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Impaired cytokine signaling

MedGen UID:
1612622
•Concept ID:
C4531144
•
Finding
Synonyms: Cytokine signaling defect; Cytokine signalling defect; Impaired cytokine signalling
 
HPO: HP:0031407

Definition

A defect or impairment in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired cytokine signaling

Professional guidelines

PubMed

Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment.
Bisgaard TH, Allin KH, Keefer L, Ananthakrishnan AN, Jess T
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):717-726. Epub 2022 Jun 22 doi: 10.1038/s41575-022-00634-6. PMID: 35732730
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome.
Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L, Liu C, Yang D, Song J, Rech JC, Guo Y, Wang H, Zhao G, Liang W, Koike Y, Lu H, Koike T, Hayek T, Pennathur S, Xi C, Wen B, Sun D, Garcia-Barrio MT, Aviram M, Gottlieb E, Mor I, Liu W, Zhang J, Chen YE
Sci Transl Med 2020 Dec 2;12(572) doi: 10.1126/scitranslmed.aaz2841. PMID: 33268508Free PMC Article
Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights.
Baltzis D, Eleftheriadou I, Veves A
Adv Ther 2014 Aug;31(8):817-36. Epub 2014 Jul 29 doi: 10.1007/s12325-014-0140-x. PMID: 25069580

Recent clinical studies

Etiology

Arming CAR-T cells with cytokines and more: Innovations in the fourth-generation CAR-T development.
Tang L, Pan S, Wei X, Xu X, Wei Q
Mol Ther 2023 Nov 1;31(11):3146-3162. Epub 2023 Oct 5 doi: 10.1016/j.ymthe.2023.09.021. PMID: 37803832Free PMC Article
Association between obesity, inflammation and insulin resistance: Insights into signaling pathways and therapeutic interventions.
Suren Garg S, Kushwaha K, Dubey R, Gupta J
Diabetes Res Clin Pract 2023 Jun;200:110691. Epub 2023 May 6 doi: 10.1016/j.diabres.2023.110691. PMID: 37150407
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.
Incalza MA, D'Oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F
Vascul Pharmacol 2018 Jan;100:1-19. Epub 2017 Jun 1 doi: 10.1016/j.vph.2017.05.005. PMID: 28579545
Insulin Resistance, Obesity and Lipotoxicity.
Yazıcı D, Sezer H
Adv Exp Med Biol 2017;960:277-304. doi: 10.1007/978-3-319-48382-5_12. PMID: 28585204
Physiological and pathological cardiac hypertrophy.
Shimizu I, Minamino T
J Mol Cell Cardiol 2016 Aug;97:245-62. Epub 2016 Jun 2 doi: 10.1016/j.yjmcc.2016.06.001. PMID: 27262674

Diagnosis

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.
Marzio A, Kurz E, Sahni JM, Di Feo G, Puccini J, Jiang S, Hirsch CA, Arbini AA, Wu WL, Pass HI, Bar-Sagi D, Papagiannakopoulos T, Pagano M
Cell 2022 Jan 6;185(1):169-183.e19. Epub 2021 Dec 27 doi: 10.1016/j.cell.2021.12.005. PMID: 34963055Free PMC Article
Fibrous Dysplasia of Bone and McCune-Albright Syndrome: A Bench to Bedside Review.
Hartley I, Zhadina M, Collins MT, Boyce AM
Calcif Tissue Int 2019 May;104(5):517-529. Epub 2019 Apr 29 doi: 10.1007/s00223-019-00550-z. PMID: 31037426Free PMC Article
Developmental pathways in the pathogenesis of lung fibrosis.
Chanda D, Otoupalova E, Smith SR, Volckaert T, De Langhe SP, Thannickal VJ
Mol Aspects Med 2019 Feb;65:56-69. Epub 2018 Aug 23 doi: 10.1016/j.mam.2018.08.004. PMID: 30130563Free PMC Article
Physiological and pathological cardiac hypertrophy.
Shimizu I, Minamino T
J Mol Cell Cardiol 2016 Aug;97:245-62. Epub 2016 Jun 2 doi: 10.1016/j.yjmcc.2016.06.001. PMID: 27262674
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
Ceni E, Mello T, Galli A
World J Gastroenterol 2014 Dec 21;20(47):17756-72. doi: 10.3748/wjg.v20.i47.17756. PMID: 25548474Free PMC Article

