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Leukemia, Philadelphia chromosome-positive, resistant to imatinib

MedGen UID:
864833
Concept ID:
C4016396
Finding
Synonym: LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
 
OMIM®: 189980

Professional guidelines

PubMed

Roskoski R Jr
Pharmacol Res 2022 Apr;178:106156. Epub 2022 Mar 4 doi: 10.1016/j.phrs.2022.106156. PMID: 35257901
Saini L, Brandwein J
Curr Hematol Malig Rep 2017 Apr;12(2):136-142. doi: 10.1007/s11899-017-0372-3. PMID: 28243848
Maino E, Sancetta R, Viero P, Imbergamo S, Scattolin AM, Vespignani M, Bassan R
Expert Rev Anticancer Ther 2014 Jun;14(6):723-40. Epub 2014 Mar 10 doi: 10.1586/14737140.2014.895669. PMID: 24611626

Recent clinical studies

Etiology

Jabbour E, Kantarjian HM, Aldoss I, Montesinos P, Leonard JT, Gómez-Almaguer D, Baer MR, Gambacorti-Passerini C, McCloskey J, Minami Y, Papayannidis C, Rocha V, Rousselot P, Vachhani P, Wang ES, Wang B, Hennessy M, Vorog A, Patel N, Yeh T, Ribera JM
JAMA 2024 Jun 4;331(21):1814-1823. doi: 10.1001/jama.2024.4783. PMID: 38722621Free PMC Article
Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, Chang BH, Mullighan C, Iacobucci I, Silverman LB, Borowitz MJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy SL, Merchant T, Brown VI, Sieger L, Siegel MJ, Raetz EA, Winick NJ, Loh ML, Carroll WL, Hunger SP
J Clin Oncol 2018 Aug 1;36(22):2306-2314. Epub 2018 May 29 doi: 10.1200/JCO.2017.76.7228. PMID: 29812996Free PMC Article
Yilmaz M, Kantarjian H, Ravandi-Kashani F, Short NJ, Jabbour E
Clin Adv Hematol Oncol 2018 Mar;16(3):216-223. PMID: 29742077
Saini L, Brandwein J
Curr Hematol Malig Rep 2017 Apr;12(2):136-142. doi: 10.1007/s11899-017-0372-3. PMID: 28243848
Lindauer M, Hochhaus A
Recent Results Cancer Res 2010;184:83-102. doi: 10.1007/978-3-642-01222-8_7. PMID: 20072833

Diagnosis

Jabbour E, Kantarjian HM, Aldoss I, Montesinos P, Leonard JT, Gómez-Almaguer D, Baer MR, Gambacorti-Passerini C, McCloskey J, Minami Y, Papayannidis C, Rocha V, Rousselot P, Vachhani P, Wang ES, Wang B, Hennessy M, Vorog A, Patel N, Yeh T, Ribera JM
JAMA 2024 Jun 4;331(21):1814-1823. doi: 10.1001/jama.2024.4783. PMID: 38722621Free PMC Article
Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, Chang BH, Mullighan C, Iacobucci I, Silverman LB, Borowitz MJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy SL, Merchant T, Brown VI, Sieger L, Siegel MJ, Raetz EA, Winick NJ, Loh ML, Carroll WL, Hunger SP
J Clin Oncol 2018 Aug 1;36(22):2306-2314. Epub 2018 May 29 doi: 10.1200/JCO.2017.76.7228. PMID: 29812996Free PMC Article
Cortes JE, Gambacorti-Passerini C, Deininger MW, Mauro MJ, Chuah C, Kim DW, Dyagil I, Glushko N, Milojkovic D, le Coutre P, Garcia-Gutierrez V, Reilly L, Jeynes-Ellis A, Leip E, Bardy-Bouxin N, Hochhaus A, Brümmendorf TH
J Clin Oncol 2018 Jan 20;36(3):231-237. Epub 2017 Nov 1 doi: 10.1200/JCO.2017.74.7162. PMID: 29091516Free PMC Article
Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, De Propris MS, Elia L, Paoloni F, Fazi P, Cimino G, Nobile F, Ferrara F, Castagnola C, Sica S, Leoni P, Zuffa E, Fozza C, Luppi M, Candoni A, Iacobucci I, Soverini S, Mandelli F, Martinelli G, Baccarani M; GIMEMA Acute Leukemia Working Party
Blood 2011 Dec 15;118(25):6521-8. Epub 2011 Sep 19 doi: 10.1182/blood-2011-05-351403. PMID: 21931113
Ravandi F, O'Brien S, Thomas D, Faderl S, Jones D, Garris R, Dara S, Jorgensen J, Kebriaei P, Champlin R, Borthakur G, Burger J, Ferrajoli A, Garcia-Manero G, Wierda W, Cortes J, Kantarjian H
Blood 2010 Sep 23;116(12):2070-7. Epub 2010 May 13 doi: 10.1182/blood-2009-12-261586. PMID: 20466853Free PMC Article

