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Items: 1 to 20 of 2714

1.
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-Apoptotic Mcl-1 and Bfl-1 Proteins
Karson J. Kump, Lei Miao, Ahmed S.A. Mady, Nurul H. Ansari, Uttar K. Shrestha, Yuting Yang, Mohan Pal, Chenzhong Liao, Andrej Perdih, Fardokht A. Abulwerdi, Krishnapriya Chinnaswamy, Jennifer L. Meagher, Jacob M. Carlson, May Khanna, Jeanne A. Stuckey, Zaneta Nikolovska-Coleska
J Med Chem. Author manuscript; available in PMC 2021 Apr 7.
Published in final edited form as: J Med Chem. 2020 Mar 12; 63(5): 2489–2510. Published online 2020 Feb 14. doi: 10.1021/acs.jmedchem.9b01442
PMCID:
PMC8024114
AbstractArticlePDF–2.8M
2.
Benzoic acid fermentation from starch and cellulose via a plant-like β-oxidation pathway in Streptomyces maritimus
Shuhei Noda, Eiichi Kitazono, Tsutomu Tanaka, Chiaki Ogino, Akihiko Kondo
Microb Cell Fact. 2012; 11: 49. Published online 2012 Apr 30. doi: 10.1186/1475-2859-11-49
PMCID:
PMC3403852
AbstractArticlePDF–676K
3.
First mesomorphic and DFT characterizations for 3- (or 4-) n-alkanoyloxy benzoic acids and their optical applications
Mohamed A. El-Atawy, Mohd Taukeer Khan, Saheed A. Popoola, Muna S. Khushaim, Mariusz Jaremko, Abdul-Hamid Emwas, Fowzia S. Alamro, Magdi M. Naoum, Hoda A. Ahmed
Heliyon. 2023 Sep; 9(9): e19384. Published online 2023 Aug 24. doi: 10.1016/j.heliyon.2023.e19384
PMCID:
PMC10472244
AbstractArticlePDF–3.5M
4.
Discovery of Antibacterials That Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors
Jiqing Ye, Adrian Jun Chu, Rachel Harper, Shu Ting Chan, Tsun Lam Shek, Yufeng Zhang, Margaret Ip, Mariya Sambir, Irina Artsimovitch, Zhong Zuo, Xiao Yang, Cong Ma
J Med Chem. Author manuscript; available in PMC 2021 Jul 23.
Published in final edited form as: J Med Chem. 2020 Jul 23; 63(14): 7695–7720. Published online 2020 Jul 7. doi: 10.1021/acs.jmedchem.0c00520
PMCID:
PMC8091929
AbstractArticlePDF–1.6M
5.
Benzenoid Aromatics from Renewable Resources
Shasha Zheng, Zhenlei Zhang, Songbo He, Huaizhou Yang, Hanan Atia, Ali M. Abdel-Mageed, Sebastian Wohlrab, Eszter Baráth, Sergey Tin, Hero J. Heeres, Peter J. Deuss, Johannes G. de Vries
Chem Rev. 2024 Oct 9; 124(19): 10701–10876. Published online 2024 Sep 17. doi: 10.1021/acs.chemrev.4c00087
PMCID:
PMC11467972
AbstractArticlePDF–48M
6.
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication
Han Wee Ong, Xuan Yang, Jeffery L. Smith, Rebekah J. Dickmander, Jason W. Brown, Tammy M. Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K. Sanders, Jacob L. Capener, Rafael M. Couñago, Edcon Chang, Andreas Krämer, Nathaniel J. Moorman, Mark Heise, Alison D. Axtman, David H. Drewry, Timothy M. Willson
J Med Chem. 2024 Jul 25; 67(14): 12261–12313. Published online 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00962
PMCID:
PMC11284802
AbstractArticlePDF–9.3M
7.
Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
Antonio Shegani, Steven Kealey, Federico Luzi, Filippo Basagni, Joana do Mar Machado, Sevban Doğan Ekici, Alessandra Ferocino, Antony D. Gee, Salvatore Bongarzone
Chem Rev. 2023 Jan 11; 123(1): 105–229. Published online 2022 Nov 18. doi: 10.1021/acs.chemrev.2c00398
Correction in:
Chem Rev. 2023 Aug 9; 123(15): 9718.
