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Select item 106714061.

Can Ashwagandha Benefit the Endocrine System?—A Review

Michał Wiciński, Anna Fajkiel-Madajczyk, Zuzanna Kurant, Dominik Kurant, Karol Gryczka, Michal Falkowski, Magdalena Wiśniewska, Maciej Słupski, Jakub Ohla, Jan Zabrzyński

Int J Mol Sci. 2023 Nov; 24(22): 16513. Published online 2023 Nov 20. doi: 10.3390/ijms242216513

PMCID:: PMC10671406

Abstract Article PDF–975K

Select item 106479172.

Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial

Stephen J Smith, Adrian L Lopresti, Timothy J Fairchild

J Psychopharmacol. 2023 Nov; 37(11): 1091–1104. Published online 2023 Sep 23. doi: 10.1177/02698811231200023

PMCID:: PMC10647917

Abstract Article PDF–694K

Select item 87621853.

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia

Alex B. Speers, Kadine A. Cabey, Amala Soumyanath, Kirsten M. Wright

Curr Neuropharmacol. 2021 Sep 14; 19(9): 1468–1495. Published online 2021 Sep 14. doi: 10.2174/1570159X19666210712151556

PMCID:: PMC8762185

Abstract Article PDF–2.0M

Select item 85330654.

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation

Jia Wang, Huayue Zhang, Ashish Kaul, Kejuan Li, Didik Priyandoko, Sunil C. Kaul, Renu Wadhwa

Biomolecules. 2021 Oct; 11(10): 1454. Published online 2021 Oct 4. doi: 10.3390/biom11101454

PMCID:: PMC8533065

Abstract Article PDF–3.6M

Select item 101470085.

Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review

Paulina Mikulska, Marta Malinowska, Miłosz Ignacyk, Paweł Szustowski, Joanna Nowak, Karolina Pesta, Monika Szeląg, Damian Szklanny, Eliza Judasz, Gabriela Kaczmarek, Ovinuchi Prince Ejiohuo, Magdalena Paczkowska-Walendowska, Anna Gościniak, Judyta Cielecka-Piontek

Pharmaceutics. 2023 Apr; 15(4): 1057. Published online 2023 Mar 24. doi: 10.3390/pharmaceutics15041057

PMCID:: PMC10147008

Abstract Article PDF–1.1M

Select item 102817256.

Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors

Chun Woong Park, Ki-Bae Hong, Hyung Joo Suh, Yejin Ahn

J Food Drug Anal. 2023; 31(2): 278–288. Published online 2023 Jun 15. doi: 10.38212/2224-6614.3456

PMCID:: PMC10281725

Abstract Article PDF–997K

Select item 84626927.

Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis

Kae Ling Cheah, Mohd Noor Norhayati, Lili Husniati Yaacob, Razlina Abdul Rahman

PLoS One. 2021; 16(9): e0257843. Published online 2021 Sep 24. doi: 10.1371/journal.pone.0257843

PMCID:: PMC8462692

Abstract Article PDF–3.9M

Select item 60918428.

Antioxidant activity and apoptotic induction as mechanisms of action of Withania somnifera (Ashwagandha) against a hepatocellular carcinoma cell line

Wafaa Ahmed, Dina Mofed, Abdel-Rahman Zekri, Nasr El-Sayed, Mohamed Rahouma, Salwa Sabet

J Int Med Res. 2018 Apr; 46(4): 1358–1369. Published online 2018 Feb 2. doi: 10.1177/0300060517752022

PMCID:: PMC6091842

Abstract Article PDF–535K

Select item 37977079.

Ashwagandha (Withania somnifera) Reverses β-Amyloid_1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

Kesava Rao Venkata Kurapati, Venkata Subba Rao Atluri, Thangavel Samikkannu, Madhavan P. N. Nair

PLoS One. 2013; 8(10): e77624. Published online 2013 Oct 16. doi: 10.1371/journal.pone.0077624

PMCID:: PMC3797707

Abstract Article PDF–3.4M

Select item 643843410.

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males

Adrian L. Lopresti, Peter D. Drummond, Stephen J. Smith

Am J Mens Health. 2019 Mar-Apr; 13(2): 1557988319835985. Published online 2019 Mar 10. doi: 10.1177/1557988319835985

PMCID:: PMC6438434

Abstract Article PDF–900K

Select item 723069711.

Effects of Ashwagandha (Withania somnifera) on VO_2max: A Systematic Review and Meta-Analysis

Jorge Pérez-Gómez, Santos Villafaina, José Carmelo Adsuar, Eugenio Merellano-Navarro, Daniel Collado-Mateo

Nutrients. 2020 Apr; 12(4): 1119. Published online 2020 Apr 17. doi: 10.3390/nu12041119

PMCID:: PMC7230697

Abstract Article PDF–1.4M

Select item 675029212.

An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study

Adrian L. Lopresti, Stephen J. Smith, Hakeemudin Malvi, Rahul Kodgule

Medicine (Baltimore) 2019 Sep; 98(37): e17186. Published online 2019 Sep 13. doi: 10.1097/MD.0000000000017186

PMCID:: PMC6750292

Abstract Article PDF–439K

Select item 744179713.

Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor

Manish Kumar Tripathi, Pushpendra Singh, Sujata Sharma, Tej P. Singh, A. S. Ethayathulla, Punit Kaur

J Biomol Struct Dyn. 2020 : 1–14. Published online 2020 Jul 8. doi: 10.1080/07391102.2020.1790425

PMCID:: PMC7441797

Abstract Article PDF–3.4M

Select item 1053135914.

