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Viral hemorrhagic fever

MedGen UID:
9213
•Concept ID:
C0019104
•
Disease or Syndrome
Synonyms: Fever, Viral Hemorrhagic; Fevers, Viral Hemorrhagic; Hemorrhagic Fever, Viral; Hemorrhagic Fevers, Viral; Viral Hemorrhagic Fever; Viral Hemorrhagic Fevers
SNOMED CT: VHF - Viral hemorrhagic fever (240523007); Viral hemorrhagic fever (240523007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018087
Orphanet: ORPHA341

Definition

Viral hemorrhagic fever is a group of recently discovered contagious viral infections characterized by severe, multiple, and often fatal hemorrhages. African fevers include Lassa fever discovered in 1969, Marburg's disease that first occurred in 1967, and Ebola fever that appeared in 1976. Other viruses may also cause hemorrhagic fevers (for example, arbovirus fever). [from ORDO]

Professional guidelines

PubMed

Management of Hemorrhagic Fever Viruses: Intervention of Natural and Synthetic Products.
Lashgari NA, Roudsari NM, Khayatan D, Samani N, Eskandari Rad N, Mortazavi M, Abdolghaffari AH, Momtaz S
Mini Rev Med Chem 2023;23(15):1575-1589. doi: 10.2174/1389557523666230202111337. PMID: 36733245
Editorial: Antibody Therapeutics for the Treatment of Filoviral Infection.
Murin CD, Gunn BM, Parren PWHI, Kobinger GP
Front Immunol 2022;13:859919. Epub 2022 Feb 18 doi: 10.3389/fimmu.2022.859919. PMID: 35251051Free PMC Article
Evidence-Based Clinical Management of Ebola Virus Disease and Epidemic Viral Hemorrhagic Fevers.
Clément C, Adhikari NKJ, Lamontagne F
Infect Dis Clin North Am 2019 Mar;33(1):247-264. doi: 10.1016/j.idc.2018.10.013. PMID: 30712765

Recent clinical studies

Etiology

Perspectives on Advancing Countermeasures for Filovirus Disease: Report From a Multisector Meeting.
Sprecher A, Cross R, Marzi A, Martins KA, Wolfe D, Montgomery JM, Spiropoulou CF, Cihlar T, Ahuka-Mundeke S, Nyhuis T, Teicher C, Crozier I, Strong J, Kobinger G, Woolsey C, Geisbert TW, Feldmann H, Muyembe JJ
J Infect Dis 2023 Nov 13;228(Suppl 7):S474-S478. doi: 10.1093/infdis/jiad354. PMID: 37596837Free PMC Article
Yellow Fever: A Perennial Threat.
Tuells J, Henao-Martínez AF, Franco-Paredes C
Arch Med Res 2022 Nov;53(7):649-657. Epub 2022 Oct 28 doi: 10.1016/j.arcmed.2022.10.005. PMID: 36404585
Rift Valley Fever Outbreak during COVID-19 Surge, Uganda, 2021.
Cossaboom CM, Nyakarahuka L, Mulei S, Kyondo J, Tumusiime A, Baluku J, Akurut GG, Namanya D, Kamugisha K, Nansikombi HT, Nyabakira A, Mutesasira S, Whitmer S, Telford C, Lutwama J, Balinandi S, Montgomery J, Klena JD, Shoemaker T
Emerg Infect Dis 2022 Nov;28(11):2290-2293. Epub 2022 Sep 23 doi: 10.3201/eid2811.220364. PMID: 36150455Free PMC Article
High-throughput screening for negative-stranded hemorrhagic fever viruses using reverse genetics.
Wendt L, Bostedt L, Hoenen T, Groseth A
Antiviral Res 2019 Oct;170:104569. Epub 2019 Jul 26 doi: 10.1016/j.antiviral.2019.104569. PMID: 31356830
Exotic emerging viral diseases: progress and challenges.
Geisbert TW, Jahrling PB
Nat Med 2004 Dec;10(12 Suppl):S110-21. doi: 10.1038/nm1142. PMID: 15577929

