E2 component of pyruvate dehydrogenase complex - PMC

Rafal Zdanowicz, Pavel Afanasyev, Adam Pruška, Julian A. Harrison, Christoph Giese, Daniel Boehringer, Alexander Leitner, Renato Zenobi, Rudi Glockshuber

Sci Adv. 2024 Jul 19; 10(29): eadn4582. Published online 2024 Jul 17. doi: 10.1126/sciadv.adn4582

PMCID:: PMC466950

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Simulations of Pathogenic E1α Variants: Allostery and Impact on Pyruvate Dehydrogenase Complex-E1 Structure and Function

Hatice Gokcan, Jirair K. Bedoyan, Olexandr Isayev

J Chem Inf Model. Author manuscript; available in PMC 2022 Jul 28.

Published in final edited form as: J Chem Inf Model. 2022 Jul 25; 62(14): 3463–3475. Published online 2022 Jul 7. doi: 10.1021/acs.jcim.2c00630

PMCID:: PMC9329271

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Global view of cognate kinase activation by the human pyruvate dehydrogenase complex

Elena L. Guevara, Luying Yang, Barbara Birkaya, Jieyu Zhou, Natalia S. Nemeria, Mulchand S. Patel, Frank Jordan

Sci Rep. 2017; 7: 42760. Published online 2017 Feb 23. doi: 10.1038/srep42760

PMCID:: PMC5322387

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Nuclear pyruvate dehydrogenase complex regulates histone acetylation and transcriptional regulation in the ethylene response

Zhengyao Shao, Liangqiao Bian, Shyon K. Ahmadi, Tyler J. Daniel, Miguel A. Belmonte, Jackson G. Burns, Prashanth Kotla, Yang Bi, Zhouxin Shen, Shou-Ling Xu, Zhi-Yong Wang, Steven P. Briggs, Hong Qiao

Sci Adv. 2024 Jul 26; 10(30): eado2825. Published online 2024 Jul 26. doi: 10.1126/sciadv.ado2825

PMCID:: PMC11277378

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Detailed evaluation of pyruvate dehydrogenase complex inhibition in simulated exercise conditions

Bodhi A. Jelinek, Michael A. Moxley

Biophys J. 2021 Mar 2; 120(5): 936–949. Published online 2021 Jan 28. doi: 10.1016/j.bpj.2021.01.018

PMCID:: PMC8008327

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The structure and evolutionary diversity of the fungal E3-binding protein

Bjoern O. Forsberg

Commun Biol. 2023; 6: 480. Published online 2023 May 3. doi: 10.1038/s42003-023-04854-7

PMCID:: PMC10156792

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Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction

Christian Tüting, Fotis L. Kyrilis, Johannes Müller, Marija Sorokina, Ioannis Skalidis, Farzad Hamdi, Yashar Sadian, Panagiotis L. Kastritis

Nat Commun. 2021; 12: 6933. Published online 2021 Nov 26. doi: 10.1038/s41467-021-27287-4

PMCID:: PMC8626477

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Pyruvate dehydrogenase complex deficiency: updating the clinical, metabolic and mutational landscapes in a cohort of Portuguese patients

Hana Pavlu-Pereira, Maria João Silva, Cristina Florindo, Sílvia Sequeira, Ana Cristina Ferreira, Sofia Duarte, Ana Luísa Rodrigues, Patrícia Janeiro, Anabela Oliveira, Daniel Gomes, Anabela Bandeira, Esmeralda Martins, Roseli Gomes, Sérgia Soares, Isabel Tavares de Almeida, João B. Vicente, Isabel Rivera

Orphanet J Rare Dis. 2020; 15: 298. Published online 2020 Oct 22. doi: 10.1186/s13023-020-01586-3

PMCID:: PMC7579914

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Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase

Tereza Golias, Martin Kery, Silvia Radenkovic, Ioanna Papandreou

Int J Cancer. Author manuscript; available in PMC 2020 Feb 15.

Published in final edited form as: Int J Cancer. 2019 Feb 15; 144(4): 674–686. Published online 2018 Oct 4. doi: 10.1002/ijc.31812

PMCID:: PMC6689402

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Plastidic pyruvate dehydrogenase complex E1 component subunit Alpha1 is involved in galactolipid biosynthesis required for amyloplast development in rice

Jie Lei, Xuan Teng, Yongfei Wang, Xiaokang Jiang, Huanhuan Zhao, Xiaoming Zheng, Yulong Ren, Hui Dong, Yunlong Wang, Erchao Duan, Yuanyan Zhang, Wenwei Zhang, Hang Yang, Xiaoli Chen, Rongbo Chen, Yu Zhang, Mingzhou Yu, Shanbin Xu, Xiuhao Bao, Pengcheng Zhang, Shijia Liu, Xi Liu, Yunlu Tian, Ling Jiang, Yihua Wang, Jianmin Wan

Plant Biotechnol J. 2022 Mar; 20(3): 437–453. Published online 2021 Nov 9. doi: 10.1111/pbi.13727

PMCID:: PMC8882802

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Insight to the Interaction of the Dihydrolipoamide Acetyltransferase (E2) Core with the Peripheral Components in the Escherichia coli Pyruvate Dehydrogenase Complex via Multifaceted Structural Approaches

Krishnamoorthy Chandrasekhar, Junjie Wang, Palaniappa Arjunan, Martin Sax, Yun-Hee Park, Natalia S. Nemeria, Sowmini Kumaran, Jaeyoung Song, Frank Jordan, William Furey

J Biol Chem. 2013 May 24; 288(21): 15402–15417. Published online 2013 Apr 11. doi: 10.1074/jbc.M113.466789

PMCID:: PMC3663558

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Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex

Jiansen Jiang, Flavius L. Baiesc, Yasuaki Hiromasa, Xuekui Yu, Wong Hoi Hui, Xinghong Dai, Thomas E. Roche, Z. Hong Zhou

Biochemistry. Author manuscript; available in PMC 2018 Jul 5.

