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Shigellosis

MedGen UID:
8513
•Concept ID:
C0013371
•
Disease or Syndrome
Synonyms: Dysenteries, Shigella; Dysentery, Shigella; Infection, Shigella; Infections, Shigella; Shigella Dysenteries; Shigella Dysentery; Shigella Infection; Shigella Infections
SNOMED CT: Shigella dysentery (36188001); Infection by Shigella (111817006); Infection caused by Shigella (111817006); Shigellosis (36188001); Shigella gastroenteritis (36188001); Japanese dysentery (36188001); Flexner's dysentery (36188001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019345
Orphanet: ORPHA810

Definition

Shigellosis is a bacterial infection leading to dysentery and is caused by <i>Shigella</i>, which are small, ubiquitous Gram-negative bacteria belonging to the enterobacteria family. There are four species: <i>S. dysenteriae</i>, <i>S. flexneri</i>, <i>S. boydii</i> and <i>S. sonnei</i>, all of which cause bacillary dysentery and are strictly limited to human hosts. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShigellosis
Follow this link to review classifications for Shigellosis in Orphanet.

Professional guidelines

PubMed

2021 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens.
de Vries HJC, Nori AV, Kiellberg Larsen H, Kreuter A, Padovese V, Pallawela S, Vall-Mayans M, Ross J
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1434-1443. Epub 2021 May 31 doi: 10.1111/jdv.17269. PMID: 34057249
Acute diarrhea with blood: diagnosis and drug treatment.
da Cruz Gouveia MA, Lins MTC, da Silva GAP
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):20-28. Epub 2019 Oct 8 doi: 10.1016/j.jped.2019.08.006. PMID: 31604059Free PMC Article
Acute diarrhea: evidence-based management.
Brandt KG, Castro Antunes MM, Silva GA
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S36-43. Epub 2015 Sep 6 doi: 10.1016/j.jped.2015.06.002. PMID: 26351768

Recent clinical studies

Etiology

Molecular Mechanisms of Shigella Pathogenesis; Recent Advances.
Pakbin B, Brück WM, Brück TB
Int J Mol Sci 2023 Jan 26;24(3) doi: 10.3390/ijms24032448. PMID: 36768771Free PMC Article
2021 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens.
de Vries HJC, Nori AV, Kiellberg Larsen H, Kreuter A, Padovese V, Pallawela S, Vall-Mayans M, Ross J
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1434-1443. Epub 2021 May 31 doi: 10.1111/jdv.17269. PMID: 34057249
Enteropathogens and antibiotics.
González-Torralba A, García-Esteban C, Alós JI
Enferm Infecc Microbiol Clin (Engl Ed) 2018 Jan;36(1):47-54. Epub 2015 Aug 12 doi: 10.1016/j.eimc.2015.06.015. PMID: 26277207
HIV and diarrhoea: what is new?
Logan C, Beadsworth MB, Beeching NJ
Curr Opin Infect Dis 2016 Oct;29(5):486-94. doi: 10.1097/QCO.0000000000000305. PMID: 27472290
Acute diarrhea.
Barr W, Smith A
Am Fam Physician 2014 Feb 1;89(3):180-9. PMID: 24506120

Diagnosis

2021 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens.
de Vries HJC, Nori AV, Kiellberg Larsen H, Kreuter A, Padovese V, Pallawela S, Vall-Mayans M, Ross J
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1434-1443. Epub 2021 May 31 doi: 10.1111/jdv.17269. PMID: 34057249
Shigella sonnei: virulence and antibiotic resistance.
Shad AA, Shad WA
Arch Microbiol 2021 Jan;203(1):45-58. Epub 2020 Sep 14 doi: 10.1007/s00203-020-02034-3. PMID: 32929595Free PMC Article
Acute diarrhea with blood: diagnosis and drug treatment.
da Cruz Gouveia MA, Lins MTC, da Silva GAP
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):20-28. Epub 2019 Oct 8 doi: 10.1016/j.jped.2019.08.006. PMID: 31604059Free PMC Article
Shigellosis.
Kotloff KL, Riddle MS, Platts-Mills JA, Pavlinac P, Zaidi AKM
Lancet 2018 Feb 24;391(10122):801-812. Epub 2017 Dec 16 doi: 10.1016/S0140-6736(17)33296-8. PMID: 29254859
Acute diarrhea.
Barr W, Smith A
Am Fam Physician 2014 Feb 1;89(3):180-9. PMID: 24506120

Therapy

Expansion of Escherichia-Shigella in Gut Is Associated with the Onset and Response to Immunosuppressive Therapy of IgA Nephropathy.
Zhao J, Bai M, Ning X, Qin Y, Wang Y, Yu Z, Dong R, Zhang Y, Sun S
J Am Soc Nephrol 2022 Dec;33(12):2276-2292. Epub 2022 Aug 30 doi: 10.1681/ASN.2022020189. PMID: 36041791Free PMC Article
Enteropathogens and antibiotics.
González-Torralba A, García-Esteban C, Alós JI
Enferm Infecc Microbiol Clin (Engl Ed) 2018 Jan;36(1):47-54. Epub 2015 Aug 12 doi: 10.1016/j.eimc.2015.06.015. PMID: 26277207
Shigellosis.
Burnett MW
J Spec Oper Med 2017 Winter;17(4):102-103. doi: 10.55460/2PLM-RQTR. PMID: 29256205
Acute diarrhea: evidence-based management.
Brandt KG, Castro Antunes MM, Silva GA
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S36-43. Epub 2015 Sep 6 doi: 10.1016/j.jped.2015.06.002. PMID: 26351768
Acute diarrhea.
Barr W, Smith A
Am Fam Physician 2014 Feb 1;89(3):180-9. PMID: 24506120

