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Items: 1 to 20 of 185

1.
Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides
Anja Beč, Marija Mioč, Branimir Bertoša, Marija Kos, Patricia Debogović, Marijeta Kralj, Kristina Starčević, Marijana Hranjec
J Enzyme Inhib Med Chem. 2022; 37(1): 1327–1339. Published online 2022 May 6. doi: 10.1080/14756366.2022.2070910
PMCID:
PMC9090388
AbstractArticlePDF–2.6M
2.
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening
Chidochangu P. Mpamhanga, Daniel Spinks, Lindsay B. Tulloch, Emma J. Shanks, David A. Robinson, Iain T. Collie, Alan H. Fairlamb, Paul G. Wyatt, Julie A. Frearson, William N. Hunter, Ian H. Gilbert, Ruth Brenk
J Med Chem. 2009 Jul 23; 52(14): 4454–4465. Published online 2009 Jun 15. doi: 10.1021/jm900414x
PMCID:
PMC2966039
AbstractArticlePDF–3.6M
3.
Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation
Anja Beč, Maja Cindrić, Leentje Persoons, Mihailo Banjanac, Vedrana Radovanović, Dirk Daelemans, Marijana Hranjec
Molecules. 2023 May; 28(9): 3720. Published online 2023 Apr 25. doi: 10.3390/molecules28093720
PMCID:
PMC10180076
AbstractArticlePDF–974K
4.
Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and in Silico Anti-HIV-1 Studies
Sabikeh G. Azimi, Ghodsieh Bagherzade, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh
Bioinorg Chem Appl. 2023; 2023: 2881582. Published online 2023 Apr 21. doi: 10.1155/2023/2881582
PMCID:
PMC10147532
AbstractArticlePDF–4.3M
5.
Synthesis and Biological Evaluation of Novel Amino and Amido Substituted Pentacyclic Benzimidazole Derivatives as Antiproliferative Agents
Nataša Perin, Marjana Gulin, Marija Kos, Leentje Persoons, Dirk Daelemans, Ivana Fabijanić, Marijana Radić Stojković, Marijana Hranjec
Int J Mol Sci. 2024 Feb; 25(4): 2288. Published online 2024 Feb 14. doi: 10.3390/ijms25042288
PMCID:
PMC10889688
AbstractArticlePDF–2.6M
6.
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
Ulviye Acar Çevik, Begüm Nurpelin Sağlık, Yusuf Özkay, Zerrin Cantürk, Juan Bueno, Fatih Demirci, Ali Savaş Koparal
Curr Pharm Des. 2017 Apr; 23(15): 2276–2286. Published online 2017 Apr. doi: 10.2174/1381612822666161201150131
PMCID:
PMC5543573
AbstractArticlePDF–1.6M
7.
Design, Synthesis, and Molecular Modeling Studies of a Novel Benzimidazole as an Aromatase Inhibitor
Ulviye Acar Çevik, Ismail Celik, Jaime Mella, Marco Mellado, Yusuf Özkay, Zafer Asım Kaplancıklı
ACS Omega. 2022 May 10; 7(18): 16152–16163. Published online 2022 Apr 28. doi: 10.1021/acsomega.2c01497
PMCID:
PMC9097188
AbstractArticlePDF–4.0M
8.
The Intestinal Barrier Protective Effect of Indole Aldehyde Derivatives on Acute Toxoplasma gondii Infection
Jieqiong Wang, Weifeng Yan, Xu Cheng, Yonggang Tong, Sihong Wang, Chunmei Jin
Molecules. 2024 Nov; 29(21): 5024. Published online 2024 Oct 24. doi: 10.3390/molecules29215024
PMCID:
PMC11547840
AbstractArticlePDF–3.4M
9.
Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives
Salih Osman Mohammed, El Sayed H. El Ashry, Asaad Khalid, Mohamed R. Amer, Ahmed M. Metwaly, Ibrahim H. Eissa, Eslam B. Elkaeed, Ahmed Elshobaky, Elsayed E. Hafez
Molecules. 2022 Feb; 27(3): 865. Published online 2022 Jan 27. doi: 10.3390/molecules27030865
PMCID:
PMC8838460
AbstractArticlePDF–38M
10.
Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1H-benzo[d]imidazole-4-carboxamide: A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer
Rui Min, Weibin Wu, Mingzhong Wang, Lin Tang, Dawei Chen, Huan Zhao, Cunlong Zhang, Yuyang Jiang
Molecules. 2019 May; 24(10): 1901. Published online 2019 May 17. doi: 10.3390/molecules24101901
PMCID:
PMC6572064
AbstractArticlePDF–7.7M
11.
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Douglas L. Orsi, Elisabeth Pook, Nico Bräuer, Anders Friberg, Philip Lienau, Christopher T. Lemke, Timo Stellfeld, Ulf Brüggemeier, Vera Pütter, Hanna Meyer, Maria Baco, Stephanie Tang, Andrew D. Cherniack, Lindsay Westlake, Samantha A. Bender, Mustafa Kocak, Craig A. Strathdee, Matthew Meyerson, Knut Eis, Jonathan T. Goldstein
J Med Chem. 2022 Nov 10; 65(21): 14843–14863. Published online 2022 Oct 21. doi: 10.1021/acs.jmedchem.2c01379
Correction in:
J Med Chem. 2023 Jan 12; 66(1): 1082.
