Ethyl 2-(3-chloro-4-fluorophenyl)acetate - PMC

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Select item 75863441.

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT_1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Joanna Sniecikowska, Monika Gluch-Lutwin, Adam Bucki, Anna Więckowska, Agata Siwek, Magdalena Jastrzebska-Wiesek, Anna Partyka, Daria Wilczyńska, Karolina Pytka, Gniewomir Latacz, Katarzyna Przejczowska-Pomierny, Elżbieta Wyska, Anna Wesołowska, Maciej Pawłowski, Adrian Newman-Tancredi, Marcin Kolaczkowski

J Med Chem. 2020 Oct 8; 63(19): 10946–10971. Published online 2020 Sep 4. doi: 10.1021/acs.jmedchem.0c00814

PMCID:: PMC7586344

Abstract Article PDF–7.2M

Select item 92331462.

Small molecule inhibitors of ferrochelatase are antiangiogenic agents

Kamakshi Sishtla, Nathan Lambert-Cheatham, Bit Lee, Duk Hee Han, Jaehui Park, Sheik Pran Babu Sardar Pasha, Sanha Lee, Sangil Kwon, Anbukkarasi Muniyandi, Bomina Park, Noa Odell, Sydney Waller, Yeong Park, II, Soo Jae Lee, Seung-Yong Seo, Timothy W. Corson

Cell Chem Biol. Author manuscript; available in PMC 2023 Jun 16.

Published in final edited form as: Cell Chem Biol. 2022 Jun 16; 29(6): 1010–1023.e14. Published online 2022 Jan 31. doi: 10.1016/j.chembiol.2022.01.001

PMCID:: PMC9233146

Abstract Article PDF–2.3M

Select item 59205593.

Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy

Anne Rietz, Hongxia Li, Kevin M. Quist, Jonathan J. Cherry, Christian L. Lorson, Barrington Burnett, Nicholas L. Kern, Alyssa N. Calder, Melanie Fritsche, Hrvoje Lusic, Patrick J. Boaler, Sungwoon Choi, Xuechao Xing, Marcie A. Glicksman, Gregory D. Cuny, Elliot J. Androphy, Kevin J. Hodgetts

J Med Chem. Author manuscript; available in PMC 2018 Jun 8.

Published in final edited form as: J Med Chem. 2017 Jun 8; 60(11): 4594–4610. Published online 2017 May 19. doi: 10.1021/acs.jmedchem.6b01885

PMCID:: PMC5920559

Abstract Article PDF–2.9M

Select item 107538604.

Identification of Novel Tetrahydroquinoxaline Derived Phenyl Ureas as Modulators of the Hepatitis B Virus Nucleocapsid Assembly

Nicky Hwang, Shuo Wu, Haiqun Ban, Huixin Luo, Julia Ma, Junjun Cheng, Qiong Zhao, Jessilyn A. Laney, Na Du, Junyang Guo, Manasa Suresh, Liangxian Shen, Gideon Tolufashe, Usha Viswanathan, John Kulp, Patrick Lam, Jinhong Chang, Jason Clement, Stephan Menne, Ju-Tao Guo, Yanming Du

Eur J Med Chem. Author manuscript; available in PMC 2024 Nov 5.

Published in final edited form as: Eur J Med Chem. 2023 Nov 5; 259: 115634. Published online 2023 Jul 17. doi: 10.1016/j.ejmech.2023.115634

PMCID:: PMC10753860

Abstract Article PDF–1.7M

Select item 84655325.

Palladium(0) Catalyzed Synthesis of (E)-4-Bromo-N-((3-bromothiophen-2-yl)methylene)-2-methylaniline Derivatives via Suzuki Cross-Coupling Reaction: An Exploration of Their Non-Linear Optical Properties, Reactivity and Structural Features

Komal Rizwan, Nasir Rasool, Muhammad Ali Hashmi, Sadia Noreen, Muhammad Zubair, Mahwish Arshad, Syed Adnan Ali Shah

Molecules. 2021 Sep; 26(18): 5605. Published online 2021 Sep 15. doi: 10.3390/molecules26185605

PMCID:: PMC8465532

Abstract Article PDF–2.2M

Select item 100995956.

