872.54545451.3190342672.0685459021.65181201373.27272731.3116310112.0864387911.65427864174.01.3038390472.108685341.65812734274.72727271.2955246682.1357858551.66341914775.45454551.2865700122.1682713651.67021942176.18181821.2768770832.2067061681.67859838476.90909091.2663702282.251692961.68863167377.63636361.2549969342.3038808591.70040095778.36363641.2427270712.3639764341.71399460679.09090911.2295508992.4327576781.72950842479.81818181.215476272.5110908381.74704645880.54545451.2005254572.5999500421.76672188481.27272731.1847319562.7004398521.78865798582.01.1681375322.8138210521.81298923882.72727271.1507896622.9415402121.83986251383.45454551.1327394193.0852638151.86943840384.18181821.114039813.2469179821.90189271384.90909091.0947445143.428735091.93741810985.63636361.074906973.6333089151.97622596886.36363641.0545797393.863660242.0185484487.09090911.033814084.1233153692.06464076487.81818181.0126596984.4164005012.11478386588.54545450.9911645914.7477556262.1692872789.27272730.9693755.1230724662.22849239990.00.9473353985.5490621352.292776262

Time-Varying Effects of Parental Alcoholism on Depression

Prev Chronic Dis. 2017;14:E136.
Figure 1

Net integrated cortisol response to oCRH or cosyntropin following high-dose dexamethasone. Columns on the left of each group reflect integrated cortisol response to oCRH infusion; columns on the right of each group reflect cortisol response to cosyntropin. For alcohol-dependent subjects: Open circles—parental FH of alcoholism. Gray circles—1st or 2nd degree FH of alcoholism, no parental FH. Black circles—no FH of alcoholism.

Family History of Alcoholism Does Not Influence Adrenocortical Hyporesponsiveness in Abstinent Alcohol-Dependent Men

Am J Drug Alcohol Abuse. ;34(2):151-160.