Nigella sativa - PMC

Bahare Salehi, Cristina Quispe, Muhammad Imran, Iahtisham Ul-Haq, Jelena Živković, Ibrahim M. Abu-Reidah, Surjit Sen, Yasaman Taheri, Krishnendu Acharya, Hamed Azadi, María del Mar Contreras, Antonio Segura-Carretero, Dima Mnayer, Gautam Sethi, Miquel Martorell, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Hafiz Ansar Rasul Suleria, Javad Sharifi-Rad

Front Pharmacol. 2021; 12: 625386. Published online 2021 Apr 26. doi: 10.3389/fphar.2021.625386

PMCID:: PMC8107825

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Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Arslan Shaukat, Arsalan Zaidi, Haseeb Anwar, Nadeem Kizilbash

Front Nutr. 2023; 10: 1126272. Published online 2023 Sep 25. doi: 10.3389/fnut.2023.1126272

PMCID:: PMC10561288

Abstract Article PDF–2.5M

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Biological Properties, Phenolic Profile, and Botanical Aspect of Nigella sativa L. and Nigella damascena L. Seeds: A Comparative Study

Leila Benazzouz-Smail, Sabiha Achat, Fatiha Brahmi, Mostapha Bachir-Bey, Radia Arab, José Manuel Lorenzo, Aicha Benbouriche, Kahina Boudiab, Didier Hauchard, Lila Boulekbache, Khodir Madani

Molecules. 2023 Jan; 28(2): 571. Published online 2023 Jan 6. doi: 10.3390/molecules28020571

PMCID:: PMC9863492

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A Narrative Review on Various Oil Extraction Methods, Encapsulation Processes, Fatty Acid Profiles, Oxidative Stability, and Medicinal Properties of Black Seed (Nigella sativa)

Muhammad Abdul Rahim, Aurbab Shoukat, Waseem Khalid, Afaf Ejaz, Nizwa Itrat, Iqra Majeed, Hyrije Koraqi, Muhammad Imran, Mahr Un Nisa, Anum Nazir, Wafa S. Alansari, Areej A. Eskandrani, Ghalia Shamlan, Ammar AL-Farga

Foods. 2022 Sep; 11(18): 2826. Published online 2022 Sep 13. doi: 10.3390/foods11182826

PMCID:: PMC9498113

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Effect of Nigella sativa on Selected Gastrointestinal Diseases

Sara Jarmakiewicz-Czaja, Magdalena Zielińska, Kacper Helma, Aneta Sokal, Rafał Filip

Curr Issues Mol Biol. 2023 Apr; 45(4): 3016–3034. Published online 2023 Apr 3. doi: 10.3390/cimb45040198

PMCID:: PMC10136991

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The effect of dietary supplementation with Nigella sativa (black seeds) mediates immunological function in male Wistar rats

Hany Salah Mahmoud, Amani A. Almallah, Heba Nageh Gad EL-Hak, Tahany Saleh Aldayel, Heba M. A. Abdelrazek, Howayda E. Khaled

Sci Rep. 2021; 11: 7542. Published online 2021 Apr 6. doi: 10.1038/s41598-021-86721-1

PMCID:: PMC8024296

Abstract Article PDF–9.3M

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Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells

Anna Czajkowska, Agnieszka Gornowicz, Natalia Pawłowska, Robert Czarnomysy, Jolanta Nazaruk, Wojciech Szymanowski, Anna Bielawska, Krzysztof Bielawski

Biomed Res Int. 2017; 2017: 9153403. Published online 2017 Dec 26. doi: 10.1155/2017/9153403

PMCID:: PMC5758943

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Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

Mohammed Dalli, Oussama Bekkouch, Salah-eddine Azizi, Ali Azghar, Nadia Gseyra, Bonglee Kim

Biomolecules. 2022 Jan; 12(1): 20. Published online 2021 Dec 23. doi: 10.3390/biom12010020

