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Estrogen-receptor positive breast cancer

MedGen UID:
1843470
•Concept ID:
C2938924
•
Neoplastic Process
Synonyms: ER+ breast cancer; estrogen receptor positive breast cancer; estrogen-receptor positive breast cancer; oestrogen receptor positive breast cancer
 
Monarch Initiative: MONDO:0006512

Definition

A subtype of breast cancer that is estrogen-receptor positive [from MONDO]

Professional guidelines

PubMed

Clinical management and biology of tumor dormancy in breast cancer.
Werner S, Heidrich I, Pantel K
Semin Cancer Biol 2022 Jan;78:49-62. Epub 2021 Feb 11 doi: 10.1016/j.semcancer.2021.02.001. PMID: 33582172
Estrogen receptor-positive (ER(+)) breast cancer treatment: Are multi-target compounds the next promising approach?
Ferreira Almeida C, Oliveira A, João Ramos M, Fernandes PA, Teixeira N, Amaral C
Biochem Pharmacol 2020 Jul;177:113989. Epub 2020 Apr 21 doi: 10.1016/j.bcp.2020.113989. PMID: 32330493
Osteoporosis management in patients with breast cancer: EMAS position statement.
Trémollieres FA, Ceausu I, Depypere H, Lambrinoudaki I, Mueck A, Pérez-López FR, van der Schouw YT, Senturk LM, Simoncini T, Stevenson JC, Stute P, Rees M
Maturitas 2017 Jan;95:65-71. Epub 2016 Oct 6 doi: 10.1016/j.maturitas.2016.10.007. PMID: 27802892

Recent clinical studies

Therapy

Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study.
Wei Z, Yang B, Tang T, Xiao Z, Ye F, Li X, Wu S, Huang JG, Jiang S
Cancer Med 2023 May;12(9):10393-10405. Epub 2023 Mar 7 doi: 10.1002/cam4.5772. PMID: 36880394Free PMC Article
Causes and Consequences of Polycystic Ovary Syndrome: Insights From Mendelian Randomization.
Zhu T, Goodarzi MO
J Clin Endocrinol Metab 2022 Feb 17;107(3):e899-e911. doi: 10.1210/clinem/dgab757. PMID: 34669940Free PMC Article
Neoadjuvant Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-analysis.
Spring LM, Gupta A, Reynolds KL, Gadd MA, Ellisen LW, Isakoff SJ, Moy B, Bardia A
JAMA Oncol 2016 Nov 1;2(11):1477-1486. doi: 10.1001/jamaoncol.2016.1897. PMID: 27367583Free PMC Article
The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer.
Kwa M, Plottel CS, Blaser MJ, Adams S
J Natl Cancer Inst 2016 Aug;108(8) Epub 2016 Apr 22 doi: 10.1093/jnci/djw029. PMID: 27107051Free PMC Article
Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs.
Yang G, Nowsheen S, Aziz K, Georgakilas AG
Pharmacol Ther 2013 Sep;139(3):392-404. Epub 2013 May 24 doi: 10.1016/j.pharmthera.2013.05.005. PMID: 23711794

Prognosis

Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study.
Wei Z, Yang B, Tang T, Xiao Z, Ye F, Li X, Wu S, Huang JG, Jiang S
Cancer Med 2023 May;12(9):10393-10405. Epub 2023 Mar 7 doi: 10.1002/cam4.5772. PMID: 36880394Free PMC Article
The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer.
Hickey TE, Selth LA, Chia KM, Laven-Law G, Milioli HH, Roden D, Jindal S, Hui M, Finlay-Schultz J, Ebrahimie E, Birrell SN, Stelloo S, Iggo R, Alexandrou S, Caldon CE, Abdel-Fatah TM, Ellis IO, Zwart W, Palmieri C, Sartorius CA, Swarbrick A, Lim E, Carroll JS, Tilley WD
Nat Med 2021 Feb;27(2):310-320. Epub 2021 Jan 18 doi: 10.1038/s41591-020-01168-7. PMID: 33462444
The Genetic Landscape and Clonal Evolution of Breast Cancer Resistance to Palbociclib plus Fulvestrant in the PALOMA-3 Trial.
O'Leary B, Cutts RJ, Liu Y, Hrebien S, Huang X, Fenwick K, André F, Loibl S, Loi S, Garcia-Murillas I, Cristofanilli M, Huang Bartlett C, Turner NC
Cancer Discov 2018 Nov;8(11):1390-1403. Epub 2018 Sep 11 doi: 10.1158/2159-8290.CD-18-0264. PMID: 30206110Free PMC Article
Neoadjuvant Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-analysis.
Spring LM, Gupta A, Reynolds KL, Gadd MA, Ellisen LW, Isakoff SJ, Moy B, Bardia A
JAMA Oncol 2016 Nov 1;2(11):1477-1486. doi: 10.1001/jamaoncol.2016.1897. PMID: 27367583Free PMC Article
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, Hiller W, Fisher ER, Wickerham DL, Bryant J, Wolmark N
N Engl J Med 2004 Dec 30;351(27):2817-26. Epub 2004 Dec 10 doi: 10.1056/NEJMoa041588. PMID: 15591335

