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Spondyloarthropathy, susceptibility to, 2(SPDA2)

MedGen UID:
355791
•Concept ID:
C1866738
•
Disease or Syndrome
Synonym: Spondyloarthropathy 2
 
Monarch Initiative: MONDO:0008468
OMIM®: 183840

Clinical features

From HPO
Abnormal joint morphology
MedGen UID:
893053
•Concept ID:
C0240083
•
Finding
An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join.
See: Feature record | Search on this feature
Abnormality of metabolism/homeostasis
MedGen UID:
867398
•Concept ID:
C4021768
•
Finding
See: Feature record | Search on this feature
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Professional guidelines

PubMed

The Interplay Between COVID-19 and Spondyloarthritis or Its Treatment.
Rosenbaum JT, Weisman MH, Hamilton H, Shafer C, Aslanyan E, Howard RA, Ogle K, Reveille JD, Winthrop KL, Choi D
J Rheumatol 2022 Feb;49(2):225-229. Epub 2021 Oct 1 doi: 10.3899/jrheum.210742. PMID: 34599048
An update on the diagnosis and management of psoriatic arthritis.
Weger W
G Ital Dermatol Venereol 2011 Feb;146(1):1-8. PMID: 21317852
Insights into the pathology and treatment of spondyloarthritis: from the bench to the clinic.
Davis JC Jr, Mease PJ
Semin Arthritis Rheum 2008 Oct;38(2):83-100. Epub 2007 Dec 31 doi: 10.1016/j.semarthrit.2007.10.007. PMID: 18166219

Recent clinical studies

Therapy

Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial.
Haberman RH, MacFarlane KA, Catron S, Samuels J, Blank RB, Toprover M, Uddin Z, Hu J, Castillo R, Gong C, Qian K, Piguet V, Tausk F, Yeung J, Neimann AL, Gulliver W, Thiele RG, Merola JF, Ogdie A, Rahman P, Chakravarty SD, Eder L, Ritchlin CT, Scher JU
BMJ Open 2022 Dec 23;12(12):e063650. doi: 10.1136/bmjopen-2022-063650. PMID: 36564123Free PMC Article
Interleukin 1 gene polymorphism and susceptibility to disease.
Khazim K, Azulay EE, Kristal B, Cohen I
Immunol Rev 2018 Jan;281(1):40-56. doi: 10.1111/imr.12620. PMID: 29247999
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.
Lee YH, Song GG
Clin Rheumatol 2016 Aug;35(8):2009-2015. Epub 2016 Apr 25 doi: 10.1007/s10067-016-3287-9. PMID: 27108589
Update on spondyloarthropathies.
Khan MA
Ann Intern Med 2002 Jun 18;136(12):896-907. doi: 10.7326/0003-4819-136-12-200206180-00011. PMID: 12069564

Prognosis

Biology of HLA class I associated inflammatory diseases.
Bordbar A, Manches O, Nowatzky J
Best Pract Res Clin Rheumatol 2024 May;38(2):101977. Epub 2024 Jul 31 doi: 10.1016/j.berh.2024.101977. PMID: 39085016Free PMC Article
Plasma proteins and psoriatic arthritis: a proteome-wide Mendelian randomization study.
Zhao H, Zhou Y, Wang Z, Zhang X, Chen L, Hong Z
Front Immunol 2024;15:1417564. Epub 2024 Jul 4 doi: 10.3389/fimmu.2024.1417564. PMID: 39026678Free PMC Article
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Genetics of spondyloarthritis--beyond the MHC.
Reveille JD
Nat Rev Rheumatol 2012 Apr 10;8(5):296-304. doi: 10.1038/nrrheum.2012.41. PMID: 22487796
Spondyloarthropathies: progress and challenges.
Jacques P, Mielants H, De Vos M, Elewaut D
Best Pract Res Clin Rheumatol 2008 Apr;22(2):325-37. doi: 10.1016/j.berh.2008.01.011. PMID: 18455688