PMCID:
PMC9662185
AbstractArticlePDF–6.1M
12.
Synthesis, Structure and Cytotoxicity Testing of Novel 7-(4,5-Dihydro-1H-imidazol-2-yl)-2-aryl-6,7-dihydro-2H-imidazo[2,1-c][1,2,4]triazol-3(5H)-Imine Derivatives
Łukasz Balewski, Franciszek Sączewski, Patrick J. Bednarski, Lisa Wolff, Anna Nadworska, Maria Gdaniec, Anita Kornicka
Molecules. 2020 Dec; 25(24): 5924. Published online 2020 Dec 14. doi: 10.3390/molecules25245924
PMCID:
PMC7765142
AbstractArticlePDF–2.9M
13.
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
Simon R. Green, Caroline Wilson, Thomas C. Eadsforth, Avinash S. Punekar, Fabio K. Tamaki, Gavin Wood, Nicola Caldwell, Barbara Forte, Neil R. Norcross, Michael Kiczun, John M. Post, Eva Maria Lopez-Román, Curtis A. Engelhart, Iva Lukac, Fabio Zuccotto, Ola Epemolu, Helena I. M. Boshoff, Dirk Schnappinger, Chris Walpole, Ian H. Gilbert, Kevin D. Read, Paul G. Wyatt, Beatriz Baragaña
J Med Chem. 2023 Nov 23; 66(22): 15380–15408. Published online 2023 Nov 10. doi: 10.1021/acs.jmedchem.3c01514
PMCID:
PMC10683028
AbstractArticlePDF–6.2M
14.
Cyanosilylation of Aromatic Aldehydes by Cationic Ruthenium(II) Complexes of Benzimidazole-Derived O-Functionalized N-Heterocyclic Carbenes at Ambient Temperature under Solvent-Free Conditions
Dharmendra Kumar, A. P. Prakasham, Sharmistha Das, Anindya Datta, Prasenjit Ghosh
ACS Omega. 2018 Feb 28; 3(2): 1922–1938. Published online 2018 Feb 14. doi: 10.1021/acsomega.7b02090
PMCID:
PMC6641528
AbstractArticlePDF–2.6M
15.
Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration
Muhammad Imran, Lina Tariq Al Kury, Humaira Nadeem, Fawad Ali Shah, Muzaffar Abbas, Shagufta Naz, Arif-ullah Khan, Shupeng Li
Biomolecules. 2020 Jan; 10(1): 108. Published online 2020 Jan 8. doi: 10.3390/biom10010108
PMCID:
PMC7023260
AbstractArticlePDF–2.8M
16.
Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening
Ram K. Modukuri, Diana Monsivais, Feng Li, Murugesan Palaniappan, Kurt M. Bohren, Zhi Tan, Angela F. Ku, Yong Wang, Chandrashekhar Madasu, Jian-Yuan Li, Suni Tang, Gabriella Miklossy, Stephen S. Palmer, Damian W. Young, Martin M. Matzuk
J Med Chem. 2023 Feb 9; 66(3): 2143–2160. Published online 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886
PMCID:
PMC9924264
AbstractArticlePDF–6.1M
17.
Structure–Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors
Mathias Elsocht, Philippe Giron, Laila Maes, Wim Versées, Gustavo J. Gutierrez, Jacques De Grève, Steven Ballet
Int J Mol Sci. 2021 Jan; 22(2): 635. Published online 2021 Jan 10. doi: 10.3390/ijms22020635
PMCID:
PMC7827406
AbstractArticlePDF–4.5M
18.
Alkylated benzimidazoles: Design, synthesis, docking, DFT analysis, ADMET property, molecular dynamics and activity against HIV and YFV
Ritika Srivastava, Sunil K. Gupta, Farha Naaz, Parth Sarthi Sen Gupta, Madhu Yadav, Vishal Kumar Singh, Anuradha Singh, Malay Kumar Rana, Satish Kumar Gupta, Dominique Schols, Ramendra K. Singh
Comput Biol Chem. 2020 Dec; 89: 107400. Published online 2020 Oct 6. doi: 10.1016/j.compbiolchem.2020.107400
PMCID:
PMC7537607
AbstractArticlePDF–9.0M
19.
An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety
Renzo Rossi, Maurizio Ciofalo
Molecules. 2020 Nov; 25(21): 5133. Published online 2020 Nov 4. doi: 10.3390/molecules25215133
PMCID:
PMC7663458
AbstractArticlePDF–19M
20.
Design and Synthesis of Poly(ADP-ribose) polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity
Uday Kiran Velagapudi, Marie-France Langelier, Cristina Delgado-Martin, Morgan E. Diolaiti, Sietske Bakker, Alan Ashworth, Bhargav A. Patel, Xuwei Shao, John M. Pascal, Tanaji T. Talele
J Med Chem. Author manuscript; available in PMC 2020 Jul 24.
Published in final edited form as: J Med Chem. 2019 Jun 13; 62(11): 5330–5357. Published online 2019 May 24. doi: 10.1021/acs.jmedchem.8b01709
PMCID:
PMC7378964
AbstractArticlePDF–2.7M

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