2,3-Difluoro-6-methoxybenzylamine - PMC

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Items: 16

Select item 63765521.

Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors

Lucie Čechová, Milan Dejmek, Ondřej Baszczyňski, David Šaman, Liping Gao, Eric Hu, George Stepan, Petr Jansa, Zlatko Janeba, Petr Šimon

Antivir Chem Chemother. 2019; 27: 2040206619826265. Published online 2019 Feb 6. doi: 10.1177/2040206619826265

PMCID:: PMC6376552

Abstract Article PDF–863K

Select item 79187932.

5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency

Ahmed K. ElHady, Dalia S. El-Gamil, Po-Jen Chen, Tsong-Long Hwang, Ashraf H. Abadi, Mohammad Abdel-Halim, Matthias Engel

Molecules. 2021 Feb; 26(4): 1001. Published online 2021 Feb 13. doi: 10.3390/molecules26041001

PMCID:: PMC7918793

Abstract Article PDF–7.0M

Select item 108241523.

Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors

Dhananjayan Vasu, Ha T. Do, Huiying Li, Christine D. Hardy, Amardeep Awasthi, Thomas L. Poulos, Richard B. Silverman

J Med Chem. Author manuscript; available in PMC 2024 Jul 27.

Published in final edited form as: J Med Chem. 2023 Jul 27; 66(14): 9934–9953. Published online 2023 Jul 11. doi: 10.1021/acs.jmedchem.3c00782

PMCID:: PMC10824152

Abstract Article PDF–1.8M

Select item 111712184.

N-Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents

Noha Mostafa, Po-Jen Chen, Sarah S. Darwish, Yu-Chieh Su, Ming-Hua Shiao, Gary A. Piazza, Ashraf H. Abadi, Matthias Engel, Mohammad Abdel-Halim

Cancers (Basel) 2024 Jun; 16(11): 2033. Published online 2024 May 27. doi: 10.3390/cancers16112033

PMCID:: PMC11171218

Abstract Article PDF–6.5M

Select item 42343085.

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

Mark Turlington, Meredith J. Noetzel, Thomas M. Bridges, Paige N. Vinson, Thomas Steckler, Hilde Lavreysen, Claire Mackie, José M. Bartolomé-Nebreda, Susana Conde-Ceide, Han Min Tong, Gregor J. Macdonald, J. Scott Daniels, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer

Bioorg Med Chem Lett. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Bioorg Med Chem Lett. 2014 Aug 1; 24(15): 3641–3646. Published online 2014 May 2. doi: 10.1016/j.bmcl.2014.04.087

PMCID:: PMC4234308

Abstract Article PDF–1.4M

Select item 103854716.

Access to 2-Fluorinated Aziridine-2-phosphonates from α,α-Halofluorinated β-Iminophosphonates—Spectroscopic and Theoretical Studies

Mateusz Klarek, Tomasz Siodła, Tahar Ayad, David Virieux, Magdalena Rapp

Molecules. 2023 Jul; 28(14): 5579. Published online 2023 Jul 22. doi: 10.3390/molecules28145579

PMCID:: PMC10385471

Abstract Article PDF–4.9M

Select item 63596807.

Palladium-Catalysed Synthesis and Transformation of Quinolones

Vera L. M. Silva, Artur M. S. Silva

Molecules. 2019 Jan; 24(2): 228. Published online 2019 Jan 9. doi: 10.3390/molecules24020228

PMCID:: PMC6359680

Abstract Article PDF–24M

Select item 65247838.

Silicon Substitution in Oxazine Dyes Yields Near-Infrared Azasiline Fluorophores that Absorb and Emit Beyond 700 nm

Adam Choi, Stephen C. Miller

Org Lett. Author manuscript; available in PMC 2019 Aug 3.

Published in final edited form as: Org Lett. 2018 Aug 3; 20(15): 4482–4485. Published online 2018 Jul 17. doi: 10.1021/acs.orglett.8b01786

PMCID:: PMC6524783

Abstract Article PDF–798K

Select item 93665999.

Towards novel tacrine analogues: Pd(dppf)Cl₂·CH₂Cl₂ catalyzed improved synthesis, in silico docking and hepatotoxicity studies

Aravinda Babu, Muthipeedika Nibin Joy, K. Sunil, Ayyiliath Meleveetil Sajith, Sougata Santra, Grigory V. Zyryanov, Olga A. Konovalova, Ilya I. Butorin, Keesaram Muniraju

RSC Adv. 2022 Aug 10; 12(35): 22476–22491. Published online 2022 Aug 11. doi: 10.1039/d2ra03225b

PMCID:: PMC9366599

Abstract Article PDF–1.9M

Select item 677734110.

Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists

Thuy Nguyen, Ann M. Decker, Tiffany L. Langston, Kelly M. Mathews, Justin N. Siemian, Jun-Xu Li, Danni L. Harris, Scott P. Runyon, Yanan Zhang

ACS Chem Neurosci. Author manuscript; available in PMC 2019 Oct 4.

Published in final edited form as: ACS Chem Neurosci. 2017 Oct 18; 8(10): 2290–2308. Published online 2017 Aug 9. doi: 10.1021/acschemneuro.7b00219

PMCID:: PMC6777341

Abstract Article PDF–1.2M

Select item 1015736211.

An updated review of fatty acid residue-tethered heterocyclic compounds: synthetic strategies and biological significance

Taghreed A. Majrashi, Ahmed Sabt, Hayam A. Abd El Salam, Ghada H. Al-Ansary, Mohamed Farouk Hamissa, Wagdy M. Eldehna

RSC Adv. 2023 May 2; 13(20): 13655–13682. Published online 2023 May 4. doi: 10.1039/d3ra01368e

PMCID:: PMC10157362

Abstract Article PDF–3.9M

Select item 615522512.

Pharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]pyridine and Imidazo[4,5-c]pyridine Derivatives

Malwina Krause, Henryk Foks, Katarzyna Gobis

Molecules. 2017 Mar; 22(3): 399. Published online 2017 Mar 4. doi: 10.3390/molecules22030399

PMCID:: PMC6155225

Abstract Article PDF–6.3M

Select item 354614213.

Structure-based drug design and potent anti-cancer activity of tricyclic 5:7:5-fused diimidazo[4,5-d:4′,5′-f][1,3]diazepines

Atul Kondaskar, Shilpi Kondaskar, James C. Fishbein, Brandon A. Carter-Cooper, Rena G. Lapidus, Mariola Sadowska, Martin J. Edelman, Ramachandra S. Hosmane

Bioorg Med Chem. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Bioorg Med Chem. 2013 Feb 1; 21(3): 618–631. Published online 2012 Dec 11. doi: 10.1016/j.bmc.2012.11.050