PMCID:
PMC9837829
AbstractArticlePDF–86M
8.
Pyrrolidinobenzoic Acid Inhibitors of Influenza Virus Neuraminidase: the Hydrophobic Side Chain Influences Type A Subtype Selectivity
Yanwu Li, Arundutt Silamkoti, Gundurao Kolavi, Liyuan Mou, Shelly Gulati, Gillian M. Air, Wayne J. Brouillette
Bioorg Med Chem. Author manuscript; available in PMC 2013 Jul 15.
Published in final edited form as: Bioorg Med Chem. 2012 Jul 15; 20(14): 4582–4589. Published online 2012 May 17. doi: 10.1016/j.bmc.2012.05.001
PMCID:
PMC3401542
AbstractArticlePDF–557K
9.
Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents
Vishal Mathur, Ozair Alam, Nadeem Siddiqui, Mukund Jha, Ajay Manaithiya, Sandhya Bawa, Naveen Sharma, Sultan Alshehri, Prawez Alam, Faiyaz Shakeel
Molecules. 2023 Aug; 28(15): 5860. Published online 2023 Aug 3. doi: 10.3390/molecules28155860
PMCID:
PMC10420935
AbstractArticlePDF–20M
10.
Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications
Faisal Haroon, Umme Farwa, Maimoona Arif, Muhammad Asam Raza, Zeshan Ali Sandhu, Mohamed El Oirdi, Mohd Farhan, Mohammed Ahmed Ismail Alhasawi
Biomedicines. 2023 Oct; 11(10): 2686. Published online 2023 Sep 30. doi: 10.3390/biomedicines11102686
PMCID:
PMC10604881
AbstractArticlePDF–4.3M
11.
Synthesis, In Silico and In Vitro Evaluation of Antimicrobial and Toxicity Features of New 4-[(4-Chlorophenyl)sulfonyl]benzoic Acid Derivatives
Theodora-Venera Apostol, Mariana Carmen Chifiriuc, Constantin Draghici, Laura-Ileana Socea, Luminita Gabriela Marutescu, Octavian Tudorel Olaru, George Mihai Nitulescu, Elena Mihaela Pahontu, Gabriel Saramet, Stefania-Felicia Barbuceanu
Molecules. 2021 Aug; 26(16): 5107. Published online 2021 Aug 23. doi: 10.3390/molecules26165107
PMCID:
PMC8399259
AbstractArticlePDF–2.8M
12.
Extending the Scope of the New Variant of the Castagnoli–Cushman Cyclocondensation onto o-Methyl Benzoic Acids Bearing Various Electron-Withdrawing Groups in the α-Position
Natalia Guranova, Lyudmila Yakovleva, Olga Bakulina, Dmitry Dar’in, Mikhail Krasavin
Molecules. 2022 Nov; 27(21): 7211. Published online 2022 Oct 25. doi: 10.3390/molecules27217211
PMCID:
PMC9659198
AbstractArticlePDF–3.6M
13.
Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents
Hatem A. Abuelizz, Hanem M. Awad, Mohamed Marzouk, Fahd A. Nasr, Ali S. Alqahtani, Ahmed H. Bakheit, Ahmed M. Naglah, Rashad Al-Salahi
RSC Adv. 2019 Jun 14; 9(33): 19065–19074. Published online 2019 Jun 17. doi: 10.1039/c9ra03151k
PMCID:
PMC9064907
AbstractArticlePDF–3.9M
14.
Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase
Muhammad Kashif, Antonio Moreno-Herrera, Juan Carlos Villalobos-Rocha, Benjamín Nogueda-Torres, Jaime Pérez-Villanueva, Karen Rodríguez-Villar, José Luis Medina-Franco, Peterson de Andrade, Ivone Carvalho, Gildardo Rivera
Molecules. 2017 Nov; 22(11): 1863. Published online 2017 Oct 30. doi: 10.3390/molecules22111863
PMCID:
PMC6150317
AbstractArticlePDF–4.2M
15.
