PMC

Representative HPLC-PDA chromatogram of noni and f. noni. (A) Standard; (B) noni extract powder; and (C) F. noni extract powder. The arrows represent DAA and AA (standard DDA Rt: 14.95 ± 0.08 min, noni and f. noni each 15.01 ± 0.04 and 15.01 ± 0.03 min; standard AA Rt: 23.27 ± 0.07 min, noni and f. noni each 23.34 ± 0.06 and 23.34 ± 0.04 min).

Treatment with noni fruit juice and disease outcome. C57BL/6 mice were exposed to dextran sulfate sodium (DSS) 2.5% and treated daily with noni fruit juice. On day 9, mice were euthanized to obtain intestinal sections. (a) Percentage of weight change. (b) Clinical disease score. Saline, healthy control mice treated with saline; DSS 2.5%, mice exposed to DSS; DSS 2.5% + pure noni, mice exposed to DSS and treated with the pure noni fruit juice; DSS 2.5% + noni 1 : 10, mice exposed to DSS and treated with a 1 : 10 dilution of the fruit juice; and DSS 2.5% + noni 1 : 100, mice exposed to DSS and treated with a 1 : 100 dilution of the fruit juice.

Representative HPLC-UV chromatogram of noni and F.NONI. (A) Standard; (B) Noni extract; (C) F.NONI extract. The arrows represent deacetylasperulosidic acid (DAA) and asperulosidic acid (AA). (Standard DDA Rt: 18.78 ± 0.06 min; noni and F.NONI each 18.78 ± 0.08 and 18.79 ± 0.07 min. Standard AA Rt: 27.31 ± 0.05 min; noni and F.NONI each 27.32 ± 0.06 and 27.32 ± 0.07 min) AU: Absorption unit.

Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) spectra of (A) Transmission spectra of water, pure noni juice, individual carrier (MD and GA) and spray-dried noni juice powders. (B) Absorption spectra of air-dried noni juice sample, individual carrier (MD and GA) and spray-dried noni juice powders. MD: maltodextrin; GA: gum acacia; P55, P73 and P91: powders produced using maltodextrin and gum acacia as carriers with the blended ratios of 5:5, 7:3 and 9:1.