3,5-Diphenyl-1H-pyrazol-4-amine - PMC

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Select item 92257221.

Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease

Ning Yan, Xiao-Long Shi, Long-Qian Tang, De-Feng Wang, Xun Li, Chao Liu, Zhao-Peng Liu

J Enzyme Inhib Med Chem. 2022; 37(1): 1724–1736. Published online 2022 Jun 14. doi: 10.1080/14756366.2022.2086867

PMCID:: PMC9225722

Abstract Article PDF–2.6M

Select item 64993892.

Probing Structural Requirements for Human Topoisomerase I Inhibition by a Novel N1-Biphenyl Fluoroquinolone

Justine L. Delgado, Sarah R.C. Lentz, Chaitanya A. Kulkarni, Pratik R. Chheda, Hailey A. Held, Hiroshi Hiasa, Robert J. Kerns

Eur J Med Chem. Author manuscript; available in PMC 2020 Jun 15.

Published in final edited form as: Eur J Med Chem. 2019 Jun 15; 172: 109–130. Published online 2019 Mar 20. doi: 10.1016/j.ejmech.2019.03.040

PMCID:: PMC6499389

Abstract Article PDF–1.6M

Select item 108956583.

BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor

Daniel Meibom, Pierre Wasnaire, Kristin Beyer, Andreas Broehl, Yolanda Cancho-Grande, Nadine Elowe, Kerstin Henninger, Sarah Johannes, Natalia Jungmann, Tanja Krainz, Niels Lindner, Stefanie Maassen, Bryan MacDonald, Denis Menshykau, Joachim Mittendorf, Guzman Sanchez, Martina Schaefer, Eric Stefan, Afra Torge, Yi Xing, Dmitry Zubov

J Med Chem. 2024 Feb 22; 67(4): 2907–2940. Published online 2024 Feb 13. doi: 10.1021/acs.jmedchem.3c02036

PMCID:: PMC10895658

Abstract Article PDF–9.3M

Select item 92271894.

Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol

Arminas Urbonavičius, Graziana Fortunato, Emilija Ambrazaitytė, Elena Plytninkienė, Aurimas Bieliauskas, Vaida Milišiūnaitė, Renzo Luisi, Eglė Arbačiauskienė, Sonata Krikštolaitytė, Algirdas Šačkus

Molecules. 2022 Jun; 27(12): 3752. Published online 2022 Jun 10. doi: 10.3390/molecules27123752

PMCID:: PMC9227189

Abstract Article PDF–2.2M

Select item 79975795.

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

Greta Bagnolini, Domenico Milano, Marcella Manerba, Fabrizio Schipani, Jose Antonio Ortega, Dario Gioia, Federico Falchi, Andrea Balboni, Fulvia Farabegoli, Francesca De Franco, Janet Robertson, Roberto Pellicciari, Isabella Pallavicini, Sebastiano Peri, Saverio Minucci, Stefania Girotto, Giuseppina Di Stefano, Marinella Roberti, Andrea Cavalli

J Med Chem. 2020 Mar 12; 63(5): 2588–2619. Published online 2020 Feb 10. doi: 10.1021/acs.jmedchem.9b01526

PMCID:: PMC7997579

Abstract Article PDF–6.8M

Select item 102745696.

A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects

Hajar A. Ali, Mohamed A. Ismail, Abd El-Aziz S. Fouda, Eslam A. Ghaith

RSC Adv. 2023 Jun 15; 13(27): 18262–18305. Published online 2023 Jun 16. doi: 10.1039/d3ra03531j

PMCID:: PMC10274569

Abstract Article PDF–8.2M

Select item 85884867.

Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines

Beatričė Razmienė, Eva Řezníčková, Vaida Dambrauskienė, Radek Ostruszka, Martin Kubala, Asta Žukauskaitė, Vladimír Kryštof, Algirdas Šačkus, Eglė Arbačiauskienė

Molecules. 2021 Nov; 26(21): 6747. Published online 2021 Nov 8. doi: 10.3390/molecules26216747

PMCID:: PMC8588486

Abstract Article PDF–3.0M

Select item 90995368.

1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research

Andrzej Danel, Ewa Gondek, Mateusz Kucharek, Paweł Szlachcic, Arkadiusz Gut

Molecules. 2022 May; 27(9): 2775. Published online 2022 Apr 26. doi: 10.3390/molecules27092775

PMCID:: PMC9099536

Abstract Article PDF–16M

Select item 102889269.

Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1^G2032R and ALK^G1202R

Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang

J Enzyme Inhib Med Chem. 2023; 38(1): 2227779. Published online 2023 Jun 22. doi: 10.1080/14756366.2023.2227779

PMCID:: PMC10288926

Abstract Article PDF–3.5M

Select item 964944310.