Prognosis

Expansion of Escherichia-Shigella in Gut Is Associated with the Onset and Response to Immunosuppressive Therapy of IgA Nephropathy.
Zhao J, Bai M, Ning X, Qin Y, Wang Y, Yu Z, Dong R, Zhang Y, Sun S
J Am Soc Nephrol 2022 Dec;33(12):2276-2292. Epub 2022 Aug 30 doi: 10.1681/ASN.2022020189. PMID: 36041791Free PMC Article
Shigellosis in Poland in 2018-2019.
Nowacka Z, Księżak E, Polański P, Sadkowska-Todys M
Przegl Epidemiol 2022;76(1):118-128. doi: 10.32394/pe.76.12. PMID: 35861099
HIV and diarrhoea: what is new?
Logan C, Beadsworth MB, Beeching NJ
Curr Opin Infect Dis 2016 Oct;29(5):486-94. doi: 10.1097/QCO.0000000000000305. PMID: 27472290
Acute diarrhea: evidence-based management.
Brandt KG, Castro Antunes MM, Silva GA
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S36-43. Epub 2015 Sep 6 doi: 10.1016/j.jped.2015.06.002. PMID: 26351768
The Shigella human challenge model.
Porter CK, Thura N, Ranallo RT, Riddle MS
Epidemiol Infect 2013 Feb;141(2):223-32. Epub 2012 Aug 21 doi: 10.1017/S0950268812001677. PMID: 22906296Free PMC Article

Clinical prediction guides

Ascorbate deficiency increases progression of shigellosis in guinea pigs and mice infection models.
Skerniskyte J, Mulet C, André AC, Anderson MC, Injarabian L, Buck A, Prade VM, Sansonetti PJ, Reibel-Foisset S, Walch AK, Lebel M, Lykkesfeldt J, Marteyn BS
Gut Microbes 2023 Dec;15(2):2271597. Epub 2023 Oct 24 doi: 10.1080/19490976.2023.2271597. PMID: 37876025Free PMC Article
The evolution and international spread of extensively drug resistant Shigella sonnei.
Mason LCE, Greig DR, Cowley LA, Partridge SR, Martinez E, Blackwell GA, Chong CE, De Silva PM, Bengtsson RJ, Draper JL, Ginn AN, Sandaradura I, Sim EM, Iredell JR, Sintchenko V, Ingle DJ, Howden BP, Lefèvre S, Njamkepo E, Weill FX, Ceyssens PJ, Jenkins C, Baker KS
Nat Commun 2023 Apr 8;14(1):1983. doi: 10.1038/s41467-023-37672-w. PMID: 37031199Free PMC Article
Expansion of Escherichia-Shigella in Gut Is Associated with the Onset and Response to Immunosuppressive Therapy of IgA Nephropathy.
Zhao J, Bai M, Ning X, Qin Y, Wang Y, Yu Z, Dong R, Zhang Y, Sun S
J Am Soc Nephrol 2022 Dec;33(12):2276-2292. Epub 2022 Aug 30 doi: 10.1681/ASN.2022020189. PMID: 36041791Free PMC Article
Shigella flexneri: an emerging pathogen.
Nisa I, Qasim M, Yasin N, Ullah R, Ali A
Folia Microbiol (Praha) 2020 Apr;65(2):275-291. Epub 2020 Feb 5 doi: 10.1007/s12223-020-00773-w. PMID: 32026288
Update on molecular epidemiology of Shigella infection.
Lima IF, Havt A, Lima AA
Curr Opin Gastroenterol 2015 Jan;31(1):30-7. doi: 10.1097/MOG.0000000000000136. PMID: 25394237

Recent systematic reviews

A systematic review of neglected tropical diseases (NTDs) in Myanmar.
Swe MMM, Phyo AP, Cooper BS, White NJ, Smithuis F, Ashley EA
PLoS Negl Trop Dis 2023 Nov;17(11):e0011706. Epub 2023 Nov 1 doi: 10.1371/journal.pntd.0011706. PMID: 37910592Free PMC Article
Shigellosis in Southeast Asia: A systematic review and meta-analysis.
Muzembo BA, Kitahara K, Mitra D, Ohno A, Khatiwada J, Dutta S, Miyoshi SI
Travel Med Infect Dis 2023 Mar-Apr;52:102554. Epub 2023 Feb 16 doi: 10.1016/j.tmaid.2023.102554. PMID: 36792021
Associations between ambient temperature and enteric infections by pathogen: a systematic review and meta-analysis.
Chua PLC, Ng CFS, Tobias A, Seposo XT, Hashizume M
Lancet Planet Health 2022 Mar;6(3):e202-e218. doi: 10.1016/S2542-5196(22)00003-1. PMID: 35278387
The Shigella human challenge model.
Porter CK, Thura N, Ranallo RT, Riddle MS
Epidemiol Infect 2013 Feb;141(2):223-32. Epub 2012 Aug 21 doi: 10.1017/S0950268812001677. PMID: 22906296Free PMC Article
Causative species and serotypes of shigellosis in mainland China: systematic review and meta-analysis.
Chang Z, Lu S, Chen L, Jin Q, Yang J
PLoS One 2012;7(12):e52515. Epub 2012 Dec 20 doi: 10.1371/journal.pone.0052515. PMID: 23285073Free PMC Article

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