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Select item 109632671.

Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening

Benjamin T. Porebski, Matthew Balmforth, Gareth Browne, Aidan Riley, Kiarash Jamali, Maximillian J. L. J. Fürst, Mirko Velic, Andrew Buchanan, Ralph Minter, Tristan Vaughan, Philipp Holliger

Nat Biomed Eng. 2024; 8(3): 214–232. Published online 2023 Oct 9. doi: 10.1038/s41551-023-01093-3

PMCID:: PMC10963267

Abstract Article PDF–3.6M

Select item 102351152.

Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex

Yunxia Xu, Yaqi Wu, Yuanyuan Zhang, Ruixin Fan, Yaxue Yang, Danyang Li, Shimin Zhu, Biao Yang, Zhengyu Zhang, Changjiang Dong

Cell Res. 2023 Jun; 33(6): 479–482. Published online 2023 Mar 27. doi: 10.1038/s41422-023-00796-1

PMCID:: PMC10235115

Article PDF–1.5M

Select item 100253173.

Formate and hydrogen in hydrothermal vents and their use by extremely thermophilic methanogens and heterotrophs

James F. Holden, Harita Sistu

Front Microbiol. 2023; 14: 1093018. Published online 2023 Mar 6. doi: 10.3389/fmicb.2023.1093018

PMCID:: PMC10025317

Abstract Article PDF–3.1M

Select item 76140594.

A two-residue nascent strand steric gate controls synthesis of 2’-O-methyl- and 2’-O-(2-methoxyethyl)-RNA

Niklas Freund, Alexander I. Taylor, Sebastian Arangundy-Franklin, Nithya Subramanian, Sew-Yeu Peak-Chew, Amy M. Whitaker, Bret D. Freudenthal, Mikhail Abramov, Piet Herdewijn, Philipp Holliger

Nat Chem. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: Nat Chem. 2022 Oct 13 : 10.1038/s41557-022-01050-8. Published online 2022 Oct 13. doi: 10.1038/s41557-022-01050-8

PMCID:: PMC7614059

Abstract Article PDF–2.0M

Select item 95088185.

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid

Mohammad Hajjar, Nicholas Chim, Chao Liu, Piet Herdewijn, John C Chaput

Nucleic Acids Res. 2022 Sep 23; 50(17): 9663–9674. Published online 2022 Sep 17. doi: 10.1093/nar/gkac792

PMCID:: PMC9508818

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Select item 85997116.

Transliteration of synthetic genetic enzymes

Yajun Wang, Xiaolin Liu, Mouhamad Shehabat, Nicholas Chim, John C Chaput

Nucleic Acids Res. 2021 Nov 18; 49(20): 11438–11446. Published online 2021 Oct 11. doi: 10.1093/nar/gkab923

PMCID:: PMC8599711

Abstract Article PDF–2.4M

Select item 85965787.

Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase

Dr. Heike M. Kropp, Dr. Samra Ludmann, Dr. Kay Diederichs, Dr. Karin Betz, Dr. Andreas Marx

Chembiochem. 2021 Nov 3; 22(21): 3060–3066. Published online 2021 Sep 14. doi: 10.1002/cbic.202100306

PMCID:: PMC8596578

Abstract Article PDF–1.1M

Select item 80885168.

TK1211 Encodes an Amino Acid Racemase towards Leucine and Methionine in the Hyperthermophilic Archaeon Thermococcus kodakarensis

Ren-Chao Zheng, Xia-Feng Lu, Hiroya Tomita, Shin-ichi Hachisuka, Yu-Guo Zheng, Haruyuki Atomi

J Bacteriol. 2021 Apr; 203(7): e00617-20. Prepublished online 2021 Jan 19. Published online 2021 Mar 8. doi: 10.1128/JB.00617-20

PMCID:: PMC8088516

Abstract Article PDF–1.4M

Select item 71162879.

Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity

Gillian Houlihan, Sebastian Arangundy-Franklin, Benjamin T. Porebski, Nithya Subramanian, Alexander I. Taylor, Philipp Holliger

Nat Chem. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Nat Chem. 2020 Aug 1; 12(8): 683–690. Published online 2020 Jul 20. doi: 10.1038/s41557-020-0502-8

PMCID:: PMC7116287

Abstract Article PDF–2.9M

Select item 728192710.

The replication machinery of LUCA: common origin of DNA replication and transcription

Eugene V. Koonin, Mart Krupovic, Sonoko Ishino, Yoshizumi Ishino

BMC Biol. 2020; 18: 61. Published online 2020 Jun 9. doi: 10.1186/s12915-020-00800-9

PMCID:: PMC7281927

Abstract Article PDF–1.5M

Select item 675509111.

DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates

Victor S Lelyveld, Derek K O’Flaherty, Lijun Zhou, Enver Cagri Izgu, Jack W Szostak

Nucleic Acids Res. 2019 Sep 26; 47(17): 8941–8949. Published online 2019 Aug 20. doi: 10.1093/nar/gkz707

PMCID:: PMC6755091

Abstract Article PDF–2.6M

Select item 654604912.

Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

Alexander I. Taylor, Gillian Houlihan, Philipp Holliger

Cold Spring Harb Perspect Biol. 2019 Jun; 11(6): a032490. doi: 10.1101/cshperspect.a032490

PMCID:: PMC6546049

Abstract Article PDF–2.1M

Select item 694212613.

Fluorescence Activated Droplet Sorting for Single Cell Directed Evolution

Derek Vallejo, Ali Nikoomanzar, Brian M. Paegel, John Chaput

ACS Synth Biol. Author manuscript; available in PMC 2020 Jun 21.

Published in final edited form as: ACS Synth Biol. 2019 Jun 21; 8(6): 1430–1440. Published online 2019 May 23. doi: 10.1021/acssynbio.9b00103

PMCID:: PMC6942126

Abstract Article PDF–1.9M

Select item 654268114.

Encoded synthesis and evolution of alkyl-phosphonate nucleic acids: a synthetic genetic polymer with an uncharged backbone chemistry

Sebastian Arangundy-Franklin, Alexander I. Taylor, Benjamin T. Porebski, Vito Genna, Sew Peak-Chew, Alexandra Vaisman, Roger Woodgate, Modesto Orozco, Philipp Holliger

Nat Chem. Author manuscript; available in PMC 2019 Oct 22.

Published in final edited form as: Nat Chem. 2019 Apr 22; 11(6): 533–542. Published online 2019 Apr 22. doi: 10.1038/s41557-019-0255-4

PMCID:: PMC6542681

Abstract Article PDF–1.8M

Select item 654741915.

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

Elena Eremeeva, Antonios Fikatas, Lia Margamuljana, Mikhail Abramov, Dominique Schols, Elisabetta Groaz, Piet Herdewijn

Nucleic Acids Res. 2019 Jun 4; 47(10): 4927–4939. Published online 2019 Apr 10. doi: 10.1093/nar/gkz252

PMCID:: PMC6547419

Abstract Article PDF–4.4M

Select item 646369416.

Human DNA polymerase η has reverse transcriptase activity in cellular environments

Yan Su, Pratibha P. Ghodke, Martin Egli, Lin Li, Yinsheng Wang, F. Peter Guengerich

J Biol Chem. 2019 Apr 12; 294(15): 6073–6081. Published online 2019 Mar 6. doi: 10.1074/jbc.RA119.007925

PMCID:: PMC6463694

Abstract Article PDF–1.1M

Select item 626533417.

Evolution of a General RNA-Cleaving FANA Enzyme

Yajun Wang, Arlene K. Ngor, Ali Nikoomanzar, John C. Chaput

Nat Commun. 2018; 9: 5067. Published online 2018 Nov 29. doi: 10.1038/s41467-018-07611-1

PMCID:: PMC6265334

Abstract Article PDF–1.0M

Select item 587968418.

Noncatalytic aspartate at the exonuclease domain of proofreading DNA polymerases regulates both degradative and synthetic activities

Alicia del Prado, Elsa Franco-Echevarría, Beatriz González, Luis Blanco, Margarita Salas, Miguel de Vega

Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13): E2921–E2929. Published online 2018 Mar 12. doi: 10.1073/pnas.1718787115

PMCID:: PMC5879684

Abstract Article PDF–1.6M

Select item 593462419.

Darwin Assembly: fast, efficient, multi-site bespoke mutagenesis

Christopher Cozens, Vitor B Pinheiro

Nucleic Acids Res. 2018 May 4; 46(8): e51. Published online 2018 Feb 2. doi: 10.1093/nar/gky067

PMCID:: PMC5934624

Abstract Article PDF–1.3M

Select item 541857320.

Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme

Jiangyu Yan, Thomas R. Beattie, Adriana L. Rojas, Kelly Schermerhorn, Tamzin Gristwood, Jonathan C. Trinidad, Sonja V. Albers, Pietro Roversi, Andrew F. Gardner, Nicola G. A. Abrescia, Stephen D. Bell

Nat Commun. 2017; 8: 15075. Published online 2017 May 2. doi: 10.1038/ncomms15075

PMCID:: PMC5418573

Abstract Article PDF–2.2M

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txid71997[Organism:noexp] (100)
PMC
Mus musculus strain C57BL/6J chromosome 8, GRCm39
Mus musculus strain C57BL/6J chromosome 8, GRCm39
gi|1877089961|gnl|ASM:GCF_000000055 f|NC_000074.7||gpp|GPC_000007820.1||gnl|NCBI_GENOMES|76

Nucleotide
Homo sapiens Rho GTPase activating protein 44 (ARHGAP44), transcript variant 1, ...
Homo sapiens Rho GTPase activating protein 44 (ARHGAP44), transcript variant 1, mRNA
gi|1519314512|ref|NM_014859.6|

Nucleotide
GSE159923[ACCN] AND gsm[ETYP] (48)
GEO DataSets
Superfamily Member Links for Conserved Domains (Select 172864) (24)
Conserved Domains

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