2-Amino-3-hydroxy-6-methylpyridine - PMC

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Select item 27826281.

Design and Synthesis of 2-Amino-4-methylpyridine Analogues as Inhibitors for Inducible Nitric Oxide Synthase and in vivo Evaluation of [¹⁸F]6-(2-Fluoropropyl)-4-methyl-pyridin-2-amine as a Potential PET Tracer for Inducible Nitric Oxide Synthase

Dong Zhou, Hsiaoju Lee, Justin M. Rothfuss, Delphine L. Chen, Datta E. Ponde, Michael J. Welch, Robert H. Mach

J Med Chem. Author manuscript; available in PMC 2010 Apr 23.

Published in final edited form as: J Med Chem. 2009 Apr 23; 52(8): 2443–2453. doi: 10.1021/jm801556h

PMCID:: PMC2782628

Abstract Article PDF–631K

Select item 41465702.

Syntheses of 3-[(Alkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones, 3-Substituted 7-Methyl-2H-pyrano[3,2-c]pyridine-2,5(6H)-dione Fluorescence Probes, and Tetrahydro-1H,9H-2,10-dioxa-9-azaanthracen-1-ones

Allan M. Prior, Medha J. Gunaratna, Daisuke Kikuchi, John Desper, Yunjeong Kim, Kyeong-Ok Chang, Izumi Maezawa, Lee-Way Jin, Duy H. Hua

Synthesis (Stuttg) Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Synthesis (Stuttg). 2014 Aug; 46(16): 2179–2190. doi: 10.1055/s-0033-1339027

PMCID:: PMC4146570

Abstract Article PDF–1.2M

Select item 25870253.

Gene identification and structural characterization of the PLP degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from Mesorhizobium loti MAFF303099

Tathagata Mukherjee, Kathryn M. McCulloch, Steven E. Ealick, Tadhg P. Begley

Biochemistry. Author manuscript; available in PMC 2008 Nov 27.

Published in final edited form as: Biochemistry. 2007 Nov 27; 46(47): 13606–13615. Published online 2007 Oct 31. doi: 10.1021/bi701439j

PMCID:: PMC2587025

Abstract Article PDF–3.0M

Select item 67094104.

Synthesis of novel Schiff bases containing arylpyrimidines as promising antibacterial agents

Soukhyarani Gopal Nayak, Boja Poojary

Heliyon. 2019 Aug; 5(8): e02318. Published online 2019 Aug 20. doi: 10.1016/j.heliyon.2019.e02318

PMCID:: PMC6709410

Abstract Article PDF–539K

Select item 46280035.

Tautomerization, molecular structure, transition state structure, and vibrational spectra of 2-aminopyridines: a combined computational and experimental study

Jamelah S. Al-Otaibi

Springerplus. 2015; 4: 586. Published online 2015 Oct 9. doi: 10.1186/s40064-015-1363-2

PMCID:: PMC4628003

Abstract Article PDF–2.4M

Select item 19158986.

2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo.

W. S. Faraci, A. A. Nagel, K. A. Verdries, L. A. Vincent, H. Xu, L. E. Nichols, J. M. Labasi, E. D. Salter, E. R. Pettipher

Br J Pharmacol. 1996 Nov; 119(6): 1101–1108. doi: 10.1111/j.1476-5381.1996.tb16010.x

PMCID:: PMC1915898

Summary Page Browse PDF–1.5M

Select item 45163157.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Marianne Lucas-Hourani, Hélène Munier-Lehmann, Farah El Mazouni, Nicholas A. Malmquist, Jane Harpon, Eloi P. Coutant, Sandrine Guillou, Olivier Helynck, Anne Noel, Artur Scherf, Margaret A. Phillips, Frédéric Tangy, Pierre-Olivier Vidalain, Yves L. Janin

J Med Chem. 2015 Jul 23; 58(14): 5579–5598. Published online 2015 Jun 16. doi: 10.1021/acs.jmedchem.5b00606

PMCID:: PMC4516315

Abstract Article PDF–1.4M

Select item 101806428.

Metabolic Biomarkers of Red Beetroot Juice Intake at Rest and after Physical Exercise

Ottavia Giampaoli, Cristian Ieno, Fabio Sciubba, Mariangela Spagnoli, Alfredo Miccheli, Alberta Tomassini, Walter Aureli, Luigi Fattorini

Nutrients. 2023 May; 15(9): 2026. Published online 2023 Apr 22. doi: 10.3390/nu15092026

PMCID:: PMC10180642

Abstract Article PDF–4.7M

Select item 62704589.

¹H-MAS-NMR Chemical Shifts in Hydrogen-Bonded Complexes of Chlorophenols (Pentachlorophenol, 2,4,6-Trichlorophenol, 2,6-Dichlorophenol, 3,5-Dichlorophenol, and p-Chlorophenol) and Amine, and H/D Isotope Effects on ¹H-MAS-NMR Spectra

Hisashi Honda

Molecules. 2013 Apr; 18(4): 4786–4802. Published online 2013 Apr 22. doi: 10.3390/molecules18044786

PMCID:: PMC6270458

Abstract Article PDF–564K

Select item 607193810.

Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs

Davide Carta, Paola Brun, Matteo Dal Pra, Giulia Bernabè, Ignazio Castagliuolo, Maria Grazia Ferlin

Medchemcomm. 2018 Jun 1; 9(6): 1017–1032. Published online 2018 Apr 24. doi: 10.1039/c8md00139a

PMCID:: PMC6071938

Abstract Article PDF–447K

Select item 840007011.