Diagnosis

Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus-Based Vaccines.
Stein DR, Sroga P, Warner BM, Deschambault Y, Poliquin G, Safronetz D
Emerg Infect Dis 2019 Aug;25(8):1563-1566. Epub 2019 Aug 17 doi: 10.3201/eid2508.190281. PMID: 31141474Free PMC Article
Ebola Virus Disease: An Update on Epidemiology, Symptoms, Laboratory Findings, Diagnostic Issues, and Infection Prevention and Control Issues for Laboratory Professionals.
Brown CS, Mepham S, Shorten RJ
Clin Lab Med 2017 Jun;37(2):269-284. doi: 10.1016/j.cll.2017.01.003. PMID: 28457350
Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity.
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M
Antiviral Res 2013 Oct;100(1):159-89. Epub 2013 Jul 29 doi: 10.1016/j.antiviral.2013.07.006. PMID: 23906741
Mosquito-borne hemorrhagic fevers.
Lupi O
Dermatol Clin 2011 Jan;29(1):33-8. doi: 10.1016/j.det.2010.09.009. PMID: 21095525
Exotic emerging viral diseases: progress and challenges.
Geisbert TW, Jahrling PB
Nat Med 2004 Dec;10(12 Suppl):S110-21. doi: 10.1038/nm1142. PMID: 15577929

Therapy

Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections.
Okogbenin S, Erameh C, Okoeguale J, Edeawe O, Ekuaze E, Iraoyah K, Agho J, Groger M, Kreuels B, Oestereich L, Babatunde FO, Akhideno P, Günther S, Ramharter M, Omansen T
Emerg Infect Dis 2022 Oct;28(10):2060-2063. doi: 10.3201/eid2810.220625. PMID: 36148915Free PMC Article
Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus-Based Vaccines.
Stein DR, Sroga P, Warner BM, Deschambault Y, Poliquin G, Safronetz D
Emerg Infect Dis 2019 Aug;25(8):1563-1566. Epub 2019 Aug 17 doi: 10.3201/eid2508.190281. PMID: 31141474Free PMC Article
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.
Arts RJW, Moorlag SJCFM, Novakovic B, Li Y, Wang SY, Oosting M, Kumar V, Xavier RJ, Wijmenga C, Joosten LAB, Reusken CBEM, Benn CS, Aaby P, Koopmans MP, Stunnenberg HG, van Crevel R, Netea MG
Cell Host Microbe 2018 Jan 10;23(1):89-100.e5. doi: 10.1016/j.chom.2017.12.010. PMID: 29324233
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever.
Mire CE, Cross RW, Geisbert JB, Borisevich V, Agans KN, Deer DJ, Heinrich ML, Rowland MM, Goba A, Momoh M, Boisen ML, Grant DS, Fullah M, Khan SH, Fenton KA, Robinson JE, Branco LM, Garry RF, Geisbert TW
Nat Med 2017 Oct;23(10):1146-1149. Epub 2017 Sep 4 doi: 10.1038/nm.4396. PMID: 28869611Free PMC Article
Molecular mechanisms of Ebola pathogenesis.
Rivera A, Messaoudi I
J Leukoc Biol 2016 Nov;100(5):889-904. Epub 2016 Sep 1 doi: 10.1189/jlb.4RI0316-099RR. PMID: 27587404Free PMC Article