Clinical prediction guides

Plasma proteins and psoriatic arthritis: a proteome-wide Mendelian randomization study.
Zhao H, Zhou Y, Wang Z, Zhang X, Chen L, Hong Z
Front Immunol 2024;15:1417564. Epub 2024 Jul 4 doi: 10.3389/fimmu.2024.1417564. PMID: 39026678Free PMC Article
Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.
Khrom M, Long M, Dube S, Robbins L, Botwin GJ, Yang S, Mengesha E, Li D, Naito T, Bonthala NN, Ha C, Melmed G, Rabizadeh S, Syal G, Vasiliauskas E, Ziring D, Brant SR, Cho J, Duerr RH, Rioux J, Schumm P, Silverberg M, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Xavier RJ, Kugathasan S, Hercules D, Targan SR, Sartor RB, Haritunians T, McGovern DPB
Gastroenterology 2024 Jul;167(2):315-332. Epub 2024 Mar 13 doi: 10.1053/j.gastro.2024.02.026. PMID: 38490347Free PMC Article
Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial.
Haberman RH, MacFarlane KA, Catron S, Samuels J, Blank RB, Toprover M, Uddin Z, Hu J, Castillo R, Gong C, Qian K, Piguet V, Tausk F, Yeung J, Neimann AL, Gulliver W, Thiele RG, Merola JF, Ogdie A, Rahman P, Chakravarty SD, Eder L, Ritchlin CT, Scher JU
BMJ Open 2022 Dec 23;12(12):e063650. doi: 10.1136/bmjopen-2022-063650. PMID: 36564123Free PMC Article
Genetics of ankylosing spondylitis--insights into pathogenesis.
Brown MA, Kenna T, Wordsworth BP
Nat Rev Rheumatol 2016 Feb;12(2):81-91. Epub 2015 Oct 6 doi: 10.1038/nrrheum.2015.133. PMID: 26439405
The genetics of psoriasis.
Elder JT, Nair RP, Guo SW, Henseler T, Christophers E, Voorhees JJ
Arch Dermatol 1994 Feb;130(2):216-24. PMID: 8304761

Recent systematic reviews

The relationship between vitamin D receptor gene polymorphisms and ankylosing spondylitis: a systematic review, meta-analysis and trial sequential analysis.
Zhou H, Zhou BY, Liang SR, Li M, Zhao J
Rheumatol Int 2023 Jan;43(1):21-32. Epub 2022 Aug 23 doi: 10.1007/s00296-022-05189-y. PMID: 35999389
Relationship Between IL1 Gene Polymorphism and Susceptibility to Ankylosing Spondylitis: An Updated and Supplemented Meta-Analysis.
Gao M, Li T, Song Z, Wang X, Zhang X, Liu W
Biochem Genet 2022 Jun;60(3):1025-1038. Epub 2021 Nov 11 doi: 10.1007/s10528-021-10149-5. PMID: 34762200
Association between cytokine gene polymorphisms and ankylosing spondylitis susceptibility: a systematic review and meta-analysis.
Xia Y, Liang Y, Guo S, Yu JG, Tang MS, Xu PH, Qin FD, Wang GP
Postgrad Med J 2018 Sep;94(1115):508-516. Epub 2018 Oct 15 doi: 10.1136/postgradmedj-2018-135665. PMID: 30322951
Genetic association between TAP1 and TAP2 polymorphisms and ankylosing spondylitis: a systematic review and meta-analysis.
Qian Y, Wang G, Xue F, Chen L, Wang Y, Tang L, Yang H
Inflamm Res 2017 Aug;66(8):653-661. Epub 2017 Apr 12 doi: 10.1007/s00011-017-1047-1. PMID: 28405734
The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review.
Chen S, Li Y, Deng C, Li J, Wen X, Wu Z, Hu C, Zhang S, Li P, Zhang X, Zhang F, Li Y
Rheumatol Int 2016 Jan;36(1):33-44. Epub 2015 Aug 1 doi: 10.1007/s00296-015-3327-9. PMID: 26232179

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