PMCID:: PMC8773974

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Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Md. Abdul Hannan, Md. Ataur Rahman, Abdullah Al Mamun Sohag, Md. Jamal Uddin, Raju Dash, Mahmudul Hasan Sikder, Md. Saidur Rahman, Binod Timalsina, Yeasmin Akter Munni, Partha Protim Sarker, Mahboob Alam, Md. Mohibbullah, Md. Nazmul Haque, Israt Jahan, Md. Tahmeed Hossain, Tania Afrin, Md. Mahbubur Rahman, Md. Tahjib-Ul-Arif, Sarmistha Mitra, Diyah Fatimah Oktaviani, Md Kawsar Khan, Ho Jin Choi, Il Soo Moon, Bonglee Kim

Nutrients. 2021 Jun; 13(6): 1784. Published online 2021 May 24. doi: 10.3390/nu13061784

PMCID:: PMC8225153

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Whole and Purified Aqueous Extracts of Nigella sativa L. Seeds Attenuate Apoptosis and the Overproduction of Reactive Oxygen Species Triggered by p53 Over-Expression in the Yeast Saccharomyces cerevisiae

Wafa Mihoubi, Emna Sahli, Fatma Rezgui, Najeh Dabebi, Rabiaa Sayehi, Hajer Hassairi, Najla Masmoudi-Fourati, Kamel Walha, Khalifa ben Khadhra, Mohamed Baklouti, Imen Ghzaiel, Sami Fattouch, Hela Menif, Raja Mokdad-Gargouri, Gérard Lizard, Ali Gargouri

Cells. 2022 Mar; 11(5): 869. Published online 2022 Mar 3. doi: 10.3390/cells11050869

PMCID:: PMC8909299

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The Role of Bioactive Compounds of Nigella sativa in Rheumatoid Arthritis Therapy—Current Reports

Magdalena Zielińska, Katarzyna Dereń, Ewelina Polak-Szczybyło, Agnieszka Ewa Stępień

Nutrients. 2021 Oct; 13(10): 3369. Published online 2021 Sep 25. doi: 10.3390/nu13103369

PMCID:: PMC8539759

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Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane

Zahrah Hikmah, Anang Endaryanto, I. Dewa Gede Ugrasena, Anny Setijo Rahaju, Syaiful Arifin

Heliyon. 2022 Apr; 8(4): e09242. Published online 2022 Apr 6. doi: 10.1016/j.heliyon.2022.e09242

PMCID:: PMC9018149

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Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis

Cinzia Nasuti, Donatella Fedeli, Laura Bordoni, Marco Piangerelli, Maurizio Servili, Roberto Selvaggini, Rosita Gabbianelli

Antioxidants (Basel) 2019 Sep; 8(9): 342. Published online 2019 Aug 25. doi: 10.3390/antiox8090342

PMCID:: PMC6769720

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Nigella sativa in controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: Molecular aspects

Vahid Hadi, Naseh Pahlavani, Mahsa Malekahmadi, Elyas Nattagh-Eshtivani, Jamshid Gholizadeh Navashenaq, Saeid Hadi, Gordon A Ferns, Majid Ghayour-Mobarhan, Gholamreza Askari, Abdolreza Norouzy

J Res Med Sci. 2021; 26: 20. Published online 2021 Mar 31. doi: 10.4103/jrms.JRMS_236_20

PMCID:: PMC8240544

Abstract Article PDF–606K

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Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Ebrahim M. Yimer, Kald Beshir Tuem, Aman Karim, Najeeb Ur-Rehman, Farooq Anwar

Evid Based Complement Alternat Med. 2019; 2019: 1528635. Published online 2019 May 12. doi: 10.1155/2019/1528635

PMCID:: PMC6535880

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Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression

Mujeeb Adekunle Adedokun, Linus Anderson Enye, Elizabeth Toyin Akinluyi, Toheeb Adesumbo Ajibola, Edem Ekpenyong Edem

IBRO Neurosci Rep. 2024 Jun; 16: 267–279. Published online 2024 Feb 1. doi: 10.1016/j.ibneur.2024.01.008

PMCID:: PMC10876594

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Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity state in the albino rats

Sayed Soliman Abdel Ghfar, Montaser Elsayed Ali, Maha Abdullah Momenah, Fatimah A. Al-Saeed, Amin A. Al-Doaiss, Yasser Sabry Mostafa, Ahmed Ezzat Ahmed, Mohamed Abdelrahman

Front Vet Sci. 2022; 9: 1042640. Published online 2022 Nov 29. doi: 10.3389/fvets.2022.1042640

Correction in:: Front Vet Sci. 2023; 10: 1160163.