Poly(aniline-co-melamine)@MnFe₂O₄ nanocatalyst for the synthesis of 4,4′-(arylmethylene) bis (1H-pyrazole-5-ol) derivatives, and 1,4- dihydropyrano[2,3-c]pyrazoles and evaluation of their antioxidant, and anticancer activities

Shefa Mirani Nezhad, Seied Ali Pourmousavi, Ehsan Nazarzadeh Zare, Golnaz Heidari, Hamed Manoochehri, Esmaeel Sharifi

Front Chem. 2022; 10: 1046120. Published online 2022 Oct 28. doi: 10.3389/fchem.2022.1046120

PMCID:: PMC9649443

Abstract Article PDF–4.4M

Select item 766345811.

An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety

Renzo Rossi, Maurizio Ciofalo

Molecules. 2020 Nov; 25(21): 5133. Published online 2020 Nov 4. doi: 10.3390/molecules25215133

PMCID:: PMC7663458

Abstract Article PDF–19M

Select item 668209012.

Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp²)–C(sp³) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones

Hamada Mohamed Ibrahim, Haider Behbehani

ACS Omega. 2019 Jul 31; 4(7): 11701–11711. Published online 2019 Jul 5. doi: 10.1021/acsomega.9b01650

PMCID:: PMC6682090

Abstract Article PDF–1.3M

Select item 405924813.

Domino Reaction of Arylglyoxals with Pyrazol-5-amines: Selective Access to Pyrazolo-Fused 1,7-Naphthyridines, 1,3-Diazocanes, and Pyrroles

Bo Jiang, Wei Fan, Mu-Yan Sun, Qin Ye, Shu-Liang Wang, Shu-Jiang Tu, Guigen Li

J Org Chem. 2014 Jun 6; 79(11): 5258–5268. Published online 2014 May 15. doi: 10.1021/jo500823z

PMCID:: PMC4059248

Abstract Article PDF–1.6M

Select item 895483114.

Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors

Md. Jahangir Alam, Ozair Alam, Ahmad Perwez, Moshahid Alam Rizvi, Mohd Javed Naim, Vegi G. M. Naidu, Mohd Imran, Mohammed M. Ghoneim, Sultan Alshehri, Faiyaz Shakeel

Pharmaceuticals (Basel) 2022 Mar; 15(3): 280. Published online 2022 Feb 24. doi: 10.3390/ph15030280

PMCID:: PMC8954831

Abstract Article PDF–5.6M

Select item 877836215.

Synthesis of Functionalized Thiophene Based Pyrazole Amides via Various Catalytic Approaches: Structural Features through Computational Applications and Nonlinear Optical Properties

Iram Kanwal, Nasir Rasool, Syeda Huda Mehdi Zaidi, Zainul Amiruddin Zakaria, Muhammad Bilal, Muhammad Ali Hashmi, Adeel Mubarik, Gulraiz Ahmad, Syed Adnan Ali Shah

Molecules. 2022 Jan; 27(2): 360. Published online 2022 Jan 7. doi: 10.3390/molecules27020360

PMCID:: PMC8778362

Abstract Article PDF–29M

Select item 1026940316.

N-phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a new class of HIV-1 non-nucleoside reverse transcriptase inhibitor

Thomas Lane, Vadim Makarov, Julie A. E. Nelson, Rick B. Meeker, Giuseppina Sanna, Olga Riabova, Elena Kazakova, Natalia Monakhova, Andrey Tsedilin, Fabio Urbina, Thane Jones, Ashley Suchy, Sean Ekins

J Med Chem. Author manuscript; available in PMC 2024 May 11.

Published in final edited form as: J Med Chem. 2023 May 11; 66(9): 6193–6217. Published online 2023 May 2. doi: 10.1021/acs.jmedchem.2c02055

PMCID:: PMC10269403

Abstract Article PDF–2.3M

Select item 1126261517.

Structure-based discovery of CFTR potentiators and inhibitors

Fangyu Liu, Anat Levit Kaplan, Jesper Levring, Jürgen Einsiedel, Stephanie Tiedt, Katharina Distler, Natalie S. Omattage, Ivan S. Kondratov, Yurii S. Moroz, Harlan L. Pietz, John J. Irwin, Peter Gmeiner, Brian K. Shoichet, Jue Chen

Cell. Author manuscript; available in PMC 2024 Jul 22.

Published in final edited form as: Cell. 2024 Jul 11; 187(14): 3712–3725.e34. Published online 2024 May 28. doi: 10.1016/j.cell.2024.04.046