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Items: 1 to 20 of 60

1.
Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Mezna Saleh Altowyan, Mohammad Shahidul Islam, Abdullah Saleh Alamary, Sajda Ashraf, Zaheer Ul-Haq
Molecules. 2020 Oct; 25(20): 4671. Published online 2020 Oct 13. doi: 10.3390/molecules25204671
PMCID:
PMC7594047
AbstractArticlePDF–5.1M
2.
Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C. Nyman, Jade M. Katinas, Mathew Schneider, Carrie O’Connor, Xun Bao, Seongho Kim, Jing Li, Zhanjun Hou, Larry H. Matherly, Charles E. Dann, III, Aleem Gangjee
ACS Pharmacol Transl Sci. 2023 May 12; 6(5): 748–770. Published online 2023 Apr 26. doi: 10.1021/acsptsci.3c00020
PMCID:
PMC10186366
AbstractArticlePDF–6.4M
3.
SYNTHESIS OF 1,3,4-OXADIAZOLES AS SELECTIVE T-TYPE CALCIUM CHANNEL INHIBITORS
Man Zhang, Bende Zou, Medha J. Gunaratna, Sahani Weerasekara, Zongbo Tong, Thi D. T. Nguyen, Serkan Koldas, William S. Cao, Conrado Pascual, Xinmin Simon Xie, Duy H. Hua
Heterocycles. Author manuscript; available in PMC 2020 Aug 7.
Published in final edited form as: Heterocycles. 2020; 101(1): 145–164. Published online 2019 Jun 20. doi: 10.3987/com-19-s(f)5
PMCID:
PMC7413294
AbstractArticlePDF–616K
4.
Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H
Suhman Chung, Michaela Wendeler, Jason W. Rausch, Greg Beilhartz, Matthias Gotte, Barry R. O'Keefe, Alun Bermingham, John A. Beutler, Shixin Liu, Xiaowei Zhuang, Stuart F. J. Le Grice
Antimicrob Agents Chemother. 2010 Sep; 54(9): 3913–3921. Published online 2010 Jun 14. doi: 10.1128/AAC.00434-10
PMCID:
PMC2935023
AbstractArticlePDF–1.1M
5.
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
Md. Junayed Nayeen, Jade M. Katinas, Tejashree Magdum, Khushbu Shah, Jennifer E. Wong, Carrie E. O’Connor, Alexandra N. Fifer, Adrianne Wallace-Povirk, Zhanjun Hou, Larry H. Matherly, Charles E. Dann, III, Aleem Gangjee
J Med Chem. 2023 Aug 24; 66(16): 11294–11323. Published online 2023 Aug 15. doi: 10.1021/acs.jmedchem.3c00763
PMCID:
PMC10461232
AbstractArticlePDF–9.5M
6.
Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies
Yiming Xu, Yulong Xu, Hallie Blevins, Chunqing Guo, Savannah Biby, Xiang-Yang Wang, Changning Wang, Shijun Zhang
Eur J Med Chem. Author manuscript; available in PMC 2023 Apr 10.
Published in final edited form as: Eur J Med Chem. 2022 Aug 5; 238: 114468. Published online 2022 May 21. doi: 10.1016/j.ejmech.2022.114468
PMCID:
PMC10084479
AbstractArticlePDF–1.7M
7.
Fluorine-Substituted Pyrrolo[2,3-d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis
Manasa Ravindra, Mike R. Wilson, Nian Tong, Carrie O’Connor, Mohammad Karim, Lisa Polin, Adrianne Wallace-Povirk, Kathryn White, Juiwanna Kushner, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee
J Med Chem. Author manuscript; available in PMC 2018 Aug 17.
Published in final edited form as: J Med Chem. 2018 May 10; 61(9): 4228–4248. Published online 2018 Apr 27. doi: 10.1021/acs.jmedchem.8b00408
PMCID:
PMC6097718
AbstractArticlePDF–2.1M
8.
Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance
Stepan K. Krymov, Alexander M. Scherbakov, Lyubov G. Dezhenkova, Diana I. Salnikova, Svetlana E. Solov’eva, Danila V. Sorokin, Daniela Vullo, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran, Andrey E. Shchekotikhin
Pharmaceuticals (Basel) 2022 Dec; 15(12): 1453. Published online 2022 Nov 23. doi: 10.3390/ph15121453
PMCID:
PMC9783868
AbstractArticlePDF–2.1M
9.
Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides
Nehaal Ahmed, André Shamsabadi, Vijay Chudasama
ACS Omega. 2019 Dec 31; 4(27): 22601–22612. Published online 2019 Dec 17. doi: 10.1021/acsomega.9b03417
PMCID:
PMC6941372
AbstractArticlePDF–705K
10.
Cyano- and Ketone-Containing Selenoesters as Multi-Target Compounds against Resistant Cancers
Nikoletta Szemerédi, Simona Dobiasová, Noemi Salardón-Jiménez, Annamária Kincses, Márta Nové, Giyaullah Habibullah, Clotilde Sevilla-Hernández, Miguel Benito-Lama, Francisco-Javier Alonso-Martínez, Jitka Viktorová, Gabriella Spengler, Enrique Domínguez-Álvarez
Cancers (Basel) 2021 Sep; 13(18): 4563. Published online 2021 Sep 11. doi: 10.3390/cancers13184563
PMCID:
PMC8465942
AbstractArticlePDF–1.1M
11.
Identification and validation of Selective Deubiquitinase Inhibitors
Anthony C. Varca, Dominick Casalena, Wai Cheung Chan, Bin Hu, Robert S. Magin, Rebekka M. Roberts, Xiaoxi Liu, He Zhu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jarrod A. Marto, Douglas Auld, Sara J. Buhrlage
Cell Chem Biol. Author manuscript; available in PMC 2022 Dec 16.