Therapy

Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy.
Fumagalli G, Monza L, Cavaletti G, Rigolio R, Meregalli C
Front Immunol 2020;11:626687. Epub 2021 Feb 4 doi: 10.3389/fimmu.2020.626687. PMID: 33613570Free PMC Article
The role of IL-1β and TNF-α in intervertebral disc degeneration.
Wang Y, Che M, Xin J, Zheng Z, Li J, Zhang S
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Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing.
Patel S, Srivastava S, Singh MR, Singh D
Biomed Pharmacother 2019 Apr;112:108615. Epub 2019 Feb 20 doi: 10.1016/j.biopha.2019.108615. PMID: 30784919
Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.
Jin X, Liu MY, Zhang DF, Zhong X, Du K, Qian P, Yao WF, Gao H, Wei MJ
CNS Neurosci Ther 2019 May;25(5):575-590. Epub 2019 Jan 24 doi: 10.1111/cns.13086. PMID: 30676698Free PMC Article
LAG3 (CD223) as a cancer immunotherapy target.
Andrews LP, Marciscano AE, Drake CG, Vignali DA
Immunol Rev 2017 Mar;276(1):80-96. doi: 10.1111/imr.12519. PMID: 28258692Free PMC Article

Prognosis

FGF19/FGFR4-mediated elevation of ETV4 facilitates hepatocellular carcinoma metastasis by upregulating PD-L1 and CCL2.
Xie M, Lin Z, Ji X, Luo X, Zhang Z, Sun M, Chen X, Zhang B, Liang H, Liu D, Feng Y, Wang Y, Li Y, Liu B, Huang W, Xia L
J Hepatol 2023 Jul;79(1):109-125. Epub 2023 Mar 11 doi: 10.1016/j.jhep.2023.02.036. PMID: 36907560
cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers.
Hong C, Schubert M, Tijhuis AE, Requesens M, Roorda M, van den Brink A, Ruiz LA, Bakker PL, van der Sluis T, Pieters W, Chen M, Wardenaar R, van der Vegt B, Spierings DCJ, de Bruyn M, van Vugt MATM, Foijer F
Nature 2022 Jul;607(7918):366-373. Epub 2022 Jun 15 doi: 10.1038/s41586-022-04847-2. PMID: 35705809
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer.
Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR
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Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression.
Song M, He J, Pan QZ, Yang J, Zhao J, Zhang YJ, Huang Y, Tang Y, Wang Q, He J, Gu J, Li Y, Chen S, Zeng J, Zhou ZQ, Yang C, Han Y, Chen H, Xiang T, Weng DS, Xia JC
Hepatology 2021 May;73(5):1717-1735. doi: 10.1002/hep.31792. PMID: 33682185
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Luan HH, Wang A, Hilliard BK, Carvalho F, Rosen CE, Ahasic AM, Herzog EL, Kang I, Pisani MA, Yu S, Zhang C, Ring AM, Young LH, Medzhitov R
Cell 2019 Aug 22;178(5):1231-1244.e11. Epub 2019 Aug 8 doi: 10.1016/j.cell.2019.07.033. PMID: 31402172Free PMC Article

Clinical prediction guides

Infection and chronic disease activate a systemic brain-muscle signaling axis.
Yang S, Tian M, Dai Y, Wang R, Yamada S, Feng S, Wang Y, Chhangani D, Ou T, Li W, Guo X, McAdow J, Rincon-Limas DE, Yin X, Tai W, Cheng G, Johnson A
Sci Immunol 2024 Jul 12;9(97):eadm7908. doi: 10.1126/sciimmunol.adm7908. PMID: 38996009
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J Hepatol 2021 Feb;74(2):380-393. Epub 2020 Sep 9 doi: 10.1016/j.jhep.2020.08.033. PMID: 32916216
Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications.
Weiskirchen R, Weiskirchen S, Tacke F
Mol Aspects Med 2019 Feb;65:2-15. Epub 2018 Jun 30 doi: 10.1016/j.mam.2018.06.003. PMID: 29958900
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.
Incalza MA, D'Oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F
Vascul Pharmacol 2018 Jan;100:1-19. Epub 2017 Jun 1 doi: 10.1016/j.vph.2017.05.005. PMID: 28579545
Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J
Nat Immunol 2010 Feb;11(2):136-40. Epub 2009 Dec 20 doi: 10.1038/ni.1831. PMID: 20023662

Recent systematic reviews

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Braddock M, Hanania NA, Sharafkhaneh A, Colice G, Carlsson M
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Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis.
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