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Select item 113894851.

TCEB2/HIF1A signaling axis promotes chemoresistance in ovarian cancer cells by enhancing glycolysis and angiogenesis

Zhuo Deng, Bin Li, Wenzhi Wang, Wei Xia, Lu Zhang, Lihong Chen, Wen Jin

Eur J Med Res. 2024; 29: 456. Published online 2024 Sep 11. doi: 10.1186/s40001-024-02050-9

PMCID:: PMC11389485

Abstract Article PDF–2.2M

Select item 84599942.

Analysis of potential genetic biomarkers and molecular mechanism of smoking-related postmenopausal osteoporosis using weighted gene co-expression network analysis and machine learning

Shaoshuo Li, Baixing Chen, Hao Chen, Zhen Hua, Yang Shao, Heng Yin, Jianwei Wang

PLoS One. 2021; 16(9): e0257343. Published online 2021 Sep 23. doi: 10.1371/journal.pone.0257343

PMCID:: PMC8459994

Abstract Article PDF–3.1M

Select item 41789093.

Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma

David A. Rowbotham, Katey S. S. Enfield, Victor D. Martinez, Kelsie L. Thu, Emily A. Vucic, Greg L. Stewart, Kevin L. Bennewith, Wan L. Lam

Int J Endocrinol. 2014; 2014: 546347. Published online 2014 Sep 14. doi: 10.1155/2014/546347

PMCID:: PMC4178909

Abstract Article PDF–753K

Select item 90526214.

Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response

Zhen Zhang, Zi-Xian Wang, Yan-Xing Chen, Hao-Xiang Wu, Ling Yin, Qi Zhao, Hui-Yan Luo, Zhao-Lei Zeng, Miao-Zhen Qiu, Rui-Hua Xu

Genome Med. 2022; 14: 45. Published online 2022 Apr 29. doi: 10.1186/s13073-022-01050-w

PMCID:: PMC9052621

Abstract Article PDF–5.4M

Select item 85934155.

Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target

Sagar Sanjiv Desai, Raksha Rao K, Anika Jain, Pushpinder Singh Bawa, Priyatam Dutta, Gaurav Atre, Anand Subhash, Vishal U. S. Rao, Suvratha J, Subhashini Srinivasan, Bibha Choudhary

Front Oncol. 2021; 11: 723162. Published online 2021 Nov 2. doi: 10.3389/fonc.2021.723162

PMCID:: PMC8593415

Abstract Article PDF–32M

Select item 75215216.

Identification of a cullin5-RING E3 ligase transcriptome signature in glioblastoma multiforme

Shuhua Zheng, Zhenhao Li

Aging (Albany NY) 2020 Sep 15; 12(17): 17380–17392. Published online 2020 Sep 14. doi: 10.18632/aging.103737

PMCID:: PMC7521521

Abstract Article PDF–1.8M

Select item 54533297.

Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice

Michael C. Saul, Christopher H. Seward, Joseph M. Troy, Huimin Zhang, Laura G. Sloofman, Xiaochen Lu, Patricia A. Weisner, Derek Caetano-Anolles, Hao Sun, Sihai Dave Zhao, Sriram Chandrasekaran, Saurabh Sinha, Lisa Stubbs

Genome Res. 2017 Jun; 27(6): 959–972. doi: 10.1101/gr.214221.116

PMCID:: PMC5453329

Abstract Article PDF–1.5M

Select item 60338388.

ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex

Marina Stantic, Johanna Wolfsberger, Habib A. M. Sakil, Margareta T. Wilhelm

Oncogene. 2018; 37(27): 3729–3739. Published online 2018 Apr 9. doi: 10.1038/s41388-018-0195-2

PMCID:: PMC6033838

Abstract Article PDF–3.1M

Select item 42275519.

Quantitative Proteomic Analysis Identifies Targets and Pathways of a 2-Aminobenzamide HDAC Inhibitor in Friedreich’s Ataxia Patient iPSC-Derived Neural Stem Cells

Bing Shan, Chunping Xu, Yaoyang Zhang, Tao Xu, Joel M. Gottesfeld, John R. Yates, III

J Proteome Res. 2014 Nov 7; 13(11): 4558–4566. Published online 2014 Jun 16. doi: 10.1021/pr500514r

PMCID:: PMC4227551

Abstract Article PDF–2.6M

Select item 885964610.

Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation

Danuta Galetzka, Julia Böck, Lukas Wagner, Marcus Dittrich, Olesja Sinizyn, Marco Ludwig, Heidi Rossmann, Claudia Spix, Markus Radsak, Peter Scholz-Kreisel, Johanna Mirsch, Matthias Linke, Walburgis Brenner, Manuela Marron, Alicia Poplawski, Thomas Haaf, Heinz Schmidberger, Dirk Prawitt

EXCLI J. 2022; 21: 117–143. Published online 2022 Jan 7. doi: 10.17179/excli2021-4482

PMCID:: PMC8859646

Abstract Article PDF–1.5M

Select item 521017811.

EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape

Robert Liefke, Violetta Karwacki-Neisius, Yang Shi

Mol Cell. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Mol Cell. 2016 Nov 17; 64(4): 659–672. doi: 10.1016/j.molcel.2016.10.019

PMCID:: PMC5210178

Abstract Article PDF–2.0M

Select item 390095312.

Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

Christina Aaen Andresen, Stine Smedegaard, Kathrine Beck Sylvestersen, Charlotte Svensson, Diego Iglesias-Gato, Giuseppe Cazzamali, Tine Kragh Nielsen, Michael Lund Nielsen, Amilcar Flores-Morales

J Biol Chem. 2014 Jan 24; 289(4): 2043–2054. Published online 2013 Dec 11. doi: 10.1074/jbc.M113.534602

PMCID:: PMC3900953

Abstract Article PDF–1.7M

Select item 424453513.

Antitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor

Jie Chen, Xiyun Ruan, Shaomei Wang, Bin Zhang, Bo Liu, Zeqiang Sun, Qingyong Liu

Tumour Biol. 2014 Nov; 35(11): 10993–11003. Published online 2014 Aug 5. doi: 10.1007/s13277-014-2393-z

PMCID:: PMC4244535

Abstract Article PDF–1.5M

Select item 792212214.

Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer

Jesús Fuentes-Antrás, Ana Lucía Alcaraz-Sanabria, Esther Cabañas Morafraile, María del Mar Noblejas-López, Eva María Galán-Moya, Mariona Baliu-Pique, Igor López-Cade, Vanesa García-Barberán, Pedro Pérez-Segura, Aránzazu Manzano, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña

Cancers (Basel) 2021 Feb; 13(4): 833. Published online 2021 Feb 17. doi: 10.3390/cancers13040833

PMCID:: PMC7922122

Abstract Article PDF–4.0M

Select item 1069622115.

Computational exploration of the significance of COPS6 in cancer: Functional and clinical relevance across tumor types

Shi-Lin Wang, Guang-Zheng Zhuo, Li-Ping Wang, Xiang-Hu Jiang, Guo-Hong Liu, Yun-Bao Pan, Yi-Rong Li

World J Clin Oncol. 2023 Nov 24; 14(11): 479–503. Published online 2023 Nov 24. doi: 10.5306/wjco.v14.i11.479

PMCID:: PMC10696221

Abstract Article PDF–27M

Select item 548969916.

HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients

Zhaobo Li, Lihong Zhou, Chrisostomos Prodromou, Velibor Savic, Laurence H. Pearl

Cell Rep. 2017 Jun 20; 19(12): 2515–2528. Published online 2017 Jun 20. doi: 10.1016/j.celrep.2017.05.078

PMCID:: PMC5489699

Abstract Article PDF–3.0M

Select item 848587717.

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Ryosuke Shirasaki, Geoffrey M. Matthews, Sara Gandolfi, Ricardo de Matos Simoes, Dennis L. Buckley, Joseline Raja Vora, Quinlan L. Sievers, Johanna B. Brüggenthies, Olga Dashevsky, Haley Poarch, Huihui Tang, Megan A. Bariteau, Michal Sheffer, Yiguo Hu, Sondra L. Downey-Kopyscinski, Paul J. Hengeveld, Brian J. Glassner, Eugen Dhimolea, Christopher J. Ott, Tinghu Zhang, Nicholas P. Kwiatkowski, Jacob P. Laubach, Robert L. Schlossman, Paul G. Richardson, Aedin C. Culhane, Richard W.J. Groen, Eric S. Fischer, Francisca Vazquez, Aviad Tsherniak, William C. Hahn, Joan Levy, Daniel Auclair, Jonathan D. Licht, Jonathan J. Keats, Lawrence H. Boise, Benjamin L. Ebert, James E. Bradner, Nathanael S. Gray, Constantine S. Mitsiades

Cell Rep. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Cell Rep. 2021 Jan 5; 34(1): 108532. doi: 10.1016/j.celrep.2020.108532

PMCID:: PMC8485877

Abstract Article PDF–1.9M

Select item 1099627818.

Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies

Minghua Xiang, Huayi Li, Yuanyuan Zhan, Ding Ma, Qinglei Gao, Yong Fang

Mol Cancer. 2024; 23: 73. Published online 2024 Apr 5. doi: 10.1186/s12943-024-01987-z

PMCID:: PMC10996278

Abstract Article PDF–4.6M

Select item 1147099919.

Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor‐mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation

Fuyan Xu, Jiao Li, Min Ai, Tingting Zhang, Yue Ming, Cong Li, Wenchen Pu, Yang Yang, Zhang Li, Yucheng Qi, Xiaomin Xu, Qingxiang Sun, Zhu Yuan, Yong Xia, Yong Peng

MedComm (2020) 2024 Oct; 5(10): e758. Published online 2024 Oct 13. doi: 10.1002/mco2.758

PMCID:: PMC11470999

Abstract Article PDF–9.6M

Select item 668940520.

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

Eric Shifrut, Julia Carnevale, Victoria Tobin, Theodore L. Roth, Jonathan M. Woo, Christina Bui, P. Jonathan Li, Morgan Diolaiti, Alan Ashworth, Alexander Marson

Cell. Author manuscript; available in PMC 2019 Aug 11.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1958–1971.e15. Published online 2018 Nov 15. doi: 10.1016/j.cell.2018.10.024

PMCID:: PMC6689405

Abstract Article PDF–1.1M

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