Clinical prediction guides

Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study.
Wei Z, Yang B, Tang T, Xiao Z, Ye F, Li X, Wu S, Huang JG, Jiang S
Cancer Med 2023 May;12(9):10393-10405. Epub 2023 Mar 7 doi: 10.1002/cam4.5772. PMID: 36880394Free PMC Article
Causes and Consequences of Polycystic Ovary Syndrome: Insights From Mendelian Randomization.
Zhu T, Goodarzi MO
J Clin Endocrinol Metab 2022 Feb 17;107(3):e899-e911. doi: 10.1210/clinem/dgab757. PMID: 34669940Free PMC Article
Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review.
Pandey K, An HJ, Kim SK, Lee SA, Kim S, Lim SM, Kim GM, Sohn J, Moon YW
Int J Cancer 2019 Sep 1;145(5):1179-1188. Epub 2019 Jan 7 doi: 10.1002/ijc.32020. PMID: 30478914Free PMC Article
Neoadjuvant Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-analysis.
Spring LM, Gupta A, Reynolds KL, Gadd MA, Ellisen LW, Isakoff SJ, Moy B, Bardia A
JAMA Oncol 2016 Nov 1;2(11):1477-1486. doi: 10.1001/jamaoncol.2016.1897. PMID: 27367583Free PMC Article
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, Hiller W, Fisher ER, Wickerham DL, Bryant J, Wolmark N
N Engl J Med 2004 Dec 30;351(27):2817-26. Epub 2004 Dec 10 doi: 10.1056/NEJMoa041588. PMID: 15591335

Recent systematic reviews

Value of the 21-gene expression assay in predicting locoregional recurrence rates in estrogen receptor-positive breast cancer: a systematic review and network meta-analysis.
Davey MG, Cleere EF, O'Donnell JP, Gaisor S, Lowery AJ, Kerin MJ
Breast Cancer Res Treat 2022 Jun;193(3):535-544. Epub 2022 Apr 15 doi: 10.1007/s10549-022-06580-w. PMID: 35426541Free PMC Article
Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies.
Karasneh RA, Murray LJ, Cardwell CR
Int J Cancer 2017 Mar 1;140(5):1035-1041. Epub 2016 Nov 27 doi: 10.1002/ijc.30520. PMID: 27861859
Neoadjuvant Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-analysis.
Spring LM, Gupta A, Reynolds KL, Gadd MA, Ellisen LW, Isakoff SJ, Moy B, Bardia A
JAMA Oncol 2016 Nov 1;2(11):1477-1486. doi: 10.1001/jamaoncol.2016.1897. PMID: 27367583Free PMC Article
Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Zhang Y, Wang Y, Wan Z, Liu S, Cao Y, Zeng Z
PLoS One 2014;9(2):e90362. Epub 2014 Feb 27 doi: 10.1371/journal.pone.0090362. PMID: 24587339Free PMC Article
mTOR inhibitors in breast cancer: a systematic review.
Zagouri F, Sergentanis TN, Chrysikos D, Filipits M, Bartsch R
Gynecol Oncol 2012 Dec;127(3):662-72. Epub 2012 Sep 9 doi: 10.1016/j.ygyno.2012.08.040. PMID: 22967800

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