Deoxyribonucleases, Type I Site-Specific
Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.
Year introduced: 1989
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Subheadings:
Tree Number(s): D08.811.150.280.250, D08.811.277.352.335.350.300.250, D08.811.277.352.355.325.300.250
MeSH Unique ID: D015253
Registry Number: EC 3.1.21.3
Entry Terms:
- Deoxyribonucleases, Type I Site Specific
- Deoxyribonucleases, Type I, Site-Specific
- Type I Site Specific Deoxyribonucleases
- Type I Site-Specific Deoxyribonucleases
- DNA Restriction Enzymes, Type I
- DNase, Site Specific, Type I
- Site-Specific DNase, Type I
- Site Specific DNase, Type I
- Type I Site Specific DNase
- Type I Site-Specific DNase
- DNase, Site-Specific, Type I
- Restriction Endonucleases, Type I
- Deoxyribonucleases, Type I, Site Specific
- Type I Restriction Enzymes
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