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Select item 97398771.

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

Shujing Xu, Lin Sun, Waleed A. Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan

Molecules. 2022 Dec; 27(23): 8415. Published online 2022 Dec 1. doi: 10.3390/molecules27238415

PMCID:: PMC9739877

Abstract Article PDF–4.8M

Select item 96588172.

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan

Molecules. 2022 Nov; 27(21): 7640. Published online 2022 Nov 7. doi: 10.3390/molecules27217640

PMCID:: PMC9658817

Abstract Article PDF–7.4M

Select item 80119913.

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

Lin Sun, Alexej Dick, Megan E. Meuser, Tianguang Huang, Waleed A. Zalloum, Chin-Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Kuo-Hsiung Lee, Xinyong Liu, Peng Zhan

J Med Chem. Author manuscript; available in PMC 2021 May 14.

Published in final edited form as: J Med Chem. 2020 May 14; 63(9): 4790–4810. Published online 2020 Apr 29. doi: 10.1021/acs.jmedchem.0c00015

PMCID:: PMC8011991

Abstract Article PDF–3.1M

Select item 107902294.

Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators

Shujing Xu, Lin Sun, Michael Barnett, Xujie Zhang, Dang Ding, Anushka Gattu, Dazhou Shi, Jamie R. H. Taka, Wenli Shen, Xiangyi Jiang, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan

J Med Chem. Author manuscript; available in PMC 2024 Jan 16.

Published in final edited form as: J Med Chem. 2023 Dec 14; 66(23): 16303–16329. Published online 2023 Dec 6. doi: 10.1021/acs.jmedchem.3c01647

PMCID:: PMC10790229

Abstract Article PDF–3.3M

Select item 95028975.

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

Xiangkai Ji, Jing Li, Prem Prakash Sharma, Xiangyi Jiang, Brijesh Rathi, Zhen Gao, Lide Hu, Dongwei Kang, Erik De Clercq, Simon Cocklin, Chuanfeng Liu, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan

Molecules. 2022 Sep; 27(18): 5995. Published online 2022 Sep 14. doi: 10.3390/molecules27185995

PMCID:: PMC9502897

Abstract Article PDF–11M

Select item 48755066.

LAT-1 Activity of meta-Substituted Phenylalanine and Tyrosine Analogs

Evan Augustyn, Karissa Finke, Arik A. Zur, Logan Hansen, Nathan Heeren, Huan-Chieh Chien, Lawrence Lin, Kathleen M. Giacomini, Claire Colas, Avner Schlessinger, Allen A. Thomas

Bioorg Med Chem Lett. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Bioorg Med Chem Lett. 2016 Jun 1; 26(11): 2616–2621. Published online 2016 Apr 11. doi: 10.1016/j.bmcl.2016.04.023

PMCID:: PMC4875506

Abstract Article PDF–1.0M

Select item 90757437.

Allylation of isatin-derived N-Boc-hydrazones followed by Pd-catalyzed carboamination reaction: an entry to 3-spiro-pyrazolidyl-oxindoles

Stefano Gazzotti, Marco Manenti, Leonardo Lo Presti, Alessandra Silvani

RSC Adv. 2019 Nov 19; 9(65): 37788–37800. Published online 2019 Nov 20. doi: 10.1039/c9ra07712j

PMCID:: PMC9075743

Abstract Article PDF–720K

Select item 98378298.

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Antonio Shegani, Steven Kealey, Federico Luzi, Filippo Basagni, Joana do Mar Machado, Sevban Doğan Ekici, Alessandra Ferocino, Antony D. Gee, Salvatore Bongarzone

Chem Rev. 2023 Jan 11; 123(1): 105–229. Published online 2022 Nov 18. doi: 10.1021/acs.chemrev.2c00398

Correction in:: Chem Rev. 2023 Aug 9; 123(15): 9718.

PMCID:: PMC9837829

Abstract Article PDF–86M

Select item 60994059.

