2-Benzylamino-N-biphenyl-2-yl-acetamide - PMC

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Select item 103480381.

PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1–AKT–mTOR/Bcl2 pathway

Hua Zhang, Shi-Jia Zhou, Chen-Feng Shen, Yong-Nan Zhou, Cai-Yun Wu, Meng-Yu Zhu, Qi-Meng Yu, Annoor Awadasseid, Yan-Ling Wu, Wen Zhang

J Enzyme Inhib Med Chem. 2023; 38(1): 2230388. Published online 2023 Jul 13. doi: 10.1080/14756366.2023.2230388

PMCID:: PMC10348038

Abstract Article PDF–3.7M

Select item 78161972.

Structure–Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D

Elliot D. Mock, Ioli Kotsogianni, Wouter P. F. Driever, Carmen S. Fonseca, Jelle M. Vooijs, Hans den Dulk, Constant A. A. van Boeckel, Mario van der Stelt

J Med Chem. 2021 Jan 14; 64(1): 481–515. Published online 2020 Dec 31. doi: 10.1021/acs.jmedchem.0c01441

PMCID:: PMC7816197

Abstract Article PDF–3.2M

Select item 87667563.

Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants

Maan T. Khayat, Abdelsattar M. Omar, Farid Ahmed, Mohammad I. Khan, Sara M. Ibrahim, Yosra A. Muhammad, Azizah M. Malebari, Thikryat Neamatallah, Moustafa E. El-Araby

Front Pharmacol. 2021; 12: 794325. Published online 2022 Jan 5. doi: 10.3389/fphar.2021.794325

PMCID:: PMC8766756

Abstract Article PDF–2.7M

Select item 91666304.

SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases

Abdelsattar M. Omar, Maan T. Khayat, Farid Ahmed, Yosra A. Muhammad, Azizah M. Malebari, Sara M. Ibrahim, Mohammad I. Khan, Dhaval K. Shah, Wayne E. Childers, Moustafa E. El-Araby

Front Oncol. 2022; 12: 879457. Published online 2022 May 20. doi: 10.3389/fonc.2022.879457

PMCID:: PMC9166630

Abstract Article PDF–4.4M

Select item 42074495.

Synthesis Characterization and Antibacterial, Antifungal Activity of N-(Benzyl Carbamoyl or Carbamothioyl)-2-hydroxy Substituted Benzamide and 2-Benzyl Amino-Substituted Benzoxazines

Tyson Belz, Saleh Ihmaid, Jasim Al-Rawi, Steve Petrovski

Int J Med Chem. 2013; 2013: 436397. Published online 2013 Oct 31. doi: 10.1155/2013/436397

PMCID:: PMC4207449

Abstract Article PDF–1020K

Select item 31582916.

Structure-Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824)

Joseph Cherian, Inhee Choi, Amit Nayyar, Ujjini H. Manjunatha, Tathagata Mukherjee, Yong Sok Lee, Helena I. Boshoff, Ramandeep Singh, Young Hwan Ha, Michael Goodwin, Suresh B. Lakshminarayana, Pornwaratt Niyomrattanakit, Jan Jiricek, Sindhu Ravindran, Thomas Dick, Thomas H. Keller, Veronique Dartois, Clifton E. Barry, 3rd

J Med Chem. Author manuscript; available in PMC 2012 Aug 25.

Published in final edited form as: J Med Chem. 2011 Aug 25; 54(16): 5639–5659. Published online 2011 Jul 26. doi: 10.1021/jm1010644

PMCID:: PMC3158291

Abstract Article PDF–1.6M

Select item 55399247.

Synthesis, Biological Evaluation and Molecular Modeling of 2-Hydroxyisoquinoline-1,3-dione Analogues as Inhibitors of HIV Reverse Transcriptase Associated Ribonuclease H and Polymerase

Jing Tang, Sanjeev Kumar V. Vernekar, Yue-Lei Chen, Lena Miller, Andrew D. Huber, Nataliya Myshakina, Stefan G. Sarafianos, Michael A. Parniak, Zhengqiang Wang

Eur J Med Chem. Author manuscript; available in PMC 2018 Jun 16.

Published in final edited form as: Eur J Med Chem. 2017 Jun 16; 133: 85–96. Published online 2017 Mar 29. doi: 10.1016/j.ejmech.2017.03.059

PMCID:: PMC5539924

Abstract Article PDF–2.8M

Select item 67264588.

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

Smit Kour, Sandeep Rana, Jacob I. Contreras, Hannah M. King, Caroline M. Robb, Yogesh A. Sonawane, Mourad Bendjennat, Ayrianne J. Crawford, Carter J. Barger, Smitha Kizhake, Xu Luo, Michael A. Hollingsworth, Amarnath Natarajan

Mol Pharmacol. 2019 Oct; 96(4): 419–429. Published online 2019 Oct. doi: 10.1124/mol.119.116855

PMCID:: PMC6726458

Abstract Article PDF–1.3M

Select item 66754619.

Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents

Yan Lu, Zhao Wang, Chien-Ming Li, Jianjun Chen, James T. Dalton, Wei Li, Duane D. Miller

Bioorg Med Chem. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Bioorg Med Chem. 2010 Jan 15; 18(2): 477–495. Published online 2009 Dec 11. doi: 10.1016/j.bmc.2009.12.020

PMCID:: PMC6675461

Abstract Article PDF–2.3M

Select item 442347510.

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

Margherita Brindisi, Simone Brogi, Nicola Relitti, Alessandra Vallone, Stefania Butini, Sandra Gemma, Ettore Novellino, Gianni Colotti, Gabriella Angiulli, Francesco Di Chiaro, Annarita Fiorillo, Andrea Ilari, Giuseppe Campiani

Sci Rep. 2015; 5: 9705. Published online 2015 May 7. doi: 10.1038/srep09705

PMCID:: PMC4423475

Abstract Article PDF–1.0M

Select item 359360511.

Structure-activity relationship study of Vitamin K derivatives yields highly potent neuroprotective agents

Benjamin J. Josey, Elizabeth S. Inks, Xuejun Wen, C. James Chou

J Med Chem. Author manuscript; available in PMC 2014 Feb 14.

Published in final edited form as: J Med Chem. 2013 Feb 14; 56(3): 1007–1022. Published online 2013 Jan 30. doi: 10.1021/jm301485d

PMCID:: PMC3593605

Abstract Article PDF–2.3M

Select item 286745112.

Merging the Structural Motifs of Functionalized Amino Acids and α-Aminoamides: Compounds with Significant Anticonvulsant Activities

Christophe Salomé, Elise Salomé-Grosjean, James P. Stables, Harold Kohn

J Med Chem. Author manuscript; available in PMC 2011 May 13.

Published in final edited form as: J Med Chem. 2010 May 13; 53(9): 3756–3771. doi: 10.1021/jm100185c

PMCID:: PMC2867451

Abstract Article PDF–1.3M

Select item 633217713.

Current Research on Antiepileptic Compounds

Cheng-Xi Wei, Ming Bian, Guo-Hua Gong

Molecules. 2015 Nov; 20(11): 20741–20776. Published online 2015 Nov 20. doi: 10.3390/molecules201119714

PMCID:: PMC6332177

Abstract Article PDF–11M

Select item 1022413314.

Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

Umberto Maria Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, Woonghee Kim, Mathias Uhlen, Jan Borén, Adil Mardinoğlu, Morten Grøtli

Pharmaceuticals (Basel) 2023 May; 16(5): 668. Published online 2023 Apr 28. doi: 10.3390/ph16050668

PMCID:: PMC10224133

Abstract Article PDF–9.7M

Select item 795673815.

Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence

Ana Bornadiego, Ana G. Neo, Carlos F. Marcos

Molecules. 2021 Mar; 26(5): 1287. Published online 2021 Feb 27. doi: 10.3390/molecules26051287

PMCID:: PMC7956738

Abstract Article PDF–2.6M

Select item 812314316.

SENP Proteases as Potential Targets for Cancer Therapy

Paulina Tokarz, Katarzyna Woźniak

Cancers (Basel) 2021 May; 13(9): 2059. Published online 2021 Apr 24. doi: 10.3390/cancers13092059

PMCID:: PMC8123143

Abstract Article PDF–682K

Select item 283231117.

Selective 5-Hydroxytrytamine 2C Receptor Agonists Derived from the Lead Compound Tranylcypromine – Identification of Drugs with Antidepressant-Like Action

Sung Jin Cho, Niels H. Jensen, Toru Kurome, Sudhakar Kadari, Michael L. Manzano, Jessica E. Malberg, Barbara Caldarone, Bryan L. Roth, Alan P. Kozikowski

J Med Chem. Author manuscript; available in PMC 2010 Apr 9.

Published in final edited form as: J Med Chem. 2009 Apr 9; 52(7): 1885–1902. doi: 10.1021/jm801354e

PMCID:: PMC2832311

Abstract Article PDF–1.6M

Select item 1098209318.

Identifying and characterising promising small molecule inhibitors of kinesin spindle protein using ligand-based virtual screening, molecular docking, molecular dynamics and MM‑GBSA calculations

Samia A. Elseginy

J Comput Aided Mol Des. 2024; 38(1): 16. Published online 2024 Apr 1. doi: 10.1007/s10822-024-00553-5

PMCID:: PMC10982093

Abstract Article PDF–3.2M

Select item 878009319.

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

Prisca Lagardère, Cyril Fersing, Nicolas Masurier, Vincent Lisowski

Pharmaceuticals (Basel) 2022 Jan; 15(1): 35. Published online 2021 Dec 27. doi: 10.3390/ph15010035

PMCID:: PMC8780093

Abstract Article PDF–76M

Select item 799524420.

Synthetic and medicinal perspective of quinolines as antiviral agents

Ramandeep Kaur, Kapil Kumar

Eur J Med Chem. 2021 Apr 5; 215: 113220. Published online 2021 Jan 24. doi: 10.1016/j.ejmech.2021.113220

PMCID:: PMC7995244

Abstract Article PDF–4.2M

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