DNA-dependent protein kinase catalytic subunit - PMC

Published in final edited form as: Prog Biophys Mol Biol. 2015 Mar; 117(0): 194–205. Published online 2014 Dec 27. doi: 10.1016/j.pbiomolbio.2014.12.003

PMCID:: PMC4502593

Abstract Article PDF–843K

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DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives angiotensin II-induced vascular remodeling through regulating mitochondrial fragmentation

Litao Wang, Lin Wu, Yuxin Du, Xiang Wang, Bingsheng Yang, Shuai Guo, Yuan Zhou, Yiming Xu, Shuofei Yang, Yingmei Zhang, Jun Ren

Redox Biol. 2023 Nov; 67: 102893. Published online 2023 Sep 16. doi: 10.1016/j.redox.2023.102893

PMCID:: PMC10520570

Abstract Article PDF–19M

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Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

James P. Lees-Miller, Alexander Cobban, Panagiotis Katsonis, Albino Bacolla, Susan E. Tsutakawa, Michal Hammel, Katheryn Meek, Dave W. Anderson, Olivier Lichtarge, John A. Tainer, Susan P. Lees-Miller

Prog Biophys Mol Biol. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Prog Biophys Mol Biol. 2021 Aug; 163: 87–108. Published online 2020 Oct 6. doi: 10.1016/j.pbiomolbio.2020.09.010

PMCID:: PMC8021618

Abstract Article PDF–5.6M

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Human DNA-dependent protein kinase activation mechanism

Shikang Liang, Tom L. Blundell

Nat Struct Mol Biol. 2023; 30(2): 140–147. Published online 2023 Jan 5. doi: 10.1038/s41594-022-00881-w

PMCID:: PMC9935390

Abstract Article PDF–8.0M

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DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair

Ye-Rim Lee, Gi-Sue Kang, Taerim Oh, Hye-Ju Jo, Hye-Joon Park, G-One Ahn

Mol Cells. 2023 Apr 30; 46(4): 200–205. Published online 2023 Feb 9. doi: 10.14348/molcells.2023.2164

PMCID:: PMC10086554

Abstract Article PDF–2.2M

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Cryoelectron Microscopy Structure of the DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) at Subnanometer Resolution Reveals α-Helices and Insight into DNA Binding

Dewight R. Williams, Kyung-Jong Lee, Jian Shi, David J. Chen, Phoebe L. Stewart

Structure. Author manuscript; available in PMC 2009 Mar 1.

Published in final edited form as: Structure. 2008 Mar; 16(3): 468–477. doi: 10.1016/j.str.2007.12.014

PMCID:: PMC2323513

Abstract Article PDF–4.5M

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Autophosphorylation and Self-Activation of DNA-Dependent Protein Kinase

Aya Kurosawa

Genes (Basel) 2021 Jul; 12(7): 1091. Published online 2021 Jul 19. doi: 10.3390/genes12071091

PMCID:: PMC8305690

Abstract Article PDF–978K

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X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double‐strand break repair impacting cell and cancer biology

Michal Hammel, John A. Tainer

Protein Sci. 2021 Sep; 30(9): 1735–1756. Published online 2021 Jun 5. doi: 10.1002/pro.4133

PMCID:: PMC8376411

Abstract Article PDF–4.8M

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Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM

Michal Hammel, Daniel J. Rosenberg, Jan Bierma, Gregory L. Hura, Susan P. Lees-Miller, John A. Tainer

Prog Biophys Mol Biol. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Prog Biophys Mol Biol. 2021 Aug; 163: 74–86. Published online 2020 Sep 20. doi: 10.1016/j.pbiomolbio.2020.09.003

PMCID:: PMC8896507

Abstract Article PDF–3.1M

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Structural insights into the role of DNA-PK as a master regulator in NHEJ

Siyu Chen, James P. Lees-Miller, Yuan He, Susan P. Lees-Miller

Genome Instab Dis. 2021; 2(4): 195–210. Published online 2021 Jul 23. doi: 10.1007/s42764-021-00047-w

PMCID:: PMC8549938

Abstract Article PDF–2.8M

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Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy

Annapoorna Kannan, Kanchan Bhatia, Dana Branzei, Laxman Gangwani

Nucleic Acids Res. 2018 Sep 19; 46(16): 8326–8346. Published online 2018 Jul 16. doi: 10.1093/nar/gky641

PMCID:: PMC6144794

Abstract Article PDF–17M

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Purification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) from HeLa cells

Linda Lee, Yaping Yu, Susan P. Lees-Miller

Methods Mol Biol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Methods Mol Biol. 2022; 2444: 227–241. doi: 10.1007/978-1-0716-2063-2_14

PMCID:: PMC9204046

Abstract Article PDF–1.1M

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Development and Evolution of DNA-Dependent Protein Kinase Inhibitors toward Cancer Therapy

Yoshihisa Matsumoto

Int J Mol Sci. 2022 Apr; 23(8): 4264. Published online 2022 Apr 12. doi: 10.3390/ijms23084264

PMCID:: PMC9032228

Abstract Article PDF–3.6M

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Cryo-EM structure of human DNA-PK holoenzyme

Xiaotong Yin, Mengjie Liu, Yuan Tian, Jiawei Wang, Yanhui Xu

Cell Res. 2017 Nov; 27(11): 1341–1350. Published online 2017 Aug 25. doi: 10.1038/cr.2017.110

PMCID:: PMC5674154

Abstract Article PDF–2.8M

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PMC Images search for DNA-dependent protein kinase catalytic subunit

Fig. 1A diagram highlighting multiple roles of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in cells.

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair

Mol Cells. 2023 Apr 30;46(4):200-205.
Figure 3

Kaplan-Meier overall survival curves for the subgroup of p16INK4A-positive patients (A); and p16INK4A -negative patients (B) stratified by DNA-dependent protein kinase catalytic subunit expression.

DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma

J Cancer. 2017;8(12):2410-2416.
Figure 2

Kaplan-Meier overall survival (A) and distant metastasis-free survival (B) curves for 208 patients with laryngeal squamous cell carcinoma stratified by DNA-dependent protein kinase catalytic subunit expression; overall survival (C) stratified by p16INK4A status.

DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma

J Cancer. 2017;8(12):2410-2416.
FIGURE 1

Kaplan-Meier survival estimates for all patients. Survival duration according to the expression of ataxia-telangiectasia mutated (ATM) (A) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) (B). MST indicates median survival time.

Prognostic Significance of Ataxia-Telangiectasia Mutated, DNA-dependent Protein Kinase Catalytic Subunit, and Ku Heterodimeric Regulatory Complex 86-kD Subunit Expression in Patients With Nonsmall Cell Lung Cancer

Cancer. ;112(12):2756-2764.