Synthesis of Both Enantiomers of Chiral Phenylalanine Derivatives Catalyzed by Cinchona Alkaloid Quaternary Ammonium Salts as Asymmetric Phase Transfer Catalysts

Lei Jin, Shuai Zhao, Xin Chen

Molecules. 2018 Jun; 23(6): 1421. Published online 2018 Jun 12. doi: 10.3390/molecules23061421

PMCID:: PMC6099405

Abstract Article PDF–2.3M

Select item 1091354010.

Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer’s Disease

Min Jae Lee, Deepak Bhattarai, Hyeryung Jang, Ahreum Baek, In Jun Yeo, Seongsoo Lee, Zachary Miller, Sukyeong Lee, Jin Tae Hong, Dong-Eun Kim, Wooin Lee, Kyung Bo Kim

J Med Chem. Author manuscript; available in PMC 2024 Mar 5.

Published in final edited form as: J Med Chem. 2021 Aug 12; 64(15): 10934–10950. Published online 2021 Jul 26. doi: 10.1021/acs.jmedchem.1c00291

Correction in:: J Med Chem. 2024 Mar 12

PMCID:: PMC10913540

Abstract Article PDF–1.3M

Select item 416287211.

Epidithiodioxopiperazines Occurrence Synthesis and Biogenesis

Timothy R. Welch, Robert M. Williams

Nat Prod Rep. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Nat Prod Rep. 2014 Oct; 31(10): 1376–1404. doi: 10.1039/c3np70097f

PMCID:: PMC4162872

Abstract Article PDF–10M

Select item 666439212.

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

Iwona E Głowacka, Aleksandra Trocha, Andrzej E Wróblewski, Dorota G Piotrowska

Beilstein J Org Chem. 2019; 15: 1722–1757. Published online 2019 Jul 23. doi: 10.3762/bjoc.15.168

PMCID:: PMC6664392

Abstract Article PDF–2.0M

Select item 630962813.

Identification of the 4-position of 3-alkynyl and 3-heteroaromatic substituted pyridine methanamines as a key modification site eliciting increased potency and enhanced selectivity for cytochrome P-450 2A6 inhibition.

Travis T. Denton, Pramod Srivastava, Zuping Xia, Gang Chen, Christy J.W. Watson, Alec Wynd, Philip Lazarus

J Med Chem. Author manuscript; available in PMC 2018 Dec 28.

Published in final edited form as: J Med Chem. 2018 Aug 23; 61(16): 7065–7086. Published online 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00084

PMCID:: PMC6309628

Abstract Article PDF–910K

Select item 766381614.

Antimicrobial Activity of Calixarenes and Related Macrocycles

Dmitriy N. Shurpik, Pavel L. Padnya, Ivan I. Stoikov, Peter J. Cragg

Molecules. 2020 Nov; 25(21): 5145. Published online 2020 Nov 5. doi: 10.3390/molecules25215145

PMCID:: PMC7663816

Abstract Article PDF–8.3M

Select item 1060379015.

Metal-Catalyzed Enantioconvergent Transformations

Miguel Yus, Carmen Nájera, Francisco Foubelo, José M. Sansano

Chem Rev. 2023 Oct 25; 123(20): 11817–11893. Published online 2023 Oct 4. doi: 10.1021/acs.chemrev.3c00059

PMCID:: PMC10603790

Abstract Article PDF–18M

Select item 1000581116.

Recent Advances in Asymmetric Synthesis of Pyrrolidine-Based Organocatalysts and Their Application: A 15-Year Update

Arianna Quintavalla, Davide Carboni, Marco Lombardo

Molecules. 2023 Mar; 28(5): 2234. Published online 2023 Feb 27. doi: 10.3390/molecules28052234

PMCID:: PMC10005811

Abstract Article PDF–34M

Select item 874164317.

Halogen Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases

Dr. Michal Česnek, Michal Šafránek, Dr. Martin Dračínský, Eva Tloušťová, Dr. Helena Mertlíková-Kaiserová, Michael P. Hayes, Dr. Val J. Watts, Dr. Zlatko Janeba

ChemMedChem. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: ChemMedChem. 2022 Jan 5; 17(1): e202100568. Published online 2021 Oct 22. doi: 10.1002/cmdc.202100568