PMCID:: PMC9745150

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Nigella sativa: Valuable perspective in the management of chronic diseases

Raluca Maria Pop, Adrian Pavel Trifa, Ada Popolo, Veronica Sanda Chedea, Claudia Militaru, Ioana Corina Bocsan, Anca Dana Buzoianu

Iran J Basic Med Sci. 2020 Jun; 23(6): 699–713. doi: 10.22038/ijbms.2020.37734.8978

PMCID:: PMC7351440

Abstract Article PDF–694K

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PMC Images search for Nigella sativa

Figure 8

Morphological changes in cultured AGS gastric adenocarcinoma cells exposed to Nigella sativa seed oil (2.4 mg/mL), Nigella sativa seed extract (0.5 mg/mL), OM-90 (20 μM), etoposide (20 μM), Nigella sativa seed oil + OM-90 (2.4 mg/mL + 20 μM), Nigella sativa seed oil + etoposide (2.4 mg/mL + 20 μM), Nigella sativa seed methanolic extract + OM-90 (0.5 mg/mL + 20 μM), and Nigella sativa seed methanolic extract + etoposide (0.5 mg/mL + 20 μM) for 24 hours. Images were taken using a microscope with an inverted camera (Nikon Eclipse Ti, Nikon Instruments Inc., Melville, NY, USA) at 100x magnification.

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells

Biomed Res Int. 2017;2017:9153403.
Figure 11

The loss of mitochondrial membrane potential of AGS gastric adenocarcinoma cells after 24 hours incubation with Nigella sativa seed oil (2.4 mg/mL), Nigella sativa seed extract (0.5 mg/mL), OM-90 (20 μM), etoposide (20 μM), Nigella sativa seed oil + OM-90 (2.4 mg/mL + 20 μM), Nigella sativa seed oil + etoposide (2.4 mg/mL + 20 μM), Nigella sativa seed methanolic extract + OM-90 (0.5 mg/mL + 20 μM), and Nigella sativa seed methanolic extract + etoposide (0.5 mg/mL + 20 μM) as measured JC-1 fluorescence. Mean percentage values from three independent experiments (n = 3) done in duplicate are presented.

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells

Biomed Res Int. 2017;2017:9153403.
Figure 10

Proapoptotic properties of Nigella sativa seed oil (2.4 mg/mL), Nigella sativa seed extract (0.5 mg/mL), OM-90 (20 μM), etoposide (20 μM), Nigella sativa seed oil + OM-90 (2.4 mg/mL + 20 μM), Nigella sativa seed oil + etoposide (2.4 mg/mL + 20 μM), Nigella sativa seed methanolic extract + OM-90 (0.5 mg/mL + 20 μM), and Nigella sativa seed methanolic extract + etoposide (0.5 mg/mL + 20 μM) in AGS gastric adenocarcinoma cells after 24 hours of incubation, obtained using dual acridine orange/ethidium bromide (AO/EB) fluorescent staining. Images were taken using a microscope with an inverted camera (Nikon Eclipse Ti, Nikon Instruments Inc., Melville, NY, USA) at 100x magnification.

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells

Biomed Res Int. 2017;2017:9153403.
Fig. 2Nissl stained sections of the mouse cortex. The stained sections of the mouse cortex show marked neurotoxicity in comparison with the respective control group. Reduced cell count and structural deformity are also visible in the sections treated with Pb while restoration of cell count is evident after the administration of Nigella sativa L. seed extract. (a) Control, (b) Pb 0.1% treated, (c) Pb 0.2% treated, (d) Pb 0.1% + Nigella sativa L. (250 mg kg–1), (e) Pb 0.1% + Nigella sativa L. (500 mg kg–1), (f) Pb 0.2% + Nigella sativa L. (250 mg kg–1), (g) Pb 0.2% + Nigella sativa L. (500 mg kg–1), (h) Nigella sativa L. (250 mg kg–1), (i) Nigella sativa L. (500 mg kg–1), and (j) prophylactic group.

Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx00201g

Toxicol Res (Camb). 2018 Jan 1;7(1):32-40.