Ashwagandha-induced liver injury—A case series from India and literature review

Cyriac A. Philips, Arun Valsan, Arif H. Theruvath, Resmi Ravindran, Tharun T. Oommen, Sasidharan Rajesh, Saptarshi Bishnu, Philip Augustine

Hepatol Commun. 2023 Oct; 7(10): e0270. Published online 2023 Sep 27. doi: 10.1097/HC9.0000000000000270

PMCID:: PMC10531359

Abstract Article PDF–1.0M

Select item 942137315.

Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy

Manali Singh, Kuldeep Jayant, Dipti Singh, Shivani Bhutani, Nitesh Kumar Poddar, Anis Ahmad Chaudhary, Salah-Ud-Din Khan, Mohd Adnan, Arif Jamal Siddiqui, Md Imtaiyaz Hassan, Faez Iqbal Khan, Dakun Lai, Shahanavaj Khan

Front Cell Infect Microbiol. 2022; 12: 933824. Published online 2022 Aug 15. doi: 10.3389/fcimb.2022.933824

PMCID:: PMC9421373

Abstract Article PDF–2.5M

Select item 531322116.

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

Mahesh K. Kaushik, Sunil C. Kaul, Renu Wadhwa, Masashi Yanagisawa, Yoshihiro Urade

PLoS One. 2017; 12(2): e0172508. Published online 2017 Feb 16. doi: 10.1371/journal.pone.0172508

PMCID:: PMC5313221

Abstract Article PDF–1.7M

Select item 514785717.

Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts

Sunil C. Kaul, Yoshiyuki Ishida, Kazuya Tamura, Teruo Wada, Tomoko Iitsuka, Sukant Garg, Mijung Kim, Ran Gao, Shoichi Nakai, Youji Okamoto, Keiji Terao, Renu Wadhwa

PLoS One. 2016; 11(12): e0166945. Published online 2016 Dec 9. doi: 10.1371/journal.pone.0166945

PMCID:: PMC5147857

Abstract Article PDF–2.1M

Select item 1082384118.

Study of Drug Targets Associated With Oncogenesis and Cancer Cell Survival and the Therapeutic Activity of Engineered Ashwagandha Extract Having Differential Withanolide Constitutions

Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee

Integr Cancer Ther. 2024; 23: 15347354231223499. Published online 2024 Jan 28. doi: 10.1177/15347354231223499

PMCID:: PMC10823841

Abstract Article PDF–1.1M

Select item 748458119.

Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) – a molecular docking study

Priya Shree, Priyanka Mishra, Chandrabose Selvaraj, Sanjeev Kumar Singh, Radha Chaube, Neha Garg, Yamini Bhusan Tripathi

J Biomol Struct Dyn. 2020 : 1–14. Published online 2020 Aug 27. doi: 10.1080/07391102.2020.1810778

PMCID:: PMC7484581

Abstract Article PDF–3.7M

Select item 460935720.

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study

Swati Dongre, Deepak Langade, Sauvik Bhattacharyya

Biomed Res Int. 2015; 2015: 284154. Published online 2015 Oct 4. doi: 10.1155/2015/284154

PMCID:: PMC4609357

Abstract Article PDF–897K

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Figure 2Representative Giemsa stained flasks showing the effect of β-amyloid1-42, Ashwagandha and Ashwagandha plus β-amyloid1-42 on SK-N-MC cell line

1. Control, 2. β- Amyloid _1-42 treated, 3. Ashwagandha treated and 4. Ashwagandha plus β- Amyloid_1-42 treated.

Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

PLoS One. 2013;8(10):e77624.
Figure 3Representative microscopic observations of Sulforhodamine B (SRB) stained cultures showing the effect of β-amyloid1-42, Ashwagandha and Ashwagandha plus β-amyloid1-42 on SK-N-MC cell line (X80).

A. Control, B. β- Amyloid _1-42 treated, C. Ashwagandha treated and D. Ashwagandha plus β- Amyloid_1-42 treated.

Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

PLoS One. 2013;8(10):e77624.
Figure 1Analysis of β-Amyloid toxicity and its reversal by Ashwagandha.

Untreated, ashwagandha and ashwagandha plus β-Amyloid treated cells exhibited good viability as evidenced by exclusion of trypan blue dye, contrary to the positive trypan blue staining of SK-N-MC cells treated with β-Amyloid. A. Control, B. β- Amyloid _1-42 treated, C. Ashwagandha treated and D. Ashwagandha plus β- Amyloid_1-42 treated. Scale bar: 100 µm. Experiment was repeated three times.

β-Amyloid1-42, HIV-1Ba-L (Clade B) Infection and Drugs of Abuse Induced Degeneration in Human Neuronal Cells and Protective Effects of Ashwagandha (Withania somnifera) and Its Constituent Withanolide A

PLoS One. 2014;9(11):e112818.
Figure 3Effect of β-Amyloid toxicity on the appearance of needle-like MTT formazan exocytosis and its reversal by Ashwagandha.

Untreated, ashwagandha and ashwagandha plus β-Amyloid treated cells showed even intracellular distribution of formazan crystals, contrary to the MTT formazan exocytosis and needle-like formazan crystals on the cell surface of SK-N-MC cells treated with β-Amyloid. A. Control, B. β- Amyloid _1-42 treated, C. Ashwagandha treated and D. Ashwagandha plus β- Amyloid_1-42 treated. Scale bar: 100 µm. Experiment was repeated three times.

β-Amyloid1-42, HIV-1Ba-L (Clade B) Infection and Drugs of Abuse Induced Degeneration in Human Neuronal Cells and Protective Effects of Ashwagandha (Withania somnifera) and Its Constituent Withanolide A

PLoS One. 2014;9(11):e112818.