4-Chloro-5-iodo-pyrimidin-2-ylamine - PMC

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Items: 17

Select item 84696291.

Radiosynthesis of 5-[¹⁸F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[¹⁸F]Fluorine Exchange Reaction

Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson

Molecules. 2021 Sep; 26(18): 5522. Published online 2021 Sep 11. doi: 10.3390/molecules26185522

PMCID:: PMC8469629

Abstract Article PDF–2.4M

Select item 111813322.

Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases

Oscar Mammoliti, Sébastien Martina, Pieter Claes, Ghjuvanni Coti, Roland Blanque, Catherine Jagerschmidt, Kenji Shoji, Monica Borgonovi, Steve De Vos, Florence Marsais, Line Oste, Evelyne Quinton, Miriam López-Ramos, David Amantini, Reginald Brys, Juan-Miguel Jimenez, René Galien, Steven van der Plas

J Med Chem. 2024 Jun 13; 67(11): 8545–8568. Published online 2024 May 28. doi: 10.1021/acs.jmedchem.4c00769

PMCID:: PMC11181332

Abstract Article PDF–8.1M

Select item 42663423.

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Emily J. Hanan, Charles Eigenbrot, Marian C. Bryan, Daniel J. Burdick, Bryan K. Chan, Yuan Chen, Jennafer Dotson, Robert A. Heald, Philip S. Jackson, Hank La, Michael D. Lainchbury, Shiva Malek, Hans E. Purkey, Gabriele Schaefer, Stephen Schmidt, Eileen M. Seward, Steve Sideris, Christine Tam, Shumei Wang, Siew Kuen Yeap, Ivana Yen, Jianping Yin, Christine Yu, Inna Zilberleyb, Timothy P. Heffron

J Med Chem. 2014 Dec 11; 57(23): 10176–10191. Published online 2014 Nov 10. doi: 10.1021/jm501578n

PMCID:: PMC4266342

Abstract Article PDF–4.5M

Select item 93546384.

Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice

Yuancheng Mao, Eun Lee, Xiaohui Yang, Eun Ju Bae, Raok Jeon, Byung-Hyun Park

J Enzyme Inhib Med Chem. 2022; 37(1): 2133–2146. Published online 2022 Aug 3. doi: 10.1080/14756366.2022.2106478

PMCID:: PMC9354638

Abstract Article PDF–3.2M

Select item 41369635.

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

Abedawn I. Khalaf, Judith K. Huggan, Colin J. Suckling, Colin L. Gibson, Kirsten Stewart, Federica Giordani, Michael P. Barrett, Pui Ee Wong, Keri L. Barrack, William N. Hunter

J Med Chem. 2014 Aug 14; 57(15): 6479–6494. Published online 2014 Jul 9. doi: 10.1021/jm500483b

PMCID:: PMC4136963

Abstract Article PDF–5.4M

Select item 36989366.

Adenosine Kinase: Exploitation for Therapeutic Gain

Detlev Boison

Pharmacol Rev. 2013 Jul; 65(3): 906–943. doi: 10.1124/pr.112.006361

PMCID:: PMC3698936

Abstract Article PDF–1.5M

Select item 61207307.

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

Sreekanth Kokkonda, Farah El Mazouni, Karen L. White, John White, David M. Shackleford, Maria Jose Lafuente-Monasterio, Paul Rowland, Krishne Manjalanagara, Jayan T. Joseph, Adolfo Garcia-Pérez, Jorge Fernandez, Francisco Javier Gamo, David Waterson, Jeremy N. Burrows, Michael J. Palmer, Susan A. Charman, Pradipsinh K. Rathod, Margaret A. Phillips

ACS Omega. 2018 Aug 31; 3(8): 9227–9240. Published online 2018 Aug 15. doi: 10.1021/acsomega.8b01573

PMCID:: PMC6120730

Abstract Article PDF–1.6M

Select item 49042468.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Sreekanth Kokkonda, Xiaoyi Deng, Karen L. White, Jose M. Coteron, Maria Marco, Laura de las Heras, John White, Farah El Mazouni, Diana R. Tomchick, Krishne Manjalanagara, Kakali Rani Rudra, Gong Chen, Julia Morizzi, Eileen Ryan, Werner Kaminsky, Didier Leroy, María Santos Martínez-Martínez, Maria Belen Jimenez-Diaz, Santiago Ferrer Bazaga, Iñigo Angulo-Barturen, David Waterson, Jeremy N. Burrows, Dave Matthews, Susan A. Charman, Margaret A. Phillips, Pradipsinh K. Rathod

J Med Chem. 2016 Jun 9; 59(11): 5416–5431. Published online 2016 Apr 29. doi: 10.1021/acs.jmedchem.6b00275

PMCID:: PMC4904246

Abstract Article PDF–1.6M

Select item 34468209.

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

Alka Marwaha, John White, Farah El_Mazouni, Sharon A Creason, Sreekanth Kokkonda, Frederick S. Buckner, Susan A. Charman, Margaret A. Phillips, Pradipsinh K. Rathod

J Med Chem. Author manuscript; available in PMC 2013 Sep 13.

