Folic Acid Antagonists

Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)

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Tree Number(s): D27.505.519.389.350

MeSH Unique ID: D005493

Entry Terms:

• Acid Antagonists, Folic
• Antagonists, Folic Acid
• Folic Acid Antagonist
• Acid Antagonist, Folic
• Antagonist, Folic Acid
• Antifolate
• Dihydrofolate Reductase Inhibitor
• Inhibitor, Dihydrofolate Reductase
• Reductase Inhibitor, Dihydrofolate
• Antifolates
• Dihydrofolate Reductase Inhibitors
• Inhibitors, Dihydrofolate Reductase
• Reductase Inhibitors, Dihydrofolate
• Folic Acid Metabolism Inhibitors

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Chemicals and Drugs Category
Chemical Actions and Uses
Pharmacologic Actions
Molecular Mechanisms of Pharmacological Action
Enzyme Inhibitors
Folic Acid Antagonists