Therapy

Jabbour E, Kantarjian HM, Aldoss I, Montesinos P, Leonard JT, Gómez-Almaguer D, Baer MR, Gambacorti-Passerini C, McCloskey J, Minami Y, Papayannidis C, Rocha V, Rousselot P, Vachhani P, Wang ES, Wang B, Hennessy M, Vorog A, Patel N, Yeh T, Ribera JM
JAMA 2024 Jun 4;331(21):1814-1823. doi: 10.1001/jama.2024.4783. PMID: 38722621Free PMC Article
Lindauer M, Hochhaus A
Recent Results Cancer Res 2018;212:29-68. doi: 10.1007/978-3-319-91439-8_2. PMID: 30069624
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
Ostendorf BN, le Coutre P, Kim TD, Quintás-Cardama A
Recent Results Cancer Res 2014;201:67-80. doi: 10.1007/978-3-642-54490-3_3. PMID: 24756785
Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, De Propris MS, Elia L, Paoloni F, Fazi P, Cimino G, Nobile F, Ferrara F, Castagnola C, Sica S, Leoni P, Zuffa E, Fozza C, Luppi M, Candoni A, Iacobucci I, Soverini S, Mandelli F, Martinelli G, Baccarani M; GIMEMA Acute Leukemia Working Party
Blood 2011 Dec 15;118(25):6521-8. Epub 2011 Sep 19 doi: 10.1182/blood-2011-05-351403. PMID: 21931113

Prognosis

Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, Chang BH, Mullighan C, Iacobucci I, Silverman LB, Borowitz MJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy SL, Merchant T, Brown VI, Sieger L, Siegel MJ, Raetz EA, Winick NJ, Loh ML, Carroll WL, Hunger SP
J Clin Oncol 2018 Aug 1;36(22):2306-2314. Epub 2018 May 29 doi: 10.1200/JCO.2017.76.7228. PMID: 29812996Free PMC Article
Yilmaz M, Kantarjian H, Ravandi-Kashani F, Short NJ, Jabbour E
Clin Adv Hematol Oncol 2018 Mar;16(3):216-223. PMID: 29742077
Ravandi F
Clin Lymphoma Myeloma Leuk 2011 Apr;11(2):198-203. Epub 2011 Apr 8 doi: 10.1016/j.clml.2011.03.002. PMID: 21575924Free PMC Article
Lee HJ, Thompson JE, Wang ES, Wetzler M
Cancer 2011 Apr 15;117(8):1583-94. Epub 2010 Nov 8 doi: 10.1002/cncr.25690. PMID: 21472706
Lindauer M, Hochhaus A
Recent Results Cancer Res 2010;184:83-102. doi: 10.1007/978-3-642-01222-8_7. PMID: 20072833

Clinical prediction guides

Brattås MK, Reikvam H, Tvedt THA, Bruserud Ø
Expert Opin Investig Drugs 2019 May;28(5):411-420. Epub 2019 Apr 5 doi: 10.1080/13543784.2019.1597052. PMID: 30916583
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
Korashy HM, Rahman AF, Kassem MG
Profiles Drug Subst Excip Relat Methodol 2014;39:205-37. doi: 10.1016/B978-0-12-800173-8.00004-0. PMID: 24794907
Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, De Propris MS, Elia L, Paoloni F, Fazi P, Cimino G, Nobile F, Ferrara F, Castagnola C, Sica S, Leoni P, Zuffa E, Fozza C, Luppi M, Candoni A, Iacobucci I, Soverini S, Mandelli F, Martinelli G, Baccarani M; GIMEMA Acute Leukemia Working Party
Blood 2011 Dec 15;118(25):6521-8. Epub 2011 Sep 19 doi: 10.1182/blood-2011-05-351403. PMID: 21931113
Shah NP
Drugs Today (Barc) 2007 Jan;43(1):5-12. doi: 10.1358/dot.2007.43.1.1050791. PMID: 17315048

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