Multimodal 4-arylchromene derivatives with microtubule-destabilizing, anti-angiogenic, and MYB-inhibitory activities

Leonhard H. F. Köhler, Sebastian Reich, Maria Yusenko, Karl-Heinz Klempnauer, Gerrit Begemann, Rainer Schobert, Bernhard Biersack

Cancer Drug Resist. 2023; 6(1): 59–77. Published online 2023 Feb 1. doi: 10.20517/cdr.2022.90

PMCID:: PMC10099595

Abstract Article PDF–2.9M

Select item 88079477.

Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds

Mohamed A Abdelgawad, Mohammad M Al-Sanea, Arafa Musa, Mohammed Elmowafy, Ashraf K El-Damasy, Amany A Azouz, Mohammed M Ghoneim, Rania B Bakr

J Inflamm Res. 2022; 15: 451–463. Published online 2022 Jan 20. doi: 10.2147/JIR.S343263

PMCID:: PMC8807947

Abstract Article PDF–2.0M

Select item 103436868.

Integration of Hybridization Strategies in Pyridine–Urea Scaffolds for Novel Anticancer Agents: Design, Synthesis, and Mechanistic Insights

Sreenivasulu Godesi, Hossam Nada, Joohan Lee, Joon-Hee Kang, Soo-Youl Kim, Yongseok Choi, Kyeong Lee

Molecules. 2023 Jul; 28(13): 4952. Published online 2023 Jun 23. doi: 10.3390/molecules28134952

PMCID:: PMC10343686

Abstract Article PDF–1.9M

Select item 79621349.

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

Mohamed Farouk Elsadek, Badreldin Mohamed Ahmed, Mohamed Fawzi Farahat

Molecules. 2021 Mar; 26(5): 1449. Published online 2021 Mar 7. doi: 10.3390/molecules26051449

PMCID:: PMC7962134

Abstract Article PDF–12M

Select item 814174710.

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Rafael Fernades Costa, Larissa Córdova Turones, Keilah Valéria Naves Cavalcante, Ismael Aureliano Rosa Júnior, Carlos Henrique Xavier, Lucimar Pinheiro Rosseto, Hamilton Barbosa Napolitano, Patrícia Ferreira da Silva Castro, Marcos Luiz Ferreira Neto, Gustavo Mota Galvão, Ricardo Menegatti, Gustavo Rodrigues Pedrino, Elson Alves Costa, José Luis Rodrigues Martins, James Oluwagbamigbe Fajemiroye

Front Pharmacol. 2021; 12: 666725. Published online 2021 May 10. doi: 10.3389/fphar.2021.666725

PMCID:: PMC8141747

Abstract Article PDF–1.0M

Select item 1010835911.

Discovery of Nanomolar DCAF1 Small Molecule Ligands

Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi

J Med Chem. 2023 Apr 13; 66(7): 5041–5060. Published online 2023 Mar 22. doi: 10.1021/acs.jmedchem.2c02132

PMCID:: PMC10108359

Abstract Article PDF–7.9M

Select item 926411512.

Pd-catalyzed C–C and C–N cross-coupling reactions in 2-aminothieno[3,2-d]pyrimidin-4(3H)-one series for antiplasmodial pharmacomodulation

Romain Mustière, Prisca Lagardère, Sébastien Hutter, Céline Deraeve, Florian Schwalen, Dyhia Amrane, Nicolas Masurier, Nadine Azas, Vincent Lisowski, Pierre Verhaeghe, Dominique Mazier, Patrice Vanelle, Nicolas Primas

RSC Adv. 2022 Jul 6; 12(31): 20004–20021. Published online 2022 Jul 8. doi: 10.1039/d2ra01687g

PMCID:: PMC9264115

Abstract Article PDF–774K

Select item 1097647613.

Facile synthesis of substituted 2-aroylbenzo[b]thiophen-3-ols to form novel triazole hybrids using click chemistry

Asma Mukhtar, Arif Hussain, Faiza Younas, Sammer Yousuf, Muhammad Saeed

RSC Adv. 2024 Mar 26; 14(15): 10270–10279. Published online 2024 Mar 28. doi: 10.1039/d4ra01146e

PMCID:: PMC10976476

Abstract Article PDF–746K

Select item 843621314.

Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia

Monika Marcinkowska, Adam Bucki, Joanna Sniecikowska, Agnieszka Zagórska, Nikola Fajkis-Zajączkowska, Agata Siwek, Monika Gluch-Lutwin, Paweł Żmudzki, Magdalena Jastrzebska-Wiesek, Anna Partyka, Anna Wesołowska, Michał Abram, Katarzyna Przejczowska-Pomierny, Agnieszka Cios, Elżbieta Wyska, Kamil Mika, Magdalena Kotańska, Paweł Mierzejewski, Marcin Kolaczkowski

J Med Chem. 2021 Sep 9; 64(17): 12603–12629. Published online 2021 Aug 26. doi: 10.1021/acs.jmedchem.1c00497

PMCID:: PMC8436213

Abstract Article PDF–5.5M

Select item 892608415.

A biomimetic S_H2 cross-coupling mechanism for quaternary sp³-carbon formation

Wei Liu, Marissa N. Lavagnino, Colin A. Gould, Jesús Alcázar, David W. C. MacMillan

Science. Author manuscript; available in PMC 2022 Mar 16.

Published in final edited form as: Science. 2021 Dec 3; 374(6572): 1258–1263. Published online 2021 Nov 11. doi: 10.1126/science.abl4322

PMCID:: PMC8926084

Abstract Article PDF–1.2M

Select item 918092616.

Discovery of Novel 3-Hydroxyquinazoline-2,4(1H,3H)-Dione Derivatives: A Series of Metal Ion Chelators with Potent Anti-HCV Activities

Yang Cao, Abudumijiti Aimaiti, Zeyun Zhu, Lu Zhou, Deyong Ye

Int J Mol Sci. 2022 Jun; 23(11): 5930. Published online 2022 May 25. doi: 10.3390/ijms23115930

PMCID:: PMC9180926

Abstract Article PDF–9.5M

Select item 1150897417.

Computational Approach to Identifying New Chemical Entities as Elastase Inhibitors with Potential Antiaging Effects

Giovanna Pitasi, Andrea Brancale, Sonia Floris, Antonella Fais, Rosaria Gitto, Laura De Luca

Int J Mol Sci. 2024 Oct; 25(20): 11174. Published online 2024 Oct 17. doi: 10.3390/ijms252011174

PMCID:: PMC11508974

Abstract Article PDF–2.7M

Select item 759378318.

The Diaryliodonium(III) Salts Reaction With Free-Radicals Enables One-Pot Double Arylation of Naphthols

Yuvraj Satkar, Kazimierz Wrobel, Daniel E. Trujillo-González, Rafael Ortiz-Alvarado, J. Oscar C. Jiménez-Halla, César R. Solorio-Alvarado

Front Chem. 2020; 8: 563470. Published online 2020 Oct 15. doi: 10.3389/fchem.2020.563470

PMCID:: PMC7593783

Abstract Article PDF–2.4M

Select item 875855519.

Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K_Ca2 Channels

Naglaa Salem El-Sayed, Young-Woo Nam, Polina A Egorova, Hai Minh Nguyen, Razan Orfali, Mohammad Asikur Rahman, Grace Yang, Heike Wulff, Ilya Bezprozvanny, Keykavous Parang, Miao Zhang

J Med Chem. Author manuscript; available in PMC 2023 Jan 13.

Published in final edited form as: J Med Chem. 2022 Jan 13; 65(1): 303–322. Published online 2021 Dec 28. doi: 10.1021/acs.jmedchem.1c01473

PMCID:: PMC8758555

Abstract Article PDF–1.7M

Select item 632704020.

A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives

Daniel Nascimento do Amaral, Jonas Lategahn, Harold Hilarion Fokoue, Eduardo Miguez Bastos da Silva, Carlos Mauricio R. Sant’Anna, Daniel Rauh, Eliezer J. Barreiro, Stefan Laufer, Lidia Moreira Lima

Sci Rep. 2019; 9: 14. Published online 2019 Jan 9. doi: 10.1038/s41598-018-36846-7

PMCID:: PMC6327040

Abstract Article PDF–1.6M

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