2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 2: Structure–based optimization and investigation of effects specific to the allosteric mode of action
Benoît Bestgen, Irina Kufareva, Weiguang Seetoh, Chris Abell, Rolf W. Hartmann, Ruben Abagyan, Marc Le Borgne, Odile Filhol, Claude Cochet, Thierry Lomberget, Matthias Engel
J Med Chem. Author manuscript; available in PMC 2020 Oct 22.
Published in final edited form as: J Med Chem. 2019 Feb 28; 62(4): 1817–1836. Published online 2019 Feb 13. doi: 10.1021/acs.jmedchem.8b01765
PMCID:
PMC7579840
AbstractArticlePDF–3.1M
16.
Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2
Yunhang Guo, Hai Xue, Nan Hu, Ye Liu, Hanzi Sun, Desheng Yu, Ling Qin, Gongyin Shi, Fan Wang, Lei Xin, Weihua Sun, Fan Zhang, Xiaomin Song, Shuran Li, Qiang Wei, Ying Guo, Yong Li, Xiaoxin Liu, Shuaishuai Chen, Taichang Zhang, Yue Wu, Dan Su, Yutong Zhu, Aiying Xu, Haipeng Xu, Shasha Yang, Zhijun Zheng, Junhua Liu, Xuefei Yang, Xi Yuan, Yuan Hong, Xuebing Sun, Yin Guo, Changyou Zhou, Xuesong Liu, Lai Wang, Zhiwei Wang
J Med Chem. 2024 May 23; 67(10): 7836–7858. Published online 2024 May 2. doi: 10.1021/acs.jmedchem.4c00027
PMCID:
PMC11129194
AbstractArticlePDF–5.5M
17.
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
Galina Karabanovich, Viktória Fabiánová, Anthony Vocat, Jan Dušek, Lenka Valášková, Jiřina Stolaříková, Russell R. A. Kitson, Petr Pávek, Kateřina Vávrová, Kamel Djaout, Katarína Mikušová, Alain R. Baulard, Stewart T. Cole, Jana Korduláková, Jaroslav Roh
J Med Chem. 2024 Jan 11; 67(1): 81–109. Published online 2023 Dec 29. doi: 10.1021/acs.jmedchem.3c00925
PMCID:
PMC10788908
AbstractArticlePDF–5.8M
18.
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)
Peter W. Jurutka, Orsola di Martino, Sabeeha Reshi, Sanchita Mallick, Zhela L. Sabir, Lech J. P. Staniszewski, Ankedo Warda, Emma L. Maiorella, Ani Minasian, Jesse Davidson, Samir J. Ibrahim, San Raban, Dena Haddad, Madleen Khamisi, Stephanie L. Suban, Bradley J. Dawson, Riley Candia, Joseph W. Ziller, Ming-Yue Lee, Chang Liu, Wei Liu, Pamela A. Marshall, John S. Welch, Carl E. Wagner
Int J Mol Sci. 2021 Nov; 22(22): 12371. Published online 2021 Nov 16. doi: 10.3390/ijms222212371
PMCID:
PMC8624485
AbstractArticlePDF–9.0M
19.
Multispectral and Molecular Docking Studies Reveal Potential Effectiveness of Antidepressant Fluoxetine by Forming π-Acceptor Complexes
Ahmed Gaber, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Hussain Alyami, Sonam Shakya, Hamza Habeeballah, Heba A. Alkhatabi, Raed I. Felimban, Abdulwahab Alamri, Abdulhameed Abdullah Alhabeeb, Bassem M. Raafat, Moamen S. Refat
Molecules. 2022 Sep; 27(18): 5883. Published online 2022 Sep 10. doi: 10.3390/molecules27185883
PMCID:
PMC9505585
AbstractArticlePDF–9.0M
20.
Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand Enigmatic Drug/Substrate-Binding Site of P-glycoprotein
Bhargav A. Patel, Biebele Abel, Anna Maria Barbuti, Uday Kiran Velagapudi, Zhe-Sheng Chen, Suresh V. Ambudkar, Tanaji T. Talele
J Med Chem. Author manuscript; available in PMC 2019 Feb 8.
Published in final edited form as: J Med Chem. 2018 Feb 8; 61(3): 834–864. Published online 2018 Jan 23. doi: 10.1021/acs.jmedchem.7b01340
PMCID:
PMC5805629
AbstractArticlePDF–2.2M

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