Published in final edited form as: J Med Chem. 2012 Sep 13; 55(17): 7425–7436. Published online 2012 Aug 21. doi: 10.1021/jm300351w

PMCID:: PMC3446820

Abstract Article PDF–936K

Select item 969782610.

Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition

Letizia Crocetti, Giuseppe Floresta, Chiara Zagni, Divya Merugu, Francesca Mazzacuva, Renan Rodrigues de Oliveira Silva, Claudia Vergelli, Maria Paola Giovannoni, Agostino Cilibrizzi

Pharmaceuticals (Basel) 2022 Nov; 15(11): 1335. Published online 2022 Oct 28. doi: 10.3390/ph15111335

PMCID:: PMC9697826

Abstract Article PDF–5.1M

Select item 415290811.

New Positive Ca²⁺-Activated K⁺ Channel Gating Modulators with Selectivity for K_Ca3.1

Nichole Coleman, Brandon M. Brown, Aida Oliván-Viguera, Vikrant Singh, Marilyn M. Olmstead, Marta Sofia Valero, Ralf Köhler, Heike Wulff

Mol Pharmacol. 2014 Sep; 86(3): 342–357. Published online 2014 Sep. doi: 10.1124/mol.114.093286

PMCID:: PMC4152908

Abstract Article PDF–1.5M

Select item 1021268312.

Recent Advances in Pyridine Scaffold: Focus on Chemistry, Synthesis, and Antibacterial Activities

Md. Badrul Islam, Md. Inshaful Islam, Nikhil Nath, Talha Bin Emran, Md. Rezaur Rahman, Rohit Sharma, Mohammed Mahbubul Matin

Biomed Res Int. 2023; 2023: 9967591. Published online 2023 May 18. doi: 10.1155/2023/9967591

PMCID:: PMC10212683

Abstract Article PDF–1.6M

Select item 343732813.

Recent developments in adenosine receptor ligands and their potential as novel drugs

Christa E. Müller, Kenneth A. Jacobson

Biochim Biophys Acta. Author manuscript; available in PMC 2012 Sep 9.

Published in final edited form as: Biochim Biophys Acta. 2011 May; 1808(5): 1290–1308. Published online 2010 Dec 23. doi: 10.1016/j.bbamem.2010.12.017

PMCID:: PMC3437328

Abstract Article PDF–3.2M

Select item 336824714.

Triarylmethanes, a New Class of Cx50 Inhibitors

Silke B. Bodendiek, Clio Rubinos, Maria Pilar Trelles, Nichole Coleman, David Paul Jenkins, Heike Wulff, Miduturu Srinivas

Front Pharmacol. 2012; 3: 106. Published online 2012 Jun 6. doi: 10.3389/fphar.2012.00106

PMCID:: PMC3368247

Abstract Article PDF–2.0M

Select item 1035459615.

Chemistry of 3-cyanoacetyl indoles: synthesis, reactions and applications: a recent update

Abolfazl Olyaei, Mahdieh Sadeghpour

RSC Adv. 2023 Jul 12; 13(31): 21710–21745. Published online 2023 Jul 19. doi: 10.1039/d3ra04385a

PMCID:: PMC10354596

Abstract Article PDF–8.5M

Select item 770538116.

Microwave-Assisted Synthesis of Quinazolines and Quinazolinones: An Overview

Leyla Mohammadkhani, Majid M. Heravi

Front Chem. 2020; 8: 580086. Published online 2020 Nov 16. doi: 10.3389/fchem.2020.580086

PMCID:: PMC7705381

Abstract Article PDF–6.5M

Select item 816510117.

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Lei Zhong, Yueshan Li, Liang Xiong, Wenjing Wang, Ming Wu, Ting Yuan, Wei Yang, Chenyu Tian, Zhuang Miao, Tianqi Wang, Shengyong Yang

Signal Transduct Target Ther. 2021; 6: 201. Published online 2021 May 31. doi: 10.1038/s41392-021-00572-w

PMCID:: PMC8165101

Abstract Article PDF–6.6M

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4-Chloro-5-iodo-pyrimidin-2-ylamine (17)
PMC
bile acid:sodium symporter [Aminobacterium sp. UBA4834]
bile acid:sodium symporter [Aminobacterium sp. UBA4834]
gi|2743943587|ref|WP_349679280.1|

Protein
Pomadasys olivaceus voucher KUT 6467 cytochrome oxidase subunit 1 (COI) gene, pa...
Pomadasys olivaceus voucher KUT 6467 cytochrome oxidase subunit 1 (COI) gene, partial cds; mitochondrial
gi|584296612|gnl|uoguelph|UKFBJ883- I-5P|gb|KF930300.1|

Nucleotide
Pomadasys olivaceus voucher Smith 179.17 9_05 cytochrome oxidase subunit 1 (COI)...
Pomadasys olivaceus voucher Smith 179.17 9_05 cytochrome oxidase subunit 1 (COI) gene, partial cds; mitochondrial
gi|328486962|gnl|uoguelph|DSFSE175- I-5P|gb|JF494256.1|

Nucleotide
Pomadasys olivaceus voucher KU:6467 titin-like protein (Tmo-4c4) gene, partial c...
Pomadasys olivaceus voucher KU:6467 titin-like protein (Tmo-4c4) gene, partial cds
gi|375005967|gb|JN688801.1|

Nucleotide

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