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Select item 64934391.

Quetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair

Simon Zhornitsky, Voon Wee Yong, Marcus W. Koch, Aaron Mackie, Stéphane Potvin, Scott B. Patten, Luanne M. Metz

CNS Neurosci Ther. 2013 Oct; 19(10): 737–744. Published online 2013 Jul 22. doi: 10.1111/cns.12154

PMCID:: PMC6493439

Abstract Article PDF–112K

Select item 100094342.

Post‐therapy plasma concentrations of quetiapine in Taiwanese patients

Cho‐Yin Huang, Yen‐Feng Lin, Chia‐Ru Chen, Shih‐Ku Lin

Neuropsychopharmacol Rep. 2023 Mar; 43(1): 50–56. Published online 2023 Jan 16. doi: 10.1002/npr2.12303

PMCID:: PMC10009434

Abstract Article PDF–361K

Select item 69671363.

Quality by Design Approach for Development and Characterisation of
Solid Lipid Nanoparticles of Quetiapine Fumarate

Shweta Agarwal, Rayasa S. Ramachandra Murthy, Sasidharan Leelakumari Harikumar, Rajeev Garg

Curr Comput Aided Drug Des. 2020 Feb; 16(1): 73–91. Published online 2020 Feb. doi: 10.2174/1573409915666190722122827

PMCID:: PMC6967136

Abstract Article PDF–2.9M

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Results from a drug utilization study of extended release quetiapine fumarate prescribed by psychiatrists as treatment for major depressive disorder in selected countries in the European Union

Robert S. Brody, Charles L. Liss, Heather Wray, Kari Kastango, Allison Bryant, Alban Fabre, Anneli Thuresson

Int Clin Psychopharmacol. 2018 Mar; 33(2): 59–65. Published online 2018 Feb 5. doi: 10.1097/YIC.0000000000000202

PMCID:: PMC5805122

Abstract Article PDF–147K

Select item 107829925.

Antipsychotic quetiapine alters the mouse fecal resistome by impacting antibiotic efflux, cell membrane, and cell wall synthesis genes

Yasuhiro Kyono, Jonathan D. Magboo, Elizabeth A. Daley, Stephanie A. Flowers

Microbiol Spectr. 2024 Jan; 12(1): e03804-23. Published online 2023 Dec 15. doi: 10.1128/spectrum.03804-23

PMCID:: PMC10782992

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Select item 84254566.

Influence of Plasdone™ S630 Ultra—an improved copovidone on the processability and oxidative degradation of quetiapine fumarate amorphous solid dispersions prepared via hot-melt extrusion technique

Arun Butreddy, Sandeep Sarabu, Suresh Bandari, Amol Batra, Kamaru Lawal, Nick Ningyi Chen, Vivian Bi, Thomas Durig, Michael A. Repka

AAPS PharmSciTech. Author manuscript; available in PMC 2022 Jun 28.

Published in final edited form as: AAPS PharmSciTech. 2021 Jun 28; 22(5): 196. Published online 2021 Jun 28. doi: 10.1208/s12249-021-02069-9

PMCID:: PMC8425456

Abstract Article PDF–953K

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Post‐marketing surveillance of quetiapine fumarate extended‐release tablets in patients with bipolar depression

Taro Kishi, Nakao Iwata, Hiroyuki Irie, Masaru Aikawa

Neuropsychopharmacol Rep. 2024 Jun; 44(2): 424–436. Published online 2024 Apr 30. doi: 10.1002/npr2.12441

PMCID:: PMC11144599

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Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats

Laura Smedegaard Heisel, Freja Drost Andersen, Sâmia Joca, Lambert Kristiansen Sørensen, Ulf Simonsen, Jørgen Bo Hasselstrøm, Charlotte Uggerhøj Andersen, Kirstine Lykke Nielsen

Arch Toxicol. 2024; 98(1): 289–301. Published online 2023 Oct 23. doi: 10.1007/s00204-023-03620-2

PMCID:: PMC10761411

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Select item 62337999.

Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial

Adam Sacarny, Michael L. Barnett, Jackson Le, Frank Tetkoski, David Yokum, Shantanu Agrawal

JAMA Psychiatry. 2018 Oct; 75(10): 1003–1011. Published online 2018 Aug 1. doi: 10.1001/jamapsychiatry.2018.1867

PMCID:: PMC6233799

Abstract Article

Select item 459079010.

Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles to Improve the Oral Bioavailability

Arjun Narala, Kishan Veerabrahma

J Pharm (Cairo) 2013; 2013: 265741. Published online 2013 Jun 3. doi: 10.1155/2013/265741

PMCID:: PMC4590790

Abstract Article PDF–768K

Select item 605848811.

Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

Muhammad Akhlaq, Faiza Maryam, Abdelhamid Elaissari, Hashmat Ullah, Muhammad Adeel, Abid Hussain, Muhammad Ramzan, Obaid Ullah, Muhammad Zeeshan Danish, Shehla Iftikhar, Nighat Aziz

Drug Deliv. 2018; 25(1): 916–927. Published online 2018 Apr 12. doi: 10.1080/10717544.2018.1458922

PMCID:: PMC6058488

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Impact of low‐dose quetiapine‐use on glycosylated hemoglobin, triglyceride and cholesterol levels

Mikkel Højlund, Henrik Støvring, Kjeld Andersen, Christoph U. Correll, Jesper Hallas

Acta Psychiatr Scand. 2023 Jan; 147(1): 105–116. Published online 2022 Nov 4. doi: 10.1111/acps.13515

PMCID:: PMC10099591

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Select item 618259713.

Multi-center, randomized, double-blind, placebo-controlled study of quetiapine extended-release formulation in Japanese patients with bipolar depression

Mitsukuni Murasaki, Tsukasa Koyama, Shigenobu Kanba, Masahiro Takeuchi, Yuriko Shimizu, Eri Arita, Kentaro Kuroishi, Masahiro Takeuchi, Shinya Kamei

Psychopharmacology (Berl) 2018; 235(10): 2859–2869. Published online 2018 Aug 1. doi: 10.1007/s00213-018-4977-6

Correction in:: Psychopharmacology (Berl). 2018; 235(10): 3079–3080.

PMCID:: PMC6182597

Abstract Article PDF–532K

Select item 766988414.

New insights into quetiapine metabolism using molecular networking

Brendan Le Daré, Pierre-Jean Ferron, Pierre-Marie Allard, Bruno Clément, Isabelle Morel, Thomas Gicquel

Sci Rep. 2020; 10: 19921. Published online 2020 Nov 16. doi: 10.1038/s41598-020-77106-x

PMCID:: PMC7669884

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Select item 954137115.

Combined effects of quetiapine and opioids: A study of autopsy cases, drug users and sedation in rats

Freja Drost Andersen, Sâmia Joca, Victor Hvingelby, Shokouh Arjmand, Estefano Pinilla, Simon Comerma Steffensen, Ulf Simonsen, Charlotte Uggerhøj Andersen

Addict Biol. 2022 Sep; 27(5): e13214. Published online 2022 Jul 28. doi: 10.1111/adb.13214

PMCID:: PMC9541371

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Select item 929863116.

A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study

Xiujuan Chen, Chen Liang, Lijun Cui, Jian Le, Zheyuan Qian, Runsheng Zhang, Zhanying Hong, Yifeng Chai

J Food Drug Anal. 2019; 27(1): 323–331. Published online 2018 Aug 14. doi: 10.1016/j.jfda.2018.07.003

PMCID:: PMC9298631

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Select item 964381317.

Association between quetiapine use and self-harm outcomes among people with recorded personality disorder in UK primary care: A self-controlled case series analysis

Joseph F Hayes, Sarah Hardoon, Jessica Deighton, Essi Viding, David PJ Osborn

J Psychopharmacol. 2022 Nov; 36(11): 1218–1225. Published online 2022 Nov 1. doi: 10.1177/02698811221131990

PMCID:: PMC9643813

Abstract Article PDF–883K

Select item 1126937818.

Vitreous humor in the forensic toxicology of quetiapine and its metabolites

Danai Moschovakou, Stamatina-Panagoula Ntoupa, Artemisia Dona, Sotirios Athanaselis, Chara Spiliopoulou, Panagiota Nikolaou, Ioannis Papoutsis

Forensic Toxicol. 2024; 42(2): 212–220. Published online 2024 Apr 14. doi: 10.1007/s11419-024-00687-z

PMCID:: PMC11269378

Abstract Article PDF–841K

Select item 960392419.

The Influence of Prenatal Exposure to Quetiapine Fumarate on the Development of Dopaminergic Neurons in the Ventral Midbrain of Mouse Embryos

Walaa F. Alsanie, Sherin Abdelrahman, Majid Alhomrani, Ahmed Gaber, Ebtisam Abdulah Alosimi, Hamza Habeeballah, Heba A. Alkhatabi, Raed I. Felimban, Charlotte A. E. Hauser, Hossam H. Tayeb, Abdulhakeem S. Alamri, Abdulwahab Alamri, Bassem M. Raafat, Khaled A. Alswat, Yusuf S. Althobaiti, Yousif A. Asiri

Int J Mol Sci. 2022 Oct; 23(20): 12352. Published online 2022 Oct 15. doi: 10.3390/ijms232012352

PMCID:: PMC9603924

Abstract Article PDF–2.0M

Select item 631942720.

Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles

Xiaomei Huang, Suhua Zhang, Yanxia Ma, Heng Yang, Chuan He, Rufang Tian, Han Mei, Lipeng Liu, Bikui Zhang

Drug Des Devel Ther. 2019; 13: 255–264. Published online 2018 Dec 31. doi: 10.2147/DDDT.S182965

PMCID:: PMC6319427

Abstract Article PDF–391K

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Figure 5

Coadministration of quetiapine blocked the ethanol-induced oxidative stress in the cerebellum of rats.
Notes: (A) Quetiapine blocked the ethanol-induced increase in MDA; (B) Quetiapine blocked the ethanol-induced increase in ROS; (C) Quetiapine blocked the ethanol-induced decrease in catalase; (D) Quetiapine blocked the ethanol-induced decrease in T-SOD; (E) Quetiapine blocked the ethanol-induced decrease in TAC. Rats were killed by decapitation. Their brains were quickly removed and the cerebellum tissue samples were processed for biochemical analyses. Data are expressed as mean ± SEM. *P<0.05, **P<0.01 (compared to CNT); ^#P<0.05 (QUE + ETH versus ETH).
Abbreviations: CNT, controls; ETH, ethanol; FI, fluorescence intensity; MDA, malondialdehyde; QUE, quetiapine; QUE + ETH, quetiapine plus ethanol; ROS, reactive oxygen species; SEM, standard error of mean; TAC, total antioxidant capacity; T-SOD, total superoxide dismutase.

Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat

Neuropsychiatr Dis Treat. 2015;11:1473-1482.
Figure 2

Coadministration of quetiapine had no effect on the ethanol-induced oxidative stress in the liver.
Notes: (A) Quetiapine had no effect on the ethanol-induced increase in MDA; (B) Quetiapine had no effect on the ethanol-induced increase in ROS; (C) Quetiapine prevented the ethanol-induced decrease in GPx; (D) Quetiapine had no effect on the ethanol-induced decrease in TAC. Rats were killed by decapitation. Their livers were quickly removed and processed for biochemical analyses. Data are expressed as mean ± SEM. *P<0.05, **P<0.01 (compared to CNT); ^#P<0.05 (QUE + ETH versus ETH).
Abbreviations: CNT, controls; ETH, ethanol; FI, fluorescence intensity; GPx, glutathione peroxidase; MDA, malondialdehyde; QUE, quetiapine; QUE + ETH, quetiapine plus ethanol; ROS, reactive oxygen species; SEM, standard error of mean; TAC, total antioxidant capacity.

Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat

Neuropsychiatr Dis Treat. 2015;11:1473-1482.
Figure 4

Coadministration of quetiapine blocked the ethanol-induced oxidative stress in the hippocampus of rats.
Notes: (A) Quetiapine blocked the ethanol-induced increase in MDA; (B) Quetiapine blocked the ethanol-induced increase in ROS; (C) Quetiapine blocked the ethanol-induced increase in T-SOD; (D) Quetiapine blocked the ethanol-induced decrease in TAC. Rats were killed by decapitation. Their brains were quickly removed and the hippocampus tissue samples were processed for biochemical analyses. Data are expressed as mean ± SEM. *P<0.05, **P<0.01 (compared to CNT); ^#P<0.05 (QUE + ETH versus ETH).
Abbreviations: CNT, controls; ETH, ethanol; FI, fluorescence intensity; MDA, malondialdehyde; QUE, quetiapine; QUE + ETH, quetiapine plus ethanol; ROS, reactive oxygen species; SEM, standard error of mean; TAC, total antioxidant capacity; T-SOD, total superoxide dismutase.

Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat

Neuropsychiatr Dis Treat. 2015;11:1473-1482.
Figure 1Affinity-based fluorescence polarization screen of FDA-approved drugs identifies quetiapine as a GCase binder.

(A and B) Chemical structures of (A) fluorescence polarization (FP) probe JZ-3165 and (B) quetiapine. (C) Quetiapine FP activity in the FP assay using probe JZ-3165.

Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson’s disease models

JCI Insight. 2021 Oct 8;6(19):e148649.