Published in final edited form as: Cell Chem Biol. 2021 Dec 16; 28(12): 1758–1771.e13. Published online 2021 Jun 14. doi: 10.1016/j.chembiol.2021.05.012
PMCID:
PMC9473745
AbstractArticlePDF–2.3M
12.
Synthesis and Biological Activity of Chromeno[3,2-c]Pyridines
Anna V. Listratova, Roman S. Borisov, Nikolay Yu. Polovkov, Larisa N. Kulikova
Molecules. 2024 Nov; 29(21): 4997. Published online 2024 Oct 22. doi: 10.3390/molecules29214997
PMCID:
PMC11547192
AbstractArticlePDF–11M
13.
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
Clemens Zwergel, Michele Aventaggiato, Sabrina Garbo, Elisabetta Di Bello, Bruno Fassari, Beatrice Noce, Carola Castiello, Chiara Lambona, Federica Barreca, Dante Rotili, Rossella Fioravanti, Thomas Schmalz, Michael Weyand, Amelie Niedermeier, Marco Tripodi, Gianni Colotti, Clemens Steegborn, Cecilia Battistelli, Marco Tafani, Sergio Valente, Antonello Mai
J Med Chem. 2023 Jul 27; 66(14): 9622–9641. Published online 2023 Jul 13. doi: 10.1021/acs.jmedchem.3c00337
PMCID:
PMC10388363
AbstractArticlePDF–7.9M
14.
Aminophosphine Palladium Pincer-Catalyzed Carbonylative Sonogashira and Suzuki–Miyaura Cross-Coupling with High Catalytic Turnovers
Prashant Gautam, Neelam J. Tiwari, Bhalchandra M. Bhanage
ACS Omega. 2019 Jan 31; 4(1): 1560–1574. Published online 2019 Jan 17. doi: 10.1021/acsomega.8b02886
PMCID:
PMC6648871
AbstractArticlePDF–2.9M
15.
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors
Derun Li, Yongqi Deng, Abdelghani Achab, Indu Bharathan, Brett Andrew Hopkins, Wensheng Yu, Hongjun Zhang, Sulagna Sanyal, Qinglin Pu, Hua Zhou, Kun Liu, Jongwon Lim, Xavier Fradera, Charles A. Lesburg, Alfred Lammens, Theodore A. Martinot, Ryan D. Cohen, Amy C. Doty, Heidi Ferguson, Elliott B. Nickbarg, Mangeng Cheng, Peter Spacciapoli, Prasanthi Geda, Xuelei Song, Nadya Smotrov, Pravien Abeywickrema, Christine Andrews, Chad Chamberlin, Omar Mabrouk, Patrick Curran, Matthew Richards, Peter Saradjian, J. Richard Miller, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
ACS Med Chem Lett. 2021 Mar 11; 12(3): 389–396. Published online 2021 Feb 26. doi: 10.1021/acsmedchemlett.0c00525
PMCID:
PMC7957919
AbstractArticlePDF–2.6M
16.
Synthesis and biological evaluation of 3–(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer’s disease agents
Yu-Heng Hu, Jie Yang, Yun Zhang, Ke-Chun Liu, Teng Liu, Jie Sun, Xiao-Jing Wang
J Enzyme Inhib Med Chem. 2019; 34(1): 1083–1092. Published online 2019 May 22. doi: 10.1080/14756366.2019.1615484
PMCID:
PMC6534212
AbstractArticlePDF–1.2M
17.
Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis
Anja Meissner, Helena I. Boshoff, Mahalakshmi Vasan, Benjamin P. Duckworth, Clifton E. Barry, III, Courtney C. Aldrich
Bioorg Med Chem. Author manuscript; available in PMC 2014 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2013 Nov 1; 21(21): 10.1016/j.bmc.2013.08.048. Published online 2013 Sep 3. doi: 10.1016/j.bmc.2013.08.048
PMCID:
PMC3816974
AbstractArticlePDF–1.0M
18.
DBU-Mediated Addition of α-Nitroketones to α-Cyano-enones and α,β-Unsaturated α-Ketoesters: Synthesis of Dihydrofurans and Conjugated Dienes
Subas Chandra Sahoo, Rajendra Maity, Subhas Chandra Pan
ACS Omega. 2019 Feb 28; 4(2): 2792–2803. Published online 2019 Feb 6. doi: 10.1021/acsomega.8b03651
PMCID:
PMC6648157
AbstractArticlePDF–897K
19.
Antinociceptive properties of new coumarin derivatives bearing substituted 3,4-dihydro-2H-benzothiazines
Masoumeh Alipour, Mehdi Khoobi, Saeed Emami, Saeed Fallah-Benakohal, Seyedeh Farnaz Ghasemi-Niri, Mohammad Abdollahi, Alireza Foroumadi, Abbas Shafiee
Daru. 2014; 22(1): 9. Published online 2014 Jan 7. doi: 10.1186/2008-2231-22-9
PMCID:
PMC4029140
AbstractArticlePDF–264K
20.
Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain
Jatinder Kaur, Monica Soto-Velasquez, Zhong Ding, Ahmadreza Ghanbarpour, Markus A. Lill, Richard M. van Rijn, Val J. Watts, Daniel P. Flaherty
Eur J Med Chem. Author manuscript; available in PMC 2020 Jan 15.
Published in final edited form as: Eur J Med Chem. 2019 Jan 15; 162: 568–585. Published online 2018 Nov 16. doi: 10.1016/j.ejmech.2018.11.036
PMCID:
PMC6310635
AbstractArticlePDF–679K

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