Prognosis

The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.
Oude Munnink BB, Worp N, Nieuwenhuijse DF, Sikkema RS, Haagmans B, Fouchier RAM, Koopmans M
Nat Med 2021 Sep;27(9):1518-1524. Epub 2021 Sep 9 doi: 10.1038/s41591-021-01472-w. PMID: 34504335
Untangling introductions and persistence in COVID-19 resurgence in Europe.
Lemey P, Ruktanonchai N, Hong SL, Colizza V, Poletto C, Van den Broeck F, Gill MS, Ji X, Levasseur A, Oude Munnink BB, Koopmans M, Sadilek A, Lai S, Tatem AJ, Baele G, Suchard MA, Dellicour S
Nature 2021 Jul;595(7869):713-717. Epub 2021 Jun 30 doi: 10.1038/s41586-021-03754-2. PMID: 34192736Free PMC Article
Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus-Based Vaccines.
Stein DR, Sroga P, Warner BM, Deschambault Y, Poliquin G, Safronetz D
Emerg Infect Dis 2019 Aug;25(8):1563-1566. Epub 2019 Aug 17 doi: 10.3201/eid2508.190281. PMID: 31141474Free PMC Article
Annual Incidence of Lassa Virus Infection in Southern Mali.
Safronetz D, Sogoba N, Diawara SI, Bane S, Rosenke K, Maiga O, Boisen M, Garry RF, Branco LM, Lindsay LR, Traoré SF, Feldmann H, Doumbia S
Am J Trop Med Hyg 2017 Apr;96(4):944-946. Epub 2017 Jan 16 doi: 10.4269/ajtmh.16-0821. PMID: 28093544Free PMC Article
The Pathogenesis of Ebola Virus Disease.
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626

Clinical prediction guides

Propagation of Activated B Cells by In Vitro Severe Fever With Thrombocytopenia Syndrome Virus Infection of Human Peripheral Blood Mononuclear Cells.
Wada Y, Miyamoto S, Iida S, Sano K, Sato Y, Ainai A, Saito K, Katano H, Hasegawa H, Suzuki T
J Infect Dis 2022 Jan 18;225(2):269-281. doi: 10.1093/infdis/jiab343. PMID: 34223910
The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.
Oude Munnink BB, Worp N, Nieuwenhuijse DF, Sikkema RS, Haagmans B, Fouchier RAM, Koopmans M
Nat Med 2021 Sep;27(9):1518-1524. Epub 2021 Sep 9 doi: 10.1038/s41591-021-01472-w. PMID: 34504335
Development of a Pediatric Ebola Predictive Score, Sierra Leone(1).
Fitzgerald F, Wing K, Naveed A, Gbessay M, Ross JCG, Checchi F, Youkee D, Jalloh MB, Baion DE, Mustapha A, Jah H, Lako S, Oza S, Boufkhed S, Feury R, Bielicki J, Williamson E, Gibb DM, Klein N, Sahr F, Yeung S
Emerg Infect Dis 2018 Feb;24(2):311-319. doi: 10.3201/eid2402.171018. PMID: 29350145Free PMC Article
The Pathogenesis of Ebola Virus Disease.
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626
Meta-analysis of high-throughput datasets reveals cellular responses following hemorrhagic fever virus infection.
Bowick GC, McAuley AJ
Viruses 2011 May;3(5):613-9. Epub 2011 May 12 doi: 10.3390/v3050613. PMID: 21994748Free PMC Article

Recent systematic reviews

Risk factors associated with sustained circulation of six zoonotic arboviruses: a systematic review for selection of surveillance sites in non-endemic areas.
Esser HJ, Mögling R, Cleton NB, van der Jeugd H, Sprong H, Stroo A, Koopmans MPG, de Boer WF, Reusken CBEM
Parasit Vectors 2019 May 27;12(1):265. doi: 10.1186/s13071-019-3515-7. PMID: 31133059Free PMC Article
Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers.
Ergönül Ö, Keske Ş, Çeldir MG, Kara İA, Pshenichnaya N, Abuova G, Blumberg L, Gönen M
Emerg Infect Dis 2018 Sep;24(9):1642-1648. doi: 10.3201/eid2409.171709. PMID: 30124196Free PMC Article
Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.
Pshenichnaya NY, Leblebicioglu H, Bozkurt I, Sannikova IV, Abuova GN, Zhuravlev AS, Barut S, Shermetova MB, Fletcher TE
Int J Infect Dis 2017 May;58:58-64. Epub 2017 Feb 27 doi: 10.1016/j.ijid.2017.02.019. PMID: 28249811Free PMC Article

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