1,3,5-Triphenoxybenzene - PMC

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The following term was not found in PMC: Triphenoxybenzene.

Select item 109316321.

Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines—Synthesis and Evaluation

Karin Engen, Thomas Lundbäck, Anubha Yadav, Sharathna Puthiyaparambath, Ulrika Rosenström, Johan Gising, Annika Jenmalm-Jensen, Mathias Hallberg, Mats Larhed

Int J Mol Sci. 2024 Mar; 25(5): 2516. Published online 2024 Feb 21. doi: 10.3390/ijms25052516

PMCID:: PMC10931632

Abstract Article PDF–4.7M

Select item 109342612.

Designing Potent Anti-Cancer Agents: Synthesis and Molecular Docking Studies of Thieno[2,3-d][1,2,4]triazolo[1,5-a]pyrimidine Derivatives

Eman S. M. Elsenbawy, Zafer S. Alshehri, Nouf A. Babteen, Adel A.-H. Abdel-Rahman, Mai A. El-Manawaty, Eman S. Nossier, Reem K. Arafa, Nasser A. Hassan

Molecules. 2024 Mar; 29(5): 1067. Published online 2024 Feb 29. doi: 10.3390/molecules29051067

PMCID:: PMC10934261

Abstract Article PDF–4.8M

Select item 91070263.

Components of Out-of-Pocket Expenditure and Their Relative Contribution to Economic Burden of Diseases in India

Mayanka Ambade, Rakesh Sarwal, Nachiket Mor, Rockli Kim, S. V. Subramanian

JAMA Netw Open. 2022 May; 5(5): e2210040. Published online 2022 May 13. doi: 10.1001/jamanetworkopen.2022.10040

PMCID:: PMC9107026

Abstract Article

Select item 79568134.

Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein

Virginia Spanò, Marilia Barreca, Vincenzo Cilibrasi, Michele Genovese, Mario Renda, Alessandra Montalbano, Luis Juan Vicente Galietta, Paola Barraja

Molecules. 2021 Mar; 26(5): 1275. Published online 2021 Feb 26. doi: 10.3390/molecules26051275

PMCID:: PMC7956813

Abstract Article PDF–2.7M

Select item 112259105.

CircHTT(2,3,4,5,6)— co-evolving with the HTT CAG-repeat tract — modulates Huntington's disease phenotypes

Jasmin Morandell, Alan Monziani, Martina Lazioli, Deborah Donzel, Jessica Döring, Claudio Oss Pegorar, Angela D’Anzi, Miguel Pellegrini, Andrea Mattiello, Dalia Bortolotti, Guendalina Bergonzoni, Takshashila Tripathi, Virginia B. Mattis, Marina Kovalenko, Jessica Rosati, Christoph Dieterich, Erik Dassi, Vanessa C. Wheeler, Zdenka Ellederová, Jeremy E. Wilusz, Gabriella Viero, Marta Biagioli

Mol Ther Nucleic Acids. 2024 Sep 10; 35(3): 102234. Published online 2024 Jun 3. doi: 10.1016/j.omtn.2024.102234

PMCID:: PMC11225910

Abstract Article PDF–3.6M

Select item 102154046.

Effect of Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones in the Virulence of Resistant Bacteria

Mariana C. Almeida, Nikoletta Szemerédi, Fernando Durães, Solida Long, Diana I. S. P. Resende, Paulo Martins da Costa, Madalena Pinto, Gabriella Spengler, Emília Sousa

Antibiotics (Basel) 2023 May; 12(5): 922. Published online 2023 May 17. doi: 10.3390/antibiotics12050922

PMCID:: PMC10215404

Abstract Article PDF–5.7M

Select item 91472747.

The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2

Sittisak Oekchuae, Jitnapa Sirirak, Purin Charoensuksai, Pawaris Wongprayoon, Natthaya Chuaypen, Jutatip Boonsombat, Somsak Ruchirawat, Pisit Tangkijvanich, Apichart Suksamrarn, Panupun Limpachayaporn

Pharmaceuticals (Basel) 2022 May; 15(5): 504. Published online 2022 Apr 20. doi: 10.3390/ph15050504

PMCID:: PMC9147274

Abstract Article PDF–6.2M

Select item 109335558.

NEDD4L intramolecular interactions regulate its auto and substrate Na_V1.5 ubiquitination

Katharine M. Wright, Sara Nathan, Hanjie Jiang, Wendy Xia, HyoJeon Kim, Nourdine Chakouri, Justin N. Nwafor, Lucile Fossier, Lakshmi Srinivasan, Zan Chen, Tatiana Boronina, Jeremy Post, Suman Paul, Robert N. Cole, Manu Ben-Johny, Philip A. Cole, Sandra B. Gabelli

J Biol Chem. 2024 Mar; 300(3): 105715. Published online 2024 Feb 2. doi: 10.1016/j.jbc.2024.105715

PMCID:: PMC10933555

Abstract Article PDF–5.1M

Select item 69828769.

Synthesis of Novel Benzodifuranyl; 1,3,5-Triazines; 1,3,5-Oxadiazepines; and Thiazolopyrimidines Derived from Visnaginone and Khellinone as Anti-Inflammatory and Analgesic Agents

Ameen Ali Abu-Hashem, Sami A Al-Hussain, Magdi E. A. Zaki

Molecules. 2020 Jan; 25(1): 220. Published online 2020 Jan 5. doi: 10.3390/molecules25010220

PMCID:: PMC6982876

Abstract Article PDF–1.2M

Select item 910751710.

Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase

Glenn F. W. Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E. Anderson, Yazan M. Abbas, Danielle Brabant-Kirwan, Fernando Montaño-Rendón, Zetao Liu, Hongxian Zhu, John H. Brumell, Alexander Deiters, Len R. Stephens, Phillip T. Hawkins, Gerald R.V. Hammond, Sergio Grinstein, Gregory D. Fairn

Nat Cell Biol. Author manuscript; available in PMC 2022 Oct 28.

Published in final edited form as: Nat Cell Biol. 2022 May; 24(5): 708–722. Published online 2022 Apr 28. doi: 10.1038/s41556-022-00895-y

PMCID:: PMC9107517

Abstract Article PDF–8.0M

Select item 965678711.

Design, Synthesis and Biological Evaluation of Novel 1,3,5-Triazines: Effect of Aromatic Ring Decoration on Affinity to 5-HT₇ Receptor

Damian Kułaga, Anna Karolina Drabczyk, Grzegorz Satała, Gniewomir Latacz, Anna Boguszewska-Czubara, Damian Plażuk, Jolanta Jaśkowska

Int J Mol Sci. 2022 Nov; 23(21): 13308. Published online 2022 Nov 1. doi: 10.3390/ijms232113308

PMCID:: PMC9656787

Abstract Article PDF–5.5M

Select item 1028703712.

Identification of pyrrolo[3’,4’:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

Marilia Barreca, Virginia Spanò, Roberta Rocca, Roberta Bivacqua, Gianmarco Gualtieri, Maria Valeria Raimondi, Eugenio Gaudio, Roberta Bortolozzi, Lorenzo Manfreda, Ruoli Bai, Alessandra Montalbano, Stefano Alcaro, Ernest Hamel, Francesco Bertoni, Giampietro Viola, Paola Barraja

Eur J Med Chem. Author manuscript; available in PMC 2024 Jun 5.

Published in final edited form as: Eur J Med Chem. 2023 Jun 5; 254: 115372. Published online 2023 Apr 12. doi: 10.1016/j.ejmech.2023.115372

PMCID:: PMC10287037

Abstract Article PDF–1.9M

Select item 679000213.

Synthesis and Biological Evaluation of Structurally Varied 5′-/6′-Isonucleosides and Theobromine-Containing N-Isonucleosidyl Derivatives

Nuno M. Xavier, Eduardo C. de Sousa, Margarida P. Pereira, Anne Loesche, Immo Serbian, René Csuk, M. Conceição Oliveira

Pharmaceuticals (Basel) 2019 Sep; 12(3): 103. Published online 2019 Jul 2. doi: 10.3390/ph12030103

PMCID:: PMC6790002

Abstract Article PDF–2.6M

Select item 796719814.

Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Nadine Kretschmer, Antje Hufner, Christin Durchschein, Katrin Popodi, Beate Rinner, Birgit Lohberger, Rudolf Bauer

Int J Mol Sci. 2021 Mar; 22(5): 2774. Published online 2021 Mar 9. doi: 10.3390/ijms22052774

PMCID:: PMC7967198

Abstract Article PDF–8.2M

Select item 940926515.

Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectively Eliminate Leukemia Cells via Caspase-3 Apoptosis and Antioxidative Pathways

Joachim Greilberger, Ralf Herwig, Mehtap Kacar, Naime Brajshori, Georg Feigl, Philipp Stiegler, Reinhold Wintersteiger

Int J Mol Sci. 2022 Aug; 23(16): 9034. Published online 2022 Aug 12. doi: 10.3390/ijms23169034

PMCID:: PMC9409265

Abstract Article PDF–7.0M

Select item 884074216.

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J. Snijder, Martijn J. van Hemert, Frank van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De Jonghe, Arnaud Marchand

Molecules. 2022 Feb; 27(3): 1052. Published online 2022 Feb 4. doi: 10.3390/molecules27031052

PMCID:: PMC8840742

Abstract Article PDF–1.1M

Select item 862448517.

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

Peter W. Jurutka, Orsola di Martino, Sabeeha Reshi, Sanchita Mallick, Zhela L. Sabir, Lech J. P. Staniszewski, Ankedo Warda, Emma L. Maiorella, Ani Minasian, Jesse Davidson, Samir J. Ibrahim, San Raban, Dena Haddad, Madleen Khamisi, Stephanie L. Suban, Bradley J. Dawson, Riley Candia, Joseph W. Ziller, Ming-Yue Lee, Chang Liu, Wei Liu, Pamela A. Marshall, John S. Welch, Carl E. Wagner

Int J Mol Sci. 2021 Nov; 22(22): 12371. Published online 2021 Nov 16. doi: 10.3390/ijms222212371

PMCID:: PMC8624485

Abstract Article PDF–9.0M

Select item 822498418.

[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis

Elizabeth S. Childress, Joseph M. Salamoun, Stefan R. Hargett, Stephanie J. Alexopoulos, Sing-Young Chen, Divya P. Shah, José Santiago-Rivera, Christopher J. Garcia, Yumin Dai, Simon P. Tucker, Kyle L. Hoehn, Webster L. Santos

J Med Chem. Author manuscript; available in PMC 2021 Jun 24.

Published in final edited form as: J Med Chem. 2020 Mar 12; 63(5): 2511–2526. Published online 2020 Feb 17. doi: 10.1021/acs.jmedchem.9b01440

PMCID:: PMC8224984

Abstract Article PDF–1.6M

Select item 1078890819.

Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway

Galina Karabanovich, Viktória Fabiánová, Anthony Vocat, Jan Dušek, Lenka Valášková, Jiřina Stolaříková, Russell R. A. Kitson, Petr Pávek, Kateřina Vávrová, Kamel Djaout, Katarína Mikušová, Alain R. Baulard, Stewart T. Cole, Jana Korduláková, Jaroslav Roh

J Med Chem. 2024 Jan 11; 67(1): 81–109. Published online 2023 Dec 29. doi: 10.1021/acs.jmedchem.3c00925

PMCID:: PMC10788908

Abstract Article PDF–5.8M

Select item 968781220.

Discovery of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 2-(5-(4′-Chloro-[1,1′-biphenyl]-4-yl)-4H-1,2,4-triazol-3-yl)ethan-1-amine (LK00764) for the Treatment of Psychotic Disorders

Mikhail Krasavin, Alexey Lukin, Ilya Sukhanov, Andrey S. Gerasimov, Savelii Kuvarzin, Evgeniya V. Efimova, Mariia Dorofeikova, Anna Nichugovskaya, Andrey Matveev, Kirill Onokhin, Konstantin Zakharov, Maxim Gureev, Raul R. Gainetdinov

Biomolecules. 2022 Nov; 12(11): 1650. Published online 2022 Nov 7. doi: 10.3390/biom12111650

PMCID:: PMC9687812

Abstract Article PDF–13M

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