Published in final edited form as: Biochemistry. 2018 Apr 24; 57(16): 2325–2334. Published online 2018 Apr 12. doi: 10.1021/acs.biochem.8b00357

PMCID:: PMC6033517

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Engineering Acetyl Coenzyme A Supply: Functional Expression of a Bacterial Pyruvate Dehydrogenase Complex in the Cytosol of Saccharomyces cerevisiae

Barbara U. Kozak, Harmen M. van Rossum, Marijke A. H. Luttik, Michiel Akeroyd, Kirsten R. Benjamin, Liang Wu, Simon de Vries, Jean-Marc Daran, Jack T. Pronk, Antonius J. A. van Maris

mBio. 2014 Sep-Oct; 5(5): e01696-14. Published online 2014 Oct 21. doi: 10.1128/mBio.01696-14

PMCID:: PMC4212835

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Folding and assembly defects of pyruvate dehydrogenase deficiency-related variants in the E1α subunit of the pyruvate dehydrogenase complex

Srdja Drakulic, Jay Rai, Steen Vang Petersen, Monika M. Golas, Bjoern Sander

Cell Mol Life Sci. 2018 Aug; 75(16): 3009–3026. Published online 2018 Feb 14. doi: 10.1007/s00018-018-2775-2

PMCID:: PMC11105750

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Pyruvate dehydrogenase complex—enzyme 2, a new target for Listeria spp. detection identified using combined phage display technologies

Gustavo Marçal Schmidt Garcia Moreira, Sarah Mara Stella Köllner, Saskia Helmsing, Lothar Jänsch, Anja Meier, Sabine Gronow, Christian Boedeker, Stefan Dübel, Marcelo Mendonça, Ângela Nunes Moreira, Fabricio Rochedo Conceição, Michael Hust

Sci Rep. 2020; 10: 15267. Published online 2020 Sep 17. doi: 10.1038/s41598-020-72159-4

PMCID:: PMC7498459

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Involvement of Candida albicans pyruvate dehydrogenase complex protein X (Pdx1) in filamentation

Vincent F.Vellucci, Scott Gygax, Margaret K. Hostetter

Fungal Genet Biol. Author manuscript; available in PMC 2008 Oct 1.

Published in final edited form as: Fungal Genet Biol. 2007 Oct; 44(10): 979–990. Published online 2006 Dec 16. doi: 10.1016/j.fgb.2006.12.003

PMCID:: PMC2062515

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PMC Images search for E2 component of pyruvate dehydrogenase complex

Fig. 5

Expression of pyruvate dehydrogenase complex (PDC-E2FLAG) protein. Extracts of transgenic and wild-type mouse livers were immunoprecipitated with anti-FLAG antibody and were processed by Western blotting analysis with anti-FLAG antibody or anti-PDC-E2 antibody. Arrows indicate exogenous protein combining pyruvate dehydrogenase complex E2 (PDC-E2) and FLAG. Whole lysate of cytokeratin 19 (CK19)pPDC-E2delFLAG-transfected HuH7 cells (lane 3) was used as a positive control. (lane 1: CK19pPDC-E2delFLAG line 7, lane 2: wild-type mouse).

Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis

Clin Exp Immunol. 2006 Jul;145(1):93-100.
Figure 1

E2 acetyltransferase component from Geobacillus stearothermophilus pyruvate dehydrogenase complex. A: Schematic illustration of the native E2 chain with: lypoil domain (LD), peripheral subunit-binding domain (PSBD), and catalytic acetyltransferase core domain (CD). E2 CD forms trimers that assemble to generate a pentagonal dodecahedral scaffold_(60-mer) with icosahedral symmetry. Trimers are in cyan with monomers of one trimer shown in green, red and blue; B: E2 core from E2DISP acetyltransferase system displaying an antigen of interest (AoI) N-terminally fused to CD; C: Schematic illustration of in vitro refolding of insoluble E2 displaying HIV-1 Envelope V3 in presence of E2 wild-type (E2wt).

Novel antigen delivery systems

World J Virol. 2015 Aug 12;4(3):156-168.
Fig. 3

Transgene expression detected by reverse transcription–polymerase chain reaction (RT–PCR). Total RNA was extracted from the mouse liver. To detect mRNA, poly(dT)₁₂₋₁₈ was used as the RT primer. The arrow indicates exogenous pyruvate dehydrogenase complex E2 (PDC-E2) mRNA. HuH7 cell lysate transfected with the cytokeratin 19 promoter (CK19p) PDC-E2 transgene (lane 3) was used as a positive control [lane 1, cytokeratin 19-pyruvate dehydrogenase complex E2FLAG (CK19pPDC-E2delFLAG line 7); lane 2, wild-type].

Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis

Clin Exp Immunol. 2006 Jul;145(1):93-100.
FIG 1

Autoimmune activation and biliary pathology cascade in SSc. Lists are examples of key players and are not all‐inclusive. NK, natural killer; IRF5, interferon regulatory factor 5; PDC‐E2, E2 component of pyruvate dehydrogenase complex; STAT4, signal transducer and activator of transcription 4.

Systemic Sclerosis and the Liver

Clin Liver Dis (Hoboken). 2021 Aug;18(2):76-80.