Innovations and Patent Trends in the Development of USFDA Approved Protein Kinase Inhibitors in the Last Two Decades

Mohd. Imran, Syed Mohammed Basheeruddin Asdaq, Shah Alam Khan, Dhanalekshmi Unnikrishnan Meenakshi, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed Alrashed, Mohammed AlMotairi, Eman H. Alkhaldi, Abeer K. Alorabi, Ahmed Subeh Alshrari, Mohammad Tauseef, Abida, Saleh I. Alaqel, Ozair Alam, Md. Afroz Bakht

Pharmaceuticals (Basel) 2021 Aug; 14(8): 710. Published online 2021 Jul 22. doi: 10.3390/ph14080710

PMCID:: PMC8400070

Abstract Article PDF–10M

Select item 940948312.

Anti-Inflammatory Activity of Cajanin, an Isoflavonoid Derivative Isolated from Canavalia lineata Pods

Su-Jin Hong, Ok-Kyoung Kwon, Daseul Hwang, Su Hyun Goo, Doo-Young Kim, Min Ha Kim, Soo-Young Kim, Hyun-Jae Jang, Sei-Ryang Oh

Int J Mol Sci. 2022 Aug; 23(16): 9492. Published online 2022 Aug 22. doi: 10.3390/ijms23169492

PMCID:: PMC9409483

Abstract Article PDF–1.7M

Select item 879628713.

Photochemical and Electrochemical Applications of Proton-Coupled Electron Transfer in Organic Synthesis

Philip R. D. Murray, James H. Cox, Nicholas D. Chiappini, Casey B. Roos, Elizabeth A. McLoughlin, Benjamin G. Hejna, Suong T. Nguyen, Hunter H. Ripberger, Jacob M. Ganley, Elaine Tsui, Nick Y. Shin, Brian Koronkiewicz, Guanqi Qiu, Robert R. Knowles

Chem Rev. 2022 Jan 26; 122(2): 2017–2291. Published online 2021 Nov 23. doi: 10.1021/acs.chemrev.1c00374

PMCID:: PMC8796287

Abstract Article PDF–50M

Select item 909953614.

1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research

Andrzej Danel, Ewa Gondek, Mateusz Kucharek, Paweł Szlachcic, Arkadiusz Gut

Molecules. 2022 May; 27(9): 2775. Published online 2022 Apr 26. doi: 10.3390/molecules27092775

PMCID:: PMC9099536

Abstract Article PDF–16M

Select item 1118133215.

Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases

Oscar Mammoliti, Sébastien Martina, Pieter Claes, Ghjuvanni Coti, Roland Blanque, Catherine Jagerschmidt, Kenji Shoji, Monica Borgonovi, Steve De Vos, Florence Marsais, Line Oste, Evelyne Quinton, Miriam López-Ramos, David Amantini, Reginald Brys, Juan-Miguel Jimenez, René Galien, Steven van der Plas

J Med Chem. 2024 Jun 13; 67(11): 8545–8568. Published online 2024 May 28. doi: 10.1021/acs.jmedchem.4c00769

PMCID:: PMC11181332

Abstract Article PDF–8.1M

Select item 942165416.

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections

Natalie Hawryluk, Dale Robinson, Yixing Shen, Graham Kyne, Matthew Bedore, Sanjay Menon, Stacie Canan, Thomas von Geldern, Simon Townson, Suzanne Gokool, Alexandra Ehrens, Marianne Koschel, Nathaly Lhermitte-Vallarino, Coralie Martin, Achim Hoerauf, Geraldine Hernandez, Deepak Dalvie, Sabine Specht, Marc Peter Hübner, Ivan Scandale

J Med Chem. 2022 Aug 25; 65(16): 11388–11403. Published online 2022 Aug 16. doi: 10.1021/acs.jmedchem.2c00960

PMCID:: PMC9421654

Abstract Article PDF–2.9M

Select item 912990117.

Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A₁ receptors for the potential treatment of epilepsy

Gaofenngwe Nkomba, Gisella Terre’Blanche, Helena D. Janse van Rensburg, Lesetja J. Legoabe

Med Chem Res. 2022; 31(8): 1277–1297. Published online 2022 May 24. doi: 10.1007/s00044-022-02908-9

PMCID:: PMC9129901

Abstract Article PDF–4.2M

Select item 587422918.

Biochemical properties of cholesterol aldehyde secosterol and its derivatives

Noriyuki Miyoshi

J Clin Biochem Nutr. 2018 Mar; 62(2): 107–114. Published online 2018 Feb 7. doi: 10.3164/jcbn.17-109

PMCID:: PMC5874229

Abstract Article PDF–380K

Select item 737655819.

Microbial Degradation of Pyridine: a Complete Pathway in Arthrobacter sp. Strain 68b Deciphered

Vida Časaitė, Rūta Stanislauskienė, Justas Vaitekūnas, Daiva Tauraitė, Rasa Rutkienė, Renata Gasparavičiūtė, Rolandas Meškys

Appl Environ Microbiol. 2020 Aug; 86(15): e00902-20. Prepublished online 2020 May 29. Published online 2020 Jul 20. doi: 10.1128/AEM.00902-20

PMCID:: PMC7376558

Abstract Article PDF–2.5M

Select item 957324220.

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Faiz Ullah, Sami Ullah, Muhammad Farhan Ali Khan, Muhammad Mustaqeem, Rizwan Nasir Paracha, Muhammad Fayyaz ur Rehman, Fariha Kanwal, Syed Shams ul Hassan, Simona Bungau

Molecules. 2022 Oct; 27(19): 6631. Published online 2022 Oct 6. doi: 10.3390/molecules27196631

PMCID:: PMC9573242

Abstract Article PDF–4.5M

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