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Items: 18

Select item 71893811.

Anti-glypican-1 antibody–drug conjugate is a potential therapy against pancreatic cancer

Takahiko Nishigaki, Tsuyoshi Takahashi, Satoshi Serada, Minoru Fujimoto, Tomoharu Ohkawara, Hisashi Hara, Takahito Sugase, Toru Otsuru, Yurina Saito, Shigehiro Tsujii, Taisei Nomura, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Makoto Yamasaki, Masaki Mori, Yuichiro Doki, Tetsuji Naka

Br J Cancer. 2020 Apr 28; 122(9): 1333–1341. Published online 2020 Mar 10. doi: 10.1038/s41416-020-0781-2

PMCID:: PMC7189381

Abstract Article PDF–2.7M

Select item 77567822.

Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing

Rafael W. Hartmann, Raphael Fahrner, Dr. Denys Shevshenko, Prof. Mårten Fyrknäs, Prof. Rolf Larsson, Dr. Fredrik Lehmann, Prof. Luke R. Odell

ChemMedChem. 2020 Dec 15; 15(24): 2500–2512. Published online 2020 Oct 16. doi: 10.1002/cmdc.202000497

PMCID:: PMC7756782

Abstract Article PDF–3.9M

Select item 71401143.

Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety

Yanming Wang, Lianqi Liu, Shiyong Fan, Dian Xiao, Fei Xie, Wei Li, Wu Zhong, Xinbo Zhou

Cancers (Basel) 2020 Mar; 12(3): 744. Published online 2020 Mar 21. doi: 10.3390/cancers12030744

PMCID:: PMC7140114

Abstract Article PDF–6.0M

Select item 81131974.

HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and radioimmunoimaging

Betül Altunay, Agnieszka Morgenroth, Mohsen Beheshti, Andreas Vogg, Nicholas C. L. Wong, Hong Hoi Ting, Hans-Jürgen Biersack, Elmar Stickeler, Felix M. Mottaghy

Eur J Nucl Med Mol Imaging. 2021; 48(5): 1371–1389. Published online 2020 Nov 12. doi: 10.1007/s00259-020-05094-1

Correction in:: Eur J Nucl Med Mol Imaging. 2024; 51(11): 3485.

PMCID:: PMC8113197

Abstract Article PDF–1.4M

Select item 107552925.

FDA-approved heterocyclic molecules for cancer treatment: Synthesis, dosage, mechanism of action and their adverse effect

Mossaraf Hossain, Imran Habib, Koustav Singha, Anoop Kumar

Heliyon. 2024 Jan 15; 10(1): e23172. Published online 2023 Dec 5. doi: 10.1016/j.heliyon.2023.e23172

PMCID:: PMC10755292

Abstract Article PDF–5.6M

Select item 96680686.

Natural products and drug discovery

David J Newman

Natl Sci Rev. 2022 Nov; 9(11): nwac206. Published online 2022 Sep 29. doi: 10.1093/nsr/nwac206

PMCID:: PMC9668068

Abstract Article PDF–909K

Select item 87277627.

Target-responsive subcellular catabolism analysis for early-stage antibody–drug conjugates screening and assessment

Hua Sang, Jiali Liu, Fang Zhou, Xiaofang Zhang, Jingwei Zhang, Yazhong Liu, Guangji Wang, Hui Ye

Acta Pharm Sin B. 2021 Dec; 11(12): 4020–4031. Published online 2021 May 27. doi: 10.1016/j.apsb.2021.05.024

PMCID:: PMC8727762

Abstract Article PDF–2.0M

Select item 76695848.

Potent activity of an anti-ICAM1 antibody-drug conjugate against multiple myeloma

Daniel W. Sherbenou, Yang Su, Christopher R. Behrens, Blake T. Aftab, Olivia Perez de Acha, Megan Murnane, Shelby C. Bearrows, Byron C. Hann, Jeffery L. Wolf, Thomas G. Martin, Bin Liu

Clin Cancer Res. Author manuscript; available in PMC 2021 May 15.

Published in final edited form as: Clin Cancer Res. 2020 Nov 15; 26(22): 6028–6038. Published online 2020 Sep 11. doi: 10.1158/1078-0432.CCR-20-0400

PMCID:: PMC7669584

Abstract Article PDF–3.1M

Select item 57351319.

Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Ruogu Qi, Yongheng Wang, Peter M. Bruno, Haihua Xiao, Yingjie Yu, Ting Li, Sam Lauffer, Wei Wei, Qixian Chen, Xiang Kang, Haiqin Song, Xi Yang, Xing Huang, Alexandre Detappe, Ursula Matulonis, David Pepin, Michael T. Hemann, Michael J. Birrer, P. Peter Ghoroghchian

Nat Commun. 2017; 8: 2166. Published online 2017 Dec 18. doi: 10.1038/s41467-017-02390-7

Correction in:: Nat Commun. 2020; 11: 1940.

Correction in:: Nat Commun. 2018; 9: 628.

PMCID:: PMC5735131

Abstract Article PDF–2.1M

Select item 279131310.

Charge-based analysis of antibodies with engineered cysteines: From multiple peaks to a single main peak

Xiaoying (Nancy) Chen, Mary Nguyen, Fred Jacobson, Jun Ouyang

MAbs. 2009 Nov-Dec; 1(6): 563–571. doi: 10.4161/mabs.1.6.10058

PMCID:: PMC2791313

Abstract Article PDF–3.0M

Select item 854011511.

A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

Shalom D. Goldberg, Nathan Felix, Michael McCauley, Ryan Eberwine, Lou Casta, Kathleen Haskell, Tricia Lin, Elizabeth Palovick, Donna Klein, Lori Getts, Robert Getts, Mimi Zhou, Pratima Bansal-Pakala, Vadim Dudkin

Pharmaceutics. 2021 Oct; 13(10): 1669. Published online 2021 Oct 13. doi: 10.3390/pharmaceutics13101669

PMCID:: PMC8540115

Abstract Article PDF–1.5M

Select item 894558212.

The promise and perils of immunotherapy

Stefanie Lesch, Saar Gill

Blood Adv. 2021 Sep 28; 5(18): 3709–3725. Published online 2021 Sep 28. doi: 10.1182/bloodadvances.2021004453C

PMCID:: PMC8945582

Abstract Article PDF–1.7M

Select item 757268913.

ALPPL2 is a highly specific and targetable tumor cell surface antigen

Yang Su, Xin Zhang, Scott Bidlingmaier, Christopher R. Behrens, Nam-Kyung Lee, Bin Liu

Cancer Res. Author manuscript; available in PMC 2021 Apr 15.

Published in final edited form as: Cancer Res. 2020 Oct 15; 80(20): 4552–4564. Published online 2020 Aug 31. doi: 10.1158/0008-5472.CAN-20-1418

PMCID:: PMC7572689

Abstract Article PDF–1.0M

Select item 604548714.

Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications

Michinori Akaiwa, Tioga Martin, Brian A. Mendelsohn

ACS Omega. 2018 May 31; 3(5): 5212–5221. Published online 2018 May 15. doi: 10.1021/acsomega.8b00093

PMCID:: PMC6045487

Abstract Article PDF–1.0M

Select item 245302715.

CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers

L M Smith, A Nesterova, M C Ryan, S Duniho, M Jonas, M Anderson, R F Zabinski, M K Sutherland, H-P Gerber, K L Van Orden, P A Moore, S M Ruben, P J Carter

Br J Cancer. 2008 Jul 8; 99(1): 100–109. Published online 2008 Jun 10. doi: 10.1038/sj.bjc.6604437

PMCID:: PMC2453027

Abstract Article PDF–422K

Select item 257078716.

Influence of the Linker on the Biodistribution and Catabolism of Actinium-225 Self-Immolative Tumor-Targeted Isotope Generators

Christophe Antczak, Jaspreet S. Jaggi, Clare V. LeFave, Michael J. Curcio, Michael R. McDevitt, David A. Scheinberg

Bioconjug Chem. Author manuscript; available in PMC 2008 Oct 22.

Published in final edited form as: Bioconjug Chem. 2006; 17(6): 1551–1560. doi: 10.1021/bc060156+

PMCID:: PMC2570787

Abstract Article PDF–718K

Select item 493329617.

Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists

Mallory R. Gordon, Mine Canakci, Longyu Li, Jiaming Zhuang, Barbara Osborne, S. Thayumanavan

Bioconjug Chem. Author manuscript; available in PMC 2016 Nov 18.

Published in final edited form as: Bioconjug Chem. 2015 Nov 18; 26(11): 2198–2215. Published online 2015 Sep 10. doi: 10.1021/acs.bioconjchem.5b00399

PMCID:: PMC4933296

Abstract Article PDF–1.5M

Select item 512768318.

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells

Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Marc A. Shuman, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, Thomas G. Martin, Bin Liu

J Clin Invest. 2016 Dec 1; 126(12): 4640–4653. Published online 2016 Nov 14. doi: 10.1172/JCI85856