3-(4-Fluorophenyl)propionic acid - PMC

Nikola Nedeljković, Vladimir Dobričić, Jelena Bošković, Marina Vesović, Jovana Bradić, Marijana Anđić, Aleksandar Kočović, Nevena Jeremić, Jovana Novaković, Vladimir Jakovljević, Zorica Vujić, Miloš Nikolić

Pharmaceuticals (Basel) 2023 May; 16(5): 666. Published online 2023 Apr 28. doi: 10.3390/ph16050666

PMCID:: PMC10222328

Abstract Article PDF–31M

Select item 73159355.

Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability

Phillip R. Lazzara, Brian P. David, Aparna Ankireddy, Benjamin G. Richardson, Katherine Dye, Kiira M. Ratia, Sekhar P. Reddy, Terry W. Moore

J Med Chem. Author manuscript; available in PMC 2021 Jun 25.

Published in final edited form as: J Med Chem. 2020 Jun 25; 63(12): 6547–6560. Published online 2019 Nov 14. doi: 10.1021/acs.jmedchem.9b01074

PMCID:: PMC7315935

Abstract Article PDF–1.2M

Select item 77232346.

Drug Design Targeting T-Cell Factor (TCF)-Driven Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Strategy for Colorectal Cancer

Adedoyin D. Abraham, Hector Esquer, Qiong Zhou, Nicholas Tomlinson, Brayden D. Hamill, Joshua M. Abbott, Linfeng Li, Laura A. Pike, Sébastien Rinaldetti, Dominique A. Ramirez, Paul J. Lunghofer, Jose D. Gomez, Jerome Schaack, Travis Nemkov, Angelo D’Alessandro, Kirk C. Hansen, Daniel L. Gustafson, Wells A. Messersmith, Daniel V. LaBarbera

J Med Chem. Author manuscript; available in PMC 2020 Dec 8.

Published in final edited form as: J Med Chem. 2019 Nov 27; 62(22): 10182–10203. Published online 2019 Nov 18. doi: 10.1021/acs.jmedchem.9b01065

PMCID:: PMC7723234

Abstract Article PDF–3.0M

Select item 102236947.

Synthetic Routes to Approved Drugs Containing a Spirocycle

Nazar Moshnenko, Alexander Kazantsev, Evgeny Chupakhin, Olga Bakulina, Dmitry Dar’in

Molecules. 2023 May; 28(10): 4209. Published online 2023 May 20. doi: 10.3390/molecules28104209

PMCID:: PMC10223694

Abstract Article PDF–33M

Select item 69572528.

2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

Jihyae Ann, Yooran Ki, Suyoung Yoon, Myeong Seop Kim, Jung-Un Lee, Changhoon Kim, Sunho Lee, Aeran Jung, Jisoo Baek, Sunhye Hong, Sun Choi, Larry V. Pearce, Timothy E. Esch, Noe A. Turcios, Nancy E. Lewin, Adebowale E. Ogunjirin, Brienna K. A. Herold, Anna K. McCall, Peter M. Blumberg, Jeewoo Lee

Bioorg Med Chem. Author manuscript; available in PMC 2020 Jan 13.

Published in final edited form as: Bioorg Med Chem. 2016 Mar 15; 24(6): 1231–1240. Published online 2016 Jan 28. doi: 10.1016/j.bmc.2016.01.051

PMCID:: PMC6957252

Abstract Article PDF–1.7M

Select item 26641019.

Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping

Haitao Ji, Huiying Li, Pavel Martásek, Linda J. Roman, Thomas L. Poulos, Richard B. Silverman

J Med Chem. Author manuscript; available in PMC 2010 Feb 12.

Published in final edited form as: J Med Chem. 2009 Feb 12; 52(3): 779–797. doi: 10.1021/jm801220a

PMCID:: PMC2664101

Abstract Article PDF–2.4M

Select item 944728810.

Synthesis and Functionalization of Challenging meso-Substituted Aryl Bis-pocket Porphyrins Accessed via Suzuki–Miyaura Cross-Coupling

Daniel G. Droege, A. Leila Parker, Griffin M. Milligan, Robert Jenkins, Timothy C. Johnstone

J Org Chem. 2022 Sep 2; 87(17): 11783–11795. Published online 2022 Aug 17. doi: 10.1021/acs.joc.2c01538

PMCID:: PMC9447288

Abstract Article PDF–4.3M

Select item 1056473711.

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan M. Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

Nat Commun. 2023; 14: 6345. Published online 2023 Oct 10. doi: 10.1038/s41467-023-41894-3

PMCID:: PMC10564737

Abstract Article PDF–2.9M

Select item 1075529212.

FDA-approved heterocyclic molecules for cancer treatment: Synthesis, dosage, mechanism of action and their adverse effect

Mossaraf Hossain, Imran Habib, Koustav Singha, Anoop Kumar

Heliyon. 2024 Jan 15; 10(1): e23172. Published online 2023 Dec 5. doi: 10.1016/j.heliyon.2023.e23172

PMCID:: PMC10755292

Abstract Article PDF–5.6M

Select item 688075313.

1-Aminopyridinium Ylides as Monodentate Directing Groups for sp³ C—H Bond Functionalization

Ky Khac Anh Le, Hanh Nguyen, Olafs Daugulis

J Am Chem Soc. Author manuscript; available in PMC 2020 Sep 18.

Published in final edited form as: J Am Chem Soc. 2019 Sep 18; 141(37): 14728–14735. Published online 2019 Sep 6. doi: 10.1021/jacs.9b06643

PMCID:: PMC6880753

Abstract Article PDF–1.4M

Select item 903089914.

Improved Synthesis of Asymmetric Curcuminoids and Their Assessment as Antioxidants

Yang-Je Cheng, Cai-Wei Li, Cing-Ling Kuo, Tzenge-Lien Shih, Jih-Jung Chen

Molecules. 2022 Apr; 27(8): 2547. Published online 2022 Apr 14. doi: 10.3390/molecules27082547

PMCID:: PMC9030899

Abstract Article PDF–1.7M

Select item 632799215.

A comprehensive review on tyrosinase inhibitors

Samaneh Zolghadri, Asieh Bahrami, Mahmud Tareq Hassan Khan, J. Munoz-Munoz, F. Garcia-Molina, F. Garcia-Canovas, Ali Akbar Saboury

J Enzyme Inhib Med Chem. 2019; 34(1): 279–309. Published online 2019 Jan 3. doi: 10.1080/14756366.2018.1545767

PMCID:: PMC6327992

Abstract Article PDF–3.4M

Select item 936849016.

Exploring the Molecular Interactions of Symmetrical and Unsymmetrical Selenoglycosides with Human Galectin-1 and Galectin-3

Luciano Pirone, Ferran Nieto-Fabregat, Sonia Di Gaetano, Domenica Capasso, Rita Russo, Serena Traboni, Antonio Molinaro, Alfonso Iadonisi, Michele Saviano, Roberta Marchetti, Alba Silipo, Emilia Pedone

Int J Mol Sci. 2022 Aug; 23(15): 8273. Published online 2022 Jul 27. doi: 10.3390/ijms23158273

PMCID:: PMC9368490

Abstract Article PDF–3.0M

Select item 780909717.

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

Seyedeh Roya Alizadeh, Seyedeh Mahdieh Hashemi

Med Chem Res. 2021; 30(4): 771–806. Published online 2021 Jan 15. doi: 10.1007/s00044-020-02686-2

PMCID:: PMC7809097

Abstract Article PDF–2.0M

Select item 695954418.

t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

Sunho Lee, Dong Wook Kang, HyungChul Ryu, Changhoon Kim, Jihyae Ann, Hobin Lee, Eunhye Kim, Sunhye Hong, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph, Jeewoo Lee

Bioorg Med Chem. Author manuscript; available in PMC 2020 Jan 14.

Published in final edited form as: Bioorg Med Chem. 2017 Apr 15; 25(8): 2451–2462. Published online 2017 Mar 6. doi: 10.1016/j.bmc.2017.03.004