6-(Difluoromethyl)pyridin-2-amine - PMC

Select item 77596351.

Mono-Alkylated Ligands Based on Pyrazole and Triazole Derivatives Tested Against Fusarium oxysporum f. sp. albedinis: Synthesis, Characterization, DFT, and Phytase Binding Site Identification Using Blind Docking/Virtual Screening for Potent Fophy Inhibitors

Yassine Kaddouri, Farid Abrigach, Sabir Ouahhoud, Redouane Benabbes, Mohamed El Kodadi, Ali Alsalme, Nabil Al-Zaqri, Ismail Warad, Rachid Touzani

Front Chem. 2020; 8: 559262. Published online 2020 Dec 11. doi: 10.3389/fchem.2020.559262

PMCID:: PMC7759635

Abstract Article PDF–2.9M

Select item 108241522.

Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors

Dhananjayan Vasu, Ha T. Do, Huiying Li, Christine D. Hardy, Amardeep Awasthi, Thomas L. Poulos, Richard B. Silverman

J Med Chem. Author manuscript; available in PMC 2024 Jul 27.

Published in final edited form as: J Med Chem. 2023 Jul 27; 66(14): 9934–9953. Published online 2023 Jul 11. doi: 10.1021/acs.jmedchem.3c00782

PMCID:: PMC10824152

Abstract Article PDF–1.8M

Select item 98378003.

Discovery of an orally bioavailable and selective PKMYT1 inhibitor RP-6306

Janek Szychowski, Robert Papp, Evelyne Dietrich, Bingcan Liu, Frédéric Vallée, Marie-Ève Leclaire, Jimmy Fourtounis, Giovanni Martino, Alexander L. Perryman, Victor Pau, Shou Yun Yin, Pavel Mader, Anne Roulston, Jean-Francois Truchon, C. Gary Marshall, Mohamed Diallo, Nicole M. Duffy, Rino Stocco, Claude Godbout, Alexanne Bonneau-Fortin, Rosie Kryczka, Vivek Bhaskaran, Daniel Mao, Stephen Orlicky, Patrick Beaulieu, Pascal Turcotte, Igor Kurinov, Frank Sicheri, Yael Mamane, Michel Gallant, W. Cameron Black

J Med Chem. Author manuscript; available in PMC 2023 Aug 11.

Published in final edited form as: J Med Chem. 2022 Aug 11; 65(15): 10251–10284. Published online 2022 Jul 26. doi: 10.1021/acs.jmedchem.2c00552

PMCID:: PMC9837800

Abstract Article PDF–4.0M

Select item 92977324.

PI3K inhibitors are finally coming of age

Bart Vanhaesebroeck, Matthew W.D. Perry, Jennifer R. Brown, Fabrice André, Klaus Okkenhaug

Nat Rev Drug Discov. Author manuscript; available in PMC 2022 Jul 20.

Published in final edited form as: Nat Rev Drug Discov. 2021 Oct; 20(10): 741–769. Published online 2021 Jun 14. doi: 10.1038/s41573-021-00209-1

Correction in:: Nat Rev Drug Discov. 2021 Sep 1

PMCID:: PMC9297732

Abstract Article PDF–2.0M

Select item 109259935.

6-Aryl-4-cycloamino-1,3,5-triazine-2-amines: synthesis, antileukemic activity, and 3D-QSAR modelling

Muhammad Syafiq Bin Shahari, Ahmad Junaid, Edward R. T. Tiekink, Anton V. Dolzhenko

RSC Adv. 2024 Mar 6; 14(12): 8264–8282. Published online 2024 Mar 11. doi: 10.1039/d3ra08091a

PMCID:: PMC10925993

Abstract Article PDF–1.0M

Select item 95031126.

Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway

Maria V. Zapevalova, Ekaterina S. Shchegravina, Irina P. Fonareva, Diana I. Salnikova, Danila V. Sorokin, Alexander M. Scherbakov, Alexander A. Maleev, Stanislav K. Ignatov, Ivan D. Grishin, Alexander N. Kuimov, Maryia V. Konovalova, Elena V. Svirshchevskaya, Alexey Yu. Fedorov

Int J Mol Sci. 2022 Sep; 23(18): 10854. Published online 2022 Sep 17. doi: 10.3390/ijms231810854

PMCID:: PMC9503112

Abstract Article PDF–6.2M

Select item 101165277.

Novel Sulfonamide–Triazine Hybrid Derivatives: Docking, Synthesis, and Biological Evaluation as Anticancer Agents

Mahmoud A. Alelaimat, Mahmoud A. Al-Sha’er, Haneen A. Basheer

ACS Omega. 2023 Apr 18; 8(15): 14247–14263. Published online 2023 Apr 5. doi: 10.1021/acsomega.3c01273

PMCID:: PMC10116527

Abstract Article PDF–4.4M

Select item 94287918.

Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions

Arryn T. Blaine, Yiming Miao, Jinling Yuan, Sophia Palant, Rebecca J. Liu, Zhong-Yin Zhang, Richard. M. van Rijn

Front Pharmacol. 2022; 13: 914651. Published online 2022 Aug 11. doi: 10.3389/fphar.2022.914651

PMCID:: PMC9428791

Abstract Article PDF–2.3M

Select item 96742169.

Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα

Xiao Liu, Qingtong Zhou, Jonathan R. Hart, Yingna Xu, Su Yang, Dehua Yang, Peter K. Vogt, Ming-Wei Wang

Proc Natl Acad Sci U S A. 2022 Nov 15; 119(46): e2215621119. Published online 2022 Nov 7. doi: 10.1073/pnas.2215621119

PMCID:: PMC9674216

Abstract Article PDF–3.4M

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