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Select item 85054181.

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E. Bianchi, Hitoshi Okazawa

Commun Biol. 2021; 4: 1175. Published online 2021 Oct 11. doi: 10.1038/s42003-021-02671-4

PMCID:: PMC8505418

Abstract Article PDF–13M

Select item 100741522.

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita

iScience. 2023 Apr 21; 26(4): 106375. Published online 2023 Mar 13. doi: 10.1016/j.isci.2023.106375

PMCID:: PMC10074152

Abstract Article PDF–7.1M

Select item 97016043.

Optogenetic induction of hibernation-like state with modified human Opsin4 in mice

Tohru M. Takahashi, Arisa Hirano, Takeshi Kanda, Viviane M. Saito, Hiroto Ashitomi, Kazumasa Z. Tanaka, Yasufumi Yokoshiki, Kosaku Masuda, Masashi Yanagisawa, Kaspar E. Vogt, Takashi Tokuda, Takeshi Sakurai

Cell Rep Methods. 2022 Nov 21; 2(11): 100336. Published online 2022 Nov 14. doi: 10.1016/j.crmeth.2022.100336

PMCID:: PMC9701604

Abstract Article PDF–24M

Select item 105307374.

Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model

Toshihiro Kurahashi, Chiyoko Nishime, Eiko Nishinaka, Yuji Komaki, Fumiko Seki, Koji Urano, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai

Int J Mol Sci. 2023 Sep; 24(18): 13853. Published online 2023 Sep 8. doi: 10.3390/ijms241813853

PMCID:: PMC10530737

Abstract Article PDF–11M

Select item 113500095.

PKCδ serves as a potential biomarker and therapeutic target for microglia‐mediated neuroinflammation in Alzheimer's disease

Ying Du, Tiantian Guo, Yunfeng Hao, Chuan Li, Linghui Tang, Xia Li, Xiaoxiao Zhang, Lin Li, Dan Yao, Xia Xu, Huaxing Si, Jinghan Zhang, Nana Zhao, Tong Yu, Yingjun Zhao, Wei Zhang, Huaxi Xu

Alzheimers Dement. 2024 Aug; 20(8): 5511–5527. Published online 2024 Jun 28. doi: 10.1002/alz.14047

PMCID:: PMC11350009

Abstract Article PDF–7.9M

Select item 109683426.

Oxygen–Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes

Kengo Moriyama, Asako Horino, Kuniko Kohyama, Yasumasa Nishito, Tomohiro Morio, Hiroshi Sakuma

Brain Sci. 2024 Mar; 14(3): 244. Published online 2024 Feb 29. doi: 10.3390/brainsci14030244

PMCID:: PMC10968342

Abstract Article PDF–2.5M

Select item 102536297.

High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

Conghui Wang, Hong Li, Chen Chen, Xiuting Yao, Chenxi Yang, Zhehao Yu, Jiayi Ren, Yue Ming, Yi Huang, Yi Rong, Yu Ma, Lijie Liu

Int J Mol Sci. 2023 Jun; 24(11): 9394. Published online 2023 May 28. doi: 10.3390/ijms24119394

PMCID:: PMC10253629

Abstract Article PDF–3.1M

Select item 100157168.

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease

Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C. Saido, Minako Ito

Inflamm Regen. 2023; 43: 20. Published online 2023 Mar 15. doi: 10.1186/s41232-023-00257-7

PMCID:: PMC10015716

Abstract Article PDF–8.5M

Select item 93913479.

Long-term microglial phase-specific dynamics during single vessel occlusion and recanalization

Xiaoke Xie, Xuanting Liu, Jiazhu Zhu, Yongxian Xu, Xiaojing Li, Yameng Zheng, Shangyue Gong, Xiao Xiao, Yiwen Chen, Jianmin Zhang, Wei Gong, Ke Si

Commun Biol. 2022; 5: 841. Published online 2022 Aug 19. doi: 10.1038/s42003-022-03784-0

PMCID:: PMC9391347

Abstract Article PDF–21M

Select item 936863610.

High-Fat Diet Consumption in Adolescence Induces Emotional Behavior Alterations and Hippocampal Neurogenesis Deficits Accompanied by Excessive Microglial Activation

Xiuting Yao, Chenxi Yang, Conghui Wang, Hong Li, Jingyi Zhao, Xiaomin Kang, Zhuodong Liu, Lingyan Chen, Xinyu Chen, Tianshu Pu, Qinyang Li, Lijie Liu

Int J Mol Sci. 2022 Aug; 23(15): 8316. Published online 2022 Jul 27. doi: 10.3390/ijms23158316

PMCID:: PMC9368636

Abstract Article PDF–5.3M

Select item 806851911.

Rosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage

Liu Zi, Wencheng Zhou, Jiake Xu, Junshu Li, Ning Li, Jianguo Xu, Chao You, Chengwei Wang, Meng Tian

Int J Nanomedicine. 2021; 16: 2933–2947. Published online 2021 Apr 20. doi: 10.2147/IJN.S294916

PMCID:: PMC8068519

Abstract Article PDF–935K

Select item 968267512.

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu, Chia-Chen Liu

Mol Neurodegener. 2022; 17: 75. Published online 2022 Nov 23. doi: 10.1186/s13024-022-00577-1

PMCID:: PMC9682675

Abstract Article PDF–16M

Select item 975392913.

Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-Ko mice

Macarena S. Aloi, Samantha J. Thompson, Nicholas Quartapella, Jeffrey L. Noebels

Cell Rep. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Cell Rep. 2022 Nov 22; 41(8): 111696. doi: 10.1016/j.celrep.2022.111696

PMCID:: PMC9753929

Abstract Article PDF–1.8M

Select item 1127218514.

P2Y1R silencing in Astrocytes Protected Neuroinflammation and Cognitive Decline in a Mouse Model of Alzheimer's Disease

Shan Luo, Ami Tamada, Yuichi Saikawa, Yifei Wang, Qing Yu, Tatsuhiro Hisatsune

Aging Dis. 2024 Aug 1; 15(4): 1969–1988. Published online 2024 Aug 1. doi: 10.14336/AD.2023.1006

PMCID:: PMC11272185

Abstract Article PDF–2.0M

Select item 1134757115.

TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARγ and CD36

Wenchuan Zhou, Jincan He, Guiyan Shen, Ya Liu, Peiquan Zhao, Jing Li

Cell Death Dis. 2024 Aug; 15(8): 623. Published online 2024 Aug 26. doi: 10.1038/s41419-024-07002-z

PMCID:: PMC11347571

Abstract Article PDF–7.9M

Select item 1133323016.

Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer’s disease in a APP/PS1 transgenic mouse model

Daniele Lana, Chiara Traini, Irene Bulli, Giorgia Sarti, Giada Magni, Selene Attorre, Maria Grazia Giovannini, Maria Giuliana Vannucchi

Front Pharmacol. 2024; 15: 1451114. Published online 2024 Aug 6. doi: 10.3389/fphar.2024.1451114

PMCID:: PMC11333230

Abstract Article PDF–7.7M

Select item 1109638817.

Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson’s disease

Ping Fang, Lewis W. Yu, Hannah Espey, Gulistan Agirman, Sabeen A. Kazmi, Kai Li, Yongning Deng, Jamie Lee, Haley Hrncir, Arlene Romero-Lopez, Arthur P. Arnold, Elaine Y. Hsiao

Commun Biol. 2024; 7: 570. Published online 2024 May 15. doi: 10.1038/s42003-024-06256-9

PMCID:: PMC11096388

Abstract Article PDF–4.6M

Select item 1052765918.

Differential Effects of Regulatory T Cells in the Meninges and Spinal Cord of Male and Female Mice with Neuropathic Pain

Nathan T. Fiore, Brooke A. Keating, Yuting Chen, Sarah I. Williams, Gila Moalem-Taylor

Cells. 2023 Sep; 12(18): 2317. Published online 2023 Sep 20. doi: 10.3390/cells12182317

PMCID:: PMC10527659

Abstract Article PDF–4.7M

Select item 1124190919.

Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury

Rami A. Shahror, Esraa Shosha, Carol Morris, Melissa Wild, Shengyu Mu, Gabor Csanyi, Marjan Boerma, Nancy J. Rusch, Abdelrahman Y. Fouda

J Neuroinflammation. 2024; 21: 170. Published online 2024 Jul 12. doi: 10.1186/s12974-024-03159-8

PMCID:: PMC11241909

Abstract Article PDF–14M

Select item 1068489120.

INPP5D regulates inflammasome activation in human microglia

Vicky Chou, Richard V. Pearse, II, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioglu, Masashi Fujita, Seeley B. Fancher, Alina Sigalov, Courtney R. Benoit, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young-Pearse

Nat Commun. 2023; 14: 7552. Published online 2023 Nov 29. doi: 10.1038/s41467-023-42819-w