3-Morpholin-4-yl-5-trifluoromethyl-benzonitrile - PMC

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Select item 90144101.

Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”

Juan M. Decara, Henar Vázquez-Villa, José Brea, Mónica Alonso, Raj Kamal Srivastava, Laura Orio, Francisco Alén, Juan Suárez, Elena Baixeras, Javier García-Cárceles, Andrea Escobar-Peña, Beat Lutz, Ramón Rodríguez, Eva Codesido, F. Javier Garcia-Ladona, Teresa A. Bennett, Juan A. Ballesteros, Jacobo Cruces, María I. Loza, Bellinda Benhamú, Fernando Rodríguez de Fonseca, María L. López-Rodríguez

J Med Chem. 2022 Apr 14; 65(7): 5449–5461. Published online 2022 Mar 29. doi: 10.1021/acs.jmedchem.1c01842

PMCID:: PMC9014410

Abstract Article PDF–4.4M

Select item 31518572.

4-(Morpholin-4-yl)-3-(trifluoromethyl)benzonitrile

Hoong-Kun Fun, Safra Izuani Jama Asik, Rajesha Kumar, Arun M. Isloor, K. N. Shivananda

Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1; 67(Pt 7): o1600. Published online 2011 Jun 11. doi: 10.1107/S1600536811020666

PMCID:: PMC3151857

Abstract Article PDF–794K

Select item 68689133.

Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents

Praveen Kumar Reddy Nagireddy, Vamsi Krishna Kommalapati, Vagolu Siva Krishna, Dharmarajan Sriram, Anjana Devi Tangutur, Srinivas Kantevari

ACS Omega. 2019 Nov 19; 4(21): 19382–19398. Published online 2019 Nov 5. doi: 10.1021/acsomega.9b02789

PMCID:: PMC6868913

Abstract Article PDF–8.8M

Select item 84000704.

Innovations and Patent Trends in the Development of USFDA Approved Protein Kinase Inhibitors in the Last Two Decades

Mohd. Imran, Syed Mohammed Basheeruddin Asdaq, Shah Alam Khan, Dhanalekshmi Unnikrishnan Meenakshi, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed Alrashed, Mohammed AlMotairi, Eman H. Alkhaldi, Abeer K. Alorabi, Ahmed Subeh Alshrari, Mohammad Tauseef, Abida, Saleh I. Alaqel, Ozair Alam, Md. Afroz Bakht

Pharmaceuticals (Basel) 2021 Aug; 14(8): 710. Published online 2021 Jul 22. doi: 10.3390/ph14080710

PMCID:: PMC8400070

Abstract Article PDF–10M

Select item 107797885.

Synthesis of Trifluoromethylated Pyrimido[1,2-b]indazole Derivatives through the Cyclocondensation of 3-Aminoindazoles with Ketoester and Their Functionalization via Suzuki-Miyaura Cross-Coupling and SN_Ar Reactions

Sakina Tellal, Badr Jismy, Djamila Hikem-Oukacha, Mohamed Abarbri

Molecules. 2024 Jan; 29(1): 44. Published online 2023 Dec 20. doi: 10.3390/molecules29010044

PMCID:: PMC10779788

Abstract Article PDF–2.1M

Select item 76708446.

C3 amino-substituted chalcone derivative with selective adenosine rA₁ receptor affinity in the micromolar range

Helena D. Janse van Rensburg, Lesetja J. Legoabe, Gisella Terre’Blanche

Chem Zvesti. 2021; 75(4): 1581–1605. Published online 2020 Nov 17. doi: 10.1007/s11696-020-01414-9

PMCID:: PMC7670844

Abstract Article PDF–1.5M

Select item 69595377.

Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

Jihyae Ann, Aeran Jung, Mi-Yeon Kim, Hyuk-Min Kim, HyungChul Ryu, Sunjoo Kim, Dong Wook Kang, Sunhye Hong, Minghua Cui, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph, Jeewoo Lee

Bioorg Med Chem. Author manuscript; available in PMC 2020 Jan 14.

Published in final edited form as: Bioorg Med Chem. 2015 Nov 1; 23(21): 6844–6854. Published online 2015 Oct 9. doi: 10.1016/j.bmc.2015.10.001

PMCID:: PMC6959537

Abstract Article PDF–950K

Select item 114772898.

Low-Basicity 5-HT₆ Receptor Ligands from the Group of Cyclic Arylguanidine Derivatives and Their Antiproliferative Activity Evaluation

Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Maciej Maj, Katarzyna Malarz, Patryk Rurka, Gniewomir Latacz, Beata Duszyńska, Krzesimir Ciura, Katarzyna Ewa Greber, Anna Boguszewska-Czubara, Paweł Śliwa, Julia Kuliś

Int J Mol Sci. 2024 Oct; 25(19): 10287. Published online 2024 Sep 24. doi: 10.3390/ijms251910287

PMCID:: PMC11477289

Abstract Article PDF–7.5M

Select item 87695419.

Non-nucleoside structured compounds with antiviral activity—past 10 years (2010–2020)

Marta Denel-Bobrowska, Agnieszka B. Olejniczak

Eur J Med Chem. 2022 Mar 5; 231: 114136. Published online 2022 Jan 19. doi: 10.1016/j.ejmech.2022.114136

PMCID:: PMC8769541

Abstract Article PDF–2.3M

Select item 922827010.

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

Jeanluc Bertrand, Hana Dostálová, Vladimír Kryštof, Radek Jorda, Thalía Delgado, Alejandro Castro-Alvarez, Jaime Mella, David Cabezas, Mario Faúndez, Christian Espinosa-Bustos, Cristian O. Salas

Pharmaceutics. 2022 Jun; 14(6): 1294. Published online 2022 Jun 17. doi: 10.3390/pharmaceutics14061294

PMCID:: PMC9228270

Abstract Article PDF–11M

Select item 663633511.

Design, Synthesis, and Biological Evaluation of (E)-N'-((1-Chloro-3,4-Dihydronaphthalen-2-yl)Methylene)Benzohydrazide Derivatives as Anti-prostate Cancer Agents

H. A. Arjun, Ramakrishnan Elancheran, N. Manikandan, K. Lakshmithendral, Muthiah Ramanathan, Atanu Bhattacharjee, N. K. Lokanath, Senthamaraikannan Kabilan

Front Chem. 2019; 7: 474. Published online 2019 Jul 10. doi: 10.3389/fchem.2019.00474

Correction in:: Front Chem. 2019; 7: 804.

Retraction in:: Front Chem. 2023; 11: 1332615.

PMCID:: PMC6636335

Abstract Article

Select item 1075529212.

FDA-approved heterocyclic molecules for cancer treatment: Synthesis, dosage, mechanism of action and their adverse effect

Mossaraf Hossain, Imran Habib, Koustav Singha, Anoop Kumar

Heliyon. 2024 Jan 15; 10(1): e23172. Published online 2023 Dec 5. doi: 10.1016/j.heliyon.2023.e23172

PMCID:: PMC10755292

Abstract Article PDF–5.6M

Select item 804896013.

The tale of proteolysis targeting chimeras (PROTACs) for Leucine‐Rich Repeat Kinase 2 (LRRK2)

Dr. Markella Konstantinidou, Asmaa Oun, Pragya Pathak, Bidong Zhang, Zefeng Wang, Frans ter Brake, Dr. Amalia M. Dolga, Dr. Arjan Kortholt, Dr. Alexander Dömling

ChemMedChem. 2021 Mar 18; 16(6): 959–965. Published online 2020 Dec 29. doi: